Title:
METHOD FOR PRODUCING ARYL COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2002026665
Kind Code:
A3
Abstract:
Aryl compositions are advantageously produced by carrying out a cross-coupling reaction of a substituted aryl compound with a Grignard reagent and concurrent nickel catalysis. The inventive method is further characterized by using substituted aryl compounds and a novel nickel catalyst and slowly adding the Grignard reagent when the reaction temperature is reached.
Inventors:
ECKERT MARKUS (DE)
GIFFELS GUIDO (DE)
MILITZER HANS-CHRISTIAN (DE)
PRINZ THOMAS (DE)
GIFFELS GUIDO (DE)
MILITZER HANS-CHRISTIAN (DE)
PRINZ THOMAS (DE)
Application Number:
PCT/EP2001/010558
Publication Date:
November 07, 2002
Filing Date:
September 13, 2001
Export Citation:
Assignee:
BAYER AG (DE)
ECKERT MARKUS (DE)
GIFFELS GUIDO (DE)
MILITZER HANS-CHRISTIAN (DE)
PRINZ THOMAS (DE)
ECKERT MARKUS (DE)
GIFFELS GUIDO (DE)
MILITZER HANS-CHRISTIAN (DE)
PRINZ THOMAS (DE)
International Classes:
B01J23/755; B01J37/02; C07B37/04; (IPC1-7): B01J23/755; C07B37/04
Foreign References:
| EP0262389A1 | 1988-04-06 |
Other References:
LIPSHUTZ ET AL-: "Kumada couplings catalyzed by nickel on charcoal (Ni/C)", INORG. CHIM. ACTA, vol. 296, 1999, pages 164 - 9, XP002194453
TAMAO K ET AL: "NICKEL-PHOSPHINE COMPLEX-CATALYZED GRIGNARD COUPLING. I. CROSS-COUPLING OF ALKYL, ARYL, AND ALKENYL GRIGNARD REAGENTS WITH ARYL AND ALKENYL HALIDES: GENERAL SCOPE AND LIMITATIONS", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, JAPAN PUBLICATIONS TRADING CO. TOKYO, JP, vol. 49, no. 7, July 1976 (1976-07-01), pages 1958 - 1969, XP000996380, ISSN: 0009-2673
IKOMA Y ET AL.: "Non-ligated Nickel Chloride-Catalyzed Cross-Coupling of Aromatic Grignard Reagents with Aryl Halides", SYNTHESIS, 1990, pages 147 - 8, XP002194436
GANDIA L.M., MONTES M.: "Effect of Thermal Treatments on the Properties of Nickel and Cobalt Activated-Charcoal-Supported Catalysts", J. CATAL., vol. 145, 1994, pages 276 - 288, XP002194527
LIPSHUTZ B.H.: "Development of Nickel-on-Charcoal as a "dirt-Cheap" Heterogeneous Catalyst: A Personal Account", ADV. SYNTH. CATAL., vol. 343, no. 4, 8 June 2001 (2001-06-08), XP002194454
TAMAO K ET AL: "NICKEL-PHOSPHINE COMPLEX-CATALYZED GRIGNARD COUPLING. I. CROSS-COUPLING OF ALKYL, ARYL, AND ALKENYL GRIGNARD REAGENTS WITH ARYL AND ALKENYL HALIDES: GENERAL SCOPE AND LIMITATIONS", BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, JAPAN PUBLICATIONS TRADING CO. TOKYO, JP, vol. 49, no. 7, July 1976 (1976-07-01), pages 1958 - 1969, XP000996380, ISSN: 0009-2673
IKOMA Y ET AL.: "Non-ligated Nickel Chloride-Catalyzed Cross-Coupling of Aromatic Grignard Reagents with Aryl Halides", SYNTHESIS, 1990, pages 147 - 8, XP002194436
GANDIA L.M., MONTES M.: "Effect of Thermal Treatments on the Properties of Nickel and Cobalt Activated-Charcoal-Supported Catalysts", J. CATAL., vol. 145, 1994, pages 276 - 288, XP002194527
LIPSHUTZ B.H.: "Development of Nickel-on-Charcoal as a "dirt-Cheap" Heterogeneous Catalyst: A Personal Account", ADV. SYNTH. CATAL., vol. 343, no. 4, 8 June 2001 (2001-06-08), XP002194454
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