SUMMARY OF THE INVENTION The present invention provides a method for producing a mass-coded set of chemical compounds having the general formula X (Y), where X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer greater than 1, typically from 2 to about 6. The method comprises selecting a peripheral moiety precursor subset from a peripheral moiety precursor set. The subset includes a sufficient number of peripheral moiety precursors that at least about 50,100,250 or 500 distinct

combinations of n peripheral moieties derived from the peripheral moiety precursors in the subset exist. The subset of peripheral moiety precursors is selected so that at least about 90% of all possible combinations of n peripheral moieties derived from the subset of peripheral moiety precursors have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties. The method further comprises contacting the peripheral moiety precursor subset with a scaffold precursor which has n reactive groups, each of which is capable of reacting with at least one peripheral moiety precursor to form a covalent bond. The peripheral moiety precursor subset is contacted with the scaffold precursor under conditions sufficient for the reaction of each reactive group with a peripheral moiety precursor, resulting in a mass-coded set of compounds of the general formula X (Y) n- In another embodiment, the invention provides a method of identifying a member or members of a mass-coded combinatorial library which are ligands for a biomolecule, for example, a protein or a nucleic acid molecule, such as DNA or RNA. The method comprises the steps of (1) contacting the biomolecule with the mass-coded molecular library, whereby members of the mass-coded molecular library which are ligands for the biomolecule bind to the biomolecule to form biomolecule-ligand complexes and members of the mass-coded library which are not ligands for the biomolecule remain unbound; (2) separating the biomolecule-ligand complexes from the unbound members of

the mass-coded molecular library; (3) dissociating the biomolecule-ligand complexes; and (4) determining the molecular mass of each ligand to identify the set of n peripheral moieties present in each ligand.

In a further embodiment, the invention provides a method for identifying a member or members of a mass-coded molecular library which are ligands for a biomolecule and bind to the biomolecule at the binding site of a ligand known to bind the biomolecule (a known ligand). The method comprises the steps of: (1) contacting the biomolecule with the mass-coded molecular library, so that members of the mass-coded molecular library which are ligands for the biomolecule bind to the biomolecule to form biomolecule- ligand complexes and members of the mass-coded library which are not ligands for the biomolecule remain unbound; (2) separating the biomolecule-ligand complexes from the unbound members of the mass-coded molecular library; (3) contacting the biomolecule-ligand complexes with a ligand known to bind the biomolecule, to dissociate biomolecule- ligand complexes in which the ligand binds to the biomolecule at the binding site of the known ligand, thereby forming biomolecule-known ligand complexes and dissociated ligands; (4) separating the dissociated ligands and biomolecule-ligand complexes; and (5) determining the molecular mass of each dissociated ligand to identify the set of n peripheral moieties present in each dissociated ligand.

In a yet further embodiment, the invention provides a method for identifying a member or members of a mass-coded

combinatorial library which are ligands for a first biomolecule but are not ligands for a second biomolecule.

The method comprises the steps of: (1) contacting the first biomolecule with the mass-coded molecular library, whereby members of the mass-coded molecular library which are ligands for the first biomolecule bind to the first biomolecule to form first biomolecule-ligand complexes and members of the mass-coded library which are not ligands for the first biomolecule remain unbound; (2) separating the first biomolecule-ligand complexes from the unbound members of the mass-coded molecular library; (3) dissociating the first biomolecule-ligand complexes; (4) determining the molecular mass of each ligand for the first biomolecule; (5) contacting the second biomolecule with the mass-coded molecular library, whereby members of the mass-coded molecular library which are ligands for the second biomolecule bind to the second biomolecule to form second biomolecule-ligand complexes and members of the mass-coded library which are not ligands for the second biomolecule remain unbound; (6) separating the second biomolecule- ligand complexes from the unbound members of the mass-coded molecular library; (7) dissociating the second biomolecule- ligand complexes; (8) determining the molecular mass of each ligand for the second biomolecule; and (9) determining which molecular masses determined in step (4) are not determined in step (8). This provides the molecular masses of members of the mass-coded combinatorial library which are ligands for the first biomolecule, but are not ligands for the second biomolecule.

In another embodiment, the method for identifying a member or members of a mass-coded combinatorial library which are ligands for a first biomolecule but are not ligands for a second biomolecule comprises the steps of: (1) contacting the second biomolecule with the mass-coded molecular library, so that members of the mass-coded molecular library which are ligands for the second biomolecule bind to the second biomolecule to form second biomolecule-ligand complexes and members of the mass-coded library which are not ligands for the second biomolecule remain unbound; (2) separating the second biomolecule- ligand complexes from the unbound members of the mass-coded molecular library; (3) contacting the first biomolecule with the unbound members of the mass-coded molecular library of step (2), whereby members of the mass-coded molecular library which are ligands for the first biomolecule bind to the first biomolecule to form first biomolecule-ligand complexes and members of the mass-coded library which are not ligands for the first biomolecule remain unbound; (4) dissociating the first biomolecule- ligand complexes; and (5) determining the molecular mass of each ligand for the first biomolecule. Each molecular mass determined corresponds to a set of n peripheral moieties present in a ligand for the first biomolecule which is not a ligand for the second biomolecule.

In yet another embodiment, the present invention relates to a method for identifying a member of a mass- coded combinatorial library which is a ligand for a biomolecule and assessing the the effect of the binding of

the ligand to the biomolecule. The method comprises the steps of: contacting the biomolecule with the mass-coded molecular library, whereby members of the mass-coded molecular library which are ligands for the biomolecule bind to the biomolecule to form biomolecule-ligand complexes and members of the mass-coded library which are not ligands for the biomolecule remain unbound; separating the biomolecule-ligand complexes from the unbound members of the mass-coded molecular library; dissociating the biomolecule-ligand complexes; determining the molecular mass of each ligand to identify the set of n peripheral moieties present in each ligand. The molecular mass of each ligand corresponds to a set of n peripheral moieties present in that ligand, thereby identifying a member of the mass-coded combinatorial library which is a ligand for the biomolecule. The method further comprisies assessing in an in vivo or in vitro assay the effect of the binding of the ligand to the biomolecule on the function of the biomolecule.

The method of the invention allows rapid production of mass-coded combinatorial libraries comprising large numbers of compounds. The mass-coding enables the identification of individual combinations of scaffold and peripheral moieties by molecular mass. The libraries prepared by the method of the invention also allow the rapid identification of compounds which are ligands for a given biomolecule.

BRIEF DESCRIPTION OF THE DRAWINGS Figures 1A and 1B are flow charts illustrating a procedure and alternative procedure, respectively, for selecting a subset of peripheral moiety precursors from among a larger set of peripheral moiety precursors for the production of a mass-coded combinatorial library.

Figure 2A is a graph illustrating the mass redundancy of the combinatorial libraries resulting from a computer selected set of peripheral moiety precursors selected using a mass-coding algorithm.

Figure 2B is a graph illustrating the mass redundancy of the combinatorial libraries resulting from a set of peripheral moiety precursors selected randomly.

Figure 2C presents graphs illustrating the mass redundancy of the combinatorial libraries resulting from (1) a computer optimized set of peripheral moiety precursors selected using a mass-coding algorithm (...) and (2) a set of peripheral moiety precursors selected randomly (-).

Figure 3 is a schematic diagram of a computer system employing a digital processor assembly embodying the invention method of selecting a subset of peripheral moiety precursors which minimize or eliminate mass redundancy in a library.

DETAILED DESCRIPTION OF THE INVENTION The major hurdles in drug development include a need for: 1) combinatorial chemistry technology that enables rapid production of nearly unlimited numbers of compounds

while incorporating the ability to identify efficiently single chemical compounds that bind tightly to a specific biomolecule target, such as a protein or nucleic acid molecule; 2) extremely efficient target-based screening technologies that permit rapid identification of chemical compounds within a large library mixture that become tightly associated with a target biomolecule, even when the function of that biomolecule is not well understood and 3) an information data set that describes how chemical components interact with biomolecules of medical importance.

The present invention provides a method of producing a mass-coded set of compounds, such as a mass-coded combinatorial library. The compounds are of the general formula X (Y) n, wherein X is a scaffold, each Y is a peripheral moiety and n is an integer greater than 1, typically from 2 to about 6. The term"scaffold", as used herein, refers to a molecular fragment to which two or more peripheral moieties are attached via a covalent bond. The scaffold is a molecular fragment which is common to each member of the mass-coded set of compounds. The term "peripheral moiety", as used herein, refers to a molecular fragment which is bonded to a scaffold. Each member of the set of mass-coded compounds will include a combination of n peripheral moieties bonded to the scaffold and this set of compounds forms a mass coded combinatorial library.

The term"combination", as used herein, refers to all permutations of m moieties having n members where m is an integer greater than 2, n is an integer greater than 1 and

m is greater than or equal to n, such that: (1) Permutations having n members in which a given moiety is present from 0 to n times are included.

(2) Permutations having the same n moieties but ordered differently are included once and only once.

The number of combinations of all permutations of m moieties having n members may be calculated from the formula: Combinations = k !/ ( (k-n)! *n !) where k = m + (n-1) For example, the combinations of the four moieties labeled A, B, C, D which have 3 members are: A A A; A A B; A A C; A A D; A B B; A B C; A B D; A C C; A C D; A D D; B B B; B B C; B B D; B C C; B C D; B D D; C C C; C C D; C D D and D D D. B A A and A B A, for example, are not counted as separate combinations; only A A B is counted. In this example, m = 4, n = 3 and the number of combinations is given by 6!/ ((6-3) ! *3 !) = 20.

The terms"mass-coded set of compounds"and"mass- coded combinatorial library", as used herein, refer to a set of compounds of the formula XYn, where X is a scaffold, each Y is, independently, a peripheral moiety and n is an integer greater than 1, typically from 2 to about 6. Such a set of compounds is synthesized as a mixture by the combination of a set of peripheral moiety precursors with a

scaffold precursor, and is designed to possess minimum mass redundancy, given the requirement that a fixed number (subset) of peripheral moiety precursors must be chosen from a set of available peripheral moiety precursors.

The term"mass"or"molecular mass', as used herein, refers to the exact mass of a molecule or collection of chemical moieties in which each atom is the most abundant naturally occurring isotope for the particular element.

Exact masses and their determination by mass spectrometry are discussed by Pretsch et al., Tables of Spectral Data for Structure Determination of Organic Compounds, second edition, Springer-Verlag (1989), and Holden et al., Pure <BR> <BR> <BR> <BR> Appl. Chem. 55 : 1119-1136 (1983), the contents of each of which are incorporated herein by reference in their entirety.

"Minimum mass redundancy", as the term is used herein, is exhibited by a set of compounds of the formula X (Y) n formed by reaction of a scaffold precursor having n reactive groups, where n is an integer greater than 1, typically from 2 to about 6, with a subset of peripheral moiety precursors in which at least about 90% of the possible combinations of n peripheral moieties derived from the subset of peripheral moiety precursors have a molecular mass sum which is distinct from the molecular mass sum of any other combination of n peripheral moieties derived from the subset. The molecular mass sum of a combination of peripheral moieties is the sum of the masses of each peripheral moiety within the combination. For the present purposes, two molecular masses are distinct if they can be

distinguished by mass spectrometry or high resolution mass spectrometry. For example, molecular masses which differ by at least 0.001 atomic mass units can be distinguished by high resolution mass spectrometry.

It is to be understood that the molecular mass sum of the combination of the n peripheral moieties in a particular compound of the formula X (Y) n is the collective contribution of the n peripheral moieties to the molecular mass of the compound. As each compound within the set includes a constant scaffold, the difference in the molecular masses of two compounds within the mass-coded set of compounds is the difference in the molecular mass sums of the set of peripheral moieties in each compound.

The method of the invention comprises selecting a peripheral moiety precursor subset from a larger peripheral moiety precursor set. Details of the preferred selection process are discussed later with reference to Figures 1A, 1B and 3. The subset includes a sufficient number of peripheral moiety precursors so that, in one embodiment, at least about 50 distinct combinations of n peripheral moieties derived from the peripheral moiety precursors in the subset can be formed. In another embodiment, at least about 100 distinct combinations of n peripheral moieties can be formed. In a further embodiment, at least about 250 distinct combinations of n peripheral moiety precursors can be formed, and, in yet another embodiment, at least about 500 distinct combinations of n peripheral moieties can be formed.

The subset of peripheral moiety precursors is selected

so that at least about 90% of all possible combinations of n peripheral moieties derived from the subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties. The method further comprises contacting the peripheral moiety precursor subset with a scaffold precursor which has n reactive groups, each of which is capable of reacting with at least one peripheral moiety precursor to form a covalent bond. The peripheral moiety precursor subset is contacted with the scaffold precursor under conditions sufficient for the reaction of each reactive group with a peripheral moiety precursor, resulting in a mass-coded set of compounds.

In one embodiment, at least about 95% of all possible combinations of n peripheral moieties derived from the peripheral moiety precursor subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties. In another embodiment, each of the possible combinations of n peripheral moieties derived from the subset has a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties.

The scaffold precursor can be any molecule comprising two or more reactive groups which are capable of reacting with a peripheral moiety precursor reactive group to form a covalent bond. For example, suitable scaffold precursors can have a wide range of sizes, shapes, degrees of flexibility and charges. The reactive groups should be incapable of intramolecular reaction under the conditions

employed. Further, a scaffold precursor molecule should not react with another scaffold precursor molecule under the conditions employed. The scaffold precursor can also include any additional functional groups which are masked or protected or which do not interfere with the reaction of the reactive groups with the peripheral moiety precursors.

Preferably, the scaffold precursor comprises one or more saturated, partially unsaturated or aromatic cyclic groups, such as a cyclic hydrocarbon or heterocyclic group.

In scaffold precursors comprising two or more cyclic groups, the cyclic groups can be fused, connected via a direct bond or connected via an intervening group, such as an oxygen atom, an NH group or a Cl6-alkylene group. At least one cyclic group is substituted by one or more reactive groups. The reactive groups can be attached to the cyclic group directly or via an intervening group, such as a Cl6 alkylene group, preferably a methylene group.

Examples of suitable scaffold precursors include reactive group-substituted benzene, biphenyl, cyclohexane, bipyridyl, N-phenylpyrrole, diphenyl ether, naphthalene and benzophenone. Other suitable classes of scaffold precursors are shown below.

In these examples, each of the indicated substituents R is, independently, a reactive group, and the scaffold precursor can include one or more additional functional groups which are either (1) masked or protected to prevent their reaction with a peripheral moiety precursor (e. g., scaffold precursors f and g, above) or (2) do not react either with R or with a peripheral moiety precursor under the given reaction conditions (e. g., scaffold precursor h, above, in which R = C (O) O (C6F5) and the peripheral moiety precursors include primary amino groups).

A peripheral moiety precursor is a compound which includes a reactive group which is complementary to one or more of the reactive groups of the scaffold precursor. In addition to the reactive group, a peripheral moiety precursor can include a wide variety of structural features. For example, the peripheral moiety precursor can include one or more functional groups in addition to the

reactive group. Any additional functional group should be appropriately masked or not interfere with the reaction between the scaffold precursor and the peripheral moiety precursor. In addition, two peripheral moiety precursors should not react together under the conditions employed.

For example, a subset of peripheral moiety precursors can include, in addition to the reactive groups, functionalities selected from groups spanning a range of charge, hydrophobicity/hydrophilicity, and sizes. For example, the peripheral moiety precursor can include a negative charge, a positive charge, a hydrophilic group or a hydrophobic group.

In addition to the reactive groups, peripheral moiety precursors can include, for example, functionalities selected from among amino acid side chains, a nucleotide base or nucleotide base analogue, sugar moieties, sulfonamides, peptidomimetic groups, charged or polar functional groups, alkyl groups and aryl groups.

For the present purposes, two reactive groups are complementary if they are capable of reacting together to form a covalent bond. In a preferred embodiment, the bond forming reactions occur rapidly under ambient conditions without substantial formation of side products.

Preferably, a given reactive group will react with a given complementary reactive group exactly once.

In one embodiment, the reactive group of the scaffold precursor and the reactive group of the peripheral moiety precursor react, for example, via nucleophilic substitution, to form a covalent bond. In one embodiment,

the reactive group of the scaffold precursor is an electrophilic group and the reactive group of the peripheral moiety precursor is a nucleophilic group. In another embodiment, the reactive group of the scaffold precursor is a nucleophilic group, while the reactive group of the peripheral moiety precursor is an electrophilic group.

Complementary electrophilic and nucleophilic groups include any two groups which react via nucleophilic substitution under suitable conditions to form a covalent bond. A variety of suitable bond-forming reactions are known in the art. See, for example, March, Advanced Organic Chemistry, fourth edition, New York: John Wiley and Sons (1992), Chapters 10 to 16; Carey and Sundberg, Advanced Organic Chemistry, Part B, Plenum (1990), Chapters 1-11; and Collman et al., Principles and Applications of Organotransition Metal Chemistry, University Science Books, Mill Valley, CA (1987), Chapters 13 to 20; each of which is incorporated herein by reference in its entirety. Examples of suitable electrophilic groups include reactive carbonyl groups, such as carbonyl chloride (acyl chloride) and carbonyl pentafluorophenyl ester groups, reactive sulfonyl groups, such as the sulfonyl chloride group, and reactive phosphonyl groups. Other electrophilic groups which can be used include terminal epoxide groups and the isocyanate group. Suitable nucleophilic groups include primary and secondary amino groups and alcohol (hydroxyl) groups.

Examples of suitable scaffold precursors with specified reactive groups are shown below.

In these examples, each R is, independently, an additional reactive group which can be the same as the specified reactive group or a different group.

Illustrated below are examples of suitable peripheral moiety precursors having amino groups.

R in this case is an amino acid side chain, tBoc is tbutoxycarbonyl, Ac is acetyl and tBu is tertiary butyl.

Examples of scaffold precursors and peripheral moiety precursors which have complementary reactive groups include the following, which are provided for the purposes of illustration and are not to be construed as limiting in any way: 1. The scaffold precursor includes from two to about six reactive carbonyl groups, reactive sulfonyl groups or reactive phosphonyl groups, or a combination thereof. Each peripheral moiety precursor includes a primary or secondary amino group which reacts with the scaffold precursor to form an amide, sulfonamide or phosphonamidate bond.

2. The scaffold precursor includes from two to about six primary or secondary amino groups or a combination thereof.

Each peripheral moiety precursor includes a reactive carbonyl group, a reactive sulfonyl group or a reactive phosphonyl group.

3. The scaffold precursor includes from two to about six terminal epoxide groups. Each peripheral moiety precursor includes a primary or secondary amino group. In the presence of a suitable Lewis acid, the scaffold precursor and the peripheral moiety precursors react to form D-amino alcohols.

4. The scaffold precursor includes from two to about six primary or secondary amino groups. Each peripheral moiety precursor contains a terminal epoxide group.

5. The scaffold precursor includes from two to about six isocyanate groups. Each peripheral moiety precursor contains a primary or secondary amino group which reacts with the scaffold precursor to form a urea.

6. The scaffold precursor includes from two to about six primary or secondary amino groups, or a combination thereof. Each peripheral moiety precursor contains an isocyanate group.

7. The scaffold precursor includes from two to about six isocyanate groups. Each peripheral moiety precursor

contains an alcohol group which reacts with the scaffold precursor to form a carbamate.

8. The scaffold precursor includes from 2 to about 6 aromatic bromides. Each peripheral moiety precursor is an organo-tributyl-tin compound. The scaffold precursor and the peripheral moiety precursors are reacted in the presence of a suitable palladium catalyst to form one or more carbon-carbon bonds.

9. The scaffold precursor includes from 2 to about 6 aromatic halides or triflates. Each peripheral moiety precursor includes a primary or secondary amino groups.

The scaffold precursor and the peripheral moiety precursors are reacted in the presence of a suitable palladium catalyst to form one or more carbon-nitrogen bonds.

10. The scaffold precursor includes from two to about six amino groups. Each peripheral moiety precursor contains an aldehyde or ketone group which reacts with the scaffold precursor under reducing conditions (reductive amination) to form an amine.

11. The scaffold precursor includes from two to about six aldehyde or ketone groups. Each peripheral moiety precursor contains an amino group which reacts with the scaffold precursor under reducing conditions (reductive amination) to form an amine.

12. The scaffold precursor includes from two to about six phosphorous ylide groups. Each peripheral moiety precursor contains an aldehyde or ketone group which reacts with the scaffold precursor (Wittig type reaction) to form an alkene.

13. The scaffold precursor includes from two to about six aldehyde or ketone groups. Each peripheral moiety precursor contains a phosphorous ylide group which reacts with the scaffold precursor (Wittig type reaction) to form an alkene.

The scaffold is that portion of the scaffold precursor which remains after each reactive group of the scaffold precursor has reacted with a peripheral moiety precursor.

A peripheral moiety is that portion of the peripheral moiety precursor which is bonded to the scaffold following the bond-forming reaction. A peripheral moiety which results from the reaction of a particular peripheral moiety precursor with a reactive functional group of a scaffold precursor is said to be"derived"from that peripheral moiety precursor.

A peripheral moiety precursor can include one or more functional groups in addition to the reactive group. One or more of these additional functional groups can be protected to prevent undesired reactions of these functional groups. Suitable protecting groups are known in the art for a variety of functional groups (Greene and Wuts, Protective Groups in Organic Synthesis, second

edition, New York: John Wiley and Sons (1991), incorporated herein by reference). Particularly useful protecting groups include t-butyl esters and ethers, acetals, trityl ethers and amines, acetyl esters, trimethylsilyl ethers and trichloroethyl ethers and esters.

The compounds within the set are mass-coded as a result of the selection of a subset of suitable peripheral moiety precursors. The subset of peripheral moiety precursors is selected such that for a scaffold precursor having n reactive groups, where n is an integer from 2 to about 6, there exist at least about 50,100,250 or 500 different combinations of n peripheral moieties derived from the peripheral moiety precursor subset. At least about 90% of the possible combinations of n peripheral moieties derived from the peripheral moiety precursors within the subset will have a distinct mass sum. In one embodiment, the selection of suitable peripheral moiety precursors for the production of a mass-coded set of compounds includes one or more automated steps utilizing hardware apparatus, software apparatus or any combination thereof. In the preferred embodiment, a digital processor assembly employs a suitable software routine which selects a subset of peripheral moiety precursors which minimize or eliminate mass redundancy in the library. Figure 3 is illustrative of such apparatus employing a digital processor assembly for carrying out the present invention method.

Referring to Figure 3, there is shown a computer system 25 formed of (a) a digital processor 11 having

working memory 17 for executing programs, routines, procedures and the like, (b) input means 21 coupled to the digital processor 11 for providing data, parameters and the like to support execution of the programs, routines and/or procedures in the digital processor working memory 17, and (c) output means 23 coupled to the digital processor 11 for displaying results, prompts, messages and the like from operation of the digital processor 11. The input means 21 include a keyboard, mouse and the like common in the art.

The output means 23 include a viewing monitor, printer and the like common in the art. The invention software routine 27 is executed in the working memory 17 by the digital processor 11 as follows.

First, a user interface prompts the end-user to input indications of an initial set 13 of peripheral moiety precursors and the exact masses of the peripheral moieties which are derived therefrom. This initial set 13 may be copied, transferred or otherwise obtained from a database or other source such as is known in the art. The user interface also obtains from the end-user a set of user determined/desired criteria 19. In the preferred embodiment, the user selected criteria 19 includes (i) the total count j of peripheral moiety precursors in the initial set, (ii) the value of n indicating the number of reactive groups of a subject scaffold precursor for which the invention software routine 27 is to select a subset of peripheral moiety precursors from the input initial set 13 and (iii) the number of members of the subset, k.

Preferably, the user interface enables the end-user to

interactively provide the user selected criteria 19 through the input means 21 as indicated at 15 in Figure 3.

The digital processor 11 is responsive to the foregoing input and stores the indications of the initial set 13 of peripheral moiety precursors in a memory area 29 or data storage system associated locally or off disk with the software routine 27. That is, the memory area 29 or data storage system supports the invention software routine 27. For each peripheral moiety precursor in the initial set 13 as indicated in memory area 29, an identifier and indication of respective exact mass of the the peripheral moiety derived from the peripheral moiety precursor is provided to the software routine 27. Upon receipt of the peripheral moiety precursor identifiers, indications of exact mass, and user selected criteria (n, j and k), the software routine 27 determines and generates a subset of k peripheral moiety precursors which minimize or eliminate mass redundancy in a resulting library of compounds of the formula XYn, wherein X is a scaffold, each Y is, independently, a peripheral moiety, and n is an integer greater than 1, typically from 2 to about 6. Preferably, the software routine 27 determines a subset of peripheral moiety precursors in which at least about 90% of the possible combinations of n peripheral moieties derived from the subset have a distinct mass sum. The details of the software routine 27 employed in the preferred embodiment are discussed next for purposes of illustration and not limitation. It is understood that other software or firmware routines for accomplishing the present invention

method of selecting a subset of the initial set 13 of peripheral moiety precursors are suitable and within the purview of one skilled in the art given this disclosure.

A typical situation involves a scaffold precursor with n reactive groups, where n is an integer, a set of j peripheral moiety precursors, where j is an integer 6 or greater, where the peripheral moieties derived from the peripheral moiety precursors have molecular masses yl, Y2,---Yj-An example of a software routine which can be employed to select a suitable subset of k peripheral moiety precursors (ksj) from the set of j peripheral moiety precursors includes the following steps: 1. From an initial set of j peripheral moiety precursors, choose every set of two peripheral moiety precursors.

If Ya = Yb, randomly remove either Ya or Yb- 2. From the remaining set of peripheral moiety precursors, choose every set of four peripheral moiety precursors. If Ya+ Yb = YC+ Yd, randomly remove<BR> either Ya I Yb I YC or Yd- 3. From the remaining set of peripheral moiety precursors, choose every set of six peripheral moiety precursors. If Ya+ Yb + YC = Yd + Ye + yf, randomly<BR> remove either ya, Yb, Y Yd, Ye or yf- If at any step 1 through 3 the remaining number of peripheral moiety precursors becomes < k, then there

is no mass coded subset k which can be made from set j, and a new set j must be employed.

4. From the remaining computer selected set of peripheral moiety precursors, choose any or all subsets of k peripheral moiety precursors.

5. Generate all possible combinations of n peripheral moiety precursors from this subset.

6. If the % mass redundancy of the resulting set of combinations is found to be unacceptable, repeat step 5 until a desired mass coded library has been obtained or no further possible combinations of peripheral moiety precursors remain. In the latter case, begin again with step 1.

Once an above subset of mass-coded peripheral moiety precursors is determined, the scaffold precursor is contacted with the subset of complementary peripheral moiety precursors under conditions suitable for bond- forming reactions to occur between the peripheral moiety precursors and the scaffold precursor. The mass-coded set of compounds is, preferably, synthesized in solution as a combinatorial library.

The foregoing selection of a subset from a larger peripheral moiety precursor set and generation of a mass- coded set of compounds using the selected subset is more generally illustrated in Figures 1A and 1B. Referring to

Figure lA, the larger set of peripheral moiety precursors is provided at 31 from known sources. The end-user (e. g., chemist) selects an initial set of j peripheral moiety precursors from the larger set 31 at step 33. Typically the chemist chooses all of the larger set to form the initial set at 33. The invention mass coding selection procedure 35 is applied to the initial set. The result of the mass-coding procedure 35 is a subset 37 of peripheral moiety precursors that satisfies the mass-coding criteria outlined above. In step 39, this subset of peripheral moiety precursors is used to generate all theoretical subsets of of k peripheral moiety precursors. Also in step 39, the mass redundancies of the libraries obtained from all theoretical subsets of k peripheral moieties are calculated, and only those subsets which yield mass-coded libraries, as defined above, are passed to 41. The net result is one or more subsets 41 of k peripheral moiety precursors in which there are 50,100,250, or 500 distinct combinations of n peripheral moiety precursors in a given subset and at least 90% of all possible combinations of n peripheral moieties derived from a given subset have a molecular mass sum which is distinct from the molecular mass sums of all of the other combinations of n peripheral moieties, as discussed above. The subset (s) 41 of peripheral moiety precursors would subsequently yield mass- coded sets of compounds when contacted with an appropriate scaffold precursor in the manner discussed above.

As an alternative to the single-step application of the invention mass-coding selection procedure 35 in Figure

1A, multiple or stepped application of procedure 35 is suitable and in certain cases may be advantageous. For instance, using mass-coding procedures at each level allows for rapid sorting into distinct sets, each of which may yield optimal mass-coding. During the mass-coding process, certain criteria reduce the set size as it is passed into the next layer through mass-coding. This multi-layer approach yields advantages in speed and the elimination of mass redundancy.

Multiple application of mass-coding selection procedure 35 on initial set 33 is illustrated in Figure 1B.

Here initial set 33 is divided into plural parts (the starting larger set of peripheral moiety precursors 31 and chemist selection 33 being similar to that in Fig. 1A).

The mass-coding selection procedure 35 is applied to each plural part and results in intermediate resultant sets 43A, 43B, 43C. The mass-coded selection procedure 35 is applied in a second round/level. but this time with intermediate resultant sets 43A, 43B, 43C. This produces final sets 45A, 45B, 45C. Step 39 is as in Figure 1A and generates the subsets 47A, 47B, 47C of k peripheral moiety precursors that would subsequently yield mass-coded stes of compounds when contacted with an appropriate scaffold precursor in a manner discussed above.

It is understood that other variations between the approach illustrated in Figure 1A and that in Figure 1B are within the purview of one skilled in the art. The foregoing discussion and Figures are for purposes of illustrating and not limiting the present invention method.

In one embodiment, the scaffold precursor is contacted with all members of the peripheral moiety precursor subset simultaneously. In general, a scaffold precursor having n reactive groups, where n is an integer from 2 to about 6, will be contacted with at least about n molar equivalents relative to the scaffold precursor of peripheral moiety precursors from the selected subset. For example, the scaffold precursor can be contacted with a solution comprising each member of the subset in approximately equal concentrations. For example, if the scaffold precursor includes n reactive groups, where n is an integer greater than 1, and the number of peripheral moiety precursors in the subset is denoted by p, the scaffold precursor can be contacted with about n/p to about (1.1) n/p molar equivalents of each peripheral moiety precursor.

In another embodiment, the scaffold precursor is contacted with the members of the peripheral moiety precursor subset sequentially. This results in the formation of intermediate partially reacted scaffold precursor molecules which include at least one peripheral moiety and at least one reactive group. For example, the scaffold precursor can be contacted with one or more peripheral moiety precursors under conditions suitable for bond formation to occur. The resulting intermediates can then be contacted with one or more additional peripheral moiety precursors under suitable conditions for bond formation to occur. These steps can be repeated until each scaffold precursor reactive group has reacted with a peripheral moiety precursor.

