Title:
METHOD FOR PRODUCING AROMATIC ASTATINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2021/167008
Kind Code:
A1
Abstract:
This method for producing an aromatic astatine compound comprises reacting aromatic iodonium ylide with astatine to produce an aromatic astatine compound.
Inventors:
MATSUNAGA SHIGEKI (JP)
YOSHINO TATSUHIKO (JP)
MATSUOKA KEITARO (JP)
OGAWA MIKAKO (JP)
YOSHINO TATSUHIKO (JP)
MATSUOKA KEITARO (JP)
OGAWA MIKAKO (JP)
Application Number:
PCT/JP2021/006133
Publication Date:
August 26, 2021
Filing Date:
February 18, 2021
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
C07B59/00; C07C45/63; C07C49/697; C07C67/307; C07C69/712; C07C269/06; C07C271/22; C07D209/48; C07D215/18; C07D261/20; C07D333/62; C07J1/00
Domestic Patent References:
| WO2011095517A1 | 2011-08-11 | |||
| WO2019027059A1 | 2019-02-07 | |||
| WO2019192912A1 | 2019-10-10 |
Foreign References:
| JP2018536031A | 2018-12-06 | |||
| JP2017504658A | 2017-02-09 | |||
| US20170121300A1 | 2017-05-04 | |||
| JP2017529312A | 2017-10-05 | |||
| JP2020028536A | 2020-02-27 |
Other References:
GURARD FRANÅOIS, LEE YONG-SOK, OI JEAN-FRAN, GESTIN Å S, BRECHBIEL MARTIN W: "& Astatine | Hot Paper| Unexpected Behavior of the Heaviest Halogen Astatine in the Nucleophilic Substitution of Aryliodonium Salts", CHEMISTRY, A EUROPEAN JOURNAL, vol. 22, 15 January 2016 (2016-01-15), pages 12332 - 12339, XP055850107, DOI: 10.1002/chem.201600922
GUÉRARD F.; NAVARRO L.; LEE Y.-S.; ROUMESY A.; ALLIOT C.; CHÉREL M.; BRECHBIEL M.W.; GESTIN J.-F.: "Bifunctional aryliodonium salts for highly efficient radioiodination and astatination of antibodies", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 25, no. 21, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 5975 - 5980, XP085244117, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.09.022
ROTSTEIN BENJAMIN H., STEPHENSON NICKEISHA A., VASDEV NEIL, LIANG STEVEN H.: "Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics", NATURE COMMUNICATIONS, vol. 5, no. 1, 22 September 2014 (2014-09-22), XP055850105, DOI: 10.1038/ncomms5365
MATSUOKA KEITARO, KOMAMI NARUMI, KOJIMA MASAHIRO, YOSHINO TATSUHIKO, MATSUNAGA SHIGEKI: "Synthesis of Heteroaryl Iodanes(III) via ipso ‐Substitution Reactions Using Iodine Triacetate Assisted by HFIP", ASIAN JOURNAL OF ORGANIC CHEMISTRY , 1(2), 160-165 CODEN: AJOCC7; ISSN: 2193-5807, WILEY - V C H VERLAG GMBH & CO. KGAA, GERMANY, vol. 8, no. 7, 1 July 2019 (2019-07-01), Germany, pages 1107 - 1110, XP055850104, ISSN: 2193-5807, DOI: 10.1002/ajoc.201900200
KOMAMI NARUMI, MATSUOKA KEITARO, NAKANO AYAKO, KOJIM MASAHIRO, SHINO TSUHIKO, YO TA, MATSUNAGA SHIGEKI: "Synthesis of Functionalize Monoaryl- d l 3 -iodanes ug thro h Chemo- and Site-Selective -Su titutio ipso bs n Reactions", CHEMISTRY A EUROPEAN JOURNAL, vol. 25, 24 January 2019 (2019-01-24), pages 1217 - 1220, XP055850102, DOI: 10.1002/chem.201805970
FRANCOIS GUERARDYONG-SOK LEEKWAMENA BAIDOOJEAN-FRANCOIS GESTINMARTIN W. BRECHBIEL, CHEM, EUR, J., vol. 22, 2016, pages 12332 - 12339
SEAN W. REILLYMEHRAN MAKVANDIKUIYING XUROBERT MACH, ORG. LETT., vol. 20, 2018, pages 1752 - 1755
BENJAMIN H. ROTSTEINNICKEISHA A. STEPHENSONNEIL VASDEVSTEVEN H. LIANG, NATURE COMMUNICATIONS, 2014, pages 4365
KEITARO MATSUOKANARUMI KOMAMIMASAHIRO KOJIMATATSUHIKO YOSHINOSHIGEKI MATSUNAGA, ASIAN J. ORG. CHEM., vol. 8, 2019, pages 1107 - 1110
