METHOD FOR PRODUCING DOUBLE-STRANDED RNA-RICH LACTIC ACID BACTERIUM, AND SAID LACTIC ACID BACTERIUM

Title:

METHOD FOR PRODUCING DOUBLE-STRANDED RNA-RICH LACTIC ACID BACTERIUM, AND SAID LACTIC ACID BACTERIUM

Document Type and Number:

WIPO Patent Application WO/2018/207924

Kind Code:

A1

Abstract:

The present invention addresses the problem of providing: a method for highly efficiently producing a lactic acid bacterium that can contain a large amount of double-stranded RNA; and a lactic acid bacterium having a high double-stranded RNA content, which can be produced by the method. The problem can be solved by: (1) a method for producing a lactic acid bacterium containing double-stranded RNA, including the step of subjecting a lactic acid bacterium to the culture under an aeration condition and/or a low-temperature condition where the temperature is lower than an optimum temperature to produce the lactic acid bacterium containing double-stranded RNA; (2) a lactic acid bacterium containing double-stranded RNA, in which the content of the double-stranded RNA is at least 2.0 times that achieved when a bacterium of the same strain is cultured for the same culture period at the optimum temperature and under a non-aeration condition; and others.

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Inventors:

KAWASHIMA TADAOMI (JP)
IKARI NAHO (JP)
KAWAMOTO HIROSHI (JP)

Application Number:

PCT/JP2018/018392

Publication Date:

November 15, 2018

Filing Date:

May 11, 2018

Export Citation:

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Assignee:

KIKKOMAN CORP (JP)

International Classes:

C12N1/20; A23K10/16; A23L33/135; C12N15/117; C12Q1/6834

Domestic Patent References:

WO2003082027A1	2003-10-09
WO2009005124A1	2009-01-08
WO2009005123A1	2009-01-08

Foreign References:

JP2014140330A	2014-08-07
JP2015092841A	2015-05-18
JPH10139674A	1998-05-26
JPH09238647A	1997-09-16
JP5099649B2	2012-12-19
JPS5312322B2	1978-04-28
JP2017095947A	2017-06-01

Other References:

KAWASHIMA, T. ET AL.: "Double-Stranded RNA of Intestinal Commensal but Not Pathogenic Bacteria Triggers Production of Protective Interferon-beta", IMMUNITY, vol. 38, 2013, pages 1187 - 1197, XP055561192, ISSN: 1074-7613
FRONT IMMUNOL., vol. 9, 23 January 2018 (2018-01-23), pages 27
SCI REP., vol. 8, no. 1, 22 March 2018 (2018-03-22), pages 5065
See also references of EP 3623464A4

Attorney, Agent or Firm:

Eikoh Patent Firm, P.C. (JP)

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