In one embodiment, the reactive groups of the scaffold precursor can react sequentially with the subset of peripheral moiety precursors using a suitable reactive group protection/deprotection scheme. For example, the scaffold precursor can include two or more sets of reactive groups, where one set is unprotected and another set is protected, or where two sets are masked by different protecting groups. An example is the use of the scaffold precursor

which contains one unprotected reactive group and two protected reactive groups. In this case, the unprotected pentafluorophenyl ester can react with a peripheral moiety precursor first (e. g., a primary amine). Either the C13CCH20-protected group or the benzyloxy-protected group can then be deprotected using standard methods and reacted with a set of peripheral moiety precursors. Finally, the remaining protected group or groups can be deprotected and reacted with a set of peripheral moiety precursors.

Following the reaction of each scaffold precursor reactive group with a peripheral moiety precursor, any peripheral moiety having a protected functional group can be deprotected using methods known in the art.

The ability to identify individual scaffold plus peripheral moiety combinations derived from such a mixture

is a consequence of the mass-coding of the library and the ability of mass spectrometry to identify a molecular mass.

This allows the identification of individual scaffold plus peripheral moiety combinations within the set which have a particular activity, such as binding to a particular biomolecule.

In one embodiment, the present invention provides a method for identifying a compound or compounds within a mass-coded combinatorial library which bind to, or are ligands for, a biomolecule, such as a protein or nucleic acid molecule. The mass-coded combinatorial library can be produced, for example, by the method of the invention disclosed above. The target biomolecule, such as a protein, is contacted with the mass-coded combinatorial library, and, if any members of the library are ligands for the biomolecule, biomolecule-ligand complexes form. Compounds which do not bind the biomolecule are separated from the biomolecule-ligand complexes. The biomolecule-ligand complexes are dissociated and the ligands are separated and their molecular masses are determined. Due to the mass- coding of the combinatorial library, a given molecular mass is characteristic of a unique combination of peripheral moieties or only a small number of such combinations.

Thus, a ligand's molecular mass allows the determination of its composition.

In one embodiment, the target is immobilized on a solid support by any known immobilization technique. The solid support can be, for example, a water-insoluble matrix contained within a chromatography column or a membrane.

The mass-coded set of compounds can be applied to a water- insoluble matrix contained within a chromatography column.

The column is then washed to remove non-specific binders.

Target-bound compounds (ligands) can then be dissociated by changing the pH, salt concentration, organic solvent concentration, or other methods, such as competition with a known ligand to the target. The dissociated ligands are injected directly onto a reverse phase column. The reverse phase column acts as a concentrator/collector and can be interfaced directly to a mass spectrometer, such as an electrospray mass spectrometer (ES-MS). Mass information provided by the mass spectrometer is sufficient for identifying the combination of scaffold and peripheral moieties within the ligand.

In another embodiment, the target is free in solution and is incubated with the mass-coded set of compounds.

Compounds which bind to the target (ligands) are selectively isolated by a size separation step such as gel filtration or ultrafiltration. In one embodiment, the mixture of mass-coded compounds and the target biomolecule are passed through a size exclusion chromatography column (gel filtration), which separates any ligand-target complexes from the unbound compounds. The ligand-target complexes are transferred to a reverse-phase chromatography column, which dissociates the ligands from the target. The dissociated ligands are then analyzed by mass spectrometry.

Mass information provided by the mass spectrometer is sufficient for identifying the scaffold and peripheral moiety composition of the ligand. This approach is

particularly advantageous in situations where immobilization of the target may result in a loss of activity.

Once single ligands are identified by the above- described process, various levels of analysis can be applied to yield SAR information and to guide further optimization of the affinity, specificity and bioactivity of the ligand. For ligands derived from the same scaffold, three-dimensional molecular modeling can be employed to identify significant structural features common to the ligands, thereby generating families of small-molecule ligands that presumably bind at a common site on the target biomolecule.

In order to identify a consensus, highest affinity, ligand for a particular binding site, this analysis should include a ranking of the members of a given ligand family with respect to their affinities for the target. This process can provide this information by identifying both low and high affinity ligands for a target biomolecule in one experiment. For example, when the screen utilizes an immobilized target, the dissociation rate of the ligand is inversely correlated with the number of column volumes employed during of the ligand from its target. When the screen utilizes the target free in solution, weak affinity ligands can be selected by using a higher concentration of the target.

Given that each mass-coded set of compounds is synthesized with a limited number of peripheral moiety precursors, the disclosed approach can, in certain cases,

identify a superior ligand which combines structural features of molecules synthesized in separate libraries.

When possible, the analysis of ligand structural features is based on information regarding the target biomolecule's structure, wherein the hypothetical consensus ligand is computationally docked with the putative binding site. Further computational analysis can involve a dynamic search of multiple lowest energy conformations, which allows comparison of high affinity ligands that are derived from different scaffolds. The end goal is the identification of both the optimal functionality and the optimal vectorial presentation of the peripheral moieties that yields the highest binding affinity/specificity. This may provide the basis for the synthesis of an improved, second-generation scaffold.

Due to the modular design of the mass-coded compounds, computational analysis may identify the point of attachment on the scaffold that has the least functional importance with respect to affinity for the target. In many cases, the ligand will not be completely engulfed by the target biomolecule, and one peripheral moiety will be pointed away from the biomolecule towards the bulk solvent. Three- dimensional alignment of a family of ligands will reveal a high degree of functional variability at the site that is presented to the solvent. Modification at this site can then be used to optimize the affinity. For example, the noncritical reactive site can be removed and replaced with a small unreactive group, such as a hydrogen atom or a methyl group. A set of compounds structurally identical

except for the peripheral moiety at this position can be examined to identify compounds that most effectively inhibit or promote the binding of another protein/DNA/RNA molecule. Also, the peripheral moiety at this position can be modified to link two ligands together. The joining of two ligands could in certain cases yield a ligand with improved affinity and specificity, if one joins molecules that bind to adjacent sites, or yield a designed biomolecule dimerizer.

A variety of screening approaches can be used to obtain ligands that possess high affinity for one target but significantly weaker affinity for another closely related target. One screening strategy is to identify ligands for both biomolecules in parallel experiments and to subsequently eliminate common ligands by a cross- referencing comparison. In this method, ligands for each biomolecule can be separately identified as disclosed above. This method is compatible with both immobilized target biomolecules and target biomolecules free in solution.

For immobilized target biomolecules, another strategy is to add a preselection step that eliminates all ligands that bind to the non-target biomolecule from the library.

For example, a first biomolecule can be contacted with a mass-coded combinatorial library as described above.

Compounds which do not bond to the first biomolecule are then separated from any first biomolecule-ligand complexes which form. The second biomolecule is then contacted with the compounds which did not bind to the first biomolecule.

Compounds which bind to the second biomolecule can be identified as described above and have significantly greater affinity for the second biomolecule than to the first biomolecule.

The screening approach detailed above can also be applied to identify ligands that selectively interact with an altered version of the same biomolecule, wherein the first biomolecule is the unaltered biomolecule and the second biomolecule is an altered or variant version of the biomolecule. The second biomolecule can, for example, have an amino acid sequence which differs from the amino acid sequence of the first biomolecule by the insertion, deletion or substitution of one or more amino acid residues. For example, the second biomolecule can include a specific amino acid mutation that is linked to the progression of a particular disease. Alternatively, the second biomolecule can also differ from the first biomolecule in having a different post-translational modification, such as an extra site of phosphorylation or glycosylation, or it may be truncated or aberrantly fused with another biomolecule.

The screening approach detailed above can also serve as a method for identifying small molecule ligands that bind at the same site on a biomolecule as another known, biologically relevant ligand. This known ligand can be another biomolecule, such as a protein or peptide, or it can be a DNA or RNA molecule, or a substrate or cofactor involved in an enzymatic reaction. In one embodiment, the first and second biomolecules are both proteins. The first

protein is a complex of the protein and the known ligand, while the second protein is the protein alone. Compounds which bind to the protein alone, but not to the complex of the protein with the known ligand, bind to the protein at the binding site of the known ligand. This approach is especially well suited to the development of small molecule replacements of known therapeutic ligands, such as peptides or proteins.

An advantage of the present method is that it can be used to identify chemical compounds that bind tightly to any biomolecule of interest, even when the function of that biomolecule is not well understood, as is often the case with gene products defined through genomics, or when a functional assay is not available. The screening technologies described can be miniaturized to provide massive parallel screening capabilities.

A ligand for a biomolecule of unknown function which is identified by the method disclosed above can also be used to determine the biological function of the biomolecule. This is advantageous because although new gene sequences continue to be identified, the functions of the proteins encoded by these sequences and the validity of these proteins as targets for new drug discovery and development are difficult to determine and represent perhaps the most significant obstacle to applying genomic information to the treatment of disease. Target-specific ligands obtained through the process described in this invention can be effectively employed in whole cell biological assays or in appropriate animal models to

understand both the function of the target protein and the validity of the target protein for therapeutic intervention. This approach can also confirm that the target is specifically amenable to small molecule drug discovery. The ligands obtained through the process described in this invention are small molecules and are, thus, similar to actual human therapeutics (small molecule drugs).

In one embodiment, a member of a combinatorial library is identified as a ligand for a particular biomolecule using the method described above. The ligand can then be assessed in an in vitro assay for the effect of the binding of the ligand to the biomolecule on the function of the biomolecule. For a biomolecule having a known function, the assay can include a comparison of the activity of the biomolecule in the presence and absence of the ligand. If the biomolecule is of unknown function, a cell which expresses the biomolecule can be contacted with the ligand and the effect of the ligand on the viability or function of the cell is assessed. The in vitro assay can be, for example, a cell death assay, a cell proliferation assay or a viral replication assay. For example, if the biomolecule is a protein expressed by a virus, the a cell infected with the virus can be contacted with a ligand for the protein.

The affect of the binding of binding of the ligand to the protein on viral viability can then be assessed.

A ligand identified by the method of the invention can also be assessed in an in vivo model or in a human. For example, the ligand can be evaluated in an animal or

organism which produces the biomolecule. Any resulting change in the health status (e. g., disease progression) of the animal or organism can be determined.

For a biomolecule, such as a protein or a nucleic acid molecule, of unknown function, the effect of a ligand which binds to the biomolecule on a cell or organism which produces the biomolecule can provide information regarding the biological function of the biomolecule. For example, the observation that a particular cellular process is inhibited in the presence of the ligand indicates that the process depends, at least in part, on the function of the biomolecule.

The mass-coded libraries provided by the present method enable the development of an information set that describes how the universe of small molecules interacts with any biomolecule encoded within the human and other genomes. This information set would include data regarding: 1) those libraries and components therein which bind to the target biomolecule, 2) quantitative structure- activity relationships (SAR) on chemical functionalities which contribute to the binding affinity of a compound for a biomolecule target, and 3) the domains of the biomolecule that are bound by chemical compounds. The database can be used to expedite drug development in a number of ways, for example, by identifying chemical pharmacophores that interact with high affinity with a specific drug binding site.

The invention will now be further and more specifically described in the following examples.

EXAMPLES Example 1 Application of Mass-coding by Computer Algorithms: Comparison of Mass-coded and Non-Mass-coded Combinatorial Libraries The following is an analysis of the application of mass-coding algorithms towards the design of combinatorial libraries. The sequence of steps involved in identifying subsets of peripheral moiety precursors that can be allowed to react with a predetermined scaffold precursor to yield a mass-coded combinatorial library of compounds with the molecular formula X (Y) n is shown in Figure 1A; Figure 1B is an alternate sequence of steps. It is to be understood that the molecular mass sum of the combination of the n peripheral moieties in a particular compound of the formula X (Y) n is the collective contribution of the n peripheral moieties to the molecular mass of the compound. As each compound within the library includes a constant scaffold, the mass redundancy of the mass-coded library is equivalent to the molecular mass sum redundancy of all combinations of n peripheral moieties derived from the identified subset of peripheral moiety precursors.

The mass-coding analysis was performed on the initial set of 22 peripheral moieties shown below. This initial set was selected arbitrarily. Included were peripheral moiety precursors having the same exact mass. The master set consisted of the peripheral moiety precursors shown below, along with the exact masses of the resulting

peripheral moieties. The molecular masses given are the exact molecular masses and not the isotope averages. The exact molecular masses are also adjusted for any atoms which are lost as a result of the reaction with the scaffold precursor (in this case the loss of a hydrogen atom). From the initial set of 22 peripheral moiety precursors, two sets of 16 peripheral moiety precursors were generated. One set was chosen by the computer using the mass coding algorithm described herein (computer selected set). The other set was randomly chosen.

From each set of 16 peripheral moiety precursors the computer generated every possible subset of 12 peripheral moiety precursors. These subsets were used to generate all combinations of peripheral moiety precursors taken 4 at a time (representing libraries synthesized with a scaffold precursor having four reactive groups, such as four pentafluorophenyl esters). This process yielded two sets of 16 peripheral moiety precursors containing 1820 subsets of 12 each. Theoretically, these subsets of 12 peripheral moiety precursors would each yield a library of 1365 compounds containing different peripheral moiety combinations when allowed to react simultaneously with an appropriate scaffold precursor containing four reactive groups (151/ [ (15-4)! *4!] = 1365). The computer sorted every precursor subset and checked for mass redundancy in the resultant libraries (in this example mass redundancies were checked to the second significant digit after the decimal point).

It is noteworthy that the mass coding algorithms and the mass redundancy check are both flexible in that it is possible to adjust the computational filter to check mass redundancy to any significant figure. This architecture for mass-coding allows for rapid automated mass-coding, insures that a significant portion of the libraries generated with the computer selected set have less than 10% redundancy, and includes parameters for peripheral moiety precursor selection outside of exact mass. The computational requirements for this selection are fairly significant. The mass-coding algorithms are essential because it is computationally intractable to brute force calculate and check every possible set of peripheral moiety precursors from a master set of 60 or more peripheral moiety precursors. 0 0 HN H N-v NH2 z la 202.1232 97a 73.0402 NH2 H \ N 13a 112.1126 19a 196.1126 N z N X 20a 72.0813 21a 44.0500 H N/N\ 24a 100. 1126' S8. 0657 24a 100. 1126 NH H H 36a 74.0606 52a 153.1392 H O HN N'1 HZN 53a 153.1392 54a 100.0762 H N N- H N\/\N--- (\ 69a 68.0500 70a 163.0984 ci Ber C ! HN NX 77a 161.9918 76a 195.0689 a c!! h CI ci H2N N H2N 78a 140.0034 79a 210.128 O O , 0 s S í 04 ,///NH2 -Y NH2 94a 186.1494 86a 230.1756 H /.,, O H2N C NU 104a 116.0711 108a 101.0351

RESULTS The computer selected set of 16 peripheral moiety precursors contained 86a, 79a, 13a, 108a, 76a, 20a, 69a, la, 70a, 26a, 24a, 36a, 97a, 94a, 104a, and 21a. The set of 16 randomly chosen peripheral moiety precursors contained 79a, 13a, 20a, 69a, la, 26a, 24a, 104a, 52a, 54a, 19a, 77a, 53a, 21a, 55a, 36a. The libraries generated from the computer selected set of peripheral moiety precursors had an average mass redundancy of 11.5% per library with 234 libraries having mass redundancies of less than 5% and

972 libraries having mass redundancies of less than 10% (Figure 2A). The libraries generated from the randomly chosen set of peripheral moiety precursors had an average mass redundancy of 60.7% with no libraries having a mass redundancy of less than 10% (Figure 2B). A direct graphical comparison of the mass redundancies of the two sets of libraries is shown in Figure 2C. The libraries derived from the computer-selected set of peripheral moiety precursors and the corresponding mass redundancies are listed in the Table below.

Example 2 Development of ligands for a monofunctional protein A mass-coded combinatorial library can be used to identify ligands that have a high affinity for a monofunctional protein. One such monofunctional protein is the serine protease trypsin. Ligands that exhibit a high affinity for trypsin would be candidates to screen further for their ability to inhibit the proteolytic activity of trypsin. The identification of ligands to trypsin involves the following steps: trypsin is covalently biotinylated by incubation of the protein with a chemically activated biotin precursor. The biotin-trypsin conjugate is immobilized by binding to a streptavidin-derivatized water- insoluble column matrix. The mass-coded combinatorial library is solubilized in an appropriate binding buffer and injected onto a column containing the trypsin+streptavidin complex. Compounds that do not bind to the column are

washed off with binding buffer. Compounds that bind to the column are dissociated by a change in the buffer conditions, such as a change in the pH or an increase in the percentage of organic solvent. These compounds are then loaded onto a reversed-phase column that is placed downstream of the trypsin+streptavidin column. The compounds are eluted from the reversed-phase column and analyzed by mass spectrometry. Molecular masses that correspond to ligands for trypsin are identified by eliminating those masses which are also observed when the library is similarly screened with a streptavidin column.

The molecular mass of each trypsin ligand identifies one combination of peripheral moieties plus scaffold. The individual compound or compounds that result from the identified combination of peripheral moieties plus scaffold are synthesized and tested for their in vitro activity as inhibitors of trypsin.

Example 3 Development of ligands for a multifunctional protein Many proteins, especially human proteins, are multifunctional, and these functions are often mediated through interactions with multiple proteins. Ligands that bind to different sites on the protein might therefore yield different therapeutic results. The human protein HSP70 is one such example of a multifunctional protein.

HSP70 has been shown to interact with multiple polypeptides, which are largely unfolded, to facilitate

their translocation and folding. This role of HSP70 has been implicated in a variety of physiological processes, including antigen processing/presentation, development of certain cancers, and replication of a variety of human viruses. A mass-coded combinatorial library can be used to identify ligands that have a high affinity for HSP70 and bind at different sites. These ligands for HSP70 can be further evaluated in secondary assays to establish their effects on the immune response, cancer progression, and viral infection.

The identification of ligands to HSP70 involves the following steps: HSP70 is covalently biotinylated by incubation of the protein with a chemically activated biotin precursor. The biotin-HSP70 conjugate is immobilized by binding to a streptavidin-derivatized water- insoluble column matrix. The mass-coded library is solubilized in an appropriate binding buffer and injected onto a column containing the HSP70-streptavidin complex.

Compounds that do not bind to the column are washed off with binding buffer. Compounds that bind to the column are dissociated by a change in the buffer conditions, such as a change in the pH or an increase in the percentage of organic solvent. Compounds that are dissociated from the column are loaded onto a reversed-phase column that is placed downstream of the HSP70-streptavidin column.

Compounds are eluted from the reversed-phase column and analyzed by mass spectrometry. Masses that correspond to ligands for HSP70 are identified by eliminating those masses which are also observed when the library is

similarly screened with a streptavidin column. The mass of each HSP70 ligand identifies one combination of peripheral moieties plus scaffold. The individual compound (s) that result from the identified combination of peripheral moieties plus scaffold are synthesized and tested for their in vivo ability to affect the immune response, cancer progression, and viral infection.

Example 3 Development of ligands that affect the binding of a known ligand to a protein It is often the situation that a biologically important ligand is known for a target protein, but development of a high-throughput screen for molecules that modulate the binding of that ligand is not practical. For instance, it is known that HSP70 binds unfolded polypeptides in the presence of ADP, and that the binding of ATP to HSP70 leads to the dissociation of the polypeptide. Mass-coded combinatorial libraries can be used in the discovery of small molecule ligands that affect the binding of ATP, ADP, or unfolded peptides to HSP70, and one configuration is listed below: HSP70 is covalently biotinylated by incubation of the protein with a chemically activated biotin precursor. The biotin-HSP70 conjugate is immobilized by binding to a streptavidin-derivatized water- insoluble column matrix. The mass-coded library is solubilized in an appropriate binding buffer and injected onto a column containing the HSP70-streptavidin complex.

Compounds that do not bind to the column are washed off

with binding buffer. Compounds that bind to the column are dissociated upon addition of ATP, ADP, or ADP plus an unfolded peptide. Only compounds that bind to the same sites on HSP70 as these known ligands will be eluted under these conditions. Compounds that are dissociated from the column are loaded onto a reversed-phase column that is placed downstream of the HSP70-streptavidin column.

Compounds are eluted from the reversed-phase column and analyzed by mass spectrometry. Masses that correspond to ligands for HSP70 are identified by eliminating those masses which are also observed when the library is similarly screened with a streptavidin column. The mass of each HSP70 ligand identifies one combination of peripheral moieties plus scaffold. The individual compound (s) that result from the identified combination of peripheral moieties plus scaffold are synthesized and tested in vitro for the ability to compete with these known ligands to HSP70 and for their in vivo ability to affect the immune response, cancer progression, and viral infection.

Example 4 Discovery of small molecule replacements for protein therapeutics In some instances, the known ligand to a target protein is in fact another protein, and the binding of these two proteins confers a therapeutic benefit. An example of such an interaction is the binding of granulocyte colony stimulating factor (G-CSF) to the G-CSF receptor (G-CSF-R). Replacement of G-CSF with a non-

peptide small molecule can be undertaken using a mass-coded combinatorial library, and one approach is detailed below: in two separate and parallel experiments, the mass-coded library is solubilized in an appropriate binding buffer and incubated with either the G-CSF-R alone or the G-CSF-R plus G-CSF. Compounds that bind to the protein (s) are separated from the unbound compounds by rapid size exclusion chromatography. The binding compounds are loaded with the protein (s) onto a reversed-phase column that is placed downstream of the size exclusion column. The binding compounds are dissociated from the protein (s) and are eluted from the reversed-phase column and analyzed by mass spectrometry. Masses that correspond to compounds that bind to the G-CSF/G-CSF-R interface are identified as those masses which are only observed when the library is screened with G-CSF-R alone; masses which are also observed in the screen with the G-CSF/G-CSF-R complex are ignored. The mass of each interface-specific compound identifies one combination of peripheral moieties plus scaffold. The individual compound (s) that result from the identified combination of peripheral moieties plus scaffold are then synthesized and tested for their in vitro or in vivo ability to mimic G-CSF.

Example 5 Development of small molecules that dimerize two proteins Certain therapeutic proteins, such as erythropoietin (EPO), are multivalent and act by binding two molar

equivalents of the target protein, thereby dimerizing the target protein, which, in the case of EPO is the EPO receptor (EPO-R). The protein replacement strategy outlined in Example 3 can be extended to yield non-peptide compounds that act therapeutically by inducing the dimerization of two EPO-R molecules. In two separate and parallel experiments, the mass-coded library is solubilized in an appropriate binding buffer and incubated with either EPO-R alone or EPO-R plus EPO. Compounds that bind to the protein (s) are separated from the unbound compounds by rapid size exclusion chromatography. The bound compounds are loaded with the protein (s) onto a reversed-phase column that is placed downstream of the size exclusion column.

The bound compounds are dissociated from the protein (s) and are eluted from the reversed-phase column and analyzed by mass spectrometry. Masses that correspond to compounds that bind to the EPO/EPO-R interface are identified as those masses which are observed only when the library is screened with EPO-R alone; masses which are also observed in the screen with the EPO/EPO-R complex are ignored. The mass of each interface-specific compound identifies one combination of peripheral moieties plus scaffold. The individual compound (s) that result from the identified combination of peripheral moieties plus scaffold are synthesized and tested for their in vitro ability to bind to the target protein, EPO-R. Those compounds exhibiting the highest affinity for the target protein are compared to identify similarities among them. Ideally, it is observed that one site of derivatization on the scaffold is

relatively unimportant for high affinity binding. The peripheral moiety at this site is subsequently replaced with a covalent tether that joins two molecules of the highest affinity compound to yield a non-peptide compound that dimerizes the target protein, EPO-R.

Example 6 Simultaneous target validation and small- molecule drug discovery An example of a class of target proteins whose roles in a disease process can be validated by application of target-specific ligands to a bioassay are the proteins encoded by the open reading frames (ORF) of the Herpes Simplex Virus. The identification of ligands to an ORF- encoded protein and the use of the resulting ligands to determine the function of the ORF-encoded protein and its validity as a target for anti-viral drug discovery involves the following steps : the ORF-encoded protein is covalently biotinylated by incubation of the ORF-encoded protein with a chemically activated biotin precursor. The ORF-encoded protein-biotin conjugate is immobilized by binding to a streptavidin-derivatized water-insoluble column matrix.

The mass-coded library is solubilized in an appropriate binding buffer and injected onto a column containing the ORF-encoded protein+streptavidin complex. Compounds that do not bind to the column are washed off with binding buffer. Compounds that bind to the column are dissociated by a change in the buffer conditions, such as a change in the pH or an increase in the percentage of organic solvent.

These compounds are loaded onto a reversed-phase column placed downstream of the ORF-encoded protein+streptavidin column. The binding compounds are eluted from the reversed-phase column and analyzed by mass spectrometry.

Molecular masses that correspond to ligands for the ORF- encoded protein are identified by eliminating those masses that are also observed when the library is similarly screened with a streptavidin column. The molecular mass of each ligand for the ORF-encoded protein identifies one combination of peripheral moieties plus scaffold. The individual compound (s) that result from the identified combination of peripheral moieties plus scaffold are synthesized and tested for their ability to inhibit the replication or transmission of the virus in a mammalian cell bioassay or animal model.

The observation of a virus-specific inhibitory activity implicates the ORF-encoded protein as a critical component of the viral disease process and confirms that the ORF-encoded protein is specifically amenable to small molecule anti-viral drug discovery. Observation of a direct correlation between the relative binding affinities of the ORF-encoded protein-specific ligands and the relative inhibitory concentrations of the ORF-encoded protein-specific ligands further strengthens the identification of the ORF-encoded protein as a target for small molecule anti-viral drug discovery.

Example 7 Development of small molecules that can be applied to the affinity purification of a target protein A mass-coded combinatorial library can be used to identify ligands that have a high affinity for a target protein. One such target protein is human erythropoietin (EPO), which is expressed and purified industrially for use as a therapeutic drug. Ligands that exhibit a high affinity for EPO can be immobilized on a solid support to generate an EPO-specific affinity matrix.

The identification of ligands to EPO and the construction of an EPO-specific affinity matrix involves the following steps: the mass coded library is solubilized in an appropriate binding buffer and incubated with the EPO protein. Compounds that bind to the EPO protein are separated from the unbound compounds by rapid size exclusion chromatography. These compounds are loaded with the EPO protein onto a reversed-phase column that is placed downstream of the size exclusion column. The compounds are dissociated from the EPO protein and are eluted from the reversed-phase column and analyzed by mass spectrometry.

The molecular mass of each EPO protein-specific ligand identifies one combination of peripheral moieties plus scaffold. The individual ligand (s) that result from the identified combination of peripheral moieties plus scaffold are synthesized and tested for their in vitro ability to bind to the EPO protein. Compounds exhibiting the highest affinity for the EPO protein are compared to identify

similarities between the compounds. If it is observed that one reactive site on the scaffold is relatively unimportant for high affinity binding, the peripheral moiety at this site is subsequently replaced with a covalent tether that joins the EPO-specific ligand to a water insoluble matrix, thereby generating an EPO-specific affinity matrix.

Alternatively, the covalent tether is used to join the EPO-specific ligand to a another molecule, such as biotin, which possesses a high affinity for a commercially available affinity matrix (streptavidin-derivatized agarose). The biotin-streptavidin interaction is used as a strong, non-covalent immobilization technique.

Example 8 Development of small molecules that can be applied to the visualization of a target protein A mass-coded combinatorial library can be used to identify ligands that have a high affinity for a target protein. One such target protein is the human protein telomerase, the expression of which is linked to cancer progression and aging. Ligands that exhibit a high affinity for telomerase can be functionalized with a radioactive or non-radioactive tag to thereby generate a telomerase-specific affinity probe for visualization of the enzyme in vitro or in vivo. The identification of ligands to telomerase and the construction of a telomerase-specific affinity probe would involve the following steps: a mass- coded library is solubilized in an appropriate binding

buffer and incubated with telomerase protein alone.

Compounds that bind to the telomerase protein are separated from the unbound compounds by rapid size exclusion chromatography. The binding compounds are loaded with the telomerase protein onto a reversed-phase column that is placed downstream of the size exclusion column. The compounds are dissociated from the telomerase protein and are eluted from the reversed-phase column and analyzed by mass spectrometry. mass of each telomerase protein-specific ligand identifies one combination of peripheral moieties plus scaffold. The individual ligand (s) that result from the identified combination of peripheral moieties plus scaffold are synthesized and tested for their in vitro ability to bind to the telomerase protein. Compounds exhibiting the highest affinity for the telomerase protein are compared to identify similarities between the compounds. Ideally, it is observed that one reactive site on the scaffold is relatively unimportant for high affinity binding. The peripheral moiety at this site is subsequently replaced with a covalent tether that joins the telomerase-specific ligand to a radioactive moiety or a non-radioactive moiety such as a fluorophore, thereby generating a telomerase-specific affinity probe.

Example 9 Identification of a small molecule inhibitor of bovine trypsin by affinity selection with a mass coded combinatorial library mixture A mass-coded library mixture was synthesized by the reaction of the scaffold precursor

with a set of ten peripheral moiety precursors selected as described in Example 1. This set of peripheral moiety precursors is shown below. The peripheral moiety precursors were selected to yield a mass coded combinatorial library mixture of compounds of the formula X (Y) 4, where X is this scaffold and each Y is, independently, a peripheral moiety derived from one of the peripheral moiety precursors. This library includes 715 distinct combinations of 4 peripheral moieties and 715 distinct masses.

A homogeneous solution containing 2 mM mass coded library mixture and 50 ßM bovine trypsin in binding buffer (50 mM Tris, pH 7.75; 40 mM CaCl2; 10% DMSO total v/v) was incubated for 30 minutes at room temperature and then incubated on ice for 5 minutes. 20 HL of this mixture was injected onto a 4.6x200 mm size-exclusion HPLC column and eluted with binding buffer at 1.5 ml/min. The protein eluted slightly before the unbound library components, and this protein peak was collected. Formic acid and acetonitrile were added to final concentrations of 10% each to dissociate any ligands from the protein, and the resultant mixture was analyzed by LC-MS. Mass spectroscopic analysis yielded one mass which matched with one combination of 4 peripheral moieties plus scaffold, and synthesis of a single isomer having this combination confirmed the identity of the trypsin ligand, which is shown below.

This molecule was a potent inhibitor of trypsin when assayed by a standard in vitro trypsin activity assay.

