Title:
METHOD FOR PRODUCING COMPOUND
Document Type and Number:
WIPO Patent Application WO/2022/030622
Kind Code:
A1
Abstract:
The present invention provides a method which can produce an intermediate of an azole derivative at lower cost than an existing production method. The method is for producing a compound represented by general formula (IV) and includes a step in which a compound represented by general formula (II) is converted into the compound represented by general formula (IV) in the presence of an inorganic base using both (a) dimethyl sulfide and/or dimethyl sulfoxide and (b) a methyl-LG (wherein LG is a nucleophilically replaceable leaving group and is selected from among halogen groups, alkoxysulfonyloxy groups, aryloxysulfonyloxy groups, alkylsulfonyloxy groups, haloalkylsulfonyloxy groups, and arylsulfonyloxy groups).
Inventors:
HARIGAE RYO (JP)
KOJIMA CHIEMI (JP)
KONNO SHINGO (JP)
YAMAZAKI TORU (JP)
KOJIMA CHIEMI (JP)
KONNO SHINGO (JP)
YAMAZAKI TORU (JP)
Application Number:
PCT/JP2021/029343
Publication Date:
February 10, 2022
Filing Date:
August 06, 2021
Export Citation:
Assignee:
KUREHA CORP (JP)
International Classes:
C07D301/02; C07C67/00; C07C69/738; C07D249/08; C07D303/48
Domestic Patent References:
| WO2019093522A1 | 2019-05-16 | |||
| WO2016005211A1 | 2016-01-14 | |||
| WO2019093522A1 | 2019-05-16 |
Foreign References:
| CN102491959A | 2012-06-13 | |||
| JP2012530110A | 2012-11-29 | |||
| JP2012530109A | 2012-11-29 | |||
| JPS59206375A | 1984-11-22 | |||
| CN103059004A | 2013-04-24 |
Other References:
RAGHUNADH AKULA, MERUVA SURESH, KUMAR NUKA, KUMAR GUDLA, RAO L., SYAM KUMAR U.: "An Efficient and Practical Synthesis of Aryl and Hetaryl α-Keto Esters", SYNTHESIS, vol. 2012, no. 02, 1 January 2012 (2012-01-01), STUTTGART, DE. , pages 283 - 289, XP055907477, ISSN: 0039-7881, DOI: 10.1055/s-0031-1289647
SON JUNG-HO, ZHU JIE S., PHUAN PUAY-WAH, CIL ONUR, TEUTHORN ANDREW P., KU COLTON K., LEE SUJIN, VERKMAN ALAN S., KURTH MARK J.: "High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 6, 23 March 2017 (2017-03-23), US , pages 2401 - 2410, XP055907577, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01759
KAMBALE DIGAMBAR A., THORAT SAGAR S., PRATAPURE MADHUKAR S., GONNADE RAJESH G., KONTHAM RAVINDAR: "Lewis acid catalyzed cascade annulation of alkynols with α-ketoesters: a facile access to γ-spiroketal-γ-lactones", CHEMICAL COMMUNICATIONS, vol. 53, no. 49, 1 January 2017 (2017-01-01), UK , pages 6641 - 6644, XP055796654, ISSN: 1359-7345, DOI: 10.1039/C7CC03668J
SON JUNG-HO, ZHU JIE S., PHUAN PUAY-WAH, CIL ONUR, TEUTHORN ANDREW P., KU COLTON K., LEE SUJIN, VERKMAN ALAN S., KURTH MARK J.: "High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 6, 23 March 2017 (2017-03-23), US , pages 2401 - 2410, XP055907577, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.6b01759
KAMBALE DIGAMBAR A., THORAT SAGAR S., PRATAPURE MADHUKAR S., GONNADE RAJESH G., KONTHAM RAVINDAR: "Lewis acid catalyzed cascade annulation of alkynols with α-ketoesters: a facile access to γ-spiroketal-γ-lactones", CHEMICAL COMMUNICATIONS, vol. 53, no. 49, 1 January 2017 (2017-01-01), UK , pages 6641 - 6644, XP055796654, ISSN: 1359-7345, DOI: 10.1039/C7CC03668J
Attorney, Agent or Firm:
HARAKENZO WORLD PATENT & TRADEMARK (JP)
Download PDF:
Previous Patent: ENERGY STORAGE SYSTEM
Next Patent: SLEEP ESTIMATION DEVICE, SLEEP ESTIMATION SYSTEM, WEARABLE INSTRUMENT, AND SLEEP ESTIMATION METHOD
Next Patent: SLEEP ESTIMATION DEVICE, SLEEP ESTIMATION SYSTEM, WEARABLE INSTRUMENT, AND SLEEP ESTIMATION METHOD