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Title:
METHOD FOR PRODUCING D-FORM OR L-FORM AMINO ACID DERIVATIVE HAVING THIOL GROUP
Document Type and Number:
WIPO Patent Application WO/2015/064453
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a simple method for producing, at a high yield, an optically active D-form and/or L-form amino acid derivative having a thiol group in a side chain. Provided are: a method for producing an amino acid derivative having a thiol group in a side chain, said method being characterised by producing an intermediate composition that includes D-forms and L-forms of an amino acid derivative which has a thiol group at the β-position, causing a D- or L-amino acid selective hydrolase to react, and separating the hydrolysed D- or L-amino acid derivatives; and an intermediate therefor.

Inventors:
KAJIHARA, Yasuhiro (1-1 Machikaneyamacho, Toyonaka-shi Osaka, 43, 〒5600043, JP)
MORISHITA, Yasuhito (1-1 Machikaneyamacho, Toyonaka-shi Osaka, 43, 〒5600043, JP)
MURASE, Takefumi (Inc. 134, Chudoji-minamimachi, Shimogyo-ku, Kyoto-sh, Kyoto 13, 〒6008813, JP)
Application Number:
JP2014/078136
Publication Date:
May 07, 2015
Filing Date:
October 22, 2014
Export Citation:
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Assignee:
GLYTECH, INC. (134 Chudoji-minamimachi, Shimogyo-ku Kyoto-sh, Kyoto 13, 〒6008813, JP)
International Classes:
C12P41/00; C07C319/28; C07C323/58; C07C323/59; C07B57/00; C12N9/80
Foreign References:
JP2000509016A2000-07-18
JP2004509101A2004-03-25
JPH06125786A1994-05-10
JPH1169992A1999-03-16
Other References:
MORISHITA, Y. ET AL.: "Development of a concise synthetic strategy of beta-mercapto amino acid derivatives, The 4th Asia-Pacific International Peptide Symposium", THE 50TH JAPANESE PEPTIDE SYMPOSIUM APIPS2013 KOEN YOSHISHU, 10 October 2013 (2013-10-10), pages 113, XP008183663
WONG C.T.T. ET AL.: "Synthetic cysteine surrogates used in native chemical ligation", MOLECULAR BIOSYSTEMS, vol. 9, no. 5, pages 826 - 833, XP055341571
YASUHITO MORISHITA ET AL.: "beta-i ni Thiol o Motsu Amino Acid Yudotai no Racemic Gosei", THE 94TH ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING (2014) KOEN YOKOSHU IV, 12 March 2014 (2014-03-12), pages 1471, XP008183664
See also references of EP 3067430A4
NAKAGAWA H ET AL., CHEM. PHARM. BULL., vol. 51, 2003, pages 1363 - 1367
Attorney, Agent or Firm:
NANJO, Masahiro et al. (TOKYO ACTi International Patent Office, 9-7-2-1416 Akasaka, Minato-k, Tokyo 52, 〒1070052, JP)
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