EQUIVALENTS While this invention has been particularly shown and described with references to preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. Those skilled in the art will recognize or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described specifically herein. Such equivalents are intended to be encompassed in the scope of the claims. 2.197802|86a|79a 113a 11o8aj76al20a lia_170a |26a|94a |21a 197a 2. 490843 86a108a76a J69a 1a 70a 26a24a 36a 94a) 21a 97a 2.63736 36a|13a |108al76a |69a |la 70a 126a 124ai36a 194a 97a 2.78383t 86a 79a 113a jlO8a 76a 20a 169a lla |70a j26a 94a j21a 69a (1a70a36a 94a 21a69a (1a70a36a 94a 21a 2.783883 86a 13a108a76a 20a69a 1a) 70a j24a 36a ! 94a J97a 2.78388386a79a13a 108a76a70a 26aJ24a 36a) 94a21a ! 97a"2.78388386a79a13a 108a76a70a 26aJ24a 36a) 94a21a ! 97a" 2.93040386a13a108a76a 20a69a) la 70a 36a 94a21a 97a . 2. 93040386a13a108a76a 1a 70a26at24a) 36a94a21a 97a 2.930403 86a|13a 1108a|76a 69al1a 170at26a j36a|94a |21a 97a 2.9304036a) 79a13a 108a76a20a ! 69aha) 70a26a24a J104a 3.003663|86al79a 113a 1108a|76a 120a 169a 170a ! 26al24a 194a 1104a 3.003663 86a 79a13a 108ai20a 69a 1a i70a 36a94a1a 97a 3.076923186a|13a |108a j76a 20a 69a 1a 170a 26al24a 194a i97a i 3.07692386a) l3a ! l08a76a 69ajta t70a ! 26a) 24a36a94a ! l04a 3.07692386a13a) 108a76a ! 20a69aha ! 70a J26a94a21a97a 3.07692386a 108aj76a) 20a ! 69a1a ! 70a24a ! 36a94a104a ! 97a 3.076923|79a|13a 1108a ! 76a 12oa 169a 11a 170a 36a j94a ! 21a 197a 3.07692386a) 113a 1108a|76a 20a 169a i70a i26a j94a 1104al21a 3.07692386a79a13a) l08a76a20a 1a (703 36a 94a21a J97a 3.223443186 13a 108a 76a 169a Ila 170a 126a 136a 194a 11 04a 21 a 3.223443j86a79a13a 108a6a 69a 1a ! 70a) 26a4a104a (21 a 3.223443186a 79a 113a 1oôal2oa 169a |1a ! 70a 124al36a 194a 197a 3.36996386a) 79a) l3a08aJ20a69a) la (70a ! 26at94a21a 97a3.36996386a) 79a) l3a08aJ20a69a) la (70a ! 26at94a21a 97a 3. 369g6386a13a (108a76a) 20a69a la) 70aJ26a94a104aj21a 3.369963 86a 79a13a 108a) 76a20a la j70a 26a94a104a) 21a 3.5l6484|86al13a j108a 76a 120a 169a 11a ! 70a 126a 24a 136a i97a 3. 51648486a ! 79a13a 108a20a 69a 1a ! 70a j26a ! 24a94a 97a 3.51648486a) l3a108a76a 20a69a 1a J70aJ26a ! 24a94a 104a 3.516484186a 79a 1. 3a 11082176a 120a I i 26a 11 04a 121 a 3.51648486a13a108a) 76a) 20a69a 1a) 70a 26a36a21a J97a 3. 66300486a79a13a 108a76a 20a 69a1a 70a26a94a h04a 3.66300479a13a108a76a 69a1a 70a36a 94a 104a21a 97a 3.663004 79a 13a108a76a 20a1a 70a26a 94a104a) 21a 97a 3.663004|86a 79a 108al76a 16ga 170a 126a 124a 136alg4a |21a 197a 3.66300486a79a13a 108a76a) 20a) 69a) la j70a 94ah04a21a 3.66300486a13a108a76a 20a 69a ha 70a 26a36aJ94a J97a 3.80952486a13a108a76a 69a1a 70a 24a 36a 94a) l04a97a 3. 809524 79a 13a108a76a 69a1a 70a ! 26a 94a 104a21a 97a 3.80952486a79a13a 108a76a 1a 70a26a 24a 94a21a 97a 3.80952479a13a108a76a 20a69a la 26a 94aj104a21a 97a 3. 80952479a13a108a76a 69a70a) 26a24a 36a) 94a104a 97a 3.809524|79a|13a 1108a|76a 12oa 169a i1a 170a 126a|94a |21a 197a 3.882784479a 13a l108a 76a 69a 70a 126a 36a 94a 104a 21a 97a 3.95604486a79a108a76a 20a69a ! 70a26a 24a ! 94a'104a 97a 3.956044 86a 79a13a 108a76a20a ! 69a1a 70a 24a36a 94a 3. 95604486a79a13a 108a6a20a ! 69a1a 36a 94a21a 97a 3. 956044186a|13a 110oal76a |69a|1a |70a|26a 124al36a 194a |21a 3.956044J86a) 79a 13a 108aj76a 69a 1a) 70a 26a 94aJ21a J97a 3.95604486a 108a 76a 69a'1a 70a24a36a94atl04a21a 97a 3. 95604479s 13a 108a76a 20a69a Is 703 28a24a104a97a 3.95604486a79a 13a 108aJ20a69a la 70a 24a94a) l04a97a 3 95604486a79a-t08a76a 20a) 69atla 70a 26a 94atl04a21a 1a 26a 94atl04a 21a1a 26a 94atl04a 21a 4.02930486a 79a 13a 76a 20a69a 1a 70a 26a24a) 94a 104a _ 4. 102564186al79a |13a |108al76al20a 169a 1a 170a 26a |24a 194a 4.102564j86a|13a j108a|76a 169a |1a 170a |24a |36a 94a 121a Z97a 4. 10256486a ! l08at76a 69a) la 70aj26a) 24a 36a94a ! l04a21a 4.102564i79a113a 108a 76a20a4.102564i79a113a 108a 76a20a 69a la) |94a|104a j21a l97a 4.102564) 86a79a 13a 108a6a20a69ajla 70a 26a) 24a 36a 4.10256486a ! 13a jj108a 76a 20a 69a 1a 26a 24a j36a ! 94a 197a 4.175824186aj79a 113a |108a j20a j69a |1a i70a 126al24a 194a |104a 7a7a 4.175824186ai79a |108a|76a |20a|6Da j1a 170a 36alS4a 21a 197a 4.249084j86aj79a |13a |108a ! 76a 1a 70a 126a 36ai94a |21a |g7a 4.24908486a 13a 108a76a 69aj1a) 26aJ24a) 36a94a21a) 97a 4.24908486a79a 13a tl08a76aj69aj70aj26a) 36a94a104a 21a 4.249084186al13a |108a|76a i20a |69a 1a 170a |26a|24a |36a 94a 4.24908486a79a 13a 108a76a 69a la 70a) 36a94a (21a) 97a 4.24908486a79a 13s 108a76a 20a 1a j70a 26a24a94a) 97a 4.24908479a 13a 108a76a 20a (69at70a) 26a 24a 94a104a 97a 4.249084486al79a |108a|76a |20a |69a 11a 170a j26a|94a 121a i97a 4.24908486a79a 13a j108a76at20a 69a ! ta j70a 24a) 36a J97a 4.322344179a |1 3a 11 08a 76a 20a 69a 70a 26a 36a 94a |21 a 97a 4.39560586a) 79a 13a 108a 69a 1a j70a) 26a 24a 36a94a 97a 4.395605179al13a 108a76a 20a 69a70a) 26a 94a 104a) 21a 97a 4.39560586a ! 79a 13a 108a 76a 20a) 69sjla 70aJ36a94a 97a 4.39560579all3a l08a76a 20a69a 70a) 26a 24a36a94a) 97a 1a 70a 26a 24a 97a1a 70a 26a 24a 97a 4.395605 86a79a 13a 108a76a 20a 69a 1a70a (26a36a 94a 4.39560579a13a 108a76a 20a 69a. 1a 70a 26a 104a21a 97a 4.395605 86a 79a 13a 108a20a 69a 1 a 70a 26a 94a 104a 21 a4.395605 86a 79a 13a 108a20a 69a 1 a 70a 26a 94a 104a 21 a 4.39560579a13a 108a76a 20a69a 1a 70a 26a 94a104a 21a 26a 36a 94a 21 a97a26a 36a 94a 21 a97a 4.39560586a79a 13a 108a 76a 20a 70a 26a 24a 94a104a97a 4.39560586a79a 13a 108a 76a 69a 70a 26a 24a 36a94a 21a 4.395605jl3a 108a 76a 69a la 70a 26a 36a 94a 104a21a 97a 4.39560586a ! 79a 13a 108a 76a 20a 69a la 70a 94aJ21a 97a 4.39560586a 108a 76a 20a 69a la 70a 26a 24a36a94a 97a" 4.39560586a79a 13a 108a 76a 20a 1a) 70a 26a) 36a94a 97a 4. 39560586a79a 13a 108a76a 69a 70a 26a 24a 36a94a 97a 4.468864 86a79a 13a 108aj20a 69a 70aJ26a 24a 94a104a 97a 4.46886486al79 _TI, 170a 126a4.46886486al79 _TI, 170a 126a 4.46886486a) 108a ! 76a J20a ! 69a 1a 70a 36a 94a 104a21a) 97a Ru 4.46886486a79a 13a 108aJ76a20a) 69a) 70a 26a) 24a36a 94a 4. 468864 ; 8oa79a 13a76a) 1a70a26a24a36a ; 94a 2a 97a 4.46886486s 79a) l3a08a76a20a 70a ! 26a 24a36aJ94a 97a4.46886486s 79a) l3a08a76a20a 70a ! 26a 24a36aJ94a 97a 4.54212586a79a 13a J108a69a1a 70a j24a 136a 94a 11 04a 197a 4.54212586a79a'13a 108a76a20a 69a ! 70a 26a ! 36a) 94a 21a 4.542125186aj79a |13a 108a|76a|6ga 170a} 26a 24a|36a 194a j104a 4.542125|86a ! 79a j13a j108a|76a|20a |69al1a 26a|94a |21a 197a 4.542125186ai79a |13a |76a |20a j69a |1a, 70a |24a|36a j94a 197a 4.542125|86a|108a|76a 20a 169a la 70a 126a j36a 94a21a 97a 4.542125 86a 13a 108a76a 69a (70a 26a (24a (36a 94aJ21a 97a 4.54212586a79a J13a 108a) 76a 1a70a J24a 36a 94a21a 97a 4.54212513a 108a ! 76a 20a 69a 1a 70a 26a 94a (104a (21a 97a 4.54212586a13a ! l08a) 76a 20a 69a 1a6a 36a94a) 21a 97a4.54212586a13a ! l08a) 76a 20a 69a 1a6a 36a94a) 21a 97a 4.542125J86a79ah3a) l08a76a69a) la70a"26a24a94a ! l04a4.542125J86a79ah3a) l08a76a69a) la70a"26a24a94a ! l04a 4.542125 ! 86aj79a J13a J108a76a) 20aj69a ; 70a 36a 94a21 a 97a 4.542125186al79a 113a j108a|76a|20a |69a j1a 170å|26a 194a 197a 4.615385179al108al76a 20a 69a 1a 70a 136a j94a|104a |21a j97a 4.688645j86aj79a 13a 108a 76a 20a 69a j1a 170a |26a |21a j97ä 4.688645 86a 79a 13a 108a20a69a la) 24a 36a94a104a 97a 4.68864579a108a ! 76a 69a 70a 26a 24a36s) 94a 104a 21a 97a4.68864579a108a ! 76a 69a 70a 26a 24a36s) 94a 104a 21a 97a 4.688645 86a 108a76a 69a 1a 70a 26a 24a36a 94a104a 97a4.688645 86a 108a76a 69a 1a 70a 26a 24a36a 94a104a 97a 4.683645179al108al76a |20a} 69a ! 1a 170a |26a 194al104a |21a 197a 4.688645h3a108a ! 76a) 69a 1a 70a 26a24a 36a94atl04a 97s 4.68864586a79a J13a 108a76a20a 69a J70a 24a36aJ94a 97a 4.688645'86a 79a |13a 76a 120a|69a ! 1a ! 70a |26a ! 94a ! 104a 21a 4.68864586a 108a76a J20a 69a 1a70a J26a) 24a 94a104a 97a 4.688645 86a 13a 108a76a 20a 1a70a j26a) 24a 36a94a 97a 4.68864586a79a 13a 108a76a 20a J69a) la J36aj94a) l04a) 21a 4.688645 86a79a 13a 108a76a 69a 1a 70a36a 94a104a 21a4.688645 86a79a 13a 108a76a 69a 1a 70a36a 94a104a 21a 4.76190586a13a 108aJ76a 20a 69a 1a J70a 26a24aJ36a 104a 4.76190586a79a13a 108a1a 70a 26a ! 24a 36a94a21a 97a4.76190586a79a13a 108a1a 70a 26a ! 24a 36a94a21a 97a 4.76190586a79a 13a 108a20a69a 1a ! 70a 26a24a36a J97a 4.761905 86a 79a'13a ! 76a 20a 69a 1a70a 36a 94a21a 97a 4.835165179all 3a 108a) 76a 20a 69a 1a ! 26a 24a 94a104a 97a 108a76a 20a J69a1a 26a24a94a 104a 4.835165J79a13a 108a76a69a 1a 70a J24a 36a94a'104a 97a4.835165J79a13a 108a76a69a 1a 70a J24a 36a94a'104a 97a 4.835165J86a13a 108a76a 20a 1a70a) 26a 36a 94a21a 97a 4.83516586a79a 13a 108a69a 1a 70a 126a |24a j94a 121a 97a 4.83516579a 108a76a 20a 69a 70a 26a 24a 36a 94a104a 97a 4.835165 86a 108a ! 76a 69a 1a 70a 26a 24a 36a 104a 21a 97a 4.83516586a13a 108a 76a 20a |24a j36a j94a |104a 4.835165179a 13 108a 76a 120a 69a la 136a 94a 1042 121 a 97a 4.83516513a 20a 69a1a 70a 26a 24a36a94a 97a 4.83516586a13a 108a76a 20a69a 70a 26a 36a94a21a 97a 4.83516513a108a76a 20a 69a 1a 70a ! 26a 36a94a21a 97a 4. 835165f'86a79a 13a 108a76a20a 1a J70a 24a36a94a J97a 4.83516586a79a ! t3a 108a 76a 20a69a 70a 26a) 24a94a (97a4.83516586a79a ! t3a 108a 76a 20a69a 70a 26a) 24a94a (97a 4. 83516586a|79a 113a 176a 169a 11a ! 70a |26a 24al36a 194a j104a 4. 835165 ! 86a79a 13a76a 69a1a ! 70a26a24a 36a) 94a) l04a 4.835165j79a|13a 108a76a 20a1a 26a36a94a21a97a 4.83516586a13a 76a 20a 69a1a 70a26a24a 36a94a"97a 4.83516586a13a ! l08a76a 20a69a 1a 70a ! 24a94a104a) 97a . 4. 90842586a79a jlSa108at76a 20a9a la70a36a21a97a 4.90842586a 79a 13a) l08a6a1a) 70a26a24a 36a21a7a4.90842586a 79a 13a) l08a6a1a) 70a26a24a 36a21a7a 4.981685) 79a13a 108a76aOaJ69a la 70a24a ! 36a94a) 97a 4. 98168586a13a 108a76a) 20a69aa 70a36a94a04a21a 70a26a36a) 94a 21a70a26a36a) 94a 21a 4.981685 ! 79a13a 108a20a 69a1a ! 70a6a24a 94a) l04a97a 4.981685 86ah3a 108ai76a0a9a) 70a26a24a 36a) 94a 97a 4.98168586a108a'76a ! 20a9a la 70a ! 26a4a36aJ94a 104a4.98168586a108a'76a ! 20a9a la 70a ! 26a4a36aJ94a 104a 4.981685|79a|13a 108a ! 76a) 20a 69a 1a 70aJ26a) 94aJ104a 97a 4.981685j86a|79a 176a |69a 1a 170a 124a 136a ! s4al1o4a 121a 197a 4.98168586a79a 13a (l08a69aba ! 70a ! 24a ! 36a ! 94aJ21a) 97a 4.981685|86a|79a ! 1o8al76a 12oa 169a 11a 170a 126ai24a 194a 1104a 4.981685 ! 86a ! 13a 176a ! 6sa 11a ! 70a 126a ! 24a 36a ! 94a 21a 197a 4.381685 ! 86a ! 79ah3a 108a76a0ai69a0a26a94a1a97a4.381685 ! 86a ! 79ah3a 108a76a0ai69a0a26a94a1a97a 4.98168586a) 79a ! l08a20a ! 69a1a 70a 24a36a 94ah04a97a 4.981685 86a) l3a 108a76a) 69a1a 70a26a24a 36a21 a 97a 4.98168586a13a 108a76a 69a 70a 26a ! 24a36a94a104a 97a 4. 981685J86a79a 13a) l08a76a ! 20a la ! 70a) 26a ! 36a21a) 97a 4. 98168586a79a) l3a 108a76a 69a la 70aJ26a) 24a104a) 21a 5.1282osl13al1o8al76a 120a ! 6sa 1a 170a |26a ! 24ats4a i104a|97a 5.12820 ; 86a|79a |13a 176a ! 20a |69a 11a 170a ! 26a 24a 94a 197a 26a (36a94a104a 21a26a (36a94a104a 21a 5.128205 79all 3a 11 08a 120a 70a 126a 194a 1104 121 a 97a 5.12820586a79a 13a) 76a 69aha 70a26a24a ! 36a94a 97a 5.12820586a79a"13a 108a20a 69a la (70a26a24a ! l04a97a 5.12820579a13a ! 76a 20a t69a 1a ! 70a26a24at94a104a 97a 70a26a24a 94a21a ! 97a70a26a24a 94a21a ! 97a 5.128205 86a) 79a 76a 20a 69ajla t70a) 24a36a ! 94a) l04aj97a 5.12820579a13a 76a 20a 69a) la 70aj26a94a 104a21a 97a 5.128205) 86a13a 76a 20a 69a1a ! 70a26a36a94a21a 97a 5.12820586a13a 108a69a 1a 70a 26a24a36a94aJ21a J97a" 5.201465 86a 13a) l08a76a J20a69a 1a 70a26a36a104a) 21a 5.27472586a79a 13a 108a20a 69a1a 26a24a 94a104a 97a5.27472586a79a 13a 108a20a 69a1a 26a24a 94a104a 97a 5.274725 79a 13a 108a (76a. 20at69aj70a24a36a94a104a 97a 5.27472586a79a) l3a h08a ! 20a69a ! la 70a94a 104a21a 97a 5.274725 86a 13a ! l08a20a 69a 1a70a26a36a94a21a 97a5.274725 86a 13a ! l08a20a 69a 1a70a26a36a94a21a 97a 5.27472586a79a13a 108a 76a 69a1a 70a 26a 24a 94a (21a 5.27472586a79a 13a h08a76a 20a ! 69a la70a 24a94a04a5.27472586a79a 13a h08a76a 20a ! 69a la70a 24a94a04a 5.27472586a79a 13a) 76a 20a ! 69a ! la 70a24a 36a) 94a ! l04a 5.27472586a79a 13a J108a76aj20ajla 70a26a24aJ94a 104a 5.27472586a79a 108a 76a 20a 69a1a 170a 26a 36a94a97a 5.34798586a79a 108a76a 20a69a 1a 70a36a94a ! l04a21a 5. 34798586a 79a 108a t76a20a 69a 70a 24a i36a94a i104a 97a 5. 347985179all3a 11 08a 176@ 169a 70 126a 124a 36a 194a 21 a 197a 5.347985|86a|79a |13a 1108ai20a |69a 1a 7Qa 26a36a 94a 97a 5.347985 79a ! l 3s108a76a 20a69a 70a26a 36a94a) l04a21a 5.347985 86a 13a l08a76a) 20a'69a 1a) 70a 26a36a j94a 104a 5.42124686a79a13a) 76a 20a69a 1a 70a 26a94a 21a 97a 5.421246 86a|13a |108ai76a 120a 69a j70a 26a 124a ! 94a 1104a|97a 5.42124686a79a13a 108at76a69aa 70a 26a36a 94a97a5.42124686a79a13a 108at76a69aa 70a 26a36a 94a97a 5.42l246|79a ! 13a ll08al76a 120a ! 69a ia 70a |26a|24a ! 94a |97a 5.42124679a13a108a76a 20a69a 1a J70a 24a36a104a) 97a5.42124679a13a108a76a 20a69a 1a J70a 24a36a104a) 97a 5.421246186al79a 11o8al76a j69a|70a |26a 24a 136a|94a |104a|21a 5.421246108) 76a69a 1a70a 26a) 24a 36a 94a 104a) 21a 97a 5.421246j79al13a i76a 12oa |69a|1a 70a ! 26a ! 24a|36a 194a 197a 5.421246'86a79a |108a|76a |20a 69a 170a ! 26a 136a|94a ! 5.421246 86aj79a ! l08a76a 20aj69a 70a26a 24a36a 94a 97a 5.42124686a79a108a20aJ69a ! la) 70a ! 26a24a94a 104a 97a 5.421 246i86a|79a 11 08a 176a 169a 170a 126a i24a 36a 94a 11 04a 197a 5.421246179al13a 108a76a) 20a 69a ! 70aJ36a94a) l04a J21a i97a 5.421246i86a ! 79a ! 13a ! 108a, 76a 69a ! 1a ! 70a ! 26a ! 24a 194a ! 97a 5.494505j86a|79a |13a 11o8al20al69a 170al26a 124a ! 36a ! 94a 97a 5.494505 86a79a) 108a76a J20a 69a 1a) 70a 26a 24a 36a 97a 5.494505 86a79a) l08a 76a 20a69a) 70a J26a 36a 94a 104a 21a5.494505 86a79a) l08a 76a 20a69a) 70a J26a 36a 94a 104a 21a 5.49450586a79a) l3a 76a 69a ! la J70s ! 24a 36a94a) l04a97a 5.494505) 86a79a13a) l08aj76a) 20aj70at26a 94a 104a 21a 97a 5.49450586a79a108a76a ! 20a ! 69a0a6a 24a 36a 94a 104a 5.567766179a ! 13a ! 1o8al76a |20a|1a 170al36a 194a|104a 12ía 197a 5.567766J86a79a13a) l08a76a69aj1a 70a 24a36a J94a'97a 5.567766 79a 113a 176a 120a ! 6sa ! 1a ! 70a 126a 24a 36a 97a 5.567766 86a79a108s 76a 20a ! 69a la) 70a 26a24a 94a 97a 5.567766) 86a79a108s 76a 69a) 1a 70a) 26a 24a 94a 21a 97a 5.56776679s 108a76a 20a 69a ! 70a 26a36a 94a 104a 21a 97a 5.567766j86al79a 113a ! 108ai20a 69a j70a 126a 36a|94a ! 21a j97a 5.567766|86a 113a 1108alla 20a 169a 170a 126a 124a 136a 197a 5.56776686a79a13a 108a76a20a69a1a 24a36a 94a 97a 5.56776686a79a13a 108a76a20a''69a1a 26a ! 24a 94a 97a 5.56776686a9a"13a 108a76a 69a 26a. 24a! 36a|94a j104a|97a 5.567766 86a 13a108a20a 69a1a 70a 24a 36a94a 104a 97a 5.56776679a 108a76a 69a la 70a 24a36a 94a 104a 21a 97a 5.567766 86a 79a 108a 76a 169a 1a 170a 24a 36a 94a 21a 97a 5.5677661l3al108a 76a 69a 11a 70a 126a j24a ! 36a 94a j21a 197a 5.567766 86a 79a13a) l08a) 69a 70a J26a 24a 36a94a) 21a 97a 5.64102686a79a13a 108a76a 20a) 69a 70a 26a36a21a 97a5.64102686a79a13a 108a76a 20a) 69a 70a 26a36a21a 97a 5.641026 86a ! 79a13a 108a76a20a ! 69a26a 24a36a94a 97'a5.641026 86a ! 79a13a 108a76a20a ! 69a26a 24a36a94a 97'a 5.641026|86al79a 113a 1108ai76a 12oa ! 69a jla ! 26al24a 136a 97a 5. 64102686a79a13a h08a76a70aj26a24a 36a94a 104a 97" 5.641 026|86a|1 3a ! 1 08a i76a o 5.64102686a79a76a 20a 69a1a J70a 36a 94a 104a J21a 97a 5.64102686a 13a108a76a 20a 69a1a J26a 24a 94a) l04a97a5.64102686a 13a108a76a 20a 69a1a J26a 24a 94a) l04a97a 5.64102686a79a) l3a) l08aJ76at20a 1a 70a) 26a 104a J21a 97a 5. 64102679a13a) l08a76a 20a) 69a 1a 70a26a36a J94a 97a 5.641026 79a|13a |108a|76a |20a 169a 11a 26a|36a 194a 197a 5.71428686aj79a 13a 108a69a) 1a 70a26a 24a 94a 1&4a'97a 5.71428679a13a 108a76a 1a J70a 26a36a 94a04a) 21a 97a 5.71428686a79a J13a 108a69a (70a J26a 24a t36a ! 94a 1104 97a 5.714286) 79a) t3a il08a78a) 20a 69a J1a 70a ! 26a24a 36a 97a 5.71428679a13a 108a76a 69a1a) 70a26a 24a) 94a 104a97a 5.71428686a13a 08a20a 69a 1a) 70a26a 24a36aj94sj97a 5.71428679a13a J108a76a 69a 1aOa 26a t24a104a) 21a 97a5.71428679a13a J108a76a 69a 1aOa 26a t24a104a) 21a 97a 5.714286 79a) l3a ! l08a 76a 20a) 69a) l a 70aJ36at94s J104a21a 5.71428686a) 79a) l3a 108a76a) 20aJ69a1a 70a24s 94a 97a 5. 71428679a) l3a08a76a 69a J1a 70a26a 24a 36a 104a7a 5.71428679atl3a J108a76a 20a ! 69a 70a26a 24a 36a) 94a 104a 5.714286186ai79a 76a 169a 170a 126a 124a 36a 94a 104a 121-a 197a 5.714286j86a79a h3a) l08a ! 76a ! 69aa) 70a 26a24a 36a 97a 69a 170a26a24a36a94a 104a97a69a 170a26a24a36a94a 104a97a 5.71428686al79a 13a 1108al76a 169a Ila 170a 126a24a 136a 194a 69a 1 a 124a 36a 194a104a69a 1 a 124a 36a 194a104a 5.71428613a108a76a 120a 169a Ila 170a 36a 21a 97a 5.71428686a79a 76a 20a 69a70a) 26a24a 36a 94a 104a97a 5.787546 86a79a 13a 108a76a1a) 70a26a 24a 36a) 94a J97a 5.787546'79a13a 108a76a) 6gaa 70a J26a 36a 94a J104aj97a 97a97a 5.86080686a79a) 13a 108a ! 76a69aa) 70a (26a24a 36a 104a 108aj76a 120a ; 69a 1a I, 26a 36a94a 97a108aj76a 120a ; 69a 1a I, 26a 36a94a 97a 5.86080686a 79a 108a76a 1a 69a 126a 24a 36a 94a 21a 97a 5.86080686a79a 13a J76a 69a J70a ! 26a) 24a 36a 94a 21a 97a 5.86080686a 79a 13a 108at76a ! la) 26a ! 24a) 36a94a 21a 97a 5.86080686afl08at78a 69a j70a ! 26a ! 24a 36a 94a104a) 21a J97a 5.860806 79a 76a j20a ! 69a 1a J70a J26a t24a36a94a) l04a) 97a5.860806 79a 76a j20a ! 69a 1a J70a J26a t24a36a94a) l04a) 97a 5. 86080686a79a) l3a) l08a76a69a 26a) 24a 36a 94a 21a ! 97a 5.860806 79a 108a76a) 20a 69a la 70a26a 24a 94a 104a97a 5.860806 79a 13a t108aj76a 20a 69a la 70a 26a24a 94a 104a 5. 86080686a79a 108a76a 20a 69a 1a 70a 24a 36a 94a 97a 5.86080686a79a 108a76a 20a 69a 1a 70a 26a24a 104a97a 5. 86080679a13a 76a 69a la 70a 26a24a 36a 94a 104a97a 5.86080686a79a 13a08ai20a 1a 70a 26a 24a 94a 104a 97a5.86080686a79a 13a08ai20a 1a 70a 26a 24a 94a 104a 97a 5.86080679al13a 1108a fi6a 20a 69a 1 a 70a 36a 94a 104a97a 5.860806i86a79a) 13a 108a76a 69a 1a 70a 24a 36a J94a104a5.860806i86a79a) 13a 108a76a 69a 1a 70a 24a 36a J94a104a 5.86080686a79a 13a 108a76a J20a) 69a26a 24a94a ! l04a97a 5.86080686a79a 13a 76a 20a la 70a26a 24a 36a J94a 97a 5.86080686a79a 13a 76a 69a1a 70a26a 24a 94a J21a) 97a" 5.860806 (86aJ79a*13a 76a 69a1a 70at24a 36a 94a21a 97a"5.860806 (86aJ79a*13a 76a 69a1a 70at24a 36a 94a21a 97a" 5.860806|86a|79a 13a 76a 20a 69a la 70a 36a 94a h04a2'' 5.86080686a79a 13a 108a76a 20a la 26a 36a 94a 21a 97a" 5.934066J86a79a 13a) 76a t20a69a la) 70a 26a24a 36a 94a Fieldl,., ., i 2 3 4': 5.... a: : 4 10 11 ; 12 v' 5.934066186al79a J108a20a 69a 1a) 70a 26a24a36a) 94aJ97a 5.934066186al79al13a 108a 76a|20a 69a 70a 124a 36a ! 94a 1lo4a 5.934066 86aj79a 13a ! l08a) 76a 1a 70a ! 26a 24a 104a 121a 197a 36a94a04a97a'36a94a04a97a' 69a) 70a 26a36a 94a'04aj2a9769a) 70a 26a36a 94a'04aj2a97 5.93406686a79a J13a 108a) 76a20a 69a 1a 26a 24a 36a J104a 5.934066 ! 86a|79a 113a ! 108al76al20a 11a 170a 126a ! 