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Title:
METHOD FOR PRODUCING BICYCLIC COMPOUND VIA CLAISEN REARRANGEMENT
Document Type and Number:
WIPO Patent Application WO/2012/169475
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for producing a compound having excellent activity as an α2δ ligand. The solution involves a method for producing a compound or a salt thereof having the general formula (VI) by using a rearrangement reaction. [In the formula, R1 is a hydrogen atom or a C1-C6 alkyl group.]

Inventors:
NAKAMURA YOSHITAKA
Application Number:
PCT/JP2012/064416
Publication Date:
December 13, 2012
Filing Date:
June 05, 2012
Export Citation:
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Assignee:
DAIICHI SANKYO CO LTD (JP)
NAKAMURA YOSHITAKA
International Classes:
C07C45/48; B01J31/02; C07C45/45; C07C45/51; C07C47/21; C07C49/727; C07C51/38; C07C57/03; C07C227/18; C07C229/32; C07B61/00
Domestic Patent References:
WO2009041453A12009-04-02
WO2010110361A12010-09-30
WO2006075596A12006-07-20
WO2010084798A12010-07-29
WO2010110361A12010-09-30
Foreign References:
EP0287956A21988-10-26
EP0521571A21993-01-07
US20060154929A12006-07-13
US20030220397A12003-11-27
US20040152779A12004-08-05
US20030078300A12003-04-24
US20100249229A12010-09-30
US20100110361A12010-05-06
Other References:
J J BEEREBOOM: "The Cyclization of Geranic Acids. Preparation of a Cyclobutanone", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 30, no. 12, 1965, pages 4230 - 4234, XP055137633
J BIOL. CHEM., vol. 271, no. 10, 1996, pages 5768 - 5776
J MED. CHEM., vol. 41, 1998, pages 1838 - 1845
See also references of EP 2719677A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (JP)
Kimiki Ishibashi (JP)
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