Title:
METHOD FOR PRODUCING INDUCED PLURIPOTENT STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2011/135969
Kind Code:
A1
Abstract:
Disclosed is a method for efficiently and conveniently producing iPS cells. Pluripotent stem cells are obtained by culturing bone marrow in the presence of granulocyte-monocyte colony-stimulating factor, and then genetically transforming the propagated cells.
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Inventors:
ISOBE KEN-ICHI (JP)
Application Number:
PCT/JP2011/058027
Publication Date:
November 03, 2011
Filing Date:
March 30, 2011
Export Citation:
Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
ISOBE KEN-ICHI (JP)
ISOBE KEN-ICHI (JP)
International Classes:
C12N5/10; A61K35/28; A61L27/00; C12N15/09; A61P1/16; A61P11/00; A61P13/12; A61P17/00; A61P19/02; A61P19/10; A61P21/00; A61P43/00
Domestic Patent References:
WO2009148057A1 | 2009-12-10 |
Foreign References:
JP2009507520A | 2009-02-26 |
Other References:
OKABE M. ET AL.: "Definitive proof for direct reprogramming of hematopoietic cells to pluripotency.", BLOOD, vol. 114, no. 9, 2009, pages 1764 - 1767
ZHAO CHENG ET AL.: "Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells.", J MOL CELL BIOL, vol. 3, no. 2, April 2011 (2011-04-01), pages 91 - 98
KEN'ICHI ISOBE ET AL.: "Roka to Saisei Roka Mouse kara iPS Saibo no Juritsu", KISO ROKA KENKYU, vol. 34, no. 4, 4 November 2010 (2010-11-04), pages 33 - 35
EMINLI S ET AL.: "Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells.", NAT GENET., vol. 41, no. 9, 2009, pages 968 - 976, XP055048798, DOI: doi:10.1038/ng.428
ZHAO CHENG ET AL.: "Establishment of induced pluripotent stem cells from aged mice using bone marrow-derived myeloid cells.", J MOL CELL BIOL, vol. 3, no. 2, April 2011 (2011-04-01), pages 91 - 98
KEN'ICHI ISOBE ET AL.: "Roka to Saisei Roka Mouse kara iPS Saibo no Juritsu", KISO ROKA KENKYU, vol. 34, no. 4, 4 November 2010 (2010-11-04), pages 33 - 35
EMINLI S ET AL.: "Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells.", NAT GENET., vol. 41, no. 9, 2009, pages 968 - 976, XP055048798, DOI: doi:10.1038/ng.428
Attorney, Agent or Firm:
HAGINO Mikiharu (JP)
Kanji Hagino (JP)
Kanji Hagino (JP)
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Claims:
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