Title:
METHOD FOR PRODUCING LIPOIC ACID AND DIHYDROLIPOIC ACID
Document Type and Number:
WIPO Patent Application WO2002044163
Kind Code:
A3
Abstract:
The invention relates to a method for producing R- and S-lipoic acid and R-dihydrolipoic acid comprising the following steps: (a) reaction of the compound of formula (2) with sodium sulphide and sulphur in methanol, whereby Ms represents SO<2>R`, and R and R` independently of one another represent C1-C6 alkyl, C3-C8-cycloalkyl, C3-C8-cycloalkylalkyl, aryl or aralkyl. The invention relates in particular to methods for producing pure R- or S-dihydrolipoic acid, which is either used directly or processed further to obtain R- and S-lipoic acid. The method is also used to produce medicaments. The invention also relates to a solution of sodium sulphide-trihydrate and sulphur in methanol, whereby the sulphur is present as a molar surplus in relation to the sodium sulphide-trihydrate, and to a kit that comprises the inventive solution.
Inventors:
KLATT MARTIN JOCHEN (DE)
NIEBEL MARKUS (DE)
PAUST JOACHIM (DE)
NIEBEL MARKUS (DE)
PAUST JOACHIM (DE)
Application Number:
PCT/EP2001/013955
Publication Date:
January 30, 2003
Filing Date:
November 29, 2001
Export Citation:
Assignee:
BASF AG (DE)
KLATT MARTIN JOCHEN (DE)
NIEBEL MARKUS (DE)
PAUST JOACHIM (DE)
KLATT MARTIN JOCHEN (DE)
NIEBEL MARKUS (DE)
PAUST JOACHIM (DE)
International Classes:
C07D339/04; (IPC1-7): C07D339/04
Foreign References:
| EP0487986A2 | 1992-06-03 |
Other References:
BRINGMANN G ET AL: "A SHORT AND PRODUCTIVE SYNTHESIS OF (R)-ALPHA-LIPOIC ACID", ZEITSCHRIFT FUR NATURFORSCHUNG, TEIL B: ANORGANISCHE CHEMIE, ORGANISCHE CHEMIE, VERLAG DER ZEITSCHRIFT FUR NATURFORSCHUNG. TUBINGEN, DE, no. 54B, 1999, pages 655 - 661, XP001063331, ISSN: 0932-0776
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