24a l104a|97a 5.93406679a13a) l08a20a69a1a 70a36a 94a) l04a 21a (97a"5.93406679a13a) l08a20a69a1a 70a36a 94a) l04a 21a (97a" 6.00732686a13a) l08a76a 69ajla 70a 24a 36a94a 104a21a" 6.007326186al79a 113a l08a76a! 70a! 26a ! 24al36a ! 94a ! 21a 6.00732679a113a108a76a'69a 1 a70a 24a36a 94a 21 a 97a 6.007326186a ! 79a 1 3a 20al 9a i a 70a 24a 36a ! 94a |1 04a 97a 6.007326108 76a J20a69a 1a J70a 26a 36a 94a 104s J21a 97a"6.007326108 76a J20a69a 1a J70a 26a 36a 94a 104s J21a 97a" 6.00732686a79a 108a76a J20aJ69a'70a ! 26a 94a104s ! 21a 97a 6.00732613a 108a 76a 69a1a70a ! 26a 36a94a J104a 21a" 6.00732686a79a 108a ! 76aOa 1a 70s ! 26a 36a94a J21a J97a 6.00732686a13a 108a76a 20a69a 1a 24a 36a94a104a97a6.00732686a13a 108a76a 20a69a 1a 24a 36a94a104a97a 6.00732613a108a 76a i20a (69a ha 70a 24a 36a94a J104a 97a" 6.007326 86a79a 13a ! 76a ! 69a 70a 26a 24a 36a 94a104a 97a6.007326 86a79a 13a ! 76a ! 69a 70a 26a 24a 36a 94a104a 97a 6.007326 86al79a 1108a 176a ! 2oa ! 69a lia ! 70a ! 24a 36a ! 104a 197a 6.007326 86a|13a i108a 76a j1a |70a ! 26al24a |36a 94a 104a 21a 6.00732686a79a 13a 108a20a ! 69s la70a ! 26a104a) 21a 97a"6.00732686a79a 13a 108a20a ! 69s la70a ! 26a104a) 21a 97a" 6.007326J79a108a6a J20a 69a) la J70aj24a 36a 94a04a97a6.007326J79a108a6a J20a 69a) la J70aj24a 36a 94a04a97a 6.00732679a13a 108a 20a 69aa 70a4a36a94a104a7a6.00732679a13a 108a 20a 69aa 70a4a36a94a104a7a 6.080586179a|13a ! 1o8al76a 12ûa ! 69a ! 1a 17°ä |36ai104a ! 21a 197a 6.080586j86a79a 13a 108a76a 20a ! 69a 70a 36s 94a ! l04a 21a 6.08058686a79a 13a 108a) 76a20a 69a 1a70a24a J104a 97a6.08058686a79a 13a 108a) 76a20a 69a 1a70a24a J104a 97a 6.080586 86a79a 13a 108aJ76a 20a 1a 70a J94a 104a j21a 97a 6.080586179al13a 176a 12oa 169a |70a 126a 136a [s4a ! 1o4a 121a ! 97a 6.080586 86a79a (13a J76s 20a 69a 1a) 70a 26a 36a J94a 97a 6.15384686a79a 13a 108a 76a J20a 69a70a 24a 94a 104a 97a" 6.15384686a79a 13a 108a 76a J69aJ70s 26a 24a 94a 21a 97a" 6.153846186a79a13a 108a 76a69a70a 26a24a 94a104a 21a 6.15384679a13a 76a ! 20a 69a 1a 70a 24a 36a94a104a97a6.15384679a13a 76a ! 20a 69a 1a 70a 24a 36a94a104a97a 6.15384610876a 20s 69a 1a J70a 26a 24a 36a94a 104a'97a 6.153846J86a79a 13a 108a 76a 69a 1a 70a 24a36a 94a21a" 6.15384686a79a 13a 76a 69a 70a 26a 36a 94a 104a 21a 97a 6.15384613a108a76a 69a 1a 70a 24a 36s 94aT04a'21a 97a" 6.15384686a79a 13a108a76a1a 70a 26a 24a 94a) l04a21a6.15384686a79a 13a108a76a1a 70a 26a 24a 94a) l04a21a 6.15384679a13a J108a76a 20a 69a la 70a 24a 94a 104a 97a 6.15384686a79a 13a 76a 20a1a 70a 26a 36a94a 21a) 97a 6.1538461 69a 70a 104a 121 a 197a 6.15384686a79a 13a 108at76a69a1a70aj26a36a94a 21a 6.15384686a79a 13a 108a 76a 20a 1a 70a 26a36a) 94a 21a 6.15384686a 108a 76a 20a 69a J70a 26a 24a 36a94a 104a 97a J 6.15384686a79a 13a 108a69a1a 70a ! 36a94a104a1a 97a 6. l53846|86a|79a 76a J20a 69a 70a 26at36a J94a 104a 21a J97a ,Feld1r r ; 2, >, 3, ; : ; 4,,, 5 : w 6 : 7 ;. ; 8 9. >tO.. sY (1= ; ; 12- 6.22710686a13a ! l08a76a ha 70a ! 26a 24a J36a) 94a 104a ! 97a 6.227106 ! 86a 79a 108a76a 20a69a 1s 70a 36a 94a04a ! 97a6.227106 ! 86a 79a 108a76a 20a69a 1s 70a 36a 94a04a ! 97a 6.227106j79a13a 76a J20a 69a) la 70a 36a) 94a 104a21a J97a 6.227106 86a 108a76a 20a ! 69a1a ! 70a26a) 24a36a 104a) 97a" 6.227106 ! 86a13a 108a76a) 20a 1a 70a26a 24a 36a 94a104a 6.227lO6|86a|108a|76a 120< ig4a ! 104a 121a ! 97a 6.22710686a76a J69a1a 70a26a) 24a36a 94a) l04a 21a 97*' 6.22710686a79a J13a108a ! 76a) 20a 69a1a) 70a36a 94a 104a6.22710686a79a J13a108a ! 76a) 20a 69a1a) 70a36a 94a 104a 6.227106J86a79a) l3a ! l08a76a ! 20a 69a26a ! 24a36a94a) l04a 6.227106 ! 86al13a 1108a ! 76a 20a 11a ! 70a ! 26a 124ats4a ! 104a ! 97a 6.227106J86a13a) l08at76at69ajla 70aJ26ai24a36a 104a) 21a 6.227106 ! 86a|13a 1108a ! 76a |20a ! 69a 1a ! 70a |26a|104a 121a 197a 6.22710679a13a 108a76a J70a) 26a J24a 36a J94a (l04s 21a) 97a 6.3Q0366 ! 79a13a 108a76a 20aa 70a26a24a ! 94a) l04at97a 6.300366 ! 86a) 79a 108a76a ! 20a ! 69a la) 70a26a24a ! 36a04a 6.! 86ä ! 7sa 113a j108al76al20a ! 69al26a 136a ! 94a ! 21a 197a 6.30036686a79a 13a ! l08a ! 76a ! 69aha 70a ! 26a24a 21a 97a 6.30036679ah3a 108a) 76a 20a69ala J24a !'36a94a) 104at97a 6.300366|86aj13a |108a ! 76a 12oa 11a ! 70a ! 26a j36a|94a |io4al21a 6.300366 ! 86a79a) l3a 108a ! 20a69aha ! 26a 24a 36a (94a 97a 6.300366 ! 86a79a 108a76a) 69a1a ! 70a26a 24a-104a 21a) 97a 6.300366186al79a 113a 176a 120a 169a 170a 12--6-a 124@ 36@ 94a 11 04a 6.300366 (86a13a08aj20a 69ajla) 70a ! 26a 24a 94a 104a J97a6.300366 (86a13a08aj20a 69ajla) 70a ! 26a 24a 94a 104a J97a 6.30036686a ! 79a) l3a 108aJ20a) la ! 70a26a 36a 94a 21a J97a 6.30036686a79a J13a 108aj76a) 69a ! 70a24a 36a 94a 21a J97a 6.30036679a 13a 1108al76a 69al7Oa 124a 136a 194a 11 04a 121 a 97a 6.37362686a79a h3a) 76a J20a) 69aha 70a 26a24a 36a h04a 6.373626 86a 79a 13a 1108a ! 76a 12oa 169a ! 1a ! 26a 36a 194a 1104a 6.37362679a ! l3a 108a76a ! 20a69aha 26a 36a 94a 121 a 197a 6.37362686aj- ! 3a J108a76a J20a69aa t26a 24a 36a 94a 104a 6.373626i86a ! l3a108a ! 76a ! 20a ! 69a 70a ! 26a ! 94a ! 104a 21a 97a 6.373626 86a79a 108a ! 69aha 70a6a ! 24a6a94a 21a 97a 6.373626186a 13a 1 08a 176a 120a 169a 170a 26a ! 36a 94a! 1 04a 121 a 6.373626j86a 79a 108a ! 76a ! 69a j1a j70ä 24a 136a 104a |2la j97a 94a) l04a94a) l04a 6.373626 79a 108a76a 20a 69a1a 70a) 26a) 24a36a ! 94a 97a 6.373626 86a 108a76a 69a 1a 70a 26a 36a) 94a ! l04a21 a ! 97a6.373626 86a 108a76a 69a 1a 70a 26a 36a) 94a ! l04a21 a ! 97a 6.37362686a79a 108a76a 20a69a la 70a 26a36a 94a 104a 6.37362686a79a 13a 108a69a1a 70aj26a 36a 94a 21a 97a 6.373626j86a79a 13a 108a69a1a 26a24a 36a 94a 104a97a 6.446887 86a 79a 13a h08a76a20a 1a 70a 36a 94a h04a21a 6.446887 86a 79a 108a 76a 20a 69a 26a 24a36a 94a J104a 97a6.446887 86a 79a 108a 76a 20a 69a 26a 24a36a 94a J104a 97a 6.44688713a 108a76a 20a 1a 70a) 26a36a 94a 104a 21a 97a 70a 26a 24a 94a 104a 97a70a 26a 24a 94a 104a 97a 6.44688786a 79a J13a 108a76a 69a1a 70a 26a 36a 94a 104a6.44688786a 79a J13a 108a76a 69a1a 70a 26a 36a 94a 104a 69a1a70a36a 94a 104a97a69a1a70a36a 94a 104a97a 6.446887 86a 79a) 108a ! 76a 69a ! laOaJ26a ! 24a4a 104a 21 a6.446887 86a 79a) 108a ! 76a 69a ! laOaJ26a ! 24a4a 104a 21 a ; Fielc31., a'i-. n, 2: f3::;; 4 5 x 6: 7, : 8 "9 y1: 0, 11,; 12: 6.446887) 8633310876a 20a1a 70a4a 36a94a h04a97a 6.446887 ! l3ah08a76a ha 70a26a 24a36a 94a) l04a 21a 97a 6.446887) 86a79ah08a76a 20a69a 1a.) 24a 36a94a 104a97a 6.446887 86a 79a) l3a 108a76a20a69a70a26a) 243 104a97a 6.446887186al79a 13a 176a 120a 169a 170a |26a 136a|94a 121a 197a 6.446887 86a79a76a 20a ! 69a1a ! 70a26a 24a36a 94a 104a 6.44688786a79a108a69a 1a 70a) 24a) 36a4a 104a 21a 97a 6.446887186al13ai108al69al1a ! 7oal26a ! 24a ! 36ats4a 1104a ! 97a 6.44688786a79a13a 108a76a 69a jla 26a ! 24a ! 36a 94a) l04a 6.44688786a79ah08a76a 69a 70a 26a 24a36ah04a 21a 97a6.44688786a79ah08a76a 69a 70a 26a 24a36ah04a 21a 97a 6.446887 79a) l3atl08a) 76a 1a 70a 26a 24a 36a ! 94a21 a 97a6.446887 79a) l3atl08a) 76a 1a 70a 26a 24a 36a ! 94a21 a 97a 21a 97a21a 97a 6.44688786a13a108a ! 76a ! 20a69a 1a 70a ! 24a36a J104a97a 6.44688786a79a13a) l08a76a20a 6Sa1a) 70a24a ! 36a 104a 6.44688786a79a13a 108a20a69a 1a 70a) 26a94a 104a J97a 6.44688786a79a13a 108a76a ! 20a 69a 1a ! 70a ! 26a 36a 21a 6.44688786a79a13a08at20a) 1a) 70a) 26a) 24a36a J94a ! 97a6.44688786a79a13a08at20a) 1a) 70a) 26a) 24a36a J94a ! 97a 6.52014613a ! l08a76a) 20a 69aj1a 70a ! 26a) 24a36a) 94a 104a 6.520146179a ! 13a ! 1o8al76a 120a í69a fla i26a 124ai36a 194a 197a 6.52014686a79a13a 76a ! 20a69a 70a26a 24a36a 94a97a6.52014686a79a13a 76a ! 20a69a 70a26a 24a36a 94a97a 6.520146 ! 86a 79a |13a 108a 76a 20a 1a 70a 26a ! 94a |104a 197a 6.52014686a79a13a 108a76a70a 26a) 36a 94a 104a 21a 97a 6.52014686a13a) l08a ! 76a 69a1a) 70a ! 26a 24a) 36a 104a97a 6.52014679a13a108aj76a 20aj70a 26a) 36a 94a 104a 21a 97a 6.52014686a T3a108aj76a j20a69a1a) 70a 26a24a 104a97a 6.52014686a 108a76a J20a 69a1a 70a) 26a 36a94a J104a97a 6.52014686a13a108a) 76a 69a1a70a J26a t36a 94a 104a 97a 6.52014686a13a108at76a 69a1a 70a ! 26a 36a 104a 21a 97a I 6.59340786a79a108a76a 20a) la 70a 36a 94a 104a 21a 97a 6.59340779ajl3aJ108a76a 69a1a70a26a 24a 94a 21a 97a6.59340779ajl3aJ108a76a 69a1a70a26a 24a 94a 21a 97a 6.59340786a13a l08a76a 20a 69a1a 26a 36a 94a 104a 21a 6.59340786a79a13a 108a76a 20a ! 69a ! l3 70a) 94a h04a ! 97a 6.593407 86a 79a13a 76a la 70aj24aj36a 94a104a) 21a J97a 6.59340786a79a13a 108a76a 20a 69a 70a 26a24a) 36a ! l04a 6.59340786a79a13a76a 69a1a) 70a26a 24a 94a 104a ! 21a6.59340786a79a13a76a 69a1a) 70a26a 24a 94a 104a ! 21a 6.59340786a79a108a76a 69a1a J70a24a) 36a94a 104a 21a 6.59340779a13a76a 20a 1a 70aJ26a36a 94a 104a) 21a 97a 6.59340786a79a13a 108a76a 20a J69a 70a 26a 104a 21a 97a 6.59340786a79a13a 108a20a69aha 70a 24a36a 104a97a 6.593407 86a 76a20a 69a 1a 70a) 26a24a 36a94a 104a97a 6.59340786a79a13a 76a 69a1a 70a36a 94a 104a 21a 97a 6.59340786a79a13a 108a76a 1 a 70a) 26a 36a94a 104a 21 a 6.59340786a79a13a 108a76a 20a 69a 70a 26a 36a 94a97a6.59340786a79a13a 108a76a 20a 69a 70a 26a 36a 94a97a 6.59340786a79a108a76a 20a69a Is 70a 26a 94a 104a97a 1a 70a 24a 94a 104a 21a 97a1a 70a 24a 94a 104a 21a 97a 6.593407 86a 79at76a 20a 69a1a 70a26a 24a 94a 104a97a 6. 593407 ! 86a ! 79a ! 13a 120a 169a j1a j70a 36a 194all04a 121a 197a 6.59340779a13a 108at76a 20a69a 26s 24a 36a) 94a04a97a6.59340779a13a 108at76a 20a69a 26s 24a 36a) 94a04a97a 6.593407 ! 86a13s 108a ! 76a 20a J69a J70a J24a) 36a 94a104a97a6.593407 ! 86a13s 108a ! 76a 20a J69a J70a J24a) 36a 94a104a97a 6.593407) 86a79a 108a76a J20a1a 70a26a 94a104a 21 a 97a 6.666667 86a108a76a 20a j69a1a 70a26a 36a104a 21 a7a 6.666667 86a79a 13a 76a 20a 1a 70a 26a 94a) l04a 21 a J97a 6.66666779a13a ! l08a69a la 70a26a) 24a) 36a94a 104a) 97a 6. 666667j79a) 13a J108a76a 69a1a) 70a ! 26a4a36a) 94a 97a 6.666667186a 79a 11 3a ! 76a ! 2oa ! 69a ! 70a 126a ! 36a 194a ! 1 04a 121 a 6.66666786a79a) 13a 108aJ69a1a J70a26a 94a104a) 21a) 97a 6.73992786a79a 113a! 108al76a|69a ! 1a 11 04a 197a l l739927) 79a 13a) l08a76a) la) 70a J24a'36a) 94a104a 21a 97a6. 6.739927 ! 86a79a 13a 108aJ76a ! 69a 1a) 70a ! 24a36a 21 a 97a 6.73992786a79a 108a76a) 69a) la 70aJ26a24a36a 94a 97a 36a94a) l04a97a36a94a) l04a97a 6.739927179a ! 108al76a ! 20a 169al1a 170a ! 2-6-a ! 36a ! 94a ! 21'å 197a 6.739927) 86a79a 13a ! l08aJ69a 1a 70a) 24a ! 94ajl04a ! 21a ! 97a 6.73S927) 86a79a 108a ! 76a J20aj69aha) 70a J26a) l04a 21a t97a 6.73992786a ! 79a ! 13a j76aOala 70at36a ! 94a104a 21a 97a6.73992786a ! 79a ! 13a j76aOala 70at36a ! 94a104a 21a 97a 6.739927j86aj79a j13a ! 1o8a ! 2oa 169a 11a 136a |94a|104a 121a 197a 6.739927186a 79a 113a 76a 169a Ila 170a 124 136a 194a 11 04a 21 a 6. 73992786a79a 13a J108a 76a 20a) 69a t70a 26aj36a 104a21a 6.739927 79a 13a 108a76a 20a) 70a ! 26a) 24a) 36a94a 104a97a 6.73992786a79a tl3a 108af20aj69ajla f70a 36a94a 104a97a 6.73992786a79a 108a76a 20a1a) 70a ! 24a ! 36a94a) l04a ! 97a 6.73992779a13a 108a76a 69a (la 70a (26a) 36aJ94a j21a J97a'* 6.73992786a79a 113a 108a20a69a 1 a 170a 124@ 136a 194a 11 04a 20a (1a 70a 126a24a 36a 194a97a20a (1a 70a 126a24a 36a 194a97a 6.739927) 86a79a 13a 108a20atla 70aJ26a 94ajl04a1a 97a 6.739927j86a79a (13a 108a76a69a1a J70a 24aj94a) l04a21a 6.813187 ! 86a79a 13a 108a ! 69a) 70a ! 26a6a i94a ! l04a 21a) 97a 6.813187) 79a13a 76a (20a 69a 1a J26a 24a J36aj94a ! l04a) 97a 108a76a20a69a 1 a70a26a36a97a108a76a20a69a 1 a70a26a36a97a 6.81318786a79a 13a 108a20a 69a 1a 70a ! 26a24a j36a 94a 6.81318713a76a"20a 69a la 70a 26a 24a 36a94a) l04a97a 6.81318786a79a 13a 108a76a 20a 69a 26a 36a 94a 104a21a 6.813187 86a3a"'76a 69a 1a t70a 26a 24a ! 36a 94a 104a 97a 6. 81318786a79a 108a76a 70a J26a 24a 36a 94a104a 21a 97a 6.886447pua 13a 108a 76a20a 1 a 70a 26a 36a94a 104a21 a 6.886447186al79a ! 108a 76a ! 20a 69a ! 1a 70a 24a ! 94a ! 104a ! 97a 6.88644786at79a 108a76a 20a1a 70a ! 26a 24a94a 104a97a 6.886447 ! 86a79a 108a20a 69a1a 70a 36a 94a) 104a 21a 97a 6.88644779a13a 108a76a69a70a 26a 24a 94a104a 21a 97a6.88644779a13a 108a76a69a70a 26a 24a 94a104a 21a 97a 04a21a04a21a 94a 21a94a 21a . l. l I I88644786a13a 108a76a 69a (1a6.70a 26a 24a 94a104a 21a 6.8864471a76a 20a, 69a la 70a 26a 36a 194al104a 121a 197a 6.88644786a79a 108a ! 76a 69a1a70a 26a J24a36a94a) 21a 6.886447j86a13a 108a76a J20a69a 70a26a 24a36a 943 ! l04a 6.886447 79a13a 108a) 76a la 70a J26a 24a 94a104a 21a) 97a 6.886447179a 13a 176a 169a Ila 70a 24a 36a 94a! 104a ! 21a ! 97a 6.886447j86a ! 79a 13a 108a76a69a1s 70a 24a36a 104a97a 6.959707) 86a13a 76a 69a 1a 70a 26a 36a 94a 104a 21 a) 97a 6.959707) 79a) l3a 108aj76a J20a 69a 26a 36a 94a 104a 2 Is 97a 6.959707) 863) 13a 1083 76a 69a1a 70a 26a 24a 94a J104a97a 6.959707j86al79a 13a 20a 69a 1a 70a ! 26a 24a 94a) l04a97a 6.95970786ah3a ! l08a76a 20a69aha) 70a 26a 94a) l04a97a 6.959707j86a) 79a 13a 108a76a ! 20a69a70a26a) 36a 94a 104a 6.959707j79a ! l08a76a ! 69a 1a70ai26a ! 24a) 36a) 94a 104a97a 6.95970779a13a J108a) 76a 20a69a1a) 70a) 26a4a 36a) l04a 7.032967 86a ! 79a ! 1 08a 76a 20a 70a 26a ! 24a 36a 194a j1 04a 197a 7.032967 ! 86aj79a 108a76a (20a 69a t70a 26a 24aJ36a 104a 97a 7.032967 ! 86a) l3a 108a20a 69a 1a ! 70a ! 36a 94a104a 21a97a7.032967 ! 86a) l3a 108a20a 69a 1a ! 70a ! 36a 94a104a 21a97a 7.032967186a ! 79a ! 13a 1108al20a ! 1a ! 70a ! 24a i36a ! 9 4a 104a ! 97a 7.032 Oa 169a la 170a 124a 136 194a 1104@ 7.032967l79a|108a ; 76a |69a ! 1a ! 70a t26a 24a 194a 104a 121a 197a 7.03296786a79a) 108a76a ! 20a ! 69a1aOa4ah04a ! 21a 97a 7.03296713a 108a) 76a 20a 69a) la j26a 36a ! 94a 104a) 21a ! 97a 7.032967 86a 13a |108a 76a 20a |69a ! 1a ! 70a |36a 104a |21a 197a 7.032967 86a 76a (20a 69a J1a 70a J26a 36a J94a 104a21 a 97a7.032967 86a 76a (20a 69a J1a 70a J26a 36a J94a 104a21 a 97a 76a69a1 a70a 124a36a104a21 a 97a76a69a1 a70a 124a36a104a21 a 97a 7.032967179a 13a ! 108al76a 120a ! 6sa 11a 170a 126a|24a 136a 94a 7.032967) 86a79a) 13a 108a69aha ! 70a) 26a24a94a 104a 21a 7.032967|86a|13a 176a 20a 69a |1a 70a 24a 136als4a |104a|97a 7.03296779a13a 76a 69aa 70a 26a ! 24a 94a) l04a 21a 97a 7.106227 ! 79a 13a 108al76a 1a 170a 126a ! 24a 136ai104a 121a 197a 7.106227 86a 79a 108aj76a 69a 70a (26a 36a 94a 104a) 21a t97a 7.10622786a79a 13a ! l08a76a20a ! 70a26a (36a ! 94a (104at21a 7.106227) 86a79a 13ajl08a76a ! 69a ! 70a) 24at36a) 94a 104a) 97a 7.106227 (79a) l3a ! 76a ! 20a 69a ! la 70a) 26a 36a 94a 21a97a 7.10622786a79a) 13a 76a 20a 1a 70a ! 26a 24a 94a ! l04a97a 7.10622786a79a J13a 108a76a 70a 26a 24a 36a 94a 104a 21a 7.106227 86a 79a 108a) 76a 20a69a 1a 36a 94a) 104a 21a 97a 7.10622786a79a 13a) l08a76a ! 70a 26a 24a 94a104a 21a 97a 7.106227 86a 13a 76a 20a 69a 1a 70a 26a 24a36a 94a 104a 7.10622713a 108a76a 20a 69a1a J26a 24aJ36a 94a 104a97a 7.17948786a79a 13a 108a76a 69a J1a 24a36a94a 21a 97a 7.179487186al79a 1l08al76a |69a ! 26a ! 24a ! 36a ! 94all04a 121a 197a 7. 17948779a108a76a 20a 69a1a ! 70a26a 24a36a 104a97a 104a 21 a 104a 21 a 7.17948786a79a 13a 108a76a20a ! 69a24a 36a 94a 104a97a 7. 17948786a ! l3a 108a76a 20a') a"' ! 70a26a 94a104a 21a 97a 7.17948786a79a 13a h08a76a 1a ! 70a26a 94a104a 21a 97a 7.17948786a79a 13a 108a76a 69a ha 26a36a94a 104a 21a 7. 17948786a79a 13a 108a76a 20a 69a1a24a36a 104a97a 7. l79487 ! 86a ! 79a ! 13a ! 20a ! 69a ! 1a 17oa-l26a 24a ! 36a 194a ! 97a 7. 17948786a79a13a20a (69a1 a70a26a 24a36a94a97a 7. i79487|86aj79a ! 13a |108a|20a|69a 17oaX24a 36a ! 94a i104a|97a 7.17948786a79a 13a 1Q8a20a 69a 1a 70a 36a94a04a'21a 7.179487863 79a 13a 108aj20a 69a J1a 26a 94a) l04a 2'197a 7.25274779a ! 13a 76a 20a ! la) 70a ! 26a) 24a 36a ! 94s104a97a 7.25274786a79ah3a 108at76a ! 20a) la) 70a26a24a 36a 104a 7.252747) 86a79a) 13a 108a) 20a69a 1a 70a) 26a36a) 21a) 97a 7.252747j86a79a J108a76a) 20a 69a 1a 70a J36a) l04a J21a) 97a 7.252747 ! 86a79a 13a 108a76a20a 70aJ26a 24a36a 94a 104a 7.252747j86a79a 13a 108a76a69a 1a 36a 94a 104a 21a 97a 69a 1a 70a 36a 94a104a 97a69a 1a 70a 36a 94a104a 97a 7.252747) 86a79a 13a6a t20a 69a ha) 70a 26a36a 94a 104a7.252747) 86a79a 13a6a t20a 69a ha) 70a 26a36a 94a 104a 7.252747 79a 13a 108a76a ! 69a1a t26a24a6aJ94a tl04aj97a 7.252747186a 108al76a 120a 169a Ila_ 126a 124a 136a 94a 11 04a 197a 7.252747j86a79a J108a76a ! 69a) 70a) 24a 36a 94a, ! l04a 21a 97a 7.252747186 79a 113a 11082176a. 1 9 170a 126a 24a 136a 121 a 197a 7. 326007) 86a79a J108at76a) 20a) 69a J703 36a) 94a 104a J21a} 97a 7.326007 ! 86a ! 79a ! 13a 11o8al76a 11a 170a 136a 194al1o4a |21a ! 97a 7.326007 86aj79a 76a t20a j69a 1a ! 70aj26a 94atl04a) 21a j97a 7.326007t79a13a 108a69a 1a ! 70a24a6a 94at104a ! 21a ! 97a 7.326007 86a 793 (13a 108a69a) la) 70a26a 24a 36a 94a tl04a 7.326007 86a 79a) l3a) 76a i20a 69a1a 24a) 36a94a 104aj97a7.326007 86a 79a) l3a) 76a i20a 69a1a 24a) 36a94a 104aj97a 7.32600786a79a f13a (l08a (76a203) 69a ; 1a) 36sJ94a 104a J97a 7.326007 ! 86al79a ! 13a ! 108a 76a ! 2Oa 11a ! 26a ! 94a 104a 21a 197a 7.326007J86a79a 13a ! l08aj76aj69ajla 26a 24aj36a94a j97a7.326007J86a79a 13a ! l08aj76aj69ajla 26a 24aj36a94a j97a 7.32600786a) 79a tl3a 108a) 76at69a 1a 26a ! 36a94a 21a 97a 7.32600786a79a 13a 108a76a ! 20a59a1a 70a 36a 104a 21a 7.32600786a79a 108a76a 20a ! 69a ! l3 J70a 26a 24a) 36a 94a 7.399267 86a 79a 76a 20a ! 69aj1s J70a ! 26a 24a 36a h04a97a 7.399267 86a 79a 108a) 76a 20a 69a ! 70at26a) 36aJ94a tl04a ! 97a 1a j70a 26a 136a 94a (104a i97a1a j70a 26a 136a 94a (104a i97a 7.39926786a79a 13a 108a76a1a t70a26a ! 24a36a 104a 21a 7.399267 86a 79a 13a 76a 20a 69a Is 70a 24a 94a 104a97a 7.39926713a 108a76a 20a ! la) 70a 26a 24a 36a 94a 104a97a 7.399267186a 79a 176a 69a ! 1a 70a 126a 124a 136a 94a 121a 197a 7. 39926786a79a 13a 108a76a 20a 1a 36a 94a 104a 21a 97a 7.399267 ! 86a79a 13a 108a76a20a69a1a 26a 24a 104a97a 7.399267j86a 108a76a 20a 69a 70a) 26a 36a 94a 104a 21a 97a 7.39926786a79a 13a 76a 70a) 26at24a'36a 94a104a) 21a 97a 7.39926786a79a 13a 108a76aJ20a 1a) 26a 24a 36a 94a 97a 7.399267 79a 13a 76a 20a 69a 1a 70a26a 24a 36a 104a97a 24a 36a94a 104a21a 97a24a 36a94a 104a21a 97a 7.39926786a79a 13a ! 76a 20a 69a 70a26a 24a J94a 104a97a 7.39926786a79a 76a 20a 69a 1a 70a26a 24a 36a 94a 97a 26a 94a 104a21 a 97a26a 94a 104a21 a 97a 36a94a 104a 21 a 97a36a94a 104a 21 a 97a 7.47252886a) 79a jl08a 76a 69a 1a70aJ24a36a 94a 104a 97a fief 4 7.472528 ! 86a ! 79a|13a ! 108a ! 20a|69al1a |70a|36a 104a ! 21a |97a 7.47252886a13a) 76a) 20a 69a 1a (70a 26a36a94a (l04a (21a 7.47252886a79a (l3a (76a 69a 1a) 70a 26a24a36a (94a 21 a 7.472528 79a|1 3a 11 08a 176a ! 20a 1 a 70a 24a 136a 94a 1l04a 197a 7.472528 79a13a108a76a 20a 69a) 70a 26a ! 