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Title:
METHOD FOR PRODUCING GLYCOSIDE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2016/159374
Kind Code:
A1
Abstract:
 The present invention provides a method for producing glycoside compounds represented by general formula (I) or salts thereof, said method comprising: a step (step 0) in which a thioether compound represented by general formula (103) and an alcohol compound represented by general formula (105) are made to undergo a coupling reaction in the presence of a halogenating agent, a desiccant, and a Lewis acid, and a thioether compound represented by general formula (104) is obtained by distilling the reaction product in the presence of at least one additive selected from a sulfur-containing anti-oxidant and a maleimide group-containing compound; and a step (step 1) in which, in the presence of the halogenating agent, desiccant, and Lewis acid, a glycoside compound represented by general formula (Ia) and the thioether compound represented by general formula (104) are made to undergo a coupling reaction to obtain a glycoside compound represented by general formula (Ib). This method enables phosphoramidites appropriate for the production (synthesis) of nucleic acids to be more efficiently produced with high purity. (Each compound is as defined in the specification.)

Inventors:
AOKI, Eriko (Fukuoka BIO Factory 4F 1488-4, Aikawa-machi, Kurume-sh, Fukuoka 61, 〒8390861, JP)
KINOSHITA, Takashi (Fukuoka BIO Factory 4F 1488-4, Aikawa-machi, Kurume-sh, Fukuoka 61, 〒8390861, JP)
ITOH, Akihiro (Fukuoka BIO Factory 4F 1488-4, Aikawa-machi, Kurume-sh, Fukuoka 61, 〒8390861, JP)
OHGI, Tadaaki (Fukuoka BIO Factory 4F 1488-4, Aikawa-machi, Kurume-sh, Fukuoka 61, 〒8390861, JP)
Application Number:
JP2016/060971
Publication Date:
October 06, 2016
Filing Date:
April 01, 2016
Export Citation:
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Assignee:
BONAC CORPORATION (1488-4, Aikawa-machi Kurume-sh, Fukuoka 61, 〒8390861, JP)
International Classes:
C07H19/067; C07H19/167
Domestic Patent References:
WO2013027843A12013-02-28
Foreign References:
JPH0680662A1994-03-22
JPH07149779A1995-06-13
JPS4880508A1973-10-29
JP2001199936A2001-07-24
Other References:
SERGEEV, V. A. ET AL.: "Reaction of dithiophenols with dicarboxylic acid bisimides, Vysokomolekulyarnye Soedineniya, Seriya B: Kratkie Soobshcheniya", CHEM. ABSTR., vol. 21, no. 7, 1979, pages 499 - 502, XP009510037
See also references of EP 3301103A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime (Meiji Yasuda Seimei Osaka Midosuji Bldg, 1-1 Fushimimachi 4-chome, Chuo-ku, Osaka-sh, Osaka 44, 〒5410044, JP)
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