Title:
METHOD FOR PRODUCING COENZYME Q10
Document Type and Number:
WIPO Patent Application WO/2019/208676
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method for producing coenzyme Q10, said method comprising efficiently concentrating a culture suspension of a coenzyme Q10-producing microorganism while minimizing loss of coenzyme Q10 before extraction or disruption to thereby ensure economical and stable operation. The method according to the present invention for producing coenzyme Q10 involves a filtration step for heating a culture suspension of a coenzyme Q10-producing microorganism to 35°C or higher and passing through a porous membrane. To increase the average permeation flux, it is preferred to perform, at least once, a regeneration treatment which comprises, during the passage of the culture suspension, hermetically closing and pressurizing a filtration device and then releasing the pressure, or a regeneration treatment which comprises, during the passage of the culture suspension, feeding a medium from a filtrate outlet side and, after passing the fluid for a preset period of time, restarting the common filtration step.
Inventors:
SUZUKI YASUYUKI (JP)
KAMO FUMITAKA (JP)
KHUHAPREMA CHANON (JP)
KANDA AKIHISA (JP)
KAMO FUMITAKA (JP)
KHUHAPREMA CHANON (JP)
KANDA AKIHISA (JP)
Application Number:
PCT/JP2019/017546
Publication Date:
October 31, 2019
Filing Date:
April 25, 2019
Export Citation:
Assignee:
KANEKA CORP (JP)
International Classes:
C12P7/66; B01D29/25; B01D29/37; B01D35/22; B01D37/02; B01D61/14; B01D61/16; C12N1/00; C12N1/02
Domestic Patent References:
| WO2004029076A2 | 2004-04-08 |
Foreign References:
| JPH09173792A | 1997-07-08 | |||
| JPS5791196A | 1982-06-07 | |||
| JPH11103883A | 1999-04-20 | |||
| JPS6283894A | 1987-04-17 | |||
| JPS63317092A | 1988-12-26 | |||
| JPS6336789A | 1988-02-17 | |||
| JPS5568295A | 1980-05-22 | |||
| JP2014150768A | 2014-08-25 |
Other References:
GRAVER TECHNOLOGIES, SCEPTER STAINLESS STEEL MEMBRANE, PROVEN TECHNOLOGY FOR THE MOST CHALLENGING SEPARATIONS, 2007, pages 1 - 8, XP055646650
Attorney, Agent or Firm:
USFI PATENT ATTORNEYS INTERNATIONAL OFFICE (JP)
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