24a) 36a 104a 97a 7.47252886a13a76a 20a 69a 1a) 70a 36a) 94a104a 21 a 97a 7.472528j86a79a13a 76a 20a 69a 1a 70a94a104a 21 a 97a 7.47252886a79a13a 108a 76a (20a la J24a36a94a 104a (97a 7.47252886a79a108a76a 69a) 70a 26aJ24a94a104s 21 a) 97a 7.47252886a13a108a76a 20aJ69a (la 26a94a104a) 21a) 97a 7.47252886a79a108a76a 69a) 1a (70a 26a (36a 94a 21a 97a 7.472528 (86a79a13a 108a76aj20a la 70a (24a94a 104a97a' 7.472528 13a llO8a76a la j70a-l26al36a 194a 1104 121 a 197a 7.47252886a79a) 13a 108a76a) 69a 1a 70a) 24a94a) 21a 97a 7.472528) 86a 79a (13a 108aj76at69a 1a 26a24a94a ! 21a) 97a 7.54578786a13a76a 20a 69a (la 70a 26a24a94a (104a97a 7.54578786a13a108a76a 20a (la 70a36a) 94a) l04a 21a 97a 7.54578786s 108at76a (1a) 70a (26a) 24a 36a (94a) l04a 21a) 97a 7.54578786a 79a (13a) 76a (20a (70a (26a (36a94a104a 21a 97a 7.54578786a 79a13a (108aJ76a20a) la26a24a94a 104a97a7.54578786a 79a13a (108aJ76a20a) la26a24a94a 104a97a 7.54578786a79a 13a108a76a69a26a36a94a104a21a 97a 7.54578786a79a) l3a 108a76a 69a 70a 26a94a104a 21a 97a 7.545787|86a|79a 113a ! 108al76a 169a 11a 170a |94al104a t21a 197a 7.545787186a 79a 11 3a 176a 69a Ila 170a 126a 136a 94a 121 a 7.545787j79al13a 176a 069a la) 70a26a 36a94a 104a 21a 97a 7.61904886a13a108a76a 69a) la) 70a24a94a) l04a 21a 97a 7.61904886a79a13a 108a76a 69a (la 70a26a24a J104a97a 7.61904886a13a108a76a) 69a 1a 26a) 36a94a104a 21a 97a 7.619048J86a79a"13a 108a76aj20a la26a36a94a 104a 21a 7.619048) 79a 108a76a 20a la ! 26a36a 94a 104a21a97a 7.61904879a13a108a20a 69a1a (70a 26a36a 94a) 21a 97a 7.61904886a79s"13a 76a 20a 69a1a 26a24a36a) 94a) 97a 7.61904886a79a108a76a 20a 69a 1a 70a26a 36a) 94a (21 a 7.61904886a79a13a 69a 1a 70a 24a36a94a104a ! 21a 97a 7.61904886a13a108a76a 20a 69a (1a 36a94a 104a (21a 97a 7.61904886a79a13a 108a76a20a) 69a70a26a94a 104a97a 7.61904879alO8a76a 69a Ila 170a 26a 124a 36a 104a 121 a 197a 7.61904886a79a13a 20a 69a 70a 26a24a36a94a 104a97a 7.61904879a13a108a76a 20a1a 26a 36a94a104a 21a 97a 7.61904886a79a13a 108a 69a1a 70a 26a24a104a 21a 97a 7.61904886a79a) l08a76a) 20a la 70a 26a24a36a 94a 97a 7. 619048 86a 79a 13a 20a 69a a 70a26a 94a 104a21 a 97a 7.69230786a79a13a 108a 76a 20a 70a24a36a94a (104a97a 7.692307 86a 79a108a20a 69a la 70a 26a94a104a 21a 97a 7.69230 86a 79a 113a lO8a76a 20a 169a 126a 942 104a 21 a 97a 7.692307 79a 108a 20a 69a la 70a) 26a24a36a94a (104a97a 7.69230786a79a13a 76a 69a 70s (26a24a36a94a 104a 21 a 7.69230779313a108a76a 69a 1a26aj36a94a 104a 21 a 97a7.69230779313a108a76a 69a 1a26aj36a94a 104a 21 a 97a 7.692307 ! 86a79a J13a J108a76a ! 20a 69a 1a 94a) l04a 21a"97a 7.692307 86a13a 108a76a 69aJ70a 26a 24a 36a 94a 14a 21 a 7.69230786a79a 76a 69a 1a 70a6a 24a 36a'94a 104a 97a7.69230786a79a 76a 69a 1a 70a6a 24a 36a'94a 104a 97a 7.692307186a 13a 76a 20a 69a 1a 70a|26a |94a|104a 121a 197a 7.692307 86a13a 108a76a 69a 1a 70a 26a 94a'104a 21 a 97a 7. 692307J86a79a 13a 108a6a20a 69a1a) 26a94a 104a ! 97a 7.69230786a79a 13a 108a76a20a 69a1a26a36a 21a) 97a" 1a 70a 24a 36a94a 104a 21a ! 97a1a 70a 24a 36a94a 104a 21a ! 97a 7.692307|86a|79a ! 13a |108a|76a ! 70a 126a 124a |36a|104a ! 21a 197a 7.6923076a79a) l3a 108a76a 1a ! 70a24a 36aJ94a 104a 97a 7.692307|86a|79a 113a 1108a|76a|69a 11a j70a j24a j94a j104a|97a 36a94a 104a 97a'36a94a 104a 97a' 7.765568186a ! 79a ! 13a ! 108al76al69a 1a ! 70a 126a ! 24a 136a 121a 7.765568179all 3a 108a76a69a1s 70a26a ! 24a36a 94a 14a' 7.765O68186al13a 108a76a |1a 70a 26a 24a i36a104a21a'97a 7.76556886a79a) l3a 108a69aj1a) 26a24a 36a'94aj21a J97a 7.765568 86a ! 79a 13a ! 76a la ! 7Qa 26a 24a 36a ! 94a104a21a7.765568 86a ! 79a 13a ! 76a la ! 7Qa 26a 24a 36a ! 94a104a21a 7.76556886ai79a"13a108a1a 70a 24a 36a 94a 104a J21a 97a"7.76556886ai79a"13a108a1a 70a 24a 36a 94a 104a J21a 97a" 7.76556886aj79a |13a 176a 1a 70a 26a 24a4a 104a21 a 97a" 7. 76556886a) 79a108a76a 20a 69a1a 26a 24a 36a94a 104a 7.765568186al79a ! 108a ! 76a 120a 169a 170a ! 26a 136a ! 104a ! 21a 197a 7.76556886a9a 13a 108a ! 76a ! 69a 1a 24a ! 36a94a 104a 21a la 70a 26a6a J94a104a 21a 97ala 70a 26a6a J94a104a 21a 97a 7.765568|86a|79a S108a|76a |20a 6ia 1a 026a |24a|94a 104a|97a 7.76556879a 76a 20a) 69a 1a 70a 26a 36a) 94a104a 21a97a"7.76556879a 76a 20a) 69a 1a 70a 26a 36a) 94a104a 21a97a" 7.83882886a79a13a 108a ! 76a ! 20a 69a 70a 94a 104a 2 ? a 97a7.83882886a79a13a 108a ! 76a ! 20a 69a 70a 94a 104a 2 ? a 97a 7.838828 86a) 79a 13a 76a 20a 69a1a 70a 24a 36a 104a 97a"7.838828 86a) 79a 13a 76a 20a 69a1a 70a 24a 36a 104a 97a" 7.83882886a79a 13a 108a76a 69a1a 70a 26a 104a 21a 97a7.83882886a79a 13a 108a76a 69a1a 70a 26a 104a 21a 97a 7.838828 79a 13a 76a 20a 69a1a 70a26a 24a 36a 94a 104a 104a97a"104a97a" 7.83882813a 108a76a 69a 1a 70a 26a 24a 36a104a) 21a 97a 7.83882886a79a 13a 108a76a 20a la J70a 26a36a 104a 21a" 7.838828 79a 108a76a 69a la 70a 26a 24a 36a 94a 121 a 97a 7.838828|86a 79a 13a 108a j76a 20a! 1a ! 70a 26a 36a |94a 104a 7.838828 86a13a 108a20a 69a ! la 70a26a 24a 36a 94a 104a 7.83882886a13a 108a76a 20a ! 69a 70a36a 94a 104a 21a 97a 7.838828 86a (79a 13a 108a 76a1 a 70a24a 94a 104a 21 a t97a 7.83882886a79a 13a 108a76a 20a 69a 1a70a 26a 104a 97a 7.83882886a79a 13a 108a76a 20a 69a la70a 26a36a 104a 7.83882886a79a 13a 76a 20a ! 70a 26a 24a 36a 94a 104a 97a 7.83882886a79a 13a 108a76a 20a 1a 70a ! 26a24a'36a94a 7.83882886a79a 13a 69a 1a 70a 26a 24a 36a 94a 104a 97a 7.83882886a79a 108a76a 69a1a 70a26a 24a 36a 21a"97a 94a94a 7.83882886a79a 13a 108a20a69a 1a 26a 36a 94a21a 97a7.83882886a79a 13a 108a20a69a 1a 26a 36a 94a21a 97a 7.83882886a79a |13a 108a76a20a la 70a 36a 94a 14a7a , f-,eld la r r u 7.91208886a79a) l08a76a 1a70a 24a 36a ! 94a104a 21a 97a 7.912088J86a79a 13a- ! 08a69s1a 24a36a 94a 104a 21a 97a 7.91208886a79a 108a76a 69a1a 70a26a 24a 94a 104a) 97a 7.91208886a79a J13a 76a 69a la 70a 24a 94a 104a 21a97a 7.91208886a13a 108a) 76a 69a) la 26a24a 36a'94a104a21a 94a 104a 21a 97a94a 104a 21a 97a 7.912088 (86a79a 13a 76a 20a 69a 1a) 70a 26a) 36a 94a 21a 7.91208886a79a 13a 76a 69a !-) a 70a26a 24a) 94a 104a 97a 7.91208886a79a 13a 108a76a (20a 69a (la 24aJ94a 104a 97a 7.912088186a ! 79a |76a 69a 1a 70a 26a |24a |36a ! 94a ! 104a|21a 7.912088179a ! 13a ! 108a|76a |20a |69a 11a ! 70a |26a|36a 121a 197a 7.91208886aj79a 13a108a20a) la 70a 36a 94a 104a ! 21a J97a7.91208886aj79a 13a108a20a) la 70a 36a 94a 104a ! 21a J97a 7. 912088 ! 86a79a ! l3a76a 20a 69a ! 70a 26a 94a 104a (21a 97a 7.91208886a79a (76a) 20a 1a 70a 26a24a 36a 94a ! t04a97a 7.912088j79a ! 13a |108al69a |1a ! 70a ! 26a 124a 194a 104a ! 21a 197a 7.91208886a! 20a 11a 176a 126a |36a 94a |104a |21a 7.912088 ! 86a|79a |13a |108al76a 120a |69a i1a 126al36a 194a |21a 7.985348 86a79a ! l3a 108a76a 69a 1a J70a 26a 94a104a7a 7.98534886a79a l3a 108a1a 70a 26a) 24a 94a 104a 21a J97a 7.985348 86a79a 76a 69a 1a 70a 26a 24a) 94a104a 21a 97a 7.985348|79a|13a |108a 70a26a 36a 104a 21a 97a 7.985348|86a|79a |13a |108a ! 76a |20ä |69a 11a |26al104a 21a 97a 7.98534886a79a 13a 108a76a 69a J70a 26a (36aj94a 104a 97a 7.98534886a79a 13a 76a 1a 70a 26a36a 94a 104a 21a97a7.98534886a79a 13a 76a 1a 70a 26a36a 94a 104a 21a97a 7.98534886a79a 13a 108a76a (69a 26a 24a J36a94a 104a 21a 7.98534886a79a 76a) 20a ! 69a ! ta J70a 26a ! 36aJ94a 104a 97a 7.98534879a13a ! l08a76a 69a 70a26a 24a 36a 104a 21a 97a7.98534879a13a ! l08a76a 69a 70a26a 24a 36a 104a 21a 97a 7.98534879a13a) l08a76a 20a69ajla 70a 26a36a 94a 104a 7.985348 79a 13a 11 08a 76a 120a 169a Ila 126a 124a 136a 1104a 97a 1a70a'26a24a36a94a104a97a1a70a'26a24a36a94a104a97a 8.058608 86al79a |13a |108a|76a |69a |1a 126a |24a|94a |104al21a 8.05860886a79a 13a 108a76a1a J70a24a 36a) 94a 104a) 21a 8.058608 79a 108a76a 20a 69a1a 70a26a 24a36a 94a 104a 8.05860886a79a 108a76a 69a1a 70a26a 24a36a 94a 104a 8.05860886a79a 13a J76a 20a'1a 70a26a''24a36a'94a 104a 8.05860886a79a 13a) l08a76a20a 1a 70a 24a36a 94a 104a 8.05860879a13a 108a 76a 69a 1a70a8.05860879a13a 108a 76a 69a 1a70a 26a 36a 94a 104a 21a 8.05860886a79a 108a20a 69a 70a 26a24a 36a) 94a) l04a97a 8.05860886a79a 13a 76a 20af69a la J70a 26a24a (104a 97a 8.05860886a) 79a 13a 108a20a 69a 1a 70a 26a36a 94a 21a 8.058608 79a 13a 108a76a 69a 1a 24a36a 94a 104a 21a 97a 8.13186879a13a 76a 20a 69a1a 70a26a 36a 94a 104a 97a 8.131868 86a 13a 108a76a 20a 69a 70a26a 36a 104a 21a 97a 8.13186886af79a 76a 1a70a 26a 24a 36a) 94a 104a 21a 97a 8.13186879a13a 108a76a 69a 1a 70a26a36a104a 21a 97a8.13186879a13a 108a76a 69a 1a 70a26a36a104a 21a 97a 8.1318683a 108a76a 20a 69a1a 70a26a 24a36a 104a 97a 8.131868J86a79a 108a69a 70a 26a 24a 36a 94a 104a21a 97a8.131868J86a79a 108a69a 70a 26a 24a 36a 94a 104a21a 97a 8.! S. Fie<t 2 í 8.13186813a108a76a 20a69a 70a6a 36a 94a104a1a ! 97s 8.13186886a79a 13a) 76a 20a69a1a 26a 24a) 94a 104a97a 8.13186886a ! l3a 108aJ76a 69a) la 70a24a 36ab04aJ21a"97a 8.13186813a108a76a) 20a 69a1a 70a 26a 36a104a 21a 197a 8.13186886a79a 108a76a |26a t24a |36a|104a |21a 197a 8.13186886a 79ah083 76a 69a1a70a ! 26a4a36a J104a21a8.13186886a 79ah083 76a 69a1a70a ! 26a4a36a J104a21a 8.131868|86al13a ! 76a 169a} 1a 170a |24a |36a 194a8104a |21a ! 97a 8.131868 ! 86a|79a |108a|76a |69a |1a 170a ! 26a |36a ! 94a 2104a 21a 8.13186886a79a13a 108a ! 76a1a 70a26a 24s 94a 104a97a8.13186886a79a13a 108a ! 76a1a 70a26a 24s 94a 104a97a 21a 97a21a 97a 8.131868186al79a ! 108a 76a 169a|1a |70a ! 26a 194a|104a |21a ! 97a 8.20512986aj79a 13a 108af76a1a ! 70aJ24a 36a 104a J21a 97a 8.205129186a 79 113@ 176a 120a 69a 170@ 126a 1104@ 197 8.205- ! 29J86ai79a 13a 76a 20aJ69ajla 36a 94a 104s J21a 97a 8.205129 ! 86a79a 13a 108a76a ! 26a 24a 36a 94a 104a) 21a 97a 8.205129 ! 86a) 79a 13a 108a76a 20a 26a 243363 94a J104aj97a 8.205129113a 11 08a |1a 170a 126a |24a ! 94a|104a |21a 197a 8. 20512986a ! 79s 13a76a 20a69a 70a24a 36a94a 104a97a 8.205129j86a|79a |108a|76a |69a! 1a 170a |36a 194a 104a |21a 197a 8.20512986a 79a 13a 108a76a 69a 1a 70a 24a 104a |21a 197a 8.205129|86al79a 1 08a 76a 69a 1 a 24a m 94a 104a 1212 197a 8.20512986a13a108a69a 1a 70a 24a 36s94a 104a 21a 97a8.20512986a13a108a69a 1a 70a 24a 36s94a 104a 21a 97a 8.20512986a13a ! 76a 69a1a 70a 26a) 24a 36a94a 104a21a8.20512986a13a ! 76a 69a1a 70a 26a) 24a 36a94a 104a21a 8.20512986a79a 13a 108a76a 69a70a 26a 36a 104a 21a 97a8.20512986a79a 13a 108a76a 69a70a 26a 36a 104a 21a 97a 8.278388 79a 108a76a 20a 69a1a26a 24a 36a 94a104a 97a8.278388 79a 108a76a 20a 69a1a26a 24a 36a 94a104a 97a 8.278388186a|79a 108al20a 69a {la 170a 126a 136a|94a ! 21a 197a 8.27838886a79a 108a76a 20a 69a 1a 70a 26a 36a 21a 97a 8. 351648 8&a 79a 108a76a 20a 70a 26a 36a 94a 104a J21a) 97a 8.351648 86@ 79a'13a 20a 69a1a 36a104a21a 97a 8.35164886a79a 108a76a69a1a 70a) 24a 94a104a 21a 97a8.35164886a79a 108a76a69a1a 70a) 24a 94a104a 21a 97a 8.351648 86a79a 13a 108a76a 69a 70a (24a 36a94a 104a21a 8.351648|86a 13a 108a76a 69a J70a6a 24a 36a 104a21a 8.351648 86aj79a'108a20a 69a1a 70a 26a 24a 36a 94a 104a' 8.351648 86a 79a 13a J108a76a69a 1a 70a 36a 104a 21a 97a 8.35164879a 108a76a 20a 69a1a 70a 26a 36a94a J104a21a 8.35164879a13a 76a 69a 1a 70a 26a 24a 36a 94a 21a 97a 8.35164879a 13a 108a76a la 70a 26a24a 36a94a 104a97a 8.35164879a13a 108a69a 1a 70a 26a 36a 94a104a 21a 97a 8.35164886a79a 13a 108a76a 20a 1a 70a 36a 104a21a 97a8.35164886a79a 13a 108a76a 20a 1a 70a 36a 104a21a 97a 8.42490986a79a 13a 20a 69a 70a 26a 36a 94a 104a 21a 97a 8.424909 79a 13a 108a 20a 169a la 170a 26a 24a 136a 94a 104a 8.424909 86a 13a"76a 20a 69a 70a 26a 36s 94a 104a 21a J97a 8.42490986a79a 13a 108a76a 20a 69a la26a 36a 104a 21a 8.42490986a13a 108a76a 20a 69a 70a 26a 24a 36a 104a97a 8.42490986a79a 13a 108a76a 69a 70a 26a 24a 36a 104a97a 8.424909 ! 86a79a 13a) l08a20a 69a 26a 24a 36a 94a 104a 97a gF, ield, 1 e 6ivèlm93 xo ! X ! < 8.424909186a|79a ! 13a |108a|76a ! 69a 170a |26a |24al104a ! 21a 197a 8.424909186al79a 113a ! 108a ! 69al1a ! 70al26a 136a ! 94a 1104al97a 8.424909186al79a 5108a j76a ! 20a 169a 11 a ! 26a ! 36a l94a ! 1 04a 197a 8.42490986a ! 79a! 108a20a) 69a (la (70a 26a 24a 36a-t04a 8.42490986a ! 79a 13a J108a) 76a69a) la) 70a 26a 36a 104s 21a 8.498169 79a 13a |76a 1a 70a 26a 24a 136a j94al104a |21a 197a 8.498169186a 79a 113a 1108al76a 169a 11a 170a 126a j36a ! 21a 197a 8.49816986a13a 108a) 20a) 69a1a 70a26ai24aJ36a) l04a97a 8.49816986a79afl08a ! 76a 69a ha 26a24aj36a ! 94a) l04a97a 8.498169J86313a 76a ! 20a 69a la 70a26a 24aj36a J104a97a 8.49816986a 79a 76a 20a 1a 70a26a6a94ajl04aJ2') a 37a8.49816986a 79a 76a 20a 1a 70a26a6a94ajl04aJ2') a 37a 8.49816979s 13a J108a76a 69a 1a 26a ! 24a 94a104a 21a97a 8.498169 86a 79a) l08a76a 20a 69a la 26a) 24a ! 36a 94a 97a 8.49816979a) l3a J108a76a 20a 69a 1a26a 36a ! 94s 104a 97a8.49816979a) l3a J108a76a 20a 69a 1a26a 36a ! 94s 104a 97a 8.49816986a108a69a J1a 70a26a 24a 36a 94ajt04a 21a 97a 8.498169|79a|13a ! 108al20a 169a 170a |26a 124a |36a|94a |104a 197a 21a 97a21a 97a 8.57142886a79a 13a) l08a76a70a24a ! 36a 94a 104a) 21a97a8.57142886a79a 13a) l08a76a70a24a ! 36a 94a 104a) 21a97a 8.571428 86a|79a 113a |108aj20a|69a 170a 36a |94a|104a 121a 197a 8.57142879a13a 108a76a i20a 1a 70a26a24a36a 104aJ97a8.57142879a13a 108a76a i20a 1a 70a26a24a36a 104aJ97a 8.571428J79a13a 76a 69s 70a26a 24aJ36a ! 94a104a 21a97a8.571428J79a13a 76a 69s 70a26a 24aJ36a ! 94a104a 21a97a 8571428l79al13a 108a|76a |69a|70a 126al24a |36aiS4a |104a, 21a 8.57142886a79a"13a ! 76a 20a9a 1a70a) 26a36a 21a 97a8.57142886a79a"13a ! 76a 20a9a 1a70a) 26a36a 21a 97a 8.571428J86a79a 13a) l08a) laOa 26a ! 24a) 36a94a 104a 97a 8.57142879a13a J108a76a 69a26aJ24a36a 94a 104a 21a 97a 8.57142879a13a l08a76a 20a 1a 70a26a ! 36a94a 104a 97a 8.644689|86a|79a |108a 76a 20a! 69a 1a 26a 94a 104a 21a 97a 8.64468986a79a 76a 20a 69a1a 70a26a 36a 94s 104a21a 8.64468986a13a76a 20a 69sJ70a 26a 24a 36a 94s 104aJ97a8.64468986a13a76a 20a 69sJ70a 26a 24a 36a 94s 104aJ97a 8.64468986a13a108af69a la 70a 26a 24a 36a 94a 104s 21a8.64468986a13a108af69a la 70a 26a 24a 36a 94a 104s 21a 8.644689186al79a 113a 108a69s1a 70a26aJ24a36a 94a 21a 8.644689J86a79a 108s 76a 20sJ69a 1a J26a 24aJ36s 104a 97a 8.644689J86a79a 13a76a 20a 69a la ! 70a 36s 94a 104a 97a8.644689J86a79a 13a76a 20a 69a la ! 70a 36s 94a 104a 97a , 8.644689J86a79a 108a76a) 20a69ajla 26a 36a 94a 104a21a 8.64468986a79a 13a 108a76a20a 70a26a 24a 36a 104a 97a 8.644689) 86313a 108a76a J69a 1a 24a 36a 94a) l04a 21a 97a 8.64468979a13a 76a 20a 69a 1a 26a 36a 94a 104a 21a97a8.64468979a13a 76a 20a 69a 1a 26a 36a 94a 104a 21a97a 8.64468979a13a 108a76a 69a1a 70a 24a 36a 94a 104a21a 8.64468913a108a) 76a 20a 69a 70a 26a 24a 36a 94a 104a 97s 8.71794986a79a 108a76a 20a 69a 26a 36a 94a 104a 21a 97a 8.71794986s 108s 20a 69a 1a ! 70a 26a 24a 36a 94a 104a 97a 8.717949 86a 79a 13a 108s 76a 69a 1s 26a 36a 94a 104a 97a 8.71794986a79a 13a 108a69a1a 70a 26a 24a 36a 104a 97a 8.71794979a13a 108a20a 69a 70a 26a 36a 94s ! l04a 21a 97a 8.71794986al79a 176a20a 169a 11a 126a 24a 136a 94a 104a 97a8.71794986al79a 176a20a 169a 11a 126a 24a 136a 94a 104a 97a 8.71794986a779a 13a 1108al76a 69sjls, 26a24a94a (104a 97a |EQFid3 39 P6 8.717949 ! 86a13a 108a76aj69a70a2624a36a ! l04a ! 21a 97a 8.71794986a79a 13a 76a 20a 69a 1a 26a J94a) l04a (21a 97a 8.71794979a13a 108a ! 76a 20aha ! 70a 26a36a 104a 21a 97a8.71794979a13a 108a ! 76a 20aha ! 70a 26a36a 104a 21a 97a 24a36a 104a97a24a36a 104a97a 8.79120986a) 79a 13a 108aJ76a69a 1a) 70a 24a36a 104a21a 8.79120979a 108a 76a 20a 1a70a26aJ24a 36a94a 104a97a 8.79120986a79a 13a 108aJ76a1a 26a24a 36a104a 21a J97a Oa26a) 24a 36a 94a 104a1a) 97aOa26a) 24a 36a 94a 104a1a) 97a 36a94a104a) 97a36a94a104a) 97a 8.79120986a79a J13a) t08a76a ! 69a 1a 26a 24a36a) 21a 97a 8.7912086a13a ! l08a ! 76a69a 70a 24a 36a 94a8.7912086a13a ! l08a ! 76a69a 70a 24a 36a 94a 104a! 2la 197a 87912o9186al79a |13a |108ai76al69a ! 1a ! 26a 124al36a |104a|97a i 8. 791209J86a13a108a20a 69ajta70aj26a6a 104a 21a 97a 8.79120913a108a76a 69a 1a70a ! 26a4336a94a 104a21a8.79120913a108a76a 69a 1a70a ! 26a4336a94a 104a21a . 8. 791209j86aj13a 108a ! 76a 12oa ! 69a ! 1a 126a j24al36a 11o4al97a 8.79120979a13a08a76a ! 69a 1a i70a26a ! 24a94a J104a21a8.79120979a13a08a76a ! 69a 1a i70a26a ! 24a94a J104a21a 8.79l209186ai13a |108a 76a 12oa 11a ! 70a ! 26a i36a 104a ! 21a 197a 8'79120986ai79a13a ! 76a 20a69a 70a 36a 94a 104a 21a 97a 120a Ila 1702 126a 136a 19An 104a 121a 197a 8.79120986a79a13a 108a 76a 1a 70a 26a 24a36a94a 104a 8.864469 ! 86a|79a 113a 11o8al76a 11a 26a ! 24a 136als4a ! 104a|97a 8. 86446986a79a 13a J69a J1a t70a 26a 24a 36a94a ! 21a97a 8.86446986a79a 13a 76a J20a ! 69a 1a70a 26a 104a 21s J97a8.86446986a79a 13a 76a J20a ! 69a 1a70a 26a 104a 21s J97a 8.86446986a79a 13a 108aJ76a69a 70aJ36a 94a104a 21a J97a 8.86446979a76a6S3laOa) 26aj24a36a 94a 104a 21a) 97a8.86446979a76a6S3laOa) 26aj24a36a 94a 104a 21a) 97a 8.864469 86a79ajl3a08a69a 1a70a 26a 36a 94a 104a 21a Oa 1a70a 26a J24a 36a 104a 97aOa 1a70a 26a J24a 36a 104a 97a 24a36a104a ; 97a24a36a104a ; 97a 8.86446979a13a 108a76a 20a 69a1a 26a 24a36a 94a 104a8.86446979a13a 108a76a 20a 69a1a 26a 24a36a 94a 104a 8.86446986a79ajl3a 108a 76a1a ! 24a36a 94a 104a) 21a 97a8.86446986a79ajl3a 108a 76a1a ! 24a36a 94a 104a) 21a 97a 8.864469179a|l08al76a Izoa 169a 11a 26a36a 94a 104a 21a 97a 8.86446986a79a 13a 108a76aJ20a 70a |70a ! 36a 194al1o4a 121a 197a 8.93772979a108a76a1a) 70a 26a 24a36a 94a 104a 21a 97a 8.937729|86a|79a lO8al76a 69a 112 126a 124a 136a 94a 121 a 97a 8.937729 86a79a h3a 76a 20a 69a 70a 26a 36a 104a 21a 97a 8.93772986a79a 13a 76a 20a 69a 1a 26a 24a36a 94a 104a 8.93772986a79a 20a 69a la 70a 26a 24a36a 94a 104a 97a8.93772986a79a 20a 69a la 70a 26a 24a36a 94a 104a 97a 8.93772986a79a 13a 108a) 69a 1a 70a 26a 24a36a 21a 97a 97a97a 8. 93772986a108a76a 20a la 70a 26a 36a 94a 104a 21a 97a 8.93772986a79a 13a 108a 76a 69a 1a 26a 94a 104a 21a 97a 8.93772986a 1'3sTl08a 76a 20a1a 70a 26a 36a94a 104a97a 8.93772986a79a) 13a 108a 76a j20a 70a 26a 36a104a 21a 97a 8.93772986a79a 13a 1108alla (la 26a 136a 94a 104a 21a 97a 8.937729J79a3a*108a76a 69a1a 70aj26a 24a36a 21a 97a 8.93772986a13s 108a 76a 20a 1a70a 26a 24a36a 104a97a8.93772986a13s 108a 76a 20a 1a70a 26a 24a36a 104a97a 8.93772986a79a J13a 108a 20a69a 70a 26a 24a 36a, 104a 97a iea,.. ; 3. :i, 3 :. : ;', s r. : =, a ;Fs,.o_ :x ;z 9.0l0989|86a|79a 1l3a j108a 2Ca|69a 11a 170a ! 26a|36a 194a ! 104a 9.01098986a79a 13a 108a69ajla 70a24a36a104a2137a9.01098986a79a 13a 108a69ajla 70a24a36a104a2137a 9.01098913a108a76a 20a 69a1a 70a26a36a94a104a ! 97a 9.01098979a 13a) l08a76a 20a69a 1a J70a26a36a104a97a 9.01098979a13a 20a 69a laOa 26a24a36a94a104a97a 9.084249j86al79a 1 3a 1 08a 20a 69a 11 a 26a 24a 136a 94a 104a 9.084249 ! l3ajl08a76a 69a 1a26a24a36a94a104a21 a 97a9.084249 ! l3ajl08a76a 69a 1a26a24a36a94a104a21 a 97a 9.08424979a ! l3a 108a76a 20aJ69a ! la 26a36a94a104a21a 9.034249j86a 13a 76a 20a 69a 1a 70a 26a 36a 104a ! 21a ! 97a 9.084249|86a 79a ! 13a 108a la 70a 26a 36a ! 94a|lO4a j21a 197a 9.08424979a) l3aIQSaOa J69aa 26a24a36a94a104a) 97a 9.08424986a ! l3a) l08a76a t69a1a 70a 26a ! 24ah04a ! 