Title:
METHOD FOR PRODUCING BENZYLPYRAZOLE DERIVATIVE AND PRODUCTION INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2012/133783
Kind Code:
A1
Abstract:
A production intermediate of a glucopyranosyloxypyrazole derivative which is represented by general formula (E) (wherein R3 and R4 are as defined below) and is useful as a therapeutic agent for diabetes or the like, and a method for producing a benzylpyrazole derivative, said method being indistrially more advantageous than conventional methods for producing a benzylpyrazole derivative, can be provided by causing a reaction of a compound represented by general formula (D) (wherein each of R1 and R2 represents a C1-6 alkyl group or the like; R3 represents a halogen atom, a C1-6 alkoxy group or the like; and R4 represents a hydrogen atom, a halogen atom, a C1-6 alkoxy group or the like).
Inventors:
AINAI TAKAYUKI (JP)
KOBAYASHI MASAHIRO (JP)
KOBAYASHI MASAHIRO (JP)
Application Number:
PCT/JP2012/058604
Publication Date:
October 04, 2012
Filing Date:
March 30, 2012
Export Citation:
Assignee:
KISSEI PHARMACEUTICAL (JP)
AINAI TAKAYUKI (JP)
KOBAYASHI MASAHIRO (JP)
AINAI TAKAYUKI (JP)
KOBAYASHI MASAHIRO (JP)
International Classes:
C07D317/30; C07D231/20
Domestic Patent References:
| WO2010076524A2 | 2010-07-08 |
Foreign References:
| JP2009502763A | 2009-01-29 |
Other References:
GUILLOU,S. ET AL.: "N-arylation of 3-alkoxypyrazoles, the case of the pyridines", TETRAHEDRON, vol. 66, no. 14, 2010, pages 2654 - 2663, XP026941250, DOI: doi:10.1016/j.tet.2010.02.032
MARTIN,V.A. ET AL.: "Chemistry of aldolate dianions. Effects of p-heteroatom substituents on ketone enolization", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 112, no. 19, 1990, pages 6965 - 6978
MARTIN,V.A. ET AL.: "Chemistry of aldolate dianions. Effects of p-heteroatom substituents on ketone enolization", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 112, no. 19, 1990, pages 6965 - 6978
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Claims: