Title:
METHOD FOR PRODUCING DENDRITIC CELLS
Document Type and Number:
WIPO Patent Application WO/2010/055900
Kind Code:
A1
Abstract:
Disclosed is a method for producing dendritic cells (DCs), which involves a step of culturing DC progenitor cells in the presence of multiple cytokines. Also disclosed is a DC produced by the method. Further disclosed is use of the DC.
It is found that dendritic cells (DCs) having a high IL-12-producing ability can be produced by culturing DC progenitor cells in the presence of multiple cytokines and further culturing the resulting culture product in the presence of GM-CSF and IL-4 for about 1 week. It becomes possible to produce DCs having a high IL-12-producing ability in a large quantity from a small number of DC progenitor cells. As a result, the number of DCs to be administered in an anti-tumor immunotherapy or the treatment of infectious diseases using DCs can be increased readily, and the efficacy of a DC vaccine is expected to be increased.
More Like This:
Inventors:
UEDA YASUJI (JP)
YONEMITSU YOSHIKAZU (JP)
HARADA YUI (JP)
YONEMITSU YOSHIKAZU (JP)
HARADA YUI (JP)
Application Number:
PCT/JP2009/069311
Publication Date:
May 20, 2010
Filing Date:
November 13, 2009
Export Citation:
Assignee:
DNAVEC CORP (JP)
UEDA YASUJI (JP)
YONEMITSU YOSHIKAZU (JP)
HARADA YUI (JP)
UEDA YASUJI (JP)
YONEMITSU YOSHIKAZU (JP)
HARADA YUI (JP)
International Classes:
A61P35/00; A61K39/00
Domestic Patent References:
| WO1993008268A1 | 1993-04-29 | |||
| WO1994002839A1 | 1994-02-03 | |||
| WO2005042737A1 | 2005-05-12 | |||
| WO2006001122A1 | 2006-01-05 |
Foreign References:
| JP2008515439A | 2008-05-15 | |||
| JP2008515439A | 2008-05-15 | |||
| US53914295A | 1995-10-04 | |||
| EP0627487A2 | 1994-12-07 | |||
| EP0423980A1 | 1991-04-24 | |||
| US5108910A | 1992-04-28 | |||
| US5229496A | 1993-07-20 | |||
| JP3058353B2 | 2000-07-04 | |||
| JPS6474982A | 1989-03-20 | |||
| JPH0285498A | 1990-03-26 | |||
| JPH05252965A | 1993-10-05 | |||
| JPH05192160A | 1993-08-03 | |||
| JPH07502173A | 1995-03-09 | |||
| US5744144A | 1998-04-28 |
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See also references of EP 2351599A4
PACZESNY, S ET AL.: "Efficient generation of CD34+ progenitor-derived dendritic cells from G-CSF-mobilized peripheral mononuclear cells does not require hematopoietic stem cell enrichment.", J LEUKOC BIOL., vol. 81, no. 4, April 2007 (2007-04-01), pages 957 - 967, XP008146932
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LIU, A ET AL.: "Generation of functional and mature dendritic cells from cord blood and bone marrow CD34+ cells by two-step culture combined with calcium ionophore treatment.", J IMMUNOL METHODS, vol. 261, no. 1-2, 1 March 2002 (2002-03-01), pages 49 - 63, XP004341267
HIERONYMUS, T ET AL.: "Progressive and controlled development of mouse dendritic cells from Flt3+CDllb+ progenitors in vitro.", J IMMUNOL., vol. 174, no. 5, 1 March 2005 (2005-03-01), pages 2552 - 2562, XP008146935
OBERMAIER, B ET AL.: "Development of a new protocol for 2-day generation of mature dendritic cells from human monocytes.", BIOL PROCED ONLINE., vol. 5, 2003, pages 197 - 203, XP008146940
STEINMAN, R. M., ANN. REV. IMMUNOL., vol. 9, 1991, pages 271
BANCHEREAU, J.B., R.M. STEINMAN, NATURE, vol. 392, 1998, pages 245
S. SHIBATA ET AL., J. IMMUNOL, vol. 177, 2006, pages 3564 - 3576
