Title:
METHOD FOR PRODUCING HYDROXYLATED CHALCONES AND FLAVANONES
Document Type and Number:
WIPO Patent Application WO/2021/182594
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an easy method for producing hydroxylated chalcones and flavanones. The present invention relates to a method for producing hydroxylated chalcones and flavanones, the method being characterized in that bismuth chloride is used. In a demethoxymethylation step, target chalcones or target flavanones are obtained efficiently as a single product, and thus the present invention can provide an effective method for producing chalcones and flavanones where purification is easily performed.
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Inventors:
SUZUKI HIROKAZU (JP)
MIURA MASAKAZU (JP)
KAMEI TAKASHI (JP)
KITOH SOH-ICHI (JP)
MIURA MASAKAZU (JP)
KAMEI TAKASHI (JP)
KITOH SOH-ICHI (JP)
Application Number:
PCT/JP2021/009943
Publication Date:
September 16, 2021
Filing Date:
March 12, 2021
Export Citation:
Assignee:
HOKURIKU UNIV (JP)
International Classes:
C07C45/65; C07C45/74; C07C49/835; C07D311/32
Foreign References:
| US20040235081A1 | 2004-11-25 |
Other References:
LIAO, T. G ET AL.: "Studies on the synthesis of novel chalcone and biological activity", CHINESE JOURNAL OF ORGANIC CHEMISTRY, vol. 26, no. 5, 2006, pages 685 - 689
WANG, Q. A ET AL.: "Syntesis of 7, 3', 5'- trisubstituted flavanones and flavonols", JOURNAL OF HUNAN UNIVERSITY ( NATURAL SCIENCES ), vol. 33, no. 6, 2006, pages 98 - 102
KAGAWA, H ET AL.: "Preparative monohydroxyflavanone syntheses and a protocol for gas chromatography-mass spectrometry analysis of monohydroxyflavanones", CHEM. PHARM. BULL., vol. 53, no. 5, 2005, pages 547 - 554, XP055856865
KHAN, M. K ET AL.: "A comprehensive review on flavanones, the major citrus polyphenols", JOURNAL OF FOOD COMPOSITION AND ANALYSIS, vol. 33, no. 1, February 2014 (2014-02-01), pages 85 - 104, XP055856866
WANG, Q. A ET AL.: "Syntesis of 7, 3', 5'- trisubstituted flavanones and flavonols", JOURNAL OF HUNAN UNIVERSITY ( NATURAL SCIENCES ), vol. 33, no. 6, 2006, pages 98 - 102
KAGAWA, H ET AL.: "Preparative monohydroxyflavanone syntheses and a protocol for gas chromatography-mass spectrometry analysis of monohydroxyflavanones", CHEM. PHARM. BULL., vol. 53, no. 5, 2005, pages 547 - 554, XP055856865
KHAN, M. K ET AL.: "A comprehensive review on flavanones, the major citrus polyphenols", JOURNAL OF FOOD COMPOSITION AND ANALYSIS, vol. 33, no. 1, February 2014 (2014-02-01), pages 85 - 104, XP055856866
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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