METHOD FOR PRODUCING COMPLEX DISPERSION IN OIL COMPRISING WATER-SOLUBLE COMPOUND AND LECITHIN

Title:

METHOD FOR PRODUCING COMPLEX DISPERSION IN OIL COMPRISING WATER-SOLUBLE COMPOUND AND LECITHIN

Document Type and Number:

WIPO Patent Application WO/2023/054704

Kind Code:

A1

Abstract:

The present invention addresses the problem of providing technology for dispersing a water-soluble compound in oil that can be applied to pharmaceuticals.　The present invention provides a method for producing a lecithin-water-soluble compound complex dispersion in oil, characterized by including (a) a step for mixing an oil-based base material in which lecithin is dissolved with an aqueous solution of a water-soluble compound, and (b) a step for subjecting the suspension obtained in step (a) to in-liquid drying and performing dehydration.　The present invention increases the likelihood of application to pharmaceuticals in that, inter alia: lecithin, which is highly safe and presents no problems in terms of usage record and availability, is used as a surfactant; particle size can be controlled without needing a shearing step; and a complex dispersion can be produced with good reproducibility in a single cycle of in-liquid drying.

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Inventors:

MONMA SOICHI (JP)
MATSUMOTO KEIGO (JP)

Application Number:

PCT/JP2022/036823

Publication Date:

April 06, 2023

Filing Date:

September 30, 2022

Export Citation:

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Assignee:

NISSAN CHEMICAL CORP (JP)

International Classes:

A61K47/24; A61K9/107; A61K31/138; A61K31/375; A61K31/405; A61K31/455; A61K31/4748; A61K45/00; A61K47/14; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P25/06; A01N25/04; A61K8/06; B01J13/00

Domestic Patent References:

WO2022071481A1	2022-04-07
WO2020203809A1	2020-10-08
WO2009060609A1	2009-05-14

Foreign References:

JPH01216918A	1989-08-30
JP2000026884A	2000-01-25
JP2000024482A	2000-01-25
JP2000024487A	2000-01-25
JP2000026283A	2000-01-25
JPH11113487A	1999-04-27
JPH11113486A	1999-04-27
JP2000229118A	2000-08-22
JPH11188256A	1999-07-13
JP2010260005A	2010-11-18

Other References:

SHUJI KITAGAWA: "Basic Pharmaceutical Textbook Series 20 Pharmacology, 2nd edition, 2nd printing", 2013, article "4.12 Formulations applied to the skin, etc.,", pages: 106 - 110