Title:
METHOD FOR PRODUCING HYALURONIC ACID
Document Type and Number:
WIPO Patent Application WO/2010/010631
Kind Code:
A1
Abstract:
It is intended to provide a method for simply producing hyaluronic acid in high yield. Further, it is also intended to provide a method for producing hyaluronic acid in a short time. According to the invention, the method for producing hyaluronic acid including the steps of: culturing a microorganism having an ability to product hyaluronic acid; and adding glutamine and arginine to a culture solution at a late logarithmic growth stage of the microorganism is provided.
Inventors:
HASHIMOTO MASAMICHI (JP)
KAKEMA TERUAKI (JP)
FUJII KENJI (JP)
IKEMI MASAHISA (JP)
KAKEMA TERUAKI (JP)
FUJII KENJI (JP)
IKEMI MASAHISA (JP)
Application Number:
PCT/JP2008/063427
Publication Date:
January 28, 2010
Filing Date:
July 25, 2008
Export Citation:
Assignee:
DENKI KAGAKU KOGYO KK (JP)
HASHIMOTO MASAMICHI (JP)
KAKEMA TERUAKI (JP)
FUJII KENJI (JP)
IKEMI MASAHISA (JP)
HASHIMOTO MASAMICHI (JP)
KAKEMA TERUAKI (JP)
FUJII KENJI (JP)
IKEMI MASAHISA (JP)
International Classes:
C12P19/26; C08B37/00
Foreign References:
| JPH0746992A | 1995-02-21 | |||
| JPS63141594A | 1988-06-14 | |||
| JPH0412960B2 | 1992-03-06 | |||
| JPH0746992A | 1995-02-21 | |||
| JPS62289198A | 1987-12-16 | |||
| JPS63141594A | 1988-06-14 |
Other References:
LOWTHER D.R. ET AL.: "The role of glutamine in the biosynthesis of hyaluronate by streptococcal suspencions", BIOCHEM. J., vol. 62, no. 2, 1956, pages 304 - 314, XP008141973
BLANK L.M. ET AL.: "Stable production of hyaluronic acid in Streptococcus zooepidemicus chemostats operated at high dilution rate", BIOTECHNOL. BIOENG., vol. 90, no. 6, 20 June 2005 (2005-06-20), pages 685 - 693, XP002464474
See also references of EP 2311971A4
BLANK L.M. ET AL.: "Stable production of hyaluronic acid in Streptococcus zooepidemicus chemostats operated at high dilution rate", BIOTECHNOL. BIOENG., vol. 90, no. 6, 20 June 2005 (2005-06-20), pages 685 - 693, XP002464474
See also references of EP 2311971A4
Attorney, Agent or Firm:
SONODA, Yoshitaka et al. (JP)
Yoshitaka Sonoda (JP)
Yoshitaka Sonoda (JP)
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