21a 97a 9.08424986a79a t-) 08a76a 20a69a 1a 26a36a) 94a) 21a 97a 9.084249179all3a 11 08a 11 a 170a 126 124a 36a 94a 11 04a 121 a 197a 9.084249|79a|13a j1o8al69a lia ! 70a 126a ! 24a 136als4a ! 21a 197a 9.157509 |13a 176a 20a 69a 26a 124a j36als4a |104a|97a 9. l57509j86a|13a 1l08al69a ! 1a 170a ! 26a |24a ! 36a ! 1o4a |21a ! 97a 9.157509J86a79a) l3a 108a76a 69a 1a 24a36a104a ! 21a 97a 9.15750986a79a 13a 76a 20a69a 1a 70a26a36a104a21a 9.157509 86a79a 13a 76a 69a70a ! 24aJ36a94a) l04a21a 97a 9.157509 86a 108a76a 20a 69a 1a 26a 36a94a 104a21a 97a 9.15750986a79a13a 108a20a69a) 70a26a36a94a104a21a9.15750986a79a13a 108a20a69a) 70a26a36a94a104a21a 9.157509) 86a) 79a 108a76a 20a) la) 70a26a) 36a94a) l04a97a 9.15750986at79a 13a) l08a76a) la 70a28a24a36a104a97a 9.15750979aj-t3a 108a76a 20a 1a) 70a 26a24a 36a94a 104a 9.15750986a79a 113a 76a! 69a la 26a 24a 36a 94a 21a 97a 9.23076986a79a ! t3a 76a 69a ! la 70a26a24a 36a'f04a97a 9.23076986a79a 13a 108a76ajla 26a24a36a 94a104a21a 9.23076986a79a 13a 108a76aj69s 1a 26a24a 104a) 21a 97a 9.23076986a79a'108a20a 69a ha J26a24a36a94a104a97a 9.23076986a13a 108a76a 20a 69a1a 26a36a 104a21a 97a9.23076986a13a 108a76a 20a 69a1a 26a36a 104a21a 97a 9.23076986a79a 13a 108a ! 20a69aJ70a26a24a 36a94a J104a 9.23076986a13a 76a 20a69a 1a70s 26a36a 94a04a97a9.23076986a13a 76a 20a69a 1a70s 26a36a 94a04a97a 9.23076986a79a 13a 20a 69a 1a70a) 26a36a 94a21a 97a 9.23076913a108s) 20a 69a 1a 70a 26a 36aJ94a. 104a21a 97a 9.23076986a79a 13a 108a76a 20a 70a26a36a94a104a97a 9.23076986a79a 13a 108a76a 69a 70a24a94a104a21a 97a 9.23076986a79a 13a 76a 20a69a |104axa 9.23076986a79a 108a76a 20a 1a70a 26a36a 94s104a21a 9.23076986a13a 108a76a 20a69a la 26a36a94a104a97a 904029 86a 13a 108a 76a 20a ! 70a 26a 24a36a 94a104a 97a 9.30402986a79a''13a 108a76a 20a) 69a) 70a24a 36a104a97a 9.30402986a79a 13a 69a 1a 70a 26a 24a94a 104a21a 97a 9.304029186al13a j108al76a |20a |69a 170a |26a |36a|94a ! 104al97a 9.30402913a 108a 76a 69a 70a 26a 24a 36a94a104a21a 97a 9.304029, 86a 79a13a 108a 76a 20a 69a 26a 24a 36a 104a (97a9.304029, 86a 79a13a 108a 76a 20a 69a 26a 24a 36a 104a (97a 9.30402986 79a 13a 108a 76a 20a 69a 1a70a 36a104a 97a sFi : ëidn 3-&° i 9.304029186al79a |13a ! 108a ! 76a 120a |69a |36a |94a|104a |21a 197a 9.304029i86ab3a) l08a76a 69a 1a ! 26a) 24a ! 36a104a 21a"97a Oa 26a 36a 104a21aOa 26a 36a 104a21a 9.30402986a79a13a 108a) 76a1a ! 70a ! 26a ! 36a104a2iy97a 9. 304029 ! 86a79a108a76aa 70a 26a24a 94a 104a 21a 97a 9.304029186al79a |108a|76a 20a ! 1a 70al26a 124a 36a |104al97a | 9.37729179a ! 108al69a ! 1a 170a ! 26a ! 24a j36a |94a j104a |21a j97a | 9.37729|86a|13a ! 76a 120a 169a ! 1a 126a 124a 136a 194a |104a 197a 9.3772913a 76a69a 1a70a 26a ! 24a 36a 94a 104a 21a 97a 97a97a 76a 20a ! 69a1 a (70a26a36a104a (97a76a 20a ! 69a1 a (70a26a36a104a (97a 9.37729186al79a 13a ! 76a ! 20al1a 70al26a 36a ! 94a ! 104al97a 9.37729179a ! 13a j76a ! 20a 169a ! 1a ! 70a j26a ! 36al94a ! 104a ! 21a 9.37729J86a79a13a08a69a) la 70a24a 36a94a 104a21a9.37729J86a79a13a08a69a) la 70a24a 36a94a 104a21a 04a ! 97a04a ! 97a 9.37729|86aj79a |13a ! 76a j20a |1a 170a ! 26a ! 36a|104a |21a ! 97a 70a ! 26a4a36a 94a) l04a ! 21a 97a70a ! 26a4a36a 94a) l04a ! 21a 97a 9.3772986a79a13a ! l08a76aa70a ! 26a 36a94a ! l04a97a9.3772986a79a13a ! l08a76aa70a ! 26a 36a94a ! l04a97a 9.45054979a13a08a20a 1a ! 70a 26a24a 36a ! 94a 104a97a 9.45054986a79a108a20a 69a la 70a 26a 24a36a 104a 97a 9.450549) 1108a|20a 169a 11a 170a 126a ! 24a|36a ! 104al97a 9.45054986a13a ! 76a 20a! 1a 70a 126al36a 194al104a ! 21a ! 97a 9.450549 86a79a)! 69a ! 70a ! 26a 124a 136a 194al104a 121a 197a 9.45054986a) 79a) l3a 76a 69a) la"24a36a 94a 104a 21a 97a 9.450549|86a|13a ! 108a|76a |1a 170a 126a ! 24a ! 94aTa |21a |97a 9.52380986a79ah08aJ20a 69a ! 70a 26a36a 94a04a"21a 97a 9.52380986a79a13a 108a69a70a 26a24a94a104a 21a 97a9.52380986a79a13a 108a69a70a 26a24a94a104a 21a 97a 9. 52380986a79a108a76a 69a) la 26a24a 36a 104a 21a 97a 9.52380986a79a13a 76a ! 20a69a la 70a 36a 104a 21a 97a 9.5970779a13ah08a76a 20a1a ! 26a24a36a94a J104a97a 9.59707|86a 13a ! 76a ! 20a 69a 1a 126a ! 36a ! 94a|104a 121a 197a 9.67033 86aj79a108a76a 69a1a 70a 26a (36a 94a 104a 97a 9.67033 86a79a13a 108a76a 20a 1a 26a 24a36a 94a 104a 9.6703386a79a13a 108a20a1a 70a 26a 36a 94a 104a21a 9.67033 86a|79a 13a ! 108a 69a |1a |26a 136a ! 94a 104a 21a 97a 9.6703379a13a108a20a 69a1a 70a 26a 36a 94a 104a21a 9.57033186a 13a 108a 76a 20a 70a 26a 36a94a 104a21 a97a 9.6703386a79a76a 20a69a 1a 70a 26a 36a 94a 21a ! 97a9.6703386a79a76a 20a69a 1a 70a 26a 36a 94a 21a ! 97a 9.67033 86a 13a76a 20a1a 70a 26a24a 36a 94a 104a97a9.67033 86a 13a76a 20a1a 70a 26a24a 36a 94a 104a97a 9.6703386a79a13a 108aJ76a69a 1a 26a 24a36a 94a 21a 9.6703386a79a13a 108a ! 70a 26a 24a36a 94a 104a21a 97a9.6703386a79a13a 108a ! 70a 26a 24a36a 94a 104a21a 97a 9.6703386a79a13a 108a20a 69a 70a 26a 36a 104a 21a 97a 9.6703386a79a13a 108a20a 69a 1a 26a 24a36a 104a 97a 9.74358986a79a13a 108a69a 1a 26a24a 94a 104a21a 97a9.74358986a79a13a 108a69a 1a 26a24a 94a 104a21a 97a 9.74358986a79a13a 108a76a 69a26a24a 36a 104a 21a 97a9.74358986a79a13a 108a76a 69a26a24a 36a 104a 21a 97a 1a70a 26a6a94a104a1a70a 26a6a94a104a , Field1,.2"_.... :..,... 4. <v 7 : :, r$ .... _... _. 9.743589j86a ! 79a 13a ! l08a20a 69a J1a J26a ! 36a 94a 104a 97a 9.743589j86a|79a 113a 176a 16-9al7oaX26al24a 194a|104a ! 21a 197a 9.8168586a79a 108a76a la 70a26a24a6a94a"104a ! 97a 9.8168586a13a 108a20a 69a1aOa26aJ36a94a104a 97a9.8168586a13a 108a20a 69a1aOa26aJ36a94a104a 97a 9.81685 ! 86a79a IQSaOa 69a1aOa26a ! 36a94ah04a97a9.81685 ! 86a79a IQSaOa 69a1aOa26a ! 36a94ah04a97a 9. 81685 ! 86a79a 133 76a 69a1a 70a26a 24a 36a21 a 97a 9.81685 ! 86a79a 13a 108a76aOa 26a36a 94a104a 21 a 97a9.81685 ! 86a79a 13a 108a76aOa 26a36a 94a104a 21 a 97a 9.8168586ajl3a) 76a69a) 70a'26a J24a 36a 94a'104a21a97a9.8168586ajl3a) 76a69a) 70a'26a J24a 36a 94a'104a21a97a 9.81685|86al79a 113a j108a jla 170a 126a ! 24a 136al94a ! 104a ! 21a 1 9.81685 ! 86a79a13a 108a76a) 20a 69a) 70a ! 36a94ah04a ! 97a9.81685 ! 86a79a13a 108a76a) 20a 69a) 70a ! 36a94ah04a ! 97a 9.81685J86a79a ! l3a 108a76a20a 1a26a 24a 36a J104aj97a9.81685J86a79a ! l3a 108a76a20a 1a26a 24a 36a J104aj97a 9.81685 ! 86a79a) l3a 108a20a 69a 70a ! 26a 36a 94a104a 97a9.81685 ! 86a79a) l3a 108a20a 69a 70a ! 26a 36a 94a104a 97a 9.81685j79a|13a 1108a j76a j1a 126a ! 24a 136a 194alro4a 12la 97a 9.89011186al79a 176a 169a 11a ! 70a 1262136a j94a j104a ! 21a ! 97a 9.8901lj86a79a J13a) l08a ! 76a ! 20s 69a J26a J36a104a 21a J97a 9.8901186a ! l3a 108aba ! 70a 26a 24a 36a ! 941Maj2a97a 9.89011 ! 86aj79a ! 13a ! 2oa 169a j1a 170a 126a 136ais4a ! 1o4als7a 9.89011186a 13a 1108a 69a 126a 124a 136 94a 1104 a 167-a- 9.8901lj86a ! 79a 13a 108a ! 76a) 69a 1a 26a 24a36a 104a 21a 9.890HJ79a13a 76a 20a 69a) la J70a26a 36a104a21aj97a 9.890H) 86a 108a20a 69a la ! 70a26a36a 94a 104a 21a97a' 9.96337j86a79a 76a) 69a 1a) 70a26a 24a i3614a21a97a 9.9633779a13a 108a0a ! 69aa 70a ! 26a 36a 94a104a97a" 9.9633786a79a 108a76a J69a1a 26a ! 24a 36a 94a 104a 21a 10.0366313a108aj20a 69a 1a ! 70a6a J24a J36a 94a'104a ! 97a 10. 0366386a79a 13a 108a 69a ! 26a 24a ! 36a94a 104a 21aj97a 10.0366386a79a 108a 69a J1a) 70a 26a 24a J36a94a 104aJ21a 10.03663|86a|79a 113a |108a|1a |70a 26a 124a 36a|104a |21a 97a 10. 03663 ! 86a) 79a 108a 69a ! la 70a ! 26a 24a ! 36a) l04a21a 97sT 10.03663 (86a ! l3a 108a76a 1a 26a24a (36aJ94a14a21a97a 10.03663 79ail3a ! 108a 69a 70a i26a24a ! 36a4a 104a 21aJ97a 10.0366386a79a 13a 108aj76a1a 26a J24a j94a 104a 21a) 97a 10.10989 ! 86a79a 13a 108a ! 20a69a 26a36a 94a104a'21a7a" 10.10989J86a79a 13a 108a 76a 20ata 26a 36a 94s 104a 97a 10.1098986a79a 13a 20a 1a 70a 26a 36a 94a104a'21a 97a" 10.1098979a13a 108a 76a 169a 1a 70a 26a 24a 36a 94a 21a 10.1098979a13a 108a76a 69a1a26a 24a 36a 94a 21a 97a 10.10989J86a13a 20a 69a 1a 70a 26a 36a 94a 104a 2 ? a97a 10.10989 79a') 08a 20a 69a 1a 70a 26a 36a 94a 104a 21a 97a 10.1831586a79a 13a 76a 69a 1a26a 24a 94a 104a 21a 97a 10.18315l86a79a 13a 76a 69a 1a 70a 26a 24a 36a 104aJ21a 10.1831586a79a 13a 108a 76a 20a 69a 26a 36a 94a'104a 97a 10.18315 86a 79a 108a 20a 69a 1 a70a 26a36a 94a 104a 21 a 10.1831586a79a 13a 76a 20a 69a 26a 36a 94a 104a 21a'97a 10.2564186a79a 108a76a 20a1a 70a 26a 36a 104a 21a 97a 10.2564186a 79a 13a 76a 1a 26a J24a 36a ! 94a 104a 21a"97a 10.2564186a79a 108a76a 1a 70a 26a 36a94a 104a 21a 97a Fetdi ;- 10.2564186a79a13a 108a20a1a 70a ! 26a 24a36a 94a !-) 04a 10.25641 86a 13a1083 76a 20a1a 26a24a 36a94a b04a97a 10.2564l) 86a79a 13a 108a69a70a 26a24a 36a104a 21a 97a 10.2564l) 79a108a76a 20a 69a 1a 70a 26a 36a 104a 21a 97a' 10.25641186al79a |13a ! 1a 170a ! 26a 24a|36a 94a|104a ! 21a 197a 10. 256486a13a 108a ! 20a 69a70a ! 26a24a 36a 94a 104a 97a 10.32967|86a|79a 169a 1a 70a 26a 124a 36a 94a 104a 21a ! 97a 97a97a 1a 70a) 26a 24a ! 94a 104a21 a97a1a 70a) 26a 24a ! 94a 104a21 a97a 10.32967 ! 86a ! 79a ! l3a 76a ! 69a 70a 26a 24a ! 36all04a ! 21a 197a 10.32967) 86a ! 79a ! l3a 108a ! 20a 70a 26a24a 36a94a 104a 97a 10.32967 ! 86a9a !-) 3a h08a ! 69a 70a 24a36a ! 94a104a 21a 97a 10.3296786a79aSa 76a 69a 1a70a 26a ! 24a 104a 21a 97a 10.32967186al13a ! 2oa 169a Ila 170a ! 26a ! 24a ! 36a 194a 1104a 197a 10.40293179al13a t08a76a 69aj1a 26a24a 36a104a 21a 97a 10.40293 79a 13a) l08a 76a 1a 70a 26a 24a ! 36a 94a! 104a ! 2la 36a 104a ! 21a97a36a 104a ! 21a97a 104a ! 21a104a ! 21a 10.4029386a ! l3a 108a20a69aha26a ! 24a 36a94a 104a ! 97a 10. 40293 86a 13a 108a20a 1a ! 70a 26a24a 36a94a) l04a97a 10.4761979a13a J108a76a 20a 69a 1a ! 26a) 36a) 104a 21a 97a 10.476l9186a|13a |76a 169a lia 126a 124al36a Ss4aElo4a |21a |97a 10.47619j86a|79a |13a ! 108al1a 126a 124a 136a |94a j104a 121a 197a 10.47619|86a|79a 13a 76a J20a 69a1a 26a ! 24aJ36a04a 97a 10. 4761986a 79a 13a (76a 1 a70a26a 124a36a104a2. 1 a97a 10. 4761979a108a76a69a la 26a 24a 36a 94a 104a 21a97a 10.54945186al79a 113a 108a76a69a 1a 24a 94a 104a 21a97a 10.54945 ! 86a13a 108aJ20a 69a 70a 26a) 36a 94a 104a 21a 97a 10.5494586a79a 13ajl08a76a ! 69a) 26a) 24a 94a 104a 21a 97a 10. 5494586a79a 13a 108a76a ! 69a 24a36a 94a 104a 21a 97a 10.5494513a 108a 69a 1a70a26a 24a 36a 94a 104a 21a 97a 10.62271 86a 79a 108a76a J20a1a 26a24a 36a94a 104a 97a 10.6227186a 13a 76a 69a 1a 70a 26a24a ! 36a104a 21a 97a 10. 6227186a 79a 13a 76a 20a1a 26a24a 36a ! 94a 104a 97a '10. 6227179a13a 108a76a 69a1a70a26a 24a36a ! l04a21a 10.62271 86a 79a 13a 76a 20a1a J26a36a 94a 104a 21a 97a 10.6227186a79a 13a 108a69a1a70a26a 36a104a 21a 97a10.6227186a79a 13a 108a69a1a70a26a 36a104a 21a 97a 10.6227179a 13a 108a20a 69a la 26a 36a 94a 104a 21a 97a 10.6227179a 13a 20a 69a 1a 70a 26a 36a 94a 104a 21a 97a 10.6227186a79a 13a 76a 20a69ajla 70a 26a 94a 104a 97a 10.6959786a79a 76a 20a 69a 1a 70a 26a 36a104a 21a 97a 10.6959786a79a 13a 76a 69a 26a 24a36a 94a 104a 21a 97a 10.6959786a79a 13a 108a 76a20a 1a 26a 36a104a 21a 97a 10.6959786a13a 108a76a 69a 1a 26a24a94a104a 21a 97a 10.6959786a79a 108a76a 20a 69a 1a 70a 26a 36a 104a 97a 10.7692386a13a 108a76a 69a 26a 24a36a 94a 104a 21a 97a 10. 7692386a79ajl3a 108a20a1a 26a 24a36a 94a 104a 97a' WFieid1 ; axtg 2$ 10.76923186a ! 79a 176a 169a ! 1a! 26a 124a ! 36a 194a ! 1o4a ! 21a ! 97a 10.76923 86a79a 13a 108a76a69a 1a 70a 26a36a 104a) 97a 10.84249 86a79a 108a76a 20a1a 70a26a 24a36a 94a ! l04a 10.842a986a79a 13a Ha|1a ! 26a|24a 136al94a |104a|97a 10.9157586a79a 108a76a 69a 1a 26a 36a ! 94a104a 2a97a10.9157586a79a 108a76a 69a 1a 26a 36a ! 94a104a 2a97a 10.91575 ! 86a 79a ! 13a 120a 11a ! 70a 126a ! 24a 136als4a 104a 97a 10.9890186a79a 13a 76a 20a 69a 1a) 26a 36a94a 104a21a 04a21a04a21a 10.9890186a ! l3a 108a20a la 70a6aJ36a 94a 104a21a97a 11. 0622786a ! 79a 13a 76a 20a 69a1a 26a 36a94a 104a ! 97a 11.0622786a) 79a ! l3a ! l08ab0a ! la) 70a26aJ24a36a 104a97a 11.0622786ah3a 108a69a70aJ26a 24a 36a J94a104a 21a 97a11.0622786ah3a 108a69a70aJ26a 24a 36a J94a104a 21a 97a 11.0622786a ! 79a3a 76a 69a1a 26a 36a94a 104a 21a97a 11.0622786a ! 79a 108a69a 1a6a 24a 36a 94a104a ! 21a 97a 11. 0622786aJ79a 108a) 76a 1a 26a ! 24a36a 94a ! l04a ! 21a ! 97a 108a69a 70a 26a24a 36a94a104a21a108a69a 70a 26a24a 36a94a104a21a 11.1355386a79a"108a76a 20a ! la 26a36a 94a104a 21a97a" 11.13553186a 132 108a76a20a69a26a36a 94a 104a21a 9'la 11.1355386a13a ! l08a76a 69a706a24a'94a104a 21a ! 97a 11.. 1355379a 108a76a. 69a 1a 70a ! 26a24a 36a94a 104a1a I1-t. 20879186a ! 79a 1osa ! 1a 170a |26a 24a 36a |94a|104a |21a 197a l20879 86a 79a 13a 76a 20a 69a 1a 70a 26a36a11.104a) 97a 11.20879186a 79a 13a 108a20a 70a 26a 36a 94a 104a21a 97a 11. 20879 79a ! l3a 76a 69a 1a 70a 26a 24a 36a 104a 21a 97a 11.2087986a) 79a". 108a76a 69a1a 26a24a 94a104a 21a 97a. 11. 2820586a79a 13a 108a) 20a69a1a 70a 26a36a 104a21a 11.2820586a13a 108a69a 1a70a. 26a24a 94a104a 21a 97a11.2820586a13a 108a69a 1a70a. 26a24a 94a104a 21a 97a 11.28205j86a79a 20a 69a 1a70a 26a36a 94a104a 21a 97s11.28205j86a79a 20a 69a 1a70a 26a36a 94a104a 21a 97s 11.35531|86al79a 13a 108a20a J1a 70a ! 26a 36a 104a 21a 97a 11.3553186a ! 79a 13a 108a69a 1a ! 26a24a 36a 104a 21a 97a 11. 3553186a 13a 108a76a 20a1a26a ! 36a 94a104a 21a 97a 11. 3553186a79a 108a69a J1a 70a 26a36a 94a 104s 21a 97a 11.42857 86a 79a 76a 20a 69a 1a 26a 36a 94a 104a 21a 97a 11.42857 86a 79a 13a 108a 20a1a 70a 26a36a 94a 104a97a11.42857 86a 79a 13a 108a 20a1a 70a 26a36a 94a 104a97a 11.50183 86a 13a 69a 1aOa26a24a36a 94a104a 21a 97a11.50183 86a 13a 69a 1aOa26a24a36a 94a104a 21a 97a 11.50183 86a 79a 108a (20a 1 a 70a 26a24a 36a 94a104a97a 11.50183 86a 79a 108a76a 20a 69a 1a 26a 36a104a ! 21a97a 11.5018386a79a 13a 108a76a69a 1a J26a 36a 104a21a 97a 11.57509 86a 13a 108a20a 69a1a 26a) 36a 94a104a 21a 97a 11.6483586a13a 108a69a 1a 26a 24a 36a 94a104a 21a 97a 11.7216186a79a 13a 108a20a 69a 1a 70a 26a36a 104a97a 11. 7216186a ! 79a J13a ! 20a 69a 1a 70a26a36a104a 21a 97a 11.7216179a 13a 108a69a 1a 70a 26a 24a 36a 104a ! 21a 97a 11.7216186a79a 108a76a 69a1a 70a26a 36a 104a 21a 97a 11.7948786a79a 13a! 108a ! 76a 120a 36 104 197a 11.8681'379ajl3a 108a ! 20a 69a1a 70a26a 36a 104a21a 97a11.8681'379ajl3a 108a ! 20a 69a1a 70a26a 36a 104a21a 97a 21a 97a21a 97a X i, ë'ld :} t 74 12.01465j86ai79a13a108a20a1a26a36a., 94a104a 21a97a, 12.01465J86a79a 13a 108a) 76a) 20a69a0a 2636a104a97a 12.01465 ! 86a79a 13a J108a76aj69a 70a 24a 36a 104a 21a 97a 12.08791|86a|79a! l3a 108a76a) 20a 69aj ! a2636ajl04a97a 12. 0879l) 86a79a 13a 108a20aj69a la 26a 36a 104a) 21a97a 12.1611786a79a 13a 20aJ69a) la 70a ! 26aJ36a94a 104a 21a 12.3076986a79a) l08a20a) 69a1a 70a 26a J36a 104a 21a97a 12.4542186a79a3a 76a 69a 1a 26a 24a ! 36a94a 104a 21a 12.60073 ! 86a79a ! l3a 108s69a1a) 26a24aJ36a94a 104a21a 12.60073 ! 79a13a ! 76a 69a jla J26a 24a 36a 94a) l04a 21a fa 12.74725j86a79a ! l3a108a69a1a) 70a26a 24a 36a 104a 21a12.74725j86a79a ! l3a108a69a1a) 70a26a 24a 36a 104a 21a 12.74725 ! 79a 13a ! 76a 69a ! la 70a 26a24a 36a 94a 1Q4a 21a 12.8937779a13a 108a69a 1a 26a 24a 36a ! 94a104a21a 97a 12.8937786a79a 1108alla 69ajta26a36a 94a 104a21a 97a 13.1135586a79a ! l3a J20aj69ajla J26a36a 94a 104a J21a 97a 13. 1868186a) 79a tl08a20a ttaOaJ26a ! 36a 94a 104a 21a 97a 13.26007 ! 86a ! 79a 13a 69a 1a 70a ! 26a ! 24a 36a 104a 21a 97a 13.26007t86a79a 13a 108a76a20a0a6a 24a 94a 21a) 97a 13.33333J86a79a 13a (69a J1a 70a 26aJ24a 36a 94a 104a 21a 13. 6263786ah08a) 76a) 20a 69a) ta 70a ! 26a"24a94a ! 21a 97a 13.6996386a) 79a ! l3a 108aj76a0a 1aOa 26a 24a 21a 97a 13.77289|79al13a 108a69a 11a 70a 26a24a 36a 94a 104a 21a 13. 7728986aj79a 13a 108s 76a j20a J1a 70a 26a 24a J104a21a 13¢7728sla6ai7sa j13a j108a 76a |20a 170a |26a ! 24a|36a 121a ! 97a 13.77289 ! 86a79a ! l3a ! 76a 20a69a 1s 26a 36a 104a 21a 97a 3*84615l86al7sa |13a ! 1osal76a 120a 70a 124a |36a 94a 21a 97a I 13.8461586al0s : 376a 20a 69a J1a70a24s ! 36a94a 21a 97a 13.8461586a13a 108a76a 20a1s) 70a26a 24a 94a 21s97a 1 9926779a108a76a J20a 69a 70a26a 24a 36a 94a 21a 97a 13. 99267J86a79a"13a) 76a 20a ha J70a 26a 24aJ94a) 21a 97a 13.99267 86a108a76a 20a 69a1a J70a26a 24a 36a 21a 97a 14.06593 86a79a 13a 69a 1a 26a) 24a 36a 94a 104a 21a 97a 14.1391986a ! 79a 13a 108a20a1a 70aJ26a 24a 94a 21a 97a 14.212456a) l08a76a 20a 69a1a 70a24a 36a 94a'104a21'a 14.21245 ! 86a79a 13a 76a 20a1a 70a 24a 36a 94a 21a 97a 14.2857186a) 79a'13a 76a 69a1a 26a 24a 36a 104a 21a 97a 14.2857186a 13a 108a76a 20a69a la 26a 24a 36a 21a 97a 14.2857179a 108a76a 20a 69a 70a J24a 36a 94a 104a 21a 97a 14.3589779a13a"108a76a 20a 70a 26a 24a36a94a J21a 97a14.3589779a13a"108a76a 20a 70a 26a 24a36a94a J21a 97a 14.358779a 1a"108a 76a 20a 1a 70a 26a 24a 104a 21a 97a 14.4322386a79a''108a20a 69a1a70a24a 36a 94a 21a 97a14.4322386a79a''108a20a 69a1a70a24a 36a 94a 21a 97a 14.4322386a 108a76a j20a 69a 1a 70a 26a 24a 36a 104a 21a 14.4322386a79a"108a76a 2Qa69a la J70a 26a 24a 104a 21a 26a 24a 94a 21 a26a 24a 94a 21 a 97a 14.5054986a79a''13a 108a20a1a 70a 24a 36a 94a 21a 97a 14.5787586a3a'108a76a 20a1a 70a 26a 24a 36a 21a 97a 24a 36a 94a104a 21a97a24a 36a 94a104a 21a97a , jçlQ'i ièidwlS, tlitsw2 E'"0, ! ì: 7'l 14. ? 2% ? 8 SStSsssMSS MM 14.6520186a ! l08a76a ! 20a 69aha-70a24a 36a104a 21a"97a 14.72528186al79a 113a llOBal76a 20a) la 26a ! 24a36a1a 97a 14.7252886a79a ! l08a76a 20a 69a 70a24a ! 36a94a) 21a 97a 14.7252886a79a' ! l3a) l08a76a20a 1a 70a24a36a1a 97a14.7252886a79a' ! l3a) l08a76a20a 1a 70a24a36a1a 97a 14.7985386a76a 120a 169a 1a 70a 24a36a 94a 104a21a 97a 14.7985386atl3a h08a ! 76a 20a ! 69a1a ! 70a24a) 36a 94a1a l79853) 86aj79a 13a J108a76a 20a J69ai70a ! 26a ! 24a 94a14.1a 14.79853 86a ! 79a 13a 108a76a20a69a ! la70a ! 26a 24a) 21a 14.7985386a) l3a 108a76a ! 20a69a1a i24a 36a94a1a 97a 14.87179J108 ! 76aJ20a 69aj1a J70a) 26a ! 24a36a94a) 21a 97a 4.8717986s 79a) l08a6a ! 20a ! 69a70a6a J24a) 94a 104a 21a 14.87179186al79 113a 11082176a 120a 169a 170a 126a 124a 136a 1212 14.87179) 86a79a ! l3a h08a ! 76a 20a 70a ! 26a 24ah04a ! 21a ! 97a 14.87179186al79a! 76a ! 20a69a 1a 70aJ24a 36a94a ! l04aJ21a I4. 94506 ! 86a) l3a 108aj76a 20a69ajl3 J70s 26a 24a 94a21a 14. 94506186a ! 13a flo8a 6a ! 20a 11a 170a 126a ! 24al36a |104a ! 21a 14.94506 ! l3a108a !'76a ! 20a 1a ! 70a 26a 24a 36aJ94a 21a 97a I. l l.94506 ! 86a ! l3a J108a76a 20a 69a 1a 70a 26a 24a ! 36a 21a14. 15.0183286a) l3a 108a ! 76a 20a 69a 1a 26a 24a94a 21a 97a 15.01832186a|13a |l08a ! 76a 120a 169a 170a 124a 136als4â |2la ! 97a 15.09157186al79a 113a ! 1o8a, 76a 12oa ! 1a ! 26a 124ais4a j21a 197a 1 21a 97a21a 97a 15.1648386a79a 13a ! l08aj76a 2Qa 70a 26a24a94a 104a 21a15.1648386a79a 13a ! l08aj76a 2Qa 70a 26a24a94a 104a 21a 15.16483T86a 792 i76a 120a, 69a 702 126a 12421115.16483T86a 792 i76a 120a, 69a 702 126a 124211 15.1648386a108a ! 76a 20a ! 69a1a70a26a ! 24a4a 104a 21a15.1648386a108a ! 76a 20a ! 69a1a70a26a ! 