Title:
METHOD FOR PRODUCING EUSHEARILIDES
Document Type and Number:
WIPO Patent Application WO/2016/068220
Kind Code:
A1
Abstract:
Provided are: eushearilides; a method for producing eushearilides; a production intermediate; and a pharmaceutical composition containing eushearilides. By having the Wittig reaction process, Mukaiyama Aldol reaction process and Macrolactonizaion process serve as key processes, eushearilides represented by formula (I) are efficiently produced.
More Like This:
Inventors:
SHIINA ISAMU (JP)
TONOI TAKAYUKI (JP)
TONOI TAKAYUKI (JP)
Application Number:
PCT/JP2015/080469
Publication Date:
May 06, 2016
Filing Date:
October 28, 2015
Export Citation:
Assignee:
UNIV TOKYO SCIENCE FOUNDATION (JP)
International Classes:
C07F9/655; A61K31/685; A61P31/04; C07D313/00
Foreign References:
| JP2007536194A | 2007-12-13 | |||
| JPS62265290A | 1987-11-18 | |||
| JPS59141582A | 1984-08-14 |
Other References:
YAMAUCHI, TAKAYASU ET AL.: "Total synthesis of the proposed structures of eushearilide", HETEROCYCLES, vol. 88, no. 2, 18 September 2013 (2013-09-18), pages 1175 - 1189, XP008184808
HOSOE, TOMOO ET AL.: "A new antifungal macrolide, eushearilide, isolated from Eupenicillium shearii", JOURNAL OF ANTIBIOTICS, vol. 59, no. 9, September 2006 (2006-09-01), pages 597 - 600, XP055377289
See also references of EP 3214088A4
HOSOE, TOMOO ET AL.: "A new antifungal macrolide, eushearilide, isolated from Eupenicillium shearii", JOURNAL OF ANTIBIOTICS, vol. 59, no. 9, September 2006 (2006-09-01), pages 597 - 600, XP055377289
See also references of EP 3214088A4
Attorney, Agent or Firm:
SHOBAYASHI, Masayuki (JP)
Right wood Masayuki (JP)
Right wood Masayuki (JP)
Download PDF:
Previous Patent: LUBRICANT, BEARING DEVICE, AND LUBRICANT SUPPLY DEVICE
Next Patent: OPTICAL MEMBER AND IMAGE DISPLAY DEVICE HAVING OPTICAL MEMBER
Next Patent: OPTICAL MEMBER AND IMAGE DISPLAY DEVICE HAVING OPTICAL MEMBER