Title:
METHOD FOR PRODUCING CYTOPENIA MODEL ANIMAL, CYTOPENIA MODEL ANIMAL, METHOD FOR EVALUATING BLOOD CELL FUNCTION, METHOD FOR PRODUCING BLOOD CELLS, METHOD FOR SCREENING CYTOPENIA THERAPEUTIC DRUG MATERIAL CANDIDATE, AND METHOD FOR PRODUCING CYTOPENIA THERAPEUTIC DRUG MATERIAL CANDIDATE
Document Type and Number:
WIPO Patent Application WO/2020/184685
Kind Code:
A1
Abstract:
Provided is a method for producing a cytopenia model animal having a lower blood cell count than an X-ray irradiation-induced cytopenia model animal. This method for producing a cytopenia model animal comprises: an irradiation step for irradiating a non-human animal with radiation; and an administration step for administering an anti-blood cell antibody to the non-human animal.
Inventors:
KUMAGAE YOSHIHIRO (JP)
HIROSE HIDENORI (JP)
ITO YUKITAKA (JP)
HIROSE HIDENORI (JP)
ITO YUKITAKA (JP)
Application Number:
PCT/JP2020/010961
Publication Date:
September 17, 2020
Filing Date:
March 12, 2020
Export Citation:
Assignee:
MEGAKARYON CORP (JP)
International Classes:
A01K67/027; C12N15/867; G01N33/15; G01N33/49; G01N33/50; G01N33/86
Domestic Patent References:
| WO2014123242A1 | 2014-08-14 | |||
| WO2016204256A1 | 2016-12-22 |
Foreign References:
| JPH09271294A | 1997-10-21 | |||
| JP2006271376A | 2006-10-12 |
Other References:
KATSMAN, Y. ET AL.: "Improved mouse models for the study of treatment modalities for immune-mediated platelet destruction", TRANSFUSION, vol. 50, 2010, pages 1285 - 1294, XP055739620
YANG JINGKE, ZHANG QI, LI PEIYU, DONG TINGTING, WU MEI X.: "Low-level light treatment ameliorates immune thrombocytopenia", SCIENTIFIC REPORTS, vol. 6, no. 38238, 2016, pages 1 - 10, XP055739624
YANG JINGKE, ZHANG QI, LI PEIYU, DONG TINGTING, WU MEI X.: "Low-level light treatment ameliorates immune thrombocytopenia", SCIENTIFIC REPORTS, vol. 6, no. 38238, 2016, pages 1 - 10, XP055739624
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
Download PDF: