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Title:
METHOD OF PRODUCING CHEMICAL PRODUCT AND CONTINUOUS FERMENTATION APPARATUS
Document Type and Number:
WIPO Patent Application WO/2007/097260
Kind Code:
A1
Abstract:
A method of producing a chemical product via continuous fermentation, which comprises filtering a liquid culture medium of a microorganism or cultured cells through a separation membrane, collecting the product from the filtrate, keeping the unfiltered liquid in the liquid culture medium or refluxing thereinto and additionally supplying the material to be fermented into the liquid culture medium, wherein a porous membrane having an average pore size of 0.01 μm or more but less than 1 μm is employed as the separation membrane and the filtration is carried out at an intermembrane pressure difference of from 0.1 to 20 kPa. According to this method, the fermentation productivity of the chemical product can be largely elevated at high stability and a low cost.

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Inventors:
SAWAI HIDEKI (JP)
YAMADA KATSUSHIGE (JP)
MIMITSUKA TAKASHI (JP)
SAWAI KENJI (JP)
YONEHARA TETSU (JP)
ITO YOHITO (JP)
HENMI MASAHIRO (JP)
Application Number:
PCT/JP2007/052853
Publication Date:
August 30, 2007
Filing Date:
February 16, 2007
Export Citation:
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Assignee:
TORAY INDUSTRIES (JP)
SAWAI HIDEKI (JP)
YAMADA KATSUSHIGE (JP)
MIMITSUKA TAKASHI (JP)
SAWAI KENJI (JP)
YONEHARA TETSU (JP)
ITO YOHITO (JP)
HENMI MASAHIRO (JP)
International Classes:
C12P7/56; C12M1/12; C12P7/06; C12P7/18; C12P7/46; C12P7/50; C12P13/00; C12P13/08; C12P19/30; C12N15/09
Domestic Patent References:
WO2002064240A12002-08-22
WO2002064240A12002-08-22
Foreign References:
JPH10174594A1998-06-30
JP2005028339A2005-02-03
JP2003053164A2003-02-25
JP2005111326A2005-04-28
JPH0595778A1993-04-20
JPH11113587A1999-04-27
JPH10323543A1998-12-08
JPS63248396A1988-10-14
JPH10150996A1998-06-09
JPH0669367B21994-09-07
JP2001211878A2001-08-07
JPH0698758A1994-04-12
JPS5847485A1983-03-19
JPS62138184A1987-06-20
JP2000317273A2000-11-21
JPH11215980A1999-08-10
JPH07185270A1995-07-25
JPH07185271A1995-07-25
JP2000094000A2000-04-04
JP2000167555A2000-06-20
JP2003144869A2003-05-20
JP2003135939A2003-05-13
JP2005333886A2005-12-08
JP2003135941A2003-05-13
JPH10174594A1998-06-30
JPH11137286A1999-05-25
JP2002511243A2002-04-16
Other References:
TOSHIHIKO HIRAO, APPL. MICROBIOL. BIOTECHNOL., vol. 32, 1989, pages 269 - 273
TAKESHI KOBAYASHI ET AL., CHEMICAL ENGINEER, vol. 12, 1988, pages 49
"METHODS IN YEAST GENETICS", 2000, CSHL PRESS
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