NARUMI KOMAMIKEITARO MATSUOKAAYAKO NAKANOMASAHIRO KOJIMATATSUHIKO YOSHINOAND SHIGEKI MATSUNAGA, CHEM. EUR. J., vol. 25, 2019, pages 1217 - 1220
SYNTHESIS, vol. 50, 2018, pages 206
KOTARO NAGATSUKATSUYUKI MINEGISHIMASAMI FUKUDAHISASHI SUZUKISUMITAKA HASEGAWAMING-RONG ZHANG: "Production of At by a vertical beam irradiation method", APPLIED RADIATION AND ISOTOPES, vol. 94, 2014, pages 363 - 371
KOTARO NAGATSUKATSUYUKI MINEGISHIMASAMI FUKUDAHISASHI SUZUKISUMITAKA HASEGAWAMING-RONG ZHANG: "Production of At by a vertical beam irradiation method", APPLIED RADIATION AND ISOTOPE, vol. 94, 2014, pages 363 - 371
See also references of EP 4108648A4
GUÉRARD F.; NAVARRO L.; LEE Y.-S.; ROUMESY A.; ALLIOT C.; CHÉREL M.; BRECHBIEL M.W.; GESTIN J.-F.: "Bifunctional aryliodonium salts for highly efficient radioiodination and astatination of antibodies", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 25, no. 21, 1 January 1900 (1900-01-01), AMSTERDAM, NL, pages 5975 - 5980, XP085244117, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.09.022
ROTSTEIN BENJAMIN H., STEPHENSON NICKEISHA A., VASDEV NEIL, LIANG STEVEN H.: "Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics", NATURE COMMUNICATIONS, vol. 5, no. 1, 22 September 2014 (2014-09-22), XP055850105, DOI: 10.1038/ncomms5365
MATSUOKA KEITARO, KOMAMI NARUMI, KOJIMA MASAHIRO, YOSHINO TATSUHIKO, MATSUNAGA SHIGEKI: "Synthesis of Heteroaryl Iodanes(III) via ipso ‐Substitution Reactions Using Iodine Triacetate Assisted by HFIP", ASIAN JOURNAL OF ORGANIC CHEMISTRY , 1(2), 160-165 CODEN: AJOCC7; ISSN: 2193-5807, WILEY - V C H VERLAG GMBH & CO. KGAA, GERMANY, vol. 8, no. 7, 1 July 2019 (2019-07-01), Germany, pages 1107 - 1110, XP055850104, ISSN: 2193-5807, DOI: 10.1002/ajoc.201900200
KOMAMI NARUMI, MATSUOKA KEITARO, NAKANO AYAKO, KOJIM MASAHIRO, SHINO TSUHIKO, YO TA, MATSUNAGA SHIGEKI: "Synthesis of Functionalize Monoaryl- d l 3 -iodanes ug thro h Chemo- and Site-Selective -Su titutio ipso bs n Reactions", CHEMISTRY A EUROPEAN JOURNAL, vol. 25, 24 January 2019 (2019-01-24), pages 1217 - 1220, XP055850102, DOI: 10.1002/chem.201805970
FRANCOIS GUERARDYONG-SOK LEEKWAMENA BAIDOOJEAN-FRANCOIS GESTINMARTIN W. BRECHBIEL, CHEM, EUR, J., vol. 22, 2016, pages 12332 - 12339
SEAN W. REILLYMEHRAN MAKVANDIKUIYING XUROBERT MACH, ORG. LETT., vol. 20, 2018, pages 1752 - 1755
BENJAMIN H. ROTSTEINNICKEISHA A. STEPHENSONNEIL VASDEVSTEVEN H. LIANG, NATURE COMMUNICATIONS, 2014, pages 4365
KEITARO MATSUOKANARUMI KOMAMIMASAHIRO KOJIMATATSUHIKO YOSHINOSHIGEKI MATSUNAGA, ASIAN J. ORG. CHEM., vol. 8, 2019, pages 1107 - 1110
NARUMI KOMAMIKEITARO MATSUOKAAYAKO NAKANOMASAHIRO KOJIMATATSUHIKO YOSHINOAND SHIGEKI MATSUNAGA, CHEM. EUR. J., vol. 25, 2019, pages 1217 - 1220
SYNTHESIS, vol. 50, 2018, pages 206
KOTARO NAGATSUKATSUYUKI MINEGISHIMASAMI FUKUDAHISASHI SUZUKISUMITAKA HASEGAWAMING-RONG ZHANG: "Production of At by a vertical beam irradiation method", APPLIED RADIATION AND ISOTOPES, vol. 94, 2014, pages 363 - 371
KOTARO NAGATSUKATSUYUKI MINEGISHIMASAMI FUKUDAHISASHI SUZUKISUMITAKA HASEGAWAMING-RONG ZHANG: "Production of At by a vertical beam irradiation method", APPLIED RADIATION AND ISOTOPE, vol. 94, 2014, pages 363 - 371
See also references of EP 4108648A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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