YONEYAMA, Y ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 355, 2007, pages 129 - 135
CANCER IMMUNOL IMMUNOTHER., vol. 54, 2005, pages 721 - 728
STEINMAN, R. M., ANN. REV. IMMUNOL., vol. 9, 1991, pages 271 - 296
BANCHEREAU, J. B., R. M. STEINMAN, NATURE, vol. 392, 1998, pages 245 - 252
SHIBATA, S. ET AL., J. IMMUNOL., vol. 177, 2006, pages 3564 - 3576
YONEYAMA, Y. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 355, 2007, pages 129 - 135
KNUTSON, K. L. ET AL., CANCER IMMUNOL IMMUNOTHER., vol. 54, 2005, pages 721 - 728
GENE THERAPY, vol. 7, 2000, pages 249 - 254
ARCH DERMATOL RES, vol. 292, 2000, pages 325 - 332
KNAPP, W. ET AL.: "Leucocyte Typing IV: White Cell Differentiation Antigens", 1989, OXFORD UNIVERSITY PRESS
"The Leucocyte Antigen Facts Book, CD11 Section", 1993, ACADEMIC PRESS INC., pages: 124
STACKER, S.A., T.A. SPRINGER, J. IMMUNOL., vol. 146, 1991, pages 648
"Leucocyte Typing IV: White Cell Differentiation Antigens", 1989, OXFORD UNIVERSITY PRESS
"Leucocyte Typing V: White Cell Differentiation Antigens", 1995, OXFORD UNIVERSITY PRESS
HANAU, D. ET AL., J. INVESTIGATIVE DERMATOL., vol. 95, 1990, pages 503
CALABI, F., A. BRADBURY, TISSUE ANTIGENS, vol. 37, 1991, pages 1
TODD R.F. ET AL., J. IMMUNOL., vol. 126, 1981, pages 1435 - 1442
LEONG A.S.Y, APPL. IMMUNOHISTOCHEM. SURG. PATHOL., 1993, pages 120 - 128
TODD R.F. ET AL., HYBRIDOMA, vol. 1, 1982, pages 329 - 337
COBBOLD S. ET AL., LEUCOCYTE TYPING, vol. III, 1987, pages 788 - 803
KEIZER G. ET AL., EUR. J. IMMUNOL., vol. 15, 1985, pages 1142 - 1148
LAFFON A. ET AL., J. CLIN. INVEST., vol. 88, 1991, pages 546 - 552
ACEVEDO A. ET AL., J. INVEST. DERMATOL., vol. 97, 1991, pages 659 - 666
MOLICA S. ET AL., BLOOD, vol. 81, 1993, pages 2466
VAN DER VIEREN M. ET AL., IMMUNITY, vol. 3, 1995, pages 683 - 690
HOGG N. ET AL., LEUCOCYTE TYPING, vol. III, 1987, pages 576 - 602
"Leucocyte Typing III: White Cell Differentiation Antigens", 1987, OXFORD UNIVERSITY PRESS
WRIGHT, S.D. ET AL., SCIENCE, vol. 249, 1990, pages 1434
GALY, A.H.M., H. SPITS, J. IMMUNOL., vol. 149, 1992, pages 775
CLARK, E.A., J.A. LEDBETTER, PROC. NATL. ACAD. SCI., vol. 83, 1986, pages 4494
ITOH, H. ET AL., CELL, vol. 66, 1991, pages 233
BARCLAY, N.A. ET AL.: "The Leucocyte Antigen Facts Book", 1993, ACADEMIC PRESS
SCHWARTS, R.H., CELL, vol. 71, 1992, pages 1065
AZUMA, M. ET AL., J. EXP. MED., vol. 177, 1993, pages 845
KOULOVA, L. ET AL., J. EXP. MED., vol. 173, 1991, pages 759
FREEMAN, GJ. ET AL., J. IMMUNOL., vol. 161, 1998, pages 2708
BEHRENS, L. ET AL., J. IMMUNOL., vol. 161, no. 11, 1998, pages 5943
GUESDON, J.-L. ET AL., J. HISTOCHEM. CYTOCHEM., vol. 27, 1979, pages 1131 - 1139
ZHOU, L-J., T.F. TEDDER, J. IMMUNOL., vol. 154, 1995, pages 3821
ZHOU, L-J. ET AL., J. IMMUNOL., vol. 149, 1992, pages 735
SUMMERS, K.L. ET AL., CLIN EXP. IMMUNOL., vol. 100, 1995, pages 81
WEISSMAN, D. ET AL., PROC. NATL. ACAD. SCI USA., vol. 92, 1995, pages 826
HART, D.N.J., BLOOD, vol. 90, 1997, pages 3245
AZUMA M. ET AL., NATURE, vol. 366, 1993, pages 76
NOZAVVA Y ET AL., J. PATHOLOGY, vol. 169, 1993, pages 309
ENGLE, P. ET AL., BLOOD, vol. 84, 1994, pages 1402
ENGEL, P. ET AL.: "CD86 Workshop Report. In: Leukocyte Typing V.", 1994, OXFORD UNIVERSITY PRESS
YANG, X.F. ET AL.: "Upregulation of CD86 antigen on TPA stimulated U937 cells", 1994, AMERICAN SOCIETY OF HEMATOLOGY
