Title:
METHOD FOR PRODUCING BUTANEDIOL
Document Type and Number:
WIPO Patent Application WO/2014/045781
Kind Code:
A1
Abstract:
This method for producing a butanediol includes a step for culturing a microbe containing genes coding for: an acetoacetyl-CoA synthase that catalyzes a reaction that irreversibly generates acetoacetyl-CoA from acetyl-CoA and malonyl-CoA; an acetoacetyl-CoA reductase that catalyzes a reaction that generates 3-hydroxybutyryl-CoA from acetoacetyl-CoA; and an enzyme that catalyzes a reaction for generating a butanediol from 3-hydroxybutyryl-CoA.
Inventors:
AOKI HIROBUMI (JP)
KOKIDO YUZURU (JP)
YONEDA TADASHI (JP)
KOKIDO YUZURU (JP)
YONEDA TADASHI (JP)
Application Number:
PCT/JP2013/072186
Publication Date:
March 27, 2014
Filing Date:
August 20, 2013
Export Citation:
Assignee:
SHOWA DENKO KK (JP)
International Classes:
C12N15/09; C12P7/18
Domestic Patent References:
| WO2011052718A1 | 2011-05-05 | |||
| WO2010127319A2 | 2010-11-04 | |||
| WO2011071682A1 | 2011-06-16 | |||
| WO2010141920A2 | 2010-12-09 |
Foreign References:
| JP2012501678A | 2012-01-26 | |||
| JP2011509691A | 2011-03-31 | |||
| JP2012511928A | 2012-05-31 | |||
| JP2010259388A | 2010-11-18 | |||
| JP4380704B2 | 2009-12-09 | |||
| JP2008115840A | 2008-05-22 | |||
| JP2010127319A | 2010-06-10 |
Other References:
WAKIL,SI. ET AL.: "Fatty acid metabolism and ketone body formation.", METABOLISM, vol. 11, 1962, pages 742 - 761, XP008178922
GERHARDT,A. ET AL.: "Fermentation of 4-aminobutyrate by Clostridium aminobutyricum: cloning of two genes involved in the formation and dehydration of 4-hydroxybutyryl-CoA.", ARCH MICROBIOL., vol. 174, 2000, pages 189 - 199, XP008109904
HARRY YIM ET AL.: "Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol", NATURE CHEMICAL BIOLOGY, vol. 7, 2011, pages 445 - 452
"Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway.", PROC. NATL. ACAD. SCI., U. S. A., vol. 107, 2010, pages 11265 - 11270
"Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 68, 2005, pages 498 - 504
"Poly-beta-hydroxybutyrate biosynthesis in Alcaligenes eutrophus H16. Characterization of the genes encoding beta-ketothiolase and acetoacetyl-CoA reductase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 264, 1989, pages 15293 - 15297
FRIEDRICH P; DARLEY DJ; GOLDING BT; BUCKEL W.: "The complete stereochemistry of the enzymatic dehydration of 4-hydroxybutyryl coenzyme A to crotonyl coenzyme. A.", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 47, no. 17, 2008, pages 3254 - 3257
MOSKOWITZ GJ; MERRICK JM: "Metabolism of poly-beta-hydroxybutyrate. II. Enzymatic synthesis of D-(-)-beta hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum.", JOURNAL BIOCHEMISTRY, vol. 8, 1969, pages 2748 - 2755
"Fermentation of 4-aminobutyrate by Clostridium aminobutyricum: cloning of two genes involved in the formation and dehydration of 4-hydroxybutyryl-CoA", ARCHIVES OF MICROBIOLOGY, vol. 174, no. 3, 2000, pages 189 - 199
JOSEPH SAMBROOK; DAVID W. RUSSELL: "Molecular Cloning - A LABORATORY MANUAL, 3rd ed.", COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 2899270A4
GERHARDT,A. ET AL.: "Fermentation of 4-aminobutyrate by Clostridium aminobutyricum: cloning of two genes involved in the formation and dehydration of 4-hydroxybutyryl-CoA.", ARCH MICROBIOL., vol. 174, 2000, pages 189 - 199, XP008109904
HARRY YIM ET AL.: "Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol", NATURE CHEMICAL BIOLOGY, vol. 7, 2011, pages 445 - 452
"Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway.", PROC. NATL. ACAD. SCI., U. S. A., vol. 107, 2010, pages 11265 - 11270
"Efficient production of (2S)-flavanones by Escherichia coli containing an artificial biosynthetic gene cluster", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 68, 2005, pages 498 - 504
"Poly-beta-hydroxybutyrate biosynthesis in Alcaligenes eutrophus H16. Characterization of the genes encoding beta-ketothiolase and acetoacetyl-CoA reductase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 264, 1989, pages 15293 - 15297
FRIEDRICH P; DARLEY DJ; GOLDING BT; BUCKEL W.: "The complete stereochemistry of the enzymatic dehydration of 4-hydroxybutyryl coenzyme A to crotonyl coenzyme. A.", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 47, no. 17, 2008, pages 3254 - 3257
MOSKOWITZ GJ; MERRICK JM: "Metabolism of poly-beta-hydroxybutyrate. II. Enzymatic synthesis of D-(-)-beta hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum.", JOURNAL BIOCHEMISTRY, vol. 8, 1969, pages 2748 - 2755
"Fermentation of 4-aminobutyrate by Clostridium aminobutyricum: cloning of two genes involved in the formation and dehydration of 4-hydroxybutyryl-CoA", ARCHIVES OF MICROBIOLOGY, vol. 174, no. 3, 2000, pages 189 - 199
JOSEPH SAMBROOK; DAVID W. RUSSELL: "Molecular Cloning - A LABORATORY MANUAL, 3rd ed.", COLD SPRING HARBOR LABORATORY PRESS
See also references of EP 2899270A4
Attorney, Agent or Firm:
ITOH, Tadashige et al. (JP)
Tadashige Ito (JP)
Tadashige Ito (JP)
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