Title:
METHOD FOR PRODUCING LIPOSOME AND METHOD FOR DISSOLVING CHOLESTEROL
Document Type and Number:
WIPO Patent Application WO/2010/074172
Kind Code:
A1
Abstract:
Disclosed is a method for producing a liposome, which comprises: a first mixing step wherein one or more lipids are mixed with an aqueous solution containing a water-miscible organic solvent; a heating step wherein the mixture obtained by mixing the lipids with the aqueous solution is heated to a temperature at which the lipids are dissolved in the aqueous solution; and a cooling step following the heating step, wherein the resulting mixture is cooled down to a temperature at which a liposome is produced. Uniform-sized liposomes having a high encapsulation rate can be easily obtained by the method.
Inventors:
SHIMIZU YOSHITAKA (JP)
MIBE YASUHIKO (JP)
MIBE YASUHIKO (JP)
Application Number:
PCT/JP2009/071484
Publication Date:
July 01, 2010
Filing Date:
December 24, 2009
Export Citation:
Assignee:
BIOMEDCORE INC (JP)
SHIMIZU YOSHITAKA (JP)
MIBE YASUHIKO (JP)
SHIMIZU YOSHITAKA (JP)
MIBE YASUHIKO (JP)
International Classes:
B01J13/04; A61K8/14; A61K8/55; A61K8/63; A61K9/127
Domestic Patent References:
| WO1995024201A1 | 1995-09-14 |
Foreign References:
| JP2006517594A | 2006-07-27 | |||
| JPH09501168A | 1997-02-04 | |||
| JP2006517594A | 2006-07-27 | |||
| JPH06509547A | 1994-10-27 |
Other References:
See also references of EP 2368627A4
A. D. BANGHAM ET AL., J. MOL. BIOL., vol. 13, 1965, pages 238 - 252
A. D. BANGHAM; R. W. HORNE, J. MOL. BIOL., vol. 8, 1964, pages 660 - 668
A. D. BANGHAM ET AL., J. MOL. BIOL., vol. 13, 1965, pages 238 - 252
A. D. BANGHAM; R. W. HORNE, J. MOL. BIOL., vol. 8, 1964, pages 660 - 668
Attorney, Agent or Firm:
ISSHIKI & CO. (JP)
All international patent business corporation (JP)
All international patent business corporation (JP)
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