Title:
METHOD FOR PRODUCING GRAFT MATERIAL FOR TREATING NERVE DAMAGE
Document Type and Number:
WIPO Patent Application WO/2014/185470
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for producing a graft material, which has a high restoring effect on dysfunction caused by nerve damage, at a high efficiency and a high reproducibility. Provided are a method for producing a graft material for treating nerve damage, etc., said method comprising a step for culturing dental pulp stem cells in a medium that is substantially free from growth factors other than FGF2.
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Inventors:
TEZUKA KENICHI (JP)
KAWAGUCHI TOMOKO (JP)
KUNISADA TAKAHIRO (JP)
SHIBATA TOSHIYUKI (JP)
FUKUMITSU HIDEFUMI (JP)
FURUKAWA SHOEI (JP)
KAWAGUCHI TOMOKO (JP)
KUNISADA TAKAHIRO (JP)
SHIBATA TOSHIYUKI (JP)
FUKUMITSU HIDEFUMI (JP)
FURUKAWA SHOEI (JP)
Application Number:
PCT/JP2014/062881
Publication Date:
November 20, 2014
Filing Date:
May 14, 2014
Export Citation:
Assignee:
ADVANCED CT FOR TISSUE ENGINEERING LTD (JP)
International Classes:
C12N5/071; A61K35/32; A61P25/00
Domestic Patent References:
| WO2012133803A1 | 2012-10-04 |
Foreign References:
| JP2011219432A | 2011-11-04 | |||
| JP2010268715A | 2010-12-02 |
Other References:
THANAPHUM OSATHANON ET AL.: "Basic Fibroblast Growth Factor Inhibits Mineralization but Induces Neuronal Differentiation by Human Dental Pulp Stem Cells Through a FGFR and PLCy Signaling Pathway", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 112, 2011, pages 1807 - 1816, XP055293109
RYO SASAKI ET AL.: "Neurosphere generation from dental pulp of adult rat incisor", EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 27, 2008, pages 538 - 548, XP055293111
SAKAI K. ET AL., J CLIN INVEST, vol. 122, pages 80 - 90
TAKEDA, T. ET AL., J. DENT. RES., vol. 87, 2008, pages 676 - 681
TAMAOKI ET AL., J DENT RES., vol. 89, 2010, pages 773 - 778
"Human Bone Marrow Mesenchymal Stem Cell", 1 January 2009, YODOSYA, article "Experimental Medicine, additional volume, Revised Cultured Cell Experiment Handbook"
BASSO DM ET AL., J NEUROTRAUMA., vol. 12, no. 1, February 1995 (1995-02-01), pages 1 - 21
See also references of EP 2998390A4
RYO SASAKI ET AL.: "Neurosphere generation from dental pulp of adult rat incisor", EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 27, 2008, pages 538 - 548, XP055293111
SAKAI K. ET AL., J CLIN INVEST, vol. 122, pages 80 - 90
TAKEDA, T. ET AL., J. DENT. RES., vol. 87, 2008, pages 676 - 681
TAMAOKI ET AL., J DENT RES., vol. 89, 2010, pages 773 - 778
"Human Bone Marrow Mesenchymal Stem Cell", 1 January 2009, YODOSYA, article "Experimental Medicine, additional volume, Revised Cultured Cell Experiment Handbook"
BASSO DM ET AL., J NEUROTRAUMA., vol. 12, no. 1, February 1995 (1995-02-01), pages 1 - 21
See also references of EP 2998390A4
Attorney, Agent or Firm:
INABA, Yoshiyuki et al. (JP)
Yoshiyuki Inaba (JP)
Yoshiyuki Inaba (JP)
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