Title:
METHOD FOR PRODUCING GLYCOLIPID
Document Type and Number:
WIPO Patent Application WO/2014/061459
Kind Code:
A1
Abstract:
A protein which is any one of proteins (a) to (c) as mentioned below; a gene which encodes the protein; a transformant in which the gene is deleted or mutated or the expression of the gene is suppressed; and a method for producing a glycolipid using the transformant: (a) a protein which comprises the amino acid sequence represented by SEQ ID NO: 1; (b) a protein which comprises an amino acid sequence having a 50% or more identity to the amino acid sequence represented by SEQ ID NO: 1 and has an alcohol oxidase activity; and (c) a protein which comprises an amino acid sequence produced by deleting, substituting, inserting or adding one or several amino acid residues in the amino acid sequence represented by SEQ ID NO: 1 and has an alcohol oxidase activity.
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Inventors:
TAKAHASHI FUMIKAZU (JP)
Application Number:
PCT/JP2013/076958
Publication Date:
April 24, 2014
Filing Date:
October 03, 2013
Export Citation:
Assignee:
KAO CORP (JP)
International Classes:
C12N15/09; C12N1/19; C12N5/10; C12N9/04; C12P19/00
Domestic Patent References:
| WO2011008231A2 | 2011-01-20 | |||
| WO2011061032A2 | 2011-05-26 | |||
| WO2009141407A2 | 2009-11-26 |
Foreign References:
| JP2001522597A | 2001-11-20 | |||
| US6433152B1 | 2002-08-13 |
Other References:
HOMMEL R. ET AL.: "Evidence for two fatty alcohol oxidases in the biosurfactant-producing yeast Candida (Torulopsis) bombicola.", FEMS MICROBIOL.LETT., vol. 70, no. 2, 1 January 1990 (1990-01-01), pages 183 - 186, XP055253725
HOMMEL R. ET AL.: "The inducible microsomal fatty alcohol oxidase of Candida (Torulopsis) apicola.", APPL.MICROBIOL.BIOTECHNOL., vol. 40, no. 5, 1 January 1994 (1994-01-01), pages 729 - 734, XP035168337
KEMP G.D. ET AL.: "Occurrence of fatty alcohol oxidase in alkane-and fatty-acid-utilising yeasts and moulds.", APPL.MICROBIOL.BIOTECHNOL., vol. 40, no. 6, 1 February 1994 (1994-02-01), pages 873 - 875, XP035168357
VANHANEN S. ET AL.: "A consensus sequence for long-chain fatty-acid alcohol oxidases from Candida identifies a family of genes involved in lipid omega-oxidation in yeast with homologues in plants and bacteria.", J.BIOL. CHEM., vol. 275, no. 6, 11 February 2000 (2000-02-11), pages 4445 - 4452, XP002310421
SAERENS K.M.J. ET AL.: "One-step production of unacetylated sophorolipids by an acetyltransferase negative Candida bombicola.", BIOTECHNOL.BIOENG., vol. 108, no. 12, 1 December 2011 (2011-12-01), pages 2923 - 2931, XP055027011
VAN BOGAERT I.N.A. ET AL.: "The biosynthetic gene cluster for sophorolipids: a biotechnological interesting biosurfactant produced by Starmerella bombicola.", MOL. MICROBIOL., vol. 88, no. 3, 1 May 2013 (2013-05-01), pages 501 - 509, XP055146054
BIOTECHNOLOGY LETTERS, vol. 20, no. 3, 1998, pages 215 - 218
JOSEPH SAMBROOK; DAVID W. RUSSELL: "Molecular Cloning - A LABORATORY MANUAL THIRD EDITION", COLD SPRING HARBOR LABORATORY PRESS
JOSEPH SAMBROOK; DAVID W. RUSSELL: "Molecular Cloning - A LABORATORY MANUAL", 2001, COLD SPRING HARBOR LABORATORY PRESS
HORTON ET AL., GENE, vol. 77, 1989, pages 61 - 68
HASHIMOTO-GOTOH ET AL., GENE, vol. 152, 1995, pages 271 - 276
KUNKEL, T.A., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
BESHER ET AL., METHODS IN MOLECULAR BIOLOGY, vol. 47, 1995, pages 291 - 302
VAN BOGAERT ET AL., YEAST, vol. 25, 2008, pages 273 - 278
M. D. DE. BACKER ET AL., YEAST, vol. 15, 1999, pages 1609 - 1618
G. D. KEMP ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 29, 1988, pages 370 - 374
S. FLEURACKERS ET AL., EUR. J. LIPID SCI. TECHNOL., vol. 112, 2010, pages 655 - 662
HOMMEL R. ET AL.: "The inducible microsomal fatty alcohol oxidase of Candida (Torulopsis) apicola.", APPL.MICROBIOL.BIOTECHNOL., vol. 40, no. 5, 1 January 1994 (1994-01-01), pages 729 - 734, XP035168337
KEMP G.D. ET AL.: "Occurrence of fatty alcohol oxidase in alkane-and fatty-acid-utilising yeasts and moulds.", APPL.MICROBIOL.BIOTECHNOL., vol. 40, no. 6, 1 February 1994 (1994-02-01), pages 873 - 875, XP035168357
VANHANEN S. ET AL.: "A consensus sequence for long-chain fatty-acid alcohol oxidases from Candida identifies a family of genes involved in lipid omega-oxidation in yeast with homologues in plants and bacteria.", J.BIOL. CHEM., vol. 275, no. 6, 11 February 2000 (2000-02-11), pages 4445 - 4452, XP002310421
SAERENS K.M.J. ET AL.: "One-step production of unacetylated sophorolipids by an acetyltransferase negative Candida bombicola.", BIOTECHNOL.BIOENG., vol. 108, no. 12, 1 December 2011 (2011-12-01), pages 2923 - 2931, XP055027011
VAN BOGAERT I.N.A. ET AL.: "The biosynthetic gene cluster for sophorolipids: a biotechnological interesting biosurfactant produced by Starmerella bombicola.", MOL. MICROBIOL., vol. 88, no. 3, 1 May 2013 (2013-05-01), pages 501 - 509, XP055146054
BIOTECHNOLOGY LETTERS, vol. 20, no. 3, 1998, pages 215 - 218
JOSEPH SAMBROOK; DAVID W. RUSSELL: "Molecular Cloning - A LABORATORY MANUAL THIRD EDITION", COLD SPRING HARBOR LABORATORY PRESS
JOSEPH SAMBROOK; DAVID W. RUSSELL: "Molecular Cloning - A LABORATORY MANUAL", 2001, COLD SPRING HARBOR LABORATORY PRESS
HORTON ET AL., GENE, vol. 77, 1989, pages 61 - 68
HASHIMOTO-GOTOH ET AL., GENE, vol. 152, 1995, pages 271 - 276
KUNKEL, T.A., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 488
BESHER ET AL., METHODS IN MOLECULAR BIOLOGY, vol. 47, 1995, pages 291 - 302
VAN BOGAERT ET AL., YEAST, vol. 25, 2008, pages 273 - 278
M. D. DE. BACKER ET AL., YEAST, vol. 15, 1999, pages 1609 - 1618
G. D. KEMP ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 29, 1988, pages 370 - 374
S. FLEURACKERS ET AL., EUR. J. LIPID SCI. TECHNOL., vol. 112, 2010, pages 655 - 662
Attorney, Agent or Firm:
IIDA, Toshizo et al. (JP)
Toshizo Iida (JP)
Toshizo Iida (JP)
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