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Title:
METHOD OF PRODUCING L-AMINO ACIDS
Document Type and Number:
WIPO Patent Application WO/2020/204179
Kind Code:
A1
Abstract:
A method is described for producing an L-amino acid including the steps of cultivating in a culture medium an L-amino acid-producing bacterium belonging to the family Enterobacteriaceae to produce and accumulate the L-amino acid in the culture medium, cells of the bacterium, or both, and collecting the L-amino acid from the culture medium, the cells, or both, wherein said bacterium has been modified to overexpress a gene encoding a periplasmic adaptor protein. Specifically mentioned periplasmic proteins are yibH, acrA, emrA, zneB, emrK, mdtA, mexA, macA, and mdtE and E.coli and P.ananatis are specifically mentioned bacteria. The tripartite efflux pumps exemplified contain LeuE (yeaS) and tolC in addition to yibH.

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Inventors:
STOYNOVA NATALIA VIKTOROVNA (RU)
IGONINA OLGA NIKOLAEVNA (RU)
MALYKH EVGENIYA ALEKSANDROVNA (RU)
PLEKHANOVA NATALYA SERGEEVNA (RU)
KONONOVA IRENA ALEXANDROVNA (RU)
BUTOV IVAN ALEXANDROVICH (RU)
SAMSONOV VIKTOR VASILIEVICH (RU)
BIRYUKOVA IRINA VLADIMIROVNA (RU)
SHMAGINA IRINA SEGREEVNA (RU)
Application Number:
PCT/JP2020/015390
Publication Date:
October 08, 2020
Filing Date:
April 03, 2020
Export Citation:
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Assignee:
AJINOMOTO KK (JP)
International Classes:
C12P13/04
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Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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