Title:
METHOD FOR PRODUCING FLUOROVINYL ETHER COMPOUND
Document Type and Number:
WIPO Patent Application WO/2020/004502
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a new method for synthesizing a fluorovinyl ether compound from a fluorine-containing vinyl compound, etc. To solve this problem, provided is a method for producing a compound represented by formula (1): [wherein: Ra1 represents a hydrogen atom, a halogeno group, an alkyl group, a fluoroalkyl group or an aromatic group optionally having one or more substituents; Rf represents a fluoro group or a perfluoroalkyl group; Ra2 represents a hydrogen atom, a halogeno group, an alkyl group, a fluoroalkyl group or an aromatic group optionally having one or more substituents, or (i) Ra1 and Ra2, (ii) Ra1 and Rf, or (iii) Rf and Ra2 may be linked together; Rb1 is RS; Rb2 represents a hydrogen atom or RS; Rb3 represents a hydrogen atom or RS, or two or three of Rb1, Rb2 and Rb3 may form, together with the carbon atom adjacent thereto, a ring optionally having one or more substituents; and RS's may be the same or different and each represent a hydrocarbon group optionally having one or more substituents], said production method comprising step A for reacting a compound represented by formula (2): [wherein: Rx represents a leaving group; and other symbols have the same meanings as defined above] with a compound represented by formula (3): [wherein the symbols have the same meanings as defined above] in the presence of a transition metal catalyst.
Inventors:
HOSHIYA NAOYUKI (JP)
GOTOU AKIHIRO (JP)
KISHIKAWA YOSUKE (JP)
GOTOU AKIHIRO (JP)
KISHIKAWA YOSUKE (JP)
Application Number:
PCT/JP2019/025477
Publication Date:
January 02, 2020
Filing Date:
June 26, 2019
Export Citation:
Assignee:
DAIKIN IND LTD (JP)
International Classes:
C07C41/16; B01J31/24; C07C43/17; C07C43/176; C07D213/30; C07D333/16; C07B61/00
Foreign References:
| JP2014062092A | 2014-04-10 | |||
| JP2015143199A | 2015-08-06 | |||
| US2799712A | 1957-07-16 | |||
| JPH0632763A | 1994-02-08 | |||
| JP2005281454A | 2005-10-13 | |||
| JP2009527352A | 2009-07-30 |
Other References:
MUZALEVSKIY, VASILIY M. ET AL.: "Synthetic approach to alkoxy-beta-(trifluoromethyl)stylenes and their application in the synthesis of new trifluoromethylated heterocycles", SYNTHESIS, vol. 13, 2009, pages 2249 - 2259, XP055666911
MUZALEVSKIY, VASILIY M. ET AL.: "Synthesis of trifluoromethyl alcohols from tert-butoxy-β-(trifluoromethyl)styrenes and trifluoromethylbenzyl ketones under the conditions of the Leuckart–Wallach reaction", JOURNAL OF FLUORINE CHEMISTRY, vol. 129, 2008, pages 1052 - 1055, XP025468257
GOLDBERG, ALEKSEY A. ET AL.: "Novel efficient synthesis of beta-fluoro beta- (trifluoromethyl)stylenes", JOURNAL OF FLUORINE CHEMISTRY, vol. 131, 2010, pages 384 - 388, XP026912141
T.M. SOKOLENKO ET AL., CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 46, 2011, pages 1335
PIETER J. KLEIN ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 51, 2017, pages 25 - 32
KANBARA ET AL., MACROMOLECULES, vol. 33, 2000, pages 657
YAMAMOTO ET AL., J. POLYM. SCI., vol. 40, 2002, pages 2637
See also references of EP 3816146A4
MUZALEVSKIY, VASILIY M. ET AL.: "Synthesis of trifluoromethyl alcohols from tert-butoxy-β-(trifluoromethyl)styrenes and trifluoromethylbenzyl ketones under the conditions of the Leuckart–Wallach reaction", JOURNAL OF FLUORINE CHEMISTRY, vol. 129, 2008, pages 1052 - 1055, XP025468257
GOLDBERG, ALEKSEY A. ET AL.: "Novel efficient synthesis of beta-fluoro beta- (trifluoromethyl)stylenes", JOURNAL OF FLUORINE CHEMISTRY, vol. 131, 2010, pages 384 - 388, XP026912141
T.M. SOKOLENKO ET AL., CHEMISTRY OF HETEROCYCLIC COMPOUNDS, vol. 46, 2011, pages 1335
PIETER J. KLEIN ET AL., NUCLEAR MEDICINE AND BIOLOGY, vol. 51, 2017, pages 25 - 32
KANBARA ET AL., MACROMOLECULES, vol. 33, 2000, pages 657
YAMAMOTO ET AL., J. POLYM. SCI., vol. 40, 2002, pages 2637
See also references of EP 3816146A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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