Title:
METHOD FOR PRODUCING CELL AGGREGATES
Document Type and Number:
WIPO Patent Application WO/2024/034559
Kind Code:
A1
Abstract:
The present invention provides a method for mass producing cell aggregates such as artificial organoids through an approach that differs entirely from previous methods. Specifically, provided is a method for producing cell aggregates that includes a step in which a mixture of mesenchymal stem cells, vascular endothelial cells, and organ cells are filled into microfibers, and the mixture is suspension cultured to form cell aggregates.
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Inventors:
INAMORI MASAKAZU (JP)
HINO MOTOHIRO (JP)
AMIMOTO NAOKI (JP)
TATSUMI RIE (JP)
IKEDA KAZUHIRO (JP)
TANIGUCHI HIDEKI (JP)
OKAMOTO SATOSHI (JP)
HINO MOTOHIRO (JP)
AMIMOTO NAOKI (JP)
TATSUMI RIE (JP)
IKEDA KAZUHIRO (JP)
TANIGUCHI HIDEKI (JP)
OKAMOTO SATOSHI (JP)
Application Number:
PCT/JP2023/028720
Publication Date:
February 15, 2024
Filing Date:
August 07, 2023
Export Citation:
Assignee:
HEALIOS KK (JP)
CELLFIBER CO LTD (JP)
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
CELLFIBER CO LTD (JP)
PUBLIC UNIV CORP YOKOHAMA CITY UNIV (JP)
International Classes:
C12N5/071; A61K35/28; A61K35/407; A61K35/44; A61K35/545; A61L27/38; A61P1/16; A61P43/00; C12N5/0775
Domestic Patent References:
| WO2019189324A1 | 2019-10-03 | |||
| WO2021221179A1 | 2021-11-04 |
Foreign References:
| JP2014236698A | 2014-12-18 | |||
| US20200115677A1 | 2020-04-16 |
Other References:
MIZUMOTO, HIROSHI, KAJIWARA, TOSHIHISA: " Hepatic Differentiation of Embryonic Stem Cells Using Hollow Fibers as a Scaffold and Its Application to a Bioartificial Liver. ", MEMBRAME, KITAMI SHOBO, TOKYO., JP, vol. 37, no. 3, 1 January 2012 (2012-01-01), JP , pages 125 - 131, XP009552570, ISSN: 0385-1036, DOI: 10.5360/membrane.37.125
OHASHI, KAZUO: "Development of liver failure treatment using microfiber liver organoid transplants", R&D REPORT, KAKENHI GRANTS-IN-AID FOR SCIENTIFIC RESEARCH, 16K01355, 2020, pages 2 - 4
TANIGUCHI, HIDEKI: " Artificial livers: Technology for creating human liver organoids.", JINKO ZOKI, IJI TSUSHINSHA, TOKYO,, JP, vol. 45, no. 3, 1 January 2016 (2016-01-01), JP , pages 179 - 182, XP009552492, ISSN: 0300-0818
OHASHI, KAZUO: "Development of liver failure treatment using microfiber liver organoid transplants", R&D REPORT, KAKENHI GRANTS-IN-AID FOR SCIENTIFIC RESEARCH, 16K01355, 2020, pages 2 - 4
TANIGUCHI, HIDEKI: " Artificial livers: Technology for creating human liver organoids.", JINKO ZOKI, IJI TSUSHINSHA, TOKYO,, JP, vol. 45, no. 3, 1 January 2016 (2016-01-01), JP , pages 179 - 182, XP009552492, ISSN: 0300-0818
Attorney, Agent or Firm:
MURAOKA, Koichiro et al. (JP)
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