24a4a 104a 21a 15.16483J86a 79a 13a 108a6a 20a) 69a 70a 24a36a 94a 21a 15. 16483) 86a79a 108at76a ! 20a69a ! 70a26a ! 24a36a 21a 97a 15.16483186a 13a 108a76a 20ajla 70a ! 24a36a94a h04a21a 15.1648386a79a f76a 20a J1a 70a) 24aJ36a J943l04a 21a 97a 15.1648386a79a 13a ! l08a ! 76a20a1a 24a 36a94a 21a 97a 15.238186s 13a 108a ! 76a 20a 69a 1a70a 24a 94a 21a15.238186s 13a 108a ! 76a 20a 69a 1a70a 24a 94a 21a 97a 15.2381 79a 13a 108a76a 20a 1a J70a 26a 24a 94a 21a 15.238186s 79a13a 108a76a 20a 69a 70a 26a) 24a'104a 21a 15.238- ! 86a79a 13a') 08aJ76a20a69a703J24a94a 104a 21a '15. 2381 86a 79a 108a76a 20a 69a 70a 26a 24a 94a 21a 97a. 15.238186a9a 108a 76a 20a 69a) 70a 24a 36a 94a 104a 21a 15.238186aj79a'108a76a 20a1a 70a 26a24a 94a 21a 97a 15.31136 86a 108a 76a 20a 69axa 70a! 24a! 94a 104a 21a 97a 15.3113679a13a 108a 76a 20a J69a 70a 26a 24a 36a 94a 21a 15.3113679a 13a 108a 76a 20a70a 24a 36a 94a 104a 21a 97a 15.3113686a79a"13a 76a 20a 1a 70a 26a 24a36a 21a 97a 15.38461186a 79a 1108a 762 120a 69a Ila 70a 126a 24a 194a 121 a 15.3846186a13a 108a76a 20a 69a 70a 26a 24a 94a 21a 97a 15.3846 79a 108a 20a 69a 1a 70a 24a36a 94a 104s 21a 97a 20a 1a 70a 26a 24a 94a 104a 21a20a 1a 70a 26a 24a 94a 104a 21a <l-Y 0 a7 $Ri-g ° M 15. 38461 ! 86al79a 113a 176a 12Ca ! 69a ! 1a ! 70a 126a ! 24a ! 94a ! 21a15. 3846l ! 86a79a3a ! 76a 20a69aba70a ! 26a ! 24a94a ! 21a 15.3846186a) 79a 13a08a76a ! 20a 1a J70a 26a24a36a ! 21a15.3846186a) 79a 13a08a76a ! 20a 1a J70a 26a24a36a ! 21a 97a97a 15.38461|86a 11 3a 176a 120a 69a I a 70a 24a 194a 121 a Oa 24a36a94a104321a 97aOa 24a36a94a104321a 97a 15.45788 ! 86al79a ! 13a 176a 12ca ! 1a ! 70a 124a 136a ! 94a ! 104â 121a 15.45788186al79a i108a ! 76a 12oa ! 69a ! 70a 126a 124a ! 36a 1104a ! 21a 15.45788 ! 86a13a08a76a 20a69a 1aOa 24a 94a14a'21a 15. 4578879s 13a08a76a 20a69s 26a ! 24s 36a 94a1a 97a 15.4578886allO8al76a 120a 169 la 170a 126a 24a 1104@ 121a 197a 69ajla 70a 24a36a ! 94a21a 97a69ajla 70a 24a36a ! 94a21a 97a 7a*'7a*' 15. 4578886a13a108a76a 20a69a 70a 26a 24a 36a21a7a" 15.53114 ! 86a13a 108a 76a 20a 69ala 70a 26a24a) l04a ! 21a 15.5311486a108a76a20a 69a70a 24a 36a 94a ! l04a21a97a 15.5311479a13a 108a 76a 20a1a 70a6a24a ! 94a21a97a 15.5311479a108a ! 76a 20a 69a70a26a24a6a94a ! l04a ! 21a" 15.5311486a79a! 13a 08a76a20a) laOa24a94aJ21a ! 97a 15.5311486a79a t108a76a t20a69a1a 70a 24a 36a94a) 21a 15.5311479a108a76a 20a9a1a 70a 24a 36a104a ! 21a 97a 15.53114 ! 79a13a 108a 76a) 20a69a la 26a 24a104a21a 97a 15.53114 ! 79a13a 108a 76a 20a69a 1a 70a 26a24a104a21a 15.5311479a13a 108a ! 76a 20a69a 70a24a 94a104a21a 97a Oa69a 1a 70a26a24a21a 97aOa69a 1a 70a26a24a21a 97a 15.6044 ! 86a13a) l08a ! 20a 69aa ! 70a26a ! 24a36a21a7a"' 15.6044) 86a ! 79aSa 108a 76a t20a69a 1a70a 24a36a 21a 15.604413a108a ! 76a 20a 69a) la 26a24a 36a 94a21a 97a 24a36a94a21a24a36a94a21a 15.604479a13a 76a 20a 1a ! 70aj24a36a) 94a104a21a 97a 15.604486a79a 13a 108a 20a ! 69a1a 24a 36a 94a21a 97a 15.604413a 108a 76a 20a 69a1a 70a24a 94a104a21a 97a 15.6044 86a 79a 11 08a 76a 20a 69a 1 a 70a ! 24a ! 36a 121 a 97a 15. 67766 86a 79a 13a) l08a76a 20a69a 1a ! 26a ! 24a104a21a 15.67766 86a 13a 76a 20a 69a1a 70a 26a! 24aSs4a 21a 97a 15.6776686a79a 13a 76a 20a69a 1a 70a 26a24ah04a21a 15.67766 ! 86a79a 76a 20a 69a1a 70a 26a 24a 94a21a 97a 15.6776686a79a 13a 108s 20a 69a 1a 70a 26a24a21a 97a | I I.,. I15. 6776686a79a 108a 76a 20a69a 70a 26a 24a 36a94a 21a 15.6776686a79a 13a 108a 20a1a) 70a26a 24a 36a21a 97a 15.75092 86a 13a 108a 20a 69a1a 70a24a 36a 94a21a 97a 15.7509286s 79a (13a 108a20a69a 1a 70a 24a 94a21a 97a 15.7509213a 108a 76a 20a 1a70a 24a 36a 94a104a21a 97a 15.7509279a13a 108a 20a 1a 70a 24a 36a 94a104a21a 97a 15.7509279a13a 108a 76a 20a 70a 26a24a 94a104a21a 97a 15.7509286a79a 76a 20a 69a70a 24a 36a 94a104a ! 21a 97a 15. 7509286a13a 108a 76a20a69a 1a 70a 24a 36a21a 97a 15.75092186al13a 1108al20a 169a 1a 170a 126a 124al94a 121a ! 97a Fteld ; 1 : x 2... :' : i, 4 :6 ; 7 : 8. : 9 10 ;11 ; ;,1Z 15.75092186a ! 13a ! 108a ! 76a 12oa 169a ! 1a ! 70a 126a ! 24a j21a 197a_ 15.75092 ! 86al79a |13a |108a|20a ! 69a 11a 170a 124al36a |21a 97a 15.7509279ajl3a 176a 20a! 1a j70a 126a 124a 136a|94a |21a 97a 15.75092|79a|13a 176a 120a 169a |1a 170a 124a |36a|94å ! 21a 97a 15.82418J86a79a 108a76a 20a1a 70a26a 24a04sT2197a 15.8241879a13a 108a76a J20a ! 69a 70a24a 36a) 94a J21a 97a 15.82418|13a|108a|76a 120a |1a 170a ! 26a 124a |94a|104a |21a 197a 15.82418|86aj79a ! 20a 169a |1a ! 70a j24a 136a |94a|104a ! 21a ! 97a 15.8241879a13a 108a76a 20a) la 24a36a 94a104a 21a 97a 15.82418186aj79a 13a J108a76a20a 70a26a 24a 36a 104a 21 15.82418108 76a 20a69a 1a 70a) 26a ! 24a 94a104a 21a 97a' 15. 8241886a13a 76a ! 20a 69a 1a 70aj26a 24aJ36a 21a 97a 15.8241886a79a 76a f20a 69a1a 70a24a 36a (94a 21a 97a 15. 8241886a79a 76a J20a ! 69a) la 70a26a ! 24a94a ! l04a21a 15.8241886a79a 108a ! 76a20ajla 70a24a 36a94a ! 21a 97a" 15.8241886a79a 13a J108aj20a 69a 70a 24a ! 36a94a 21a 97a 15.82418J86a79a13a 108a ! 20a la70a6a ! 24a104a 21a ! 97a 15.82418J79a3a" 76a 20a 1a 70a ! 26a 24a94a04a 21a ! 97a15.82418J79a3a" 76a 20a 1a 70a ! 26a 24a94a04a 21a ! 97a 15. 89744186al79a 76a 120a 169@ 170@ 26a 124 136a I 197a 15.89744 ! 86a|79a |13a |108a|20a 169a ! 1a 126a ! 24al94a |21a 197a 15.89744J86a79a) 13a 108a76a 20aOa 26a 24aJ36a 94a 21a15.89744J86a79a) 13a 108a76a 20aOa 26a 24aJ36a 94a 21a 15.89744j86a79a jl3a 108a !'20a 69a ha ! 70a 26af24a S4a 21a 15.8974413a108a) 76a 20a 69a ha 70a26a) 24a36a 94a 21a 15.8974486a79a J108a76a 20a1a 70aj26a 24a36a 21a 97a 15.89744 ! 79a108aj76a 20a 69a1a 70a26a 24a 94a 21a 97a15.89744 ! 79a108aj76a 20a 69a1a 70a26a 24a 94a 21a 97a 15.9707179a 108a|76a 20a 69a 70a 26a 24a 94a 104a 21a 97a 1 15.9707179a|13a 108a76aj69a1a6a24aJ36a94a 104a 21a 15. 970779a'76a 20s 69a ! 70a 26a) 24a 36a 94a 104a 21a 97a 15.9707) 86aj79a) t3a J108a20a 69a ha 70a 24a) 36a 94a 21a 15. 9707J79a13a IQSaOa 69ajlaOa24a 36a94a 21a 97a 15¢9707j86a ! 108a ! 76a 120a 169a 11a 170a 126a 124al36a Is4a |21a 15. 9707 86a79a 108a76a) 20a 69a 1a 70a 24a ! t04a21 a) 97a 15.970786a79a 13a 76a 20a1a 70a26a 24a 94a 104a 21a 15.9707 ! 86a|79a |13a 108a 76a 20a70a 24a 36a 94a104a21a 15.9707|79a|13a |108a 76a 20a1a 70a24a 36a94a 21a 97a 15. 970779a13s 76a 20a 69a1a 70a24a 94a104a 21a 97a 16.04396 79a 13a 108a76a 20a) 69a 1a 70a 24a36a 21a 97a 16.0439679a13a 108a76a 20a 69a 1a24a 36a 104a 21a 97a16.0439679a13a 108a76a 20a 69a 1a24a 36a 104a 21a 97a . l l0439679a13a 108a76a 20a 70a 26aJ24a 36a94a 1Q4a21a16. 16.0439686a79a 13a 108a76a 20a 69a1a 70a24a 104a 21a 16.0439686a 108a76a 20a 69a1a 24s 36a 94a104a 21a 97a 16.0439679a13s 108a76a 20a1a 70a ! 24a 36a 104a 21a 97a 94a 21a97a94a 21a97a 16.1172286a108a) 20a 69a 1a 70a 24a36a 94a104a 21a 97a 16.1172210876a 20a 69a 1a 70a26a) 24a 36a94a 104a 21a 16.1172286a 108a76a 20a 1a 70a 24a36a 94a104a 21a 97a 16.11722J86a79a 13s 108a76a 20a 26a ! 24a 36a94a 21a 97a) F ; ild1X « 2 < 8g °t B2 16.11722 ! 86a ! 79a13a ! l083 ! 76a20a 1a 26a 24a36a 104a21a 16. 19048J79a ! l3a) l08a76a 20aJ69a 1a 70a 24aio4aj21s97a 16.19048 ! 79ah3a 108a20a 69a 1a 70a26a 24a. 94a') 21a ! 97a 16.1904886a108a76a 120a 169a 170a 26a 124a 36a|94a |21a 97a 16.19048|79al76a 20a 169a 1a 70a ! 26a ! 24a|94a|104a 21a |97a 16.19048186al79a 13a |108a|76a|20al1a |70a|24a|104a 21a 97a 16.19048j79aj13a 108a ! 76a 20a 169a ! 24a |36a j94ad104a 21a 97a 16.19048179al13a ! 76a 20a 169a ! 1a ! 70a ! 26a ! 24ai1o4a ! 21a 97a Oa 26a J24a ! l04a (21a 97aOa 26a J24a ! l04a (21a 97a 16.2637486a13a108a76a i20a 69a (70a ! 24a ! 36a94ah04a21a' 16.2637486a79a! l3a ! 76a (20a ! 70a ! 26a ! 24a 36a104a ! 21a 97a 16.2637486ah3a108a76a ! 20a ! 69a ! 70a26a 24at36a b04a21a 16.26374186aß13a 1108a ! 76a 12oal69a |1a 126a 124al36a |104a|21a 16.26374J79a ! l3a 76a 20a 69aa) 70a26a ! 24a94a 21a"97a 16.26374 79ajl3a 108a0a 69a (la 70a4a4ah04a ! 21a 97a 16.26374 ! 86a79a 13a ! 108a 76al20a j1a ! 70a 24als4a i104a ! 21a 16.2637479ajt3a; 108a) 76a ! 20aJ69a 70a 26s 24a94a 21a7a 16.26374 86al79a |108al76a 20a |70a 26a 24a |94a ! 104a 21a 97a 16. 2637486a79a 13a 108a76a ! 20a 69a 1a ! 24a36a 21a 97a"' 16.26374186al79a 13a 108a20a j69a1a 70a6a 24a ! l04a'21a 16.2637479a 13a 108at76a'20a69a 70a 24a 36a94a 104a21a" 16.26374 79a ! l3a ! 76a 20a 69a70a 26a 24a 36a94a 21a97a" 16.26374) 79a) 13a ! 76a 20a ! 69a ha ! 24a 36a4a 104a 21a ! 97a 16.337186a 76a 120a 169a |la 70a |26a 24a |36a 104a ! 21a |97a 16.33779ajt3a 108a ! 76a ! 20aJ69a jZOa 26a J24a 104a J21a 97a 16.33786aJ79a"13a 20a 1a 70a 24a36a 94a104a 21a7a16.33786aJ79a"13a 20a 1a 70a 24a36a 94a104a 21a7a 16. 33779a) l3a 108a76a 20a la 26a 24a 94a104a 21a 97a" 16.33786a13a 108aJ76a 20a1a 26a 24a 36a 94a21 a 97a16.33786a13a 108aJ76a 20a1a 26a 24a 36a 94a21 a 97a 16.! 86al7sa j13a |108aj76a12oa |70a124a 194al104a 121a |97a 16.33786aj79a 13a 76a 20aa"70a24a 94a104a 21a 97a 16. 33786a13a J108a76a 20a69a 1a 24a 36a 94a 104a 21a 16.33786a79a ! l3a08a ! 76a0a'69a24a 36a94a 104a21a" 16.4102686a79a 13a IQSaOa 69a J70a 26a 24a36a 21a 97a 16.4102679a108a76a. 20a 69a la 70a 24s 36a94a ! l04a21a 16.4102679a13a J108a76a 20a 1a 70a 24a 94a104a21a 97a 16.41026|79aj13a |108a 76a 20al69a 26a 24a j94a 1104@ 121 a 197a 16.41026 ! 86a79a 13a tl08a'20a1a 70a 26a 24a94a 104a21a 16.41026j79a 13a108a20a 1 a 70a26a 24a 36a 94a21 a 97a 16.4102686a ! 79a 1-3a 108a 20a1a 70a 24a 94a104a 21a 97a 16.41026 76a 20a 69a 1a70a 26a 24a 36a 94a 104a 21a 97a 16.4102679a13a ! l08a76a 20a1a 70a 26a 24a 36a 21a 97a 16.4102686a ! 79a) l3a 76a 20a 69a 1a 70a 24a94a 104a21a 16.41026 79a 108a 76a 20a 69a1a 70a 24a 94a104a 21a 97a 16.41026 79s 108a 76a 20a 69a70a 26a 24a) 36a 104a 21a 97a 16.4102686a79a 13a ! 76a 20a1a 70a 26a 24a36a 104a21a 16.4102686a79a 13a 108a76a 20a 69a 26s 24a94a 104a21a 16.4102679a ! l08a ! 76a 20a 69a 26a 24a 36a 94a 104a 21a 97a i elGdr 6æ ! 3 lBli 16. 4102686a ! 79a jl3a ! 76a 20a) la 24a6aJ94ajl04at21a 97a 16.41026186a79a ! l3a 76a 12oa 170a 124a 136a 1g4al1o4a 121a ! 97a 16.41026j13a108aj76a 20a 69a 70a ! 26a 24a 36a94a 21a J97a 16.4102686a79a 13a 108a6a ! 20a69a4a36a94a21a 97a" 16.4102686a108a76a 20a 69a) la 26aJ24a 36a'94a J21a97a 6. 48352186al79a 11 3a 11 08al76a ! 2oa 169a ! 26a ! 24a ! 36a 121 a ! s7a 16.4835286a 79a76a ! 20a 69a1a 70a 24a 94a104a 21aTa" 16.48352 (l3a108a76a 20a J69a 1a 24aJ36a g4a 104a 21a97a 16.48352 ! 86a ! l3a 1108a j76a ! 2oa 170a 126a 124a ! 36al94a 121a 197a 16. 48352 ! 79ajl08a76a 20a 69a 1a 24a 36a) 94a-04a21a97a 16.48352 ! 86a ! 79a 108a76a ! 20a ! 70a 26a 24a6a4a21a97a 16.4835279a ! l3a 76a 20a ! 70a 26a 24a36a4a104a 21a 97a 16.4835286a 79a J13a 108a (76a20a 1a 26a 24a 104a 21a 97a" 16.4835286a79a3a08a76a20a69a1a 26a 24a21a 97a 16. 4835286a 79a 13a J108aj76a ; 20a 69a 26a) 24a94a 2a*'97a"' 16.48352 ! 86a79a 13a 76a0a70a26a24a6a94a 21a 97a 16.48352|86al79a 113a |108al20a 169a ! 1a ! 70a 124a ! 1o4a 121a 197a ., 16.48352|86aj79a ! 13a ! 2oa 69a lia ! 70a 124a ! 36als4a |21a 197a 16.4835286a7Sa08a20a 69a 1aOa 24a ! 94ah04a 21a97a 16.48352 79all 3a 1108al76a 120a 70a 126a 124a 36a 104a 121 a 197 16.55678|86a|79a 13a 108a) 76a 120@ la 124a 36@ 104a 121 a 197a 16. 5567813a ! 76a 20a 69a) ta ! 70a 26a 24a 36a94a ! 21a 97a" 16.5567886a ! 79a) l08a76a 2Qa 69a1a 70a 24a 94a 104a 21a 16.55678J86a79a 13s 108a76a 20a 69a 1a24a36a 94a 2a" 16.55678J86a79a 13a 108a ! 20a69a 1a J70a 24a 94a 104a 21a 16.55678179a|108a 76a |20a 1a |70a ! 24a 136a 94al104a |21a |97a 16.5567886a ! 79a 13a ! 76a ! 20a ! 69a ! 70a24a 36a94a 104a ! 21a 16.5567879a13a b08a20a 1a 70a 26a 24a J94a104a 21a ! 97a 16.5567886a79a 76a 20a 69a 1a703 24a36a104a ! 21a 97a 6. 55678113a|l08al76a ! 2Oa 169a |1a ! 70a 124a ! 36a|94a 121a 097a 16.5567879a13a 76a 20a ! 69a 70a24a 36a 94a 104a 21a 97a 16.5567886a79a h08a20a 69a 1a 70a 24a ! 36a 104a 21a 97a 16.6300486a13a 108a76a 20aJ69a 1a 26a 24a 94a 104a 21a 16.63004 86a 13a 108a76a 20a 69a 70a 26a 24a 94a 104a 21a 16.6300486a 79a 13a 108a 76a 1 20a 26a 24a 36a 104a 21a 16.63004 79a 13a 108a76a ! 20a69a 1a 70a 24a 36a 94a 21a 16.6300486a79a13a 76a 20a 69a 70a 24a 36a94a 21a 97a16.6300486a79a13a 76a 20a 69a 70a 24a 36a94a 21a 97a 70a 26a 24a 94a70a 26a 24a 94a 104a 21a 16.703386a79a 108a76a20a69a 70a 24a 94a104a 21a 97a 16.703379a13a 76a 20a 69a 1a 26a 24a 94a104a 21a 97a 16.7033 79a 13a 108a76a 20a 69a 1a 26a 24a 94a 21a 97a 16.7033J13a76a 20a 1a 70a 26a 24a 36a 94a 104a 21a 97a 16.7033 ! 86a79a 13a 108a20a 69a 70a 26a 24a 104a 21a 97a 16.703386a79a ! l3a 108a20a 1a 24a 36a 94a 104a 21a 97a 16.703386axa 20a 69a 1a 70a 26a 24a 36a94a 21a 97a 16.703379a13a 108a76a 20a69a 1a 24a 36a94a 21a 97a 16.7033186a 79a 108a 20a 69a Ila 70a 124a 136a 94a I I OAa 12 1 a tEteld 3g 5 @ 1a 97a1a 97a 16.70331, 86a|79a |13a ! l08al76a ! 20a |1a 124a 136a|94a |104a|21a 16.7033 ! 79a13a108a76a 20a) 69a70a26a 24a 36a 104a 21a 16.7033186al79a ! 108a|76a 12oa |1a 170a 124a |36a|104a j21a ! 97a 16.7033i86aJ79a'13s) 76a ! 20a 69a 70a 26a J24a94a 104a ! 21a 16.7033186a ! 79a |13a ! 76a 12oa 169a 170a ! 26aX 36a ! 104a|21a 16.77656t1 3a|108a ! 76a 20a 69a 1 a 70a 26a 24a 1 04a |21 a 197a --I 6. 77656186all 08al76E 70a26a 124a 94a 11 04a 121 a 197a 16.7765 1 169a |1a ! 70a ! 24a 136a ! 94a ! 104a|21a 16.7765686a ! 79a) l08a76a 20a 70a J24a 36a 94a104a 21a) 97a 16.7765679a ! l3a 108a76a) 20a69aa 70a 26a24a i94a 21a 16. 77656J79a) l3a 108a) 76a20a ! 69a) 70a6a 24a36a) 21a 97a 16.77656179a ! 13a ! 108a ! 76a 12oa 169a ! 1 a 124a ! 94a ! 104a ! 21 a ! 97a 16.77656 ! 86a) l3a ! l08a76aOa 1a 70a 26a 24a104a 21a) 97a16.77656 ! 86a) l3a ! l08a76aOa 1a 70a 26a 24a104a 21a) 97a 16.77656 ! 79ah3a) l08a76a 20a69a) la) 70a 26a ! 24a 21a J97a' 16.77656) 86a79a ! l3a 108a ! 76a20a69a ! la 24a36a 104a21a 16.77656 ! 79a 108a76a ! 20a J70a6a ! 24a36a 94a104a 21a 97a 16.77656f79a13a 108a) 76a 20aa ! 26a24a 36a94a ! 21a 97a 16.84982 ! 79a3a108aJ76a20a) la 70a24aj36aj94a ! l04a21a 1 6. 84982186al79a 11 08a ! 76a ! 20a 170a 126a 124a 136a 11 04a |21 a 197a 16.8498279a 13a 108a76a ! 20a6a4a36a 94a104aj21a 97a 16.84982186a 108a76a) 20a ! 69a) la t70a 26a 24a j36a 21a 16. 84982186a 79a 76a 12oa 169a |1a 124a ! 36a |94a|104a |21a 197a 16.84982i86a79a108a76a J20a69a ! la 70a 24a36a 104a 21a 16.84982 ! 79a13a 108a76a ! 20a1a70a6a 24a36a ! l04a21a16.84982 ! 79a13a 108a76a ! 20a1a70a6a 24a36a ! l04a21a 16. 84982|13a 108a) 76a 12oa |1a 170a ! 26a i24a 36a|94a j104a 21a 16.84982 ! 79a 13a ! 108a|20a 169a ! 1ia 124a 136a 94a|104a |21a 97a 16. 92308 ! 86a79a 13a 76a 20a 70a 26a 24a 94a104a 21a 97a 16. 9230886a79a"13a 20a 69a1a 70a26a4a4a 21a) 97a 108a ; 76a (20a26a24a36a104a21a97a108a ; 76a (20a26a24a36a104a21a97a 04a21a04a21a 16.9230813a 108a ! 76a 20a 1a 26a 24a 36a 94a104a21a) 97a16.9230813a 108a ! 76a 20a 1a 26a 24a 36a 94a104a21a) 97a 16.9230879a 13a) l08a76a J20a 69a 1a70a 24a 94a 21a 97a16.9230879a 13a) l08a76a J20a 69a 1a70a 24a 94a 21a 97a 69a 1a 70a) 26a 24a 104a 21a 97a69a 1a 70a) 26a 24a 104a 21a 97a 16.9230886a13a"108a76a) 20a 1a 70a 24a 94a104a 21a 97a 16.176a 120a 169a 1 a 24a 36a 104a 121 a 197a 16.9230886a13a"108a76a 20a 70a 26a 24a 36a 104a 21a 97a 16.9963486a79a 13a 108a76a J20a 69a 70a 24a36a 21s 97a 16.99634h0876a 20a 69a 1a ! 70a 26a 24a 36a 104a 21a 97a 16.9983413a 108a76a 20a 1a) 70a 26a 24a 36a 104a 21a 97a 16.99634I13a108a 76a 20a! 69a |1a 24a 94a 29a 97a 16963486a 108a76a J20a 69a 1a 26a 24a 36a 104a 21a 97a 16.9963479a 108a20a69a 1a 70a 26a 24a 94a104a 21a 97a16.9963479a 108a20a69a 1a 70a 26a 24a 94a104a 21a 97a 16.9963486a 108a20a 69a 1a70a 26a 24a 36a94a 21a 97a16.9963486a 108a20a 69a 1a70a 26a 24a 36a94a 21a 97a 16.996341a 108a76a 20a 69a 70a 24a36a 94a104a 21a 97a 16. 9963486a 79a108a 76a 20a 69a i26a24a 36a104a 21a97a 16.9963486a13a 76a 20a J1a 70a26a24a 36a 94s 2fa97a16.9963486a13a 76a 20a J1a 70a26a24a 36a 94s 2fa97a 16. 996341792113a 176a 20a Ila 70a 26a 24a 36a 104a 121 a 1972 16.99634|79a|13a ! 76a 120a |1a 170a ! 26a 124a |36a|104a ! 21a 197a 16.99634J86aJ79a) l3s) 76s 20aJ69a 1a J24a 36a'94a J21a 97a 16.9963479a ! t3a 108a76a 20a69a 70a) 24a 36a'104a 21a 97a 16.9963479a ! l3a08aJ20a 69a) la 26a 24a"94a 104a 21a 97a16.9963479a ! l3a08aJ20a 69a) la 26a 24a"94a 104a 21a 97a 16.9963479a 176a 20a 69a ! 1a 170a 26a ! 24a|94a 104a ! 21a 16. 99634 86aj79a) 76a 20a 69a 70a 26a 24a 94a'104a 21a 97a 16.9963479a) l3s08a20a 69a70a 26a24a36a94a21a"97sr16.9963479a) l3s08a20a 69a70a 26a24a36a94a21a"97sr 16.99634 ! 86a ! 79a 13a) l08a20aa70a24a ! 36a94a-) 04a21a16.99634 ! 86a ! 79a 13a) l08a20aa70a24a ! 36a94a-) 04a21a 16.99634 ! 86a13a108a'76a l20a69a1a70a24a104a21a97a 17. 0696J10876a 20a 69a 1a 26a 24a 36a ! 94a04a J21a ! 97a 17.0696186a 13a |108a 20a 69a 1a 70a ! 24a 136a 94a |104a ! 21a 17. 0696 ! 86a108a ! 76a 20a 1a (70a 26a 24a 36a94a ! 21a 97a 17.0696j79a ! 13a ! 108a|76a ! 20a j69a |70a ! 26a |a|94a 1104a 21a 17.069686a79a J13a J108a ! 76a) 20a) 69a 1a 70aJ24a94a21a 17.0696j86a ! 79a ! 13a ! 108al20al69a 11a ! 24a ! 36a j104a j21a ! 97a 17.0696186al79a 11 3a 11 08al2Oa 112 702 24a 136a 104a 121 a 1972 17.069686a ! l3a J108a76a (20a 1a (70a26a24a36a 94a21a 17.0696j13a|108a ! 76a |20a 169a |1a 126a |24a |94a ! 104a |21a ! 97a 17. 069686a79a) l3a J76a 20ajla) 70a 26a) 24a104a) 21a 9a" 17.1428686a 79a 13a08a76a20a 69a 1a. 70a24a21a97a17.1428686a 79a 13a08a76a20a 69a 1a. 70a24a21a97a 17.14286i79a|13a |108a|20a |6Sa |1a 70a 124a 136al94a 104a|21a 69a 1a 70a 24s 94s 104a 21a 97a69a 1a 70a 24s 94s 104a 21a 97a 70a24a36a4a 104a 21a"70a24a36a4a 104a 21a" 04aj21a04aj21a 17.2161286a 79a 76a 20a 1aOa 26a 24a 94a 104a 21a 97a17.2161286a 79a 76a 20a 1aOa 26a 24a 94a 104a 21a 97a 17.21612 ! 86a79a 13a 108a76a 20a26a 24a 94a 104a 21a) 97a17.21612 ! 86a79a 13a 108a76a 20a26a 24a 94a 104a 21a) 97a 17. 2161279a13a 108a76a ! 20a69a 1a 70a (24a 94a 104a J21a 17.2161279a13a 76a 20a) 69a70a 26a 24a 36a 104a 21a 97a 17. 2161286a79a ! l08a20a 69aa 24a 36a 94a 104a 21a 97a 21a97a21a97a 17. 21612 86al79a ! 13a ! 76a |20a 169a 11a 170a ! 24a ! 36a |21a 197a 17.2161286a79a 76a 20a) 69a la 70a 26a 24a 104a J21a"'97a 17.21612108 76a 20a 69a 70a26a) 24a36a 94a 104a21a) 97a 1i21612, 86a 13a ! 76a ! 20a ! 69a j1a ! 70a ! 26a 124a ! 94a ! 104a ! 21a 17.28938 6a 79a 13a 108a ! 76a20a 69a1a 26a 24a 94a 21a 17.28938 86a79a 13a 108a76a 20a 24a 36a 94a 104a 21a 97a 17.2893886s 108a76a 20a 1a 70a 26a 24a 36a 104a 21a 97a 17.2893813a108a20a 69a 1a 70a 26a 24a 36a 94a 21a97a 17.2893879a 108a76a J20a 69a1a 26a ! 24a 94a 104a 21a 97a 17.2893879a 13a76a 20a 1a 26a 24a 36a 94a 104a 21a J97a17.2893879a 13a76a 20a 1a 26a 24a 36a 94a 104a 21a J97a 1a 70a 24a 36a 104a 21a 97a1a 70a 24a 36a 104a 21a 97a 17.28938 86a 13a 76a 20a jts 70a 24a 36a 94a 104a 21a 97a 17.28938 86a 79s 108a76a 20a 69a 24a ! 