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Title:
METHOD FOR PRODUCING CALCIUM SALT OF 1, 5-BENZODIAZEPINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/008569
Kind Code:
A1
Abstract:
Provided is an industrially advantageous method for producing a compound (1), specifically a compound (1) in an amorphous form. A method for producing a calcium salt of a 1, 5-benzodiazepine compound represented by formula (1), which is characterized in that a compound represented by formula (5) is reacted with an alkali metal hydroxide in isopropyl alcohol, and subsequently an aqueous calcium chloride solution is added thereto for further reaction. (In formula (5), R1 represents a tert-butyl group; and R2 represents a cyclohexyl group.) (In formula (1), R1 and R2 are as defined above.)

Inventors:
NAKAO RYU (JP)
Application Number:
PCT/JP2017/024278
Publication Date:
January 11, 2018
Filing Date:
July 03, 2017
Export Citation:
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Assignee:
ZERIA PHARM CO LTD (JP)
International Classes:
C07D243/12; A61K31/551; A61P1/00; A61P1/04; A61P29/00; A61P29/02; A61P35/00; A61P43/00
Domestic Patent References:
WO2001040197A12001-06-07
WO1998025911A11998-06-18
WO2010113458A12010-10-07
Foreign References:
JP2004516311A2004-06-03
JP2000026434A2000-01-25
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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