Title:
METHOD FOR PRODUCING HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2015/156346
Kind Code:
A1
Abstract:
Provided is a method for producing a synthetic intermediate of a heterocyclic compound having a renin inhibitory activity and effective as a prophylactic or therapeutic drug against diabetic renal disease, hypertension, and the like. A method for producing a compound represented by formula (III-1a), (III-1b), (III-1c), and/or (III-1d) [where the symbols in the formulas are as defined in the description], or a salt thereof, said method characterized in that a compound represented by formula (Ia) or (Ib) [where the symbols in the formulas are as defined in the description] or a salt thereof is reacted with a compound represented by formula (II) [where the symbols in the formula are as defined in the description] or a salt thereof in the presence of an aluminum compound and a chiral amine compound.
Inventors:
YAMASHITA HIRONORI (JP)
MIWA KAZUHIRO (JP)
MIWA KAZUHIRO (JP)
Application Number:
PCT/JP2015/061075
Publication Date:
October 15, 2015
Filing Date:
April 09, 2015
Export Citation:
Assignee:
TAKEDA PHARMACEUTICAL (JP)
International Classes:
C07C231/02; C07C231/18; C07C233/58; C07D211/60; C07B61/00
Domestic Patent References:
| WO2013095275A1 | 2013-06-27 |
Foreign References:
| JP2011524853A | 2011-09-08 | |||
| JP2009522226A | 2009-06-11 |
Other References:
CIHANGIR TANYELI ET AL.: "Asymmetric synthesis of 1,4-amino alcohol ligands with a norbornene backbone for use in the asymmetric diethylzinc addition to benzaldehyde", TETRAHEDRON : ASYMMETRY, vol. 16, no. 11, 2005, pages 2039 - 2043, XP027676457
See also references of EP 3130581A4
See also references of EP 3130581A4
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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