Title:
METHOD FOR PRODUCING HETEROCYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/159639
Kind Code:
A1
Abstract:
Provided is a method for producing a heterocyclic compound which is useful as a prophylactic and/or therapeutic agent for Alzheimer's disease and the like. A method for producing 1,5-anhydro-2,4-dideoxy-2-(4-fluoro-5-methyl-1-oxo-6-(4-(1H-pyrazol-1-yl)benzyl)-1,3-dihydro-2H-isoindol-2-yl)-L-threo-pentitol or a salt thereof, comprising reacting 4-fluoro-3-hydroxy-5-methyl-6-[4-(1H-pyrazol-1-yl)benzyl]-2-benzofuran-1(3H)-one or a salt thereof, 3-fluoro-2-formyl-4-methyl-5-[4-(1H-pyrazol-1-yl)benzyl]benzoic acid or a salt thereof, or a mixture thereof with 2-amino-1,5-anhydro-2,4-dideoxy-L-threo-pentitol.
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Inventors:
KANEMATSU MAKOTO (JP)
ISHIMOTO KAZUHISA (JP)
KATOU TOMOAKI (JP)
ISHIMOTO KAZUHISA (JP)
KATOU TOMOAKI (JP)
Application Number:
PCT/JP2018/007349
Publication Date:
September 07, 2018
Filing Date:
February 27, 2018
Export Citation:
Assignee:
TAKEDA PHARMACEUTICALS CO (JP)
International Classes:
C07D405/14; C07D231/12; C07D405/10; A61K31/4155; A61P25/28
Domestic Patent References:
| WO2015163485A1 | 2015-10-29 | |||
| WO2017155050A1 | 2017-09-14 | |||
| WO2015163485A1 | 2015-10-29 |
Foreign References:
| JPS55141457A | 1980-11-05 | |||
| SU1502568A1 | 1989-08-23 | |||
| JP2017036898A | 2017-02-16 |
Other References:
UNO, M. ET AL.: "1-[4-(N-Benzylamino)phenyl]-3-phenylurea derivatives as a new class of hypoxia-inducible factor-1 a inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 3166 - 3169, XP026138491, DOI: doi:10.1016/j.bmcl.2009.04.122
NAYAL, ONKAR S. ET AL.: "Synthesis of tertiary arylamines: Lewis acid-catalyzed direct reductive N-alkylation of secondary amines with ketones through an alternative pathway", CHEMICAL COMMUNICATIONS, vol. 52, no. 62, 2016, pages 9648 - 9651, XP055605588
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 138, 2016, pages 2985 - 2988
ORGANIC LETTERS, vol. 18, 2016, pages 5248 - 5251
TETRAHEDRON LETTERS, vol. 57, 2016, pages 4142 - 4144
See also references of EP 3590936A4
NAYAL, ONKAR S. ET AL.: "Synthesis of tertiary arylamines: Lewis acid-catalyzed direct reductive N-alkylation of secondary amines with ketones through an alternative pathway", CHEMICAL COMMUNICATIONS, vol. 52, no. 62, 2016, pages 9648 - 9651, XP055605588
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 138, 2016, pages 2985 - 2988
ORGANIC LETTERS, vol. 18, 2016, pages 5248 - 5251
TETRAHEDRON LETTERS, vol. 57, 2016, pages 4142 - 4144
See also references of EP 3590936A4
Attorney, Agent or Firm:
TAKASHIMA, Hajime et al. (JP)
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