Title:
METHOD FOR PRODUCING GENETICALLY MODIFIED ANIMAL EMPLOYING REPRODUCTIVE CELL-DEFICIENT ANIMAL
Document Type and Number:
WIPO Patent Application WO/2017/175745
Kind Code:
A1
Abstract:
The present invention provides a method for obtaining a genetically modified animal that possesses a target genetic modification in a simple manner and with improved efficiency, for example, at nearly 100% probability. Provided is a method for producing a genetically modified animal that possesses a target genetic modification, wherein the method includes (a) introducing pluripotent cells that possess the target genetic modification both in a paternal chromosome and a maternal chromosome into an animal embryo that loses its own reproductive cells in a developmental stage.
Inventors:
NAKAUCHI HIROMITSU (JP)
YAMAGUCHI TOMOYUKI (JP)
MASAKI HIDEKI (JP)
KATO MEGUMI (JP)
SATO HIDEYUKI (JP)
YAMAGUCHI TOMOYUKI (JP)
MASAKI HIDEKI (JP)
KATO MEGUMI (JP)
SATO HIDEYUKI (JP)
Application Number:
PCT/JP2017/014042
Publication Date:
October 12, 2017
Filing Date:
April 04, 2017
Export Citation:
Assignee:
UNIV TOKYO (JP)
International Classes:
C12N15/09; C12N5/075; C12N5/076; C12N5/10
Domestic Patent References:
| WO2003071869A1 | 2003-09-04 | |||
| WO2016163386A1 | 2016-10-13 |
Other References:
YAMAJI, M. ET AL.: "Critical function of Prdml4 for the establishment of the germ cell lineage in mice", NATURE GENETICS, vol. 40, no. 8, 2008, pages 1016 - 1022, XP055167610, DOI: doi:10.1038/ng.186
Attorney, Agent or Firm:
OHNO Seiji et al. (JP)
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