SALLUSTO, F. ET AL., NATURE, vol. 401, 1999, pages 708 - 12
LIPP, M. ET AL., CURR. TOP. MICROBIOL. IMMUNOL., vol. 251, 2000, pages 173 - 9
BIRKENBACH, M. ET AL., J. VIROL., vol. 67, 1993, pages 2209 - 20
SCHWEICKART, V. L. ET AL., GENOMICS, vol. 23, 1994, pages 643 - 50
BURGSTAHLER, R. ET AL., BIOCHEM. BIOPHYS. RES. COMMUN., vol. 215, 1995, pages 737 - 43
YOSHIDA, R. ET AL., J. BIOL. CHEM., vol. 272, 1997, pages 13803 - 9
YOSHIDA, R. ET AL., J. BIOL. CHEM., vol. 273, 1998, pages 7118 - 22
YOSHIDA, R. ET AL., INT. IMMUNOL., vol. 10, 1998, pages 901 - 10
KIM, C. H. ET AL., J. IMMUNOL., vol. 161, 1998, pages 2580 - 5
YANAGIHARA, S. ET AL., J. IMMUNOL., vol. 161, 1998, pages 3096 - 102
PAWELEC, G ET AL., HUMAN IMMUNOLOGY, vol. 12, 1985, pages 165
ZIEGLER, A. ET AL., IMMUNOBIOL., vol. 171, 1986, pages 77
BARCLAY, N.A. ET AL.: "The Leucocyte Antigen Facts Book.", 1993, ACADEMIC PRESS, pages: 376
KIERTSCHER SM, ROTH MD: "Human CD 14+ leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4", J. LEUKOC. BIOL., vol. 59, no. 2, 1996, pages 208 - 18
OEHLER, L. ET AL.: "Neutrophil granulocyte-committed cells can be driven to acquire dendritic cell characteristics", J. EXP. MED., vol. 187, no. 7, 1998, pages 1019 - 28, XP000996494, DOI: doi:10.1084/jem.187.7.1019
OKANO, S. ET AL.: "Recombinant Sendai virus vectors for activated T lymphocytes", GENE THER., vol. 10, no. 16, 2003, pages 1381 - 91, XP002973825, DOI: doi:10.1038/sj.gt.3301998
STITES, D. ET AL.: "Flow cytometric analysis of lymphocyte phenotypes in AIDS using monoclonal antibodies and simultaneous dual immunofluorescence", CLIN. IMMUNOL. IMMUNOPATHOL., vol. 38, 1986, pages 161 - 177, XP026189337, DOI: doi:10.1016/0090-1229(86)90135-2
BISHOP ET AL., BLOOD, vol. 83, 1994, pages 610 - 616
BONTKES, H. J. ET AL., J. LEUKOC. BIOL., vol. 72, 2002, pages 321 - 329
KATSUAKI, S. ET AL., CRYOBIOLOGY, vol. 37, 1998, pages 362 - 371
LADAN, K. ET AL., STEM CELLS, vol. 24, 2006, pages 2150 - 2157
UEDA, T. ET AL., J. CLIN. INVEST., vol. 105, 2000, pages 1013 - 1021
BERENSON ET AL., J. IMMUNOL. METH., vol. 91, 1986, pages 11
J. EXP. MED., vol. 187, 1998, pages 1019 - 1028
BLOOD, vol. 87, 1996, pages 4520 - 4530
HSU ET AL., NATURE MED., vol. 2, 1996, pages 52
CAMERON ET AL., SCIENCE, vol. 257, 1992, pages 383
LANGHOFF ET AL., PROC. NATL. ACAD. SCI. USA, vol. 88, 1991, pages 7998
CHEHIMI ET AL., J. GEN. VIROL., vol. 74, 1993, pages 1277
CAMERON ET AL., CLIN. EXP. IMMUNOL., vol. 88, 1992, pages 226
THOMAS ET AL., J. IMMUNOL., vol. 150, 1993, pages 821
KARHUMAKI ET AL., CLIN. EXP. IMMUNOL., vol. 91, 1993, pages 482
THOMAS ET AL., J. IMMUNOL., vol. 153, 1994, pages 4016
FERBAS ET AL., J. IMMUNOL., vol. 152, 1994, pages 4649
O'DOHERTY ET AL., IMMUNOLOGY, vol. 82, 1994, pages 487
MILTENYI ET AL., CYTOMETRY, vol. 11, 1990, pages 231 - 238
MACATONIA ET AL., IMMUNOL., vol. 74, 1991, pages 399 - 406
O'DOHERTY ET AL., J. EXP. MED., vol. 178, 1993, pages 1067 - 1078
MARKOWICZ ET AL., J. CLIN. INVEST., vol. 85, 1990, pages 955 - 961
ROMANI ET AL., J. EXP. MED., vol. 180, 1994, pages 83 - 93
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See also references of EP 2351599A4
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (JP)
Spring water Original aim (JP)
Spring water Original aim (JP)
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