36a 94a 104a 21a 97a 17.2893886a79a 13a) 76a 20a 69a 70a 26a 24a 36a 21a 97a 17.2893813a108a76a 20a 69a1a 70a 26a 24a36a 104a21a 17. 2893886a 79a 13a 76a20a 1a 70a I24a 36a 104a 2a 97a ; 28938179all3a 1108176a 120@ Ila 26@ 242 36a 104a J21 a 197@ 17. 28938j79a3aOSa 76a t20a) la) 26a 24a36a 104a 21a 97a 17. 2893886a79a ! l08a) 76a 20a69ajlaOa ! 24a'94a 21a 97a 17.28938 ! 86a|13a ! 108a ! 20a i69a |1a ! 70a 24a |94a ! 104a ! 21a 197a 17.2893886a79a) l08a ! 170a |26a 24a |36a|94a ! 21a 197a 17.2893886a13a'08a 70a ! 24a ! 36a |94a|104a |21a 197a 1 17.28938J13ajl08a76a 20 ! 69a li a 170 126@ 24a 17.36264j75ai13a j76a ! 20a |69a 11a 170a |24a |36ai104a |21a 197a 4a94s J21a 97a4a94s J21a 97a 17.36264186a ! 79a 113a 176a 120al69a 11a 170a ! 26a ! 24a ! 21a ! 97a 17.3626486a13a J108a20a 69ajla t70a24a J36a ! l04a'2Ta J97a 17.36264j79ai13a 108a 76a 20a 69a 1a ! 70a |24a ! 36a ! 104a ! 21a 17.3626486a79a 13a 108a76aJ20aa J26a ! 24a94a 104aJ21a 17.435979a108a ! 76a 20a J1a 70a 26a24a J36T94a 21a97a 108a20a69a1a26a24a104a 21a97a108a20a69a1a26a24a104a 21a97a 17.4359|86a ! 13a ! 108a ! 76a |20a j69a 170a 126a |24a|104a |21a 197a | 17.4359 ! 86aj79a 13a 76a 20aj69a 1aOa 24aJ94a j21a97a17.4359 ! 86aj79a 13a 76a 20aj69a 1aOa 24aJ94a j21a97a 17.4359j79a ! l3a 108a76a 20s 1 a 70a ! 26aJ24a36a) 94a 21a" 17.4359186a ! 79a ! 13a ! 76a 20a 69a 1a 24a ! 36a 94a ! 104a 21a 17.4359 ! 86al13a 76a 20a 69ajla ! 70a26a4a36a*"104aj2j) a 17.4359j86al79a 108a|76a i20a ! 69a 126a ! 24a |36al94a ! 21a 197a 17. 4359|86aj79a 13a |108å20a |69a 170a |24a |94a j104a 121a 197a . I 17.435986a ! 79a 13a To8ai20a0a 26a24a 36a94a 21a 97a" 17.4359j86a|13a |76a |20a 169a |1a 170a |24a |94al104a |21a 197a 17. 4359 86ajl3a 108a ! 20a 1a 70a26a24a36a) 94a 21a 97a 17.4359 ! 108j76a |20a j1a 170a126a 124al36a 194al104a 21a ! 97a 17.50916j86aj79a 113a |108a|20a |69a |1a |24a |94al104a 21a 197a 17.50916) 86a 79a 13a J76a 20a 69a 70aJ26a''24a36a 94a 21a 17.50916186al79a 1108a|76a |20a ! 69a ! 70a |24a 136a|104a 21a 197a 17.5091686a ! l3a 108a76a i20a69a70a26a 24a36a 94a 21a 17.5091679ajl3a"108a76a J2Qa69a la 24a 36a94a 104a ! 21a 17.5091686s 13a 108a ! 20a (69a la 70aJ26a 24a94a 104a 21a 17.58242i86a|13a |108a|76a ! 20a 170a 124a 136a |94a|104a ! 21a 197a | 21a 97a21a 97a 17.5824286a13a) l08a76a 20a ! 69a 1a 26a 24a36a (94a J21a 17.5824286a 108a 20a 69a 1a 70a 26a 24a 36a 104a ! 21a 97a 17.5824213a108a) 76a 20a 70a 26a 24a36a 94a104a) 21a 97a 17.5824286a ! 79a 108a76a 20a 69a 1a 26a 24a94a21a 97a17.5824286a ! 79a 108a76a 20a 69a 1a 26a 24a94a21a 97a 70a 24a36a104a 21a70a 24a36a104a 21a 17.58242 86a79a 76a 20a 69a1a 70a 26a 24a36a 104a 21 a 17.5824286a13a J76a 20a 69a 1a 26a 24a 36a94a 21a 97a 17.5824286a79a 108a76a 20a 1a 70a 24a 94a104a 21a97a17.5824286a79a 108a76a 20a 1a 70a 24a 94a104a 21a97a 17.58242 86a 13a 108a76a 20a 1a 24a 36a 94a') 04a 21a) 97a 17.65568 79a 13a 108a76a 20a 69a 26a 24a 36a94a 104a 21a 17.6556886a79a 13a 108a78a20a 69a 26a 24a36a 94a 21a 17.65568 ! 79a 108a76a 20a 1a 70a 26a 24a 94a104a 21a J97a 17.6556813a108a76s 20a 69a 1a70a24a 36a 104a 21a (97a17.6556813a108a76s 20a 69a 1a70a24a 36a 104a 21a (97a 17. 66568 86a 79a108a 20a 69a 70a 24a 36a 94a 104a21 a97a w Field 1 g ! sX, 5iv 6-'8 ß o ! m 17.65568179a|13a |108a|20a ! 69a 170a 124a 136a ! 94a ! 104a |21a 197a 17.7289486aj79a ! t3a ! l08a) 20a 69a ha4a 36a94a 104a 21a17.7289486aj79a ! t3a ! l08a) 20a 69a ha4a 36a94a 104a 21a 17.72894 ! 79a|13a 1108a ! 20a 169a |1a 170a ! 24a |36a|104a |21a 197a 1 17.7289486a) 79a 108a ! 20a 69a1a 70a26a 2436a21a'97a" 17.723946aj79a 108a76a J20a 69a 26a 24a 36a 94a 104a 21a l72894186a|108a|76a 120a ! 6sa 70a |26a ! 24a 136aL94a ! 104a|21a17. 17.7289486a79a 13a J108a20a70a 263 24a 94a"104a21a) 97a 17.72894) 86aj79a) l08a76a) 20a ! 69a 1a 26a 24a04a 21a 97a 17.72894 ! 13a|108al76a 120a 169a 170a ! 26a 124a 136a ! sL4a ! 104a|21a 17. 72894 79a76a) 20a1a70a ! 26a ! 24a 36a 94a 104a) 21a 97a 17.72894 ! 79a76a ! 20a 69a 1a) 70a 26a 24a 36a 94a) 21a 97a 17.802286a13a 108a20a 69a1a 70a26a 24a 104a 21a 97a 17.802286a ! 79a) l08a76a 20a69a 1a 26a 24a) 36a) l04a21a 17.8022 86a} 79a 13a 20a 69s ! 70a 24a 36a 94a 104a21 a 97a 17.8022) 863 79a 13a j76a 20a ! 69a1a 70a 24a 36a04a ! 21a17.8022) 863 79a 13a j76a 20a ! 69a1a 70a 24a 36a04a ! 21a Oa 24a) 36a) l04a ! 21aOa 24a) 36a) l04a ! 21a 17.8022|13a|76a 120a 569a |1a t26a 124a ! 36a 194a104a |21a 197a 17.8022J13a (76a 20a 69a J1a t70a24a 363 94a 104a21a97a 17.802213a76a) 20a ! 69aa 70a 26a 24a 94a 104a 21a 97a17.802213a76a) 20a ! 69aa 70a 26a 24a 94a 104a 21a 97a 1a 70a 26a 24a 36a ! l04a 21s 97a1a 70a 26a 24a 36a ! l04a 21s 97a 17.8Q2213a ! l08a20a 69a1a 70ai24a) 36a 94a 104a 21a 97a17.8Q2213a ! l08a20a 69a1a 70ai24a) 36a 94a 104a 21a 97a 17.802286a13a 108a76a 20a ! 69a 1a 24a 36a 104a 21a 97a 17.802286a 79a) t3a 76a J20a69a 1a 70a 26a 24a 36a 21a 94a104a 21a 97a94a104a 21a 97a 17.802279a108a) 76a 20a ! 69a1a J70a26a24a ! 94a 104a 21a 17.802279a13a 76a 20a69a 70a ! 26a 24a 36a 94a (104a 21a17.802279a13a 76a 20a69a 70a ! 26a 24a 36a 94a (104a 21a 17.8022179a|13a 108a76a 20a la 70a 26a 24a 94a 104a 21a 17. 8022 ! 86a13a 108a20a 1a 70a 26a) 24a 36a 104a 21a 97a 17.802286a 79a 13a 108a76a ! 20a69ajla 24a 94a) l04a 21a 17.87546 ! 86a79a"76a 20a 1a 70a 26a 24a 36a 104a21 a J97a17.87546 ! 86a79a"76a 20a 1a 70a 26a 24a 36a 104a21 a J97a 17.87546 86a 13a 76a 20a 69a1a 70a26a24a36a 94a 21a 17.8754686a79a 108a76a 20a J69a 26a 24a94a 104a 21a 97a17.8754686a79a 108a76a 20a J69a 26a 24a94a 104a 21a 97a 26a 24a 94a 104a21a26a 24a 94a 104a21a 17. 8754. 6j86a79a 13a 108a76a 20a 69a1a 26a 24a 36s 21a 17.8754686a79a 108a 76a 20a 69a1a 24a36a 94a21a97a 17. 87546 79ajl3a 20a 69a la 70a 24a 36a J94a 104a 21a 97a 17.87546 86a 13a 108a76a 20a ! 69a 1a 24a 94a 104a 21a 97a 17.8754686a79a 13a 108s76a20a 70a 24a 36a104a 21a 97a 17. 8754686a79a 13a 76a 20a69a 70a26a 24a 94a 21a 97a 17.8754686a79a 13a 76a 20a69a 1a 26a 24a 94a 104a 21a 17.8754686a79a 108a76a 20a69a 1a 26a 24a 94a 104a 21 a 17.94872 86a3a"76a 20a 69a 70a 26a 24a 36a 94a 21a 97a17.94872 86a3a"76a 20a 69a 70a 26a 24a 36a 94a 21a 97a 17.9487286a13a 108a76s 20a 70a 26a 24a 94a 104a 21a 97a 17.9487286a79a 76a 20a 69a70a 26a 24a 36a 94a 104a 21a 17. S487286a13a 76a 20a 69a 1a 70a 24a 36a 94a 104a 21 a 17.9487286a79a 13a 108a20a 69a 70a26a 24a 94a 104a 21a 17.94872|86a 108a20a 69a1a 70a ! 26a 24a36a 94a 21a 17. 94872 ! 86a|13a ! 76a 12oa 169a ! 1a 124a 136a |94a|104a 121a 197a 17. 9487286a13a76aOa 69a1a 24a36a 94a'104a 21a 97a 17.9487286a79a J13a108a76a ! 20a 69a17.9487286a79a J13a108a76a ! 20a 69a 70a 126a|24a ! 21a 197a 17.94872113al108a j76a i20a |69a 170a |26a 24a j94a|104a j21a ! 97a | 18.0219886a13a 108a6a 20aJ69a 1a6a 24a'104a 21a 97a 18.021981 9 24. 36@ 194a 121 a 197a 1802198 ! 86a79a 108a20a 1a 70a 24a36a 94a'104a 21a 97a 18.02198J86a9a 13a08a20aJ69a 1a 26a 24a'94a 104a21a18.02198J86a9a 13a08a20aJ69a 1a 26a 24a'94a 104a21a 18.0219886a13a 176a 12oa 69a70a 24a 36a 94ah04a 2a'97a 18.0219813a108a76a 20a 69a1a 26a24a) 36a104a 21a 97a 18.0219813ai108a ! 76a 20a 69a 1a 26a 24a 36a 94a104a'21a18.0219813ai108a ! 76a 20a 69a 1a 26a 24a 36a 94a104a'21a 18.0219886a79a 13a108a20a69a 1a 26a 24a 36a 21a"97a'18.0219886a79a 13a108a20a69a 1a 26a 24a 36a 21a"97a' 18.02198186al79a ! 13a 120a 169a ! 1a ! 24a ! 36a ! 94a ! 104a 121a ! 97a 18.02198j86a|76a 20a 69a 70a 26a 24a 36a 194a 104a |21a 97a 18.0952479a13a 108a76a 20a 69a 26a 24a 36a104a 21a 97a 18.0952486a79a ! l3a) l08a20a 1a ! 70aJ26a 24aJ36a 14a'21a 21a 97a21a 97a 18. 09524J86a79a 13a 20a 69aa 70a 24a 36a'104a 21a 973' l09524 ! 86a79a 13a 76a 20a) la ! 26a24a) 36a94a 21a 97a18. 70a 26a24a94a 104a21a97a70a 26a24a94a 104a21a97a 18.0952486a79a 108a76a 20a 69a 1a J26a 24a 36a) 21a J97a 18.1685) 86a) 79a 13a ! 20a 69a 70a 26a 24a 36a 104a21a97a 18.1685J86a ! 79a 108a76a ! 20a) la"24a36a 94a104a 21a 97a 18.1685J79a108a ! 20a 69a 1a70a 26a 24a 36a 94a j21a 97a18.1685J79a108a ! 20a 69a 1a70a 26a 24a 36a 94a j21a 97a 18.1685j86a13s 108a76a 20a ! 69a 70a 24a J36a 104a1a 9'7a"18.1685j86a13s 108a76a 20a ! 69a 70a 24a J36a 104a1a 9'7a" 18.1685J86a79a 108a20a 169a 170a 126a 24a |36a|104a |21a 197a 18.1685j86a 108a76a) 20a) la 70a 26a 24a 94a104a 21a 97a 18.168586aj79a 13a h08s ! 76a20a26a24a 36a 94a 104a21a 18.168586a79a 13a 108a76a 20a 69a 26a 24a 104a 21a 97a 18.1 685 ! 86al79a 76a 20a J69a70a 26a 24a 36a 94a 21a 97a 69a1a 26a 24a 36a 21a97a69a1a 26a 24a 36a 21a97a 18.2417610820a 69a 1a 70a 26a 24a 36a 94a104a 21a 97a 18.2417686a 108a76a 20a 69a1a 26a24a 36a 94a 104a21a 18.24176J86a13a 20a 69a ! la 70a 24a 36a 94a104a 21a 97a 18.24176) 79a 13a 108a76a 2Qa69a 1a 26a 24a 94a 1Q4a21a 18.24176113a 108a ZOa69a 1 a 70a 26a24a 94a04a21 a97a 18.24176J86a79a ! t3a 108a20a 69a 26a 24a 36a 94a 21a 97a 18.2417686a 13a 108a76a 20a 69a 70a24a 94a104a 21a 97a 18.3150279a 108a76a 20a 69a 1a 70a26a 24aJ36a 21a 97a 18.31502'86a13a 108a76a 20a 1a 26a 24a 36a 104a 21a 97a 18.31502 ! 86a13a. 108s 20a 69a1a 26a 24a 36a 94a 21a 97a l l I,3150279a13a76a20a18. la 70 26a 124a 36a 94a 104a21a 18.3882886a79a 13a 20a 1a 70a 26a 24a 94a104a 21a 97a 18. 38828 86a 13a 108a76a 20a 70a 26a 24a 36a 94a 104a21a 18.3882813a 76a 20a 69a 70a 26a 24a 36a 94a104a 21a 97a 18.3882879a 108a76a 20a 69a1a 26a 24a 36a 94a 21a 97a 18.4615486a79a 13a 108a20a 69a 24a 36a 94a104a 21a 97a 18.4615479a13a20a 69a1a 70a26a 24a94a104a21a 97a -18. 46154186all3a 176a 120 Ila 170a 26a 24 36a 104@ 21 a 197@ 20a ha 70a26a ! 24a 36a 104aj21a 97a20a ha 70a26a ! 24a 36a 104aj21a 97a 18.46154|79a ! 108a j20a 169a ! 70a 26a ! 24a 36a ! 94ai104a |21a 197a 18.4615486a79a 13a 76a ! 20a1a 26a 24a94a 104a 21a 97a"18.4615486a79a 13a 76a ! 20a1a 26a 24a94a 104a 21a 97a" 18.46154 79a 108a76a 20a69a 1a 70a26a ! 24a 36a l04a 21a 18.534886a79a 13a108a20a 69a 26a 24a 94a'104a 21a 97a 18.5348J86a76a 20a J69a 1a70a 26a18.5348J86a76a 20a J69a 1a70a 26a 24a 36a 94a 104a 21a 26a 24a6a94a 21a 97a26a 24a6a94a 21a 97a 18.5348 86aj79a 76a 20a 70a26a 24a36a 94a 104a 21a 97a 18.534886a79a 108a76a 20a1a 70a 26a 24a 94a ! l04a21a 18.534886a ! 79a 13a 108a) 20aa 70a26a 24a36aj94a 21a 18.6080686a ! l08a76a 20a 69a1a26a) 24a 94a04a"21a97a'18.6080686a ! l08a76a 20a 69a1a26a) 24a 94a04a"21a97a' 18.60806|79aj13a 108a20a 69a 70a 26a 24a 94a 104a 21a97a 18.60806 86a79a13a 108a20a 70a 26a 24a 36a 104a 21a 97a18.60806 86a79a13a 108a20a 70a 26a 24a 36a 104a 21a 97a 18. 6080679a76a 20a 69a 1a) 70a 26aJ24a 36a ! l04a 2lT'97a 18.60806 86a13a 108a ! 20a 69a0a26a24a 36a 94a21 a ! 97a18.60806 86a13a 108a ! 20a 69a0a26a24a 36a 94a21 a ! 97a 1 8. 60806186al1 3a 176a 12oa 11 a ! 70a ! 26a i24a ! 94a ! 1 04a ! 21 a ! 97a 18.60806|86a j79a 113a 1108al20a |1a 126a ! 24a |94a|104a |21a ! 97a 18.6080686a79a 108a ! 76a 20a ! la70a26a 24a 36a 104a 21a 18. 60806 86a79a 13a 20a 69a ! la 70a 24a 36a 94a 104a 21a 18.6080686a79a 13a 76a 20a 70a 26a 24a 36a 94a 104a'21a 24a04a 21a 97a24a04a 21a 97a 18. 6813213a 76a20a 69a 1a70a6a243 36a 94a 104a2lV 70a ! 26a 24a ! 36a 94a ! l04a 21a 97a70a ! 26a 24a ! 36a 94a ! l04a 21a 97a 18.6813286a ! 13a 76a 20s 69a t70a 26a24a ! 36a104a 21a 97a" 18.68132186al79a 113a 176a 12oa 169a 170a 124a 194a|104a 21a 197a 18.68132 ! 86a79a 13a 108a76a 20a 69a 70a24a 104a 21a 97a18.68132 ! 86a79a 13a 108a76a 20a 69a 70a24a 104a 21a 97a 18.6813286a79a 13a) l08a20a1a ! 26a24a 36a 94a 21a 97a 18.68132 ! 86aj79a 13s 108a20a69a 70a26a 24a 36a 94a 21 a 18. 6813286a79a 20a 69a 1a 70a 26a 24a 94a 104a 21a 97a 18.6813286a79a 13a 108a ! 20a69a ! la70a ! 26a24a 36a 21a 18.7545879a13a 108a20a1a 70a) 26a24a 36a 94a 104a 21a 18. 7545886a 108a20a 69a J1a 70a 26a 24a 36a 94a 104a 21a 18. 7545879a108a ! 76a 20a 69a1a 70a26a 24a 36a 94a 21a 18.75458 86a79a 13a 76a 20a1a 70a 26a'24a 36a 94a 21a 18.7545879a13a 108a20a) la 70a 26a 24a 36a 104a 21a 97a 18.75458 86a13a (108a 20a 69a1 a 24a36a 94a104a 21 a97a 18. 75458 86a13a 76a 20a 69a 70a 26a 24a 94a 104a 21a97a 18.75458 79a 76a 20a J69a 1a 26a 24a 36a 94a 104a 21a97a" 18.7545886a 79a 13a 108a76a20a 69a1a 24a 104a 21a 97a 18.82784 86a 79a 13a 108a76a 20a 1a 24a 94a 104a 21a 97a 18.82784 86a79a 13a 20a la 70a 26a 24a 36a 104a 21a 97a 21a 97a21a 97a 18.901186a13a 108a20a 69a 70a 24a 36a 94a104a 21a 97a 18.901186a 13a 108a 20a 169a 70a 26a j24a 36a 104a 21 a 18.901186a 108a20a 69a 1a 70a 26a 24a 94a104a 21a 97a 18.901186a13a 108a76a 20a1a26a 24a 36a94a 104a 21a Pi id-i 18.901l ! 79ah3a ! 76a 20a 69a ! la) 26a24a 36a94a1a) 97a18.901l ! 79ah3a ! 76a 20a 69a ! la) 26a24a 36a94a1a) 97a 18.97436186al79a |13a ! 76a 12oa 169a ! 26a 124a 13óal94a ! 21a 197a 6a 24a 36a04a 21a) 97a6a 24a 36a04a 21a) 97a 18.9743686a79a 13a08a20a) la J26a24a 36aTo4aJ21a) 97a"18.9743686a79a 13a08a20a) la J26a24a 36aTo4aJ21a) 97a" 21 a) 97a21 a) 97a 18.97436 ! 86a79a) l3a 76a 20a 69a 11a 170a 124a 104a |21a 197a 18.97436179a ! 13a 176a 120a 16sa 1a 170a 26a 124a 36a ! 94a |21a 18.9743686a79a 13a 20a 69a1a 70a26aj24a ! 94a 104a2 18.97436186al79a 1l3a ! 76a ! 2oa 169a ! 1a 124a 194a ! 104a 121a 97a 19.04762 ! 86al79a 13a 120a ! 6sa ! 70a 126a 124a 136als4a 21a 97a 19.04762 ! 86aj79a 13a 76a 20a 1a 26a 24a ! 36a ! 104a ! 21a ! 97a 70a) 24a) 36a94a) l04a21a70a) 24a) 36a94a) l04a21a l l04762 ! 86a13a 108a20a J1a J70a ! 26a 24a 94a104a 21a19.97a ') 9. 04762 ! 86a79a 108a76a) 20a) la) 26a24a 36a104aJ21a 97a 19.04762793 76a 20a 69a ! la 26a24a ! 94a04a ! 21a 97a 9.04762 ! 86a ! 79a 13a 108a76a20a 69a 1a) 24a94a 21a97a 19.04762 ! 79a13a 20a J1a70a) 26a) 24a 36a) 94a104a 21a ! 97a 19.12088 86a79a 108a) 20a1a 70a 26a 24s 36a94a 21a J97a19.12088 86a79a 108a) 20a1a 70a 26a 24s 36a94a 21a J97a 19.12088) l3a) l08a76a 20a J69a ! 70a 26aJ24a 36ajl04a 21a97a 19.1208886a ! l3a 76a ! 20a 69a ! la 70a) 26a 24a) l04a 21a 97s 19.12088 79a 13a108a ; 20a 69a1 a26a24a36a94a 21 a 97a 19.1208813a108a20a) 69a 1a 70a 26a24a 36a) l04a 21a 97a 19. 1208879a13a 108a20a la 26a 24a) 36a 94a104a 21a 97a 19. 12088i79al13a 108a 76a 120a l69a 1a 70a 26a|24a 136a |21a 19.12088 86a3a't20a ! 69a J1a J70a'26a 24a 36aJ94a'21a 97a 19.12088113a|108al20a 169a ! 1a 170a 126a 124a 136als4a |104a|21a 19.1941479a108a76a 20a 69a1a) 26a24a 36a104a) 21a) 97a 19.19414 86a79a 108a20a 1a 70a26a24a 94a104a ! 21a 97a 19.1941486a ! l08a76a 20a 1a) 70a 26a 24a 36a94a J104a21a 19.1941486s 13a 108a ! 76a ! 20a 1a 26a 24a 94a104a 21s 97a 19.2674J86a79a 13a 108a76a20a 69a 70a 24a36a 104a21a 19.267486axa 76a 20a 69a1a26a24a 36a1Q4a 21a 97a 19.267479a13a108a 76a 20a1a26a 24a 36a 94a104a 21a 19.2674|86a|79a |76a 20a 69a 26a 24a 36a 94a 1104@ 21a 97a 19.3406686a79a 13a 108a76a20a 69a 24a ! 94a104a 21a 97a 19.34066186a 79a 11 3a 120a 169a 1 a 70a 26a 24a36a 21a 97a 19. 34066j79a13a 1Q8a20a 70a 26a24a 36a 94a104a 21a 97a 19.41392 ! 79a76a 20a 69a 1a 70a 26a 24a 36a94a 104a21a 19.4139286a79a 108a20a 69a1a 26a 24a 94a104a 21a 97a 19.4139286a13a 108a76a 20a 69a 26a 24a 94a104a 21a 97a 19.4139286a79a"13a 20a 1a 70a 26a 24a 36a94a 21a 97a 19. 4871879a13a108a) 20a J69a 70a 26a 24a 36a94a 104a21a 19. 48718 86a79a"20a 69a 70a 26a 24a 36a 94a 104a 21a 97a 19.48718 79a 108a20a la70a 26a 24a 36a 94a 104a 21a 97a 19. 4871879a 13a 108a20a 69a 1a 70a 26a 24a36a 94a 21a 19.4871886a79a'13a 108a20a 69a 70a 24a 36a104a 21a 97a 19.4871886a13a 76a ! 20a 69a 1a 26a 24a 94ajl04a 21a97a gRield1 Xit 9 9 0} 2- 19. 48718j86al13a 1108a|20a ! 1a 170a ! 26a 124a ! 36a194a ! 104a|21a 19.56044 ! 86a3a) l08a20a J69aJ70a J26a) 24a J94a104a 21 a) 97a 19.56044 ! 86a13a) 20a) 69ata 70a ! 26a 24a 36a 104a 21 a 97a19.56044 ! 86a13a) 20a) 69ata 70a ! 26a 24a 36a 104a 21 a 97a 19.56044J86a79a13a 76a 20a 69a 24a 36a 94a 104a 21 a 97a19.56044J86a79a13a 76a 20a 69a 24a 36a 94a 104a 21 a 97a 19.6337186a|79a 113@ 76a 20a 69a 170a 26a |24a|104a 121a !, 97a l08a20a69a ! 70a 26a 24a J36a104a'2Ta97a 19.6337J86a79a08a20a J69a1a J70a26a 24a 36a 104a21a19.6337J86a79a08a20a J69a1a J70a26a 24a 36a 104a21a 19. 6337 ! 86a13a 108a76aOa 69a ! 26a 24a 36a j104a 121a 197a 19.6337J86a79a 76a t20a 69a 1a J70a) 26a 24a'36ai94a21a" 21 a"97a21 a"97a 19, 6337 792113a 120a 69a J70a 126a 124a 136a 94a 104a 21a"97a 19.70696! 13a 176a ! 20a 69a 11a 126a ! 24a 36a ! 104a ! 21a ! 97a l l70696 ! 86a79a) l3a J76a 20a 69a 26a) 24a 94a 104a 21a 97a19. 19.7802211 3a ! 1 08a 176a ! 20a 69a 26a 24a 36a 94a 104a 21a ! 97a 19.78022186al79a 1108al76a 120a 112 126 124a 36a 94a 121 a, 197a 19.78022 ! 86a) l3a 20a 69a 1a70a p6a 24a 94a 104a J21a 97a19.78022 ! 86a) l3a 20a 69a 1a70a p6a 24a 94a 104a J21a 97a 19. 78022j86at79a 13a 108aJ20ai69a70a ! 24a 36a 94a) l04a21a 19.7802279a13a 76a 20a 69a1a 70a) 26a 24a 36a J21a 97a 19.85348J86a13a 108a ! 20a 69a1a 26a) 24a 36a104a) 21a 97a 19.85348179a ! 13a ! 108a ! 76a 20a ! 69a ! 1a ! 26a 124al36a 1104a ! 21a 1 19.85348 ! 86a79a 13a 108a76a 20a 69a 24a 36a 104a 21a 97a 19. 85348 ! 86a79a 13a ! 20a 69a1a 26a 24a 94a 104a 21a 97a 19.8534886a13a 108a76a 20a ! 69a ! 24a36a 94a104a 21a) 97a 19.92674 79al108al20a 169a 1a 70a ! 26al24a ! 36a j94a 1104al21a 19.92674179aj13a 1108a ! 20a 169a 11a 170a 126a 124al36a 121a 197a 19.92674 86a (79a 108aj20a 69a 1a 70a 26a 24a36a 94a 21a 2086a79a fl3a) 76aOa 69a 1a 24a 36a 104a 21a 97a 20|86a|79a |108a|76a 20a 70a 26a 24a 36a! 94a 104a 21a 20 ! 79a ! 13a j108a|20a 69a 26a 124a 36a |94ai104a 21a ! 97a 20 79a 108a76a 20a la 26aJ24a36a 94a 104a 21a 97a 2013a 20a ! 69a 1a) 70a26a 24a 36a 94a 104a 21a 97a 2086axa! l3a 108a76a20a 1a b6a 24a 36a 94a 21a 2086a79a 13a 76a 20a 26a 24a 36a 94a 104a 21a J97a 2086a79a 13a 20a 70a 26a 24a 36a 94a 104a 21a 97a 20186alla76a 20a 69a 1a 70a 24a J36a104a 21a 97a 2086a76a20a 69a 1a 26a 24a36a 94a 104a 21a 97a 20. 07326 ! 86a79a13a 108aj'20a69a 70a 26a 24a36a 104a21a 20.07326) 86a79a 13a 76a ! 20a69a la 26a 24a 104a 21a 97a 20.0732686a13a 76a 20a1a 70a 26a 24a 36a) 94a 104a21a20.0732686a13a 76a 20a1a 70a 26a 24a 36a) 94a 104a21a 20.07326 86a 79a 13a 108a20a69ajla70a 24a 36a 104a21a20.07326 86a 79a 13a 108a20a69ajla70a 24a 36a 104a21a 20 1465279a13a 76a 20a 69a1a 70a 26a 24a 36a 104a21a 20. 14652 86a 79a 13a76a 20a 69a 26a 24a 36a 104a21 a 97a 20.1465286a79a 108a76a 20a 26a 24a 36a 94a 104a 21a 97a 20.1465286a76a 20a 1a 70a26a 24a 36a 94a 104a 21a 97a 20.1465286a13a ! l08a20a 69a 1a26a 24a 94a 104a 21a 97a 20.2197886a ! 79a 13a 76a! 20a 69a 170a 24a 36a 104a 212 197a 20.21978 86a 79a 20a 69a) ts 70a 26a ! 24a 36a 104a 21a 97a 20. 29304186al79a 1108al20a 169a Ila 26a 24a J36a 194a I 20.21a 197a 20a |20a 170a 126a ! 24a 36a |94al104a 121a 197a 20.366313a08a ! 20a 69a) ta) 26a) 24a 36aJ94a 104a 21a 97a 70a26a 24a 36a ! 94a 21a 70a26a 24a 36a ! 94a 21a 20*3663 79a 13a ! 108a 76a 20a 69a 1a |26a ! 24a|36a 194a |21a 20.43956 86a ! 108a ! 75a 12oa 170a 126a 124a ! 36a 194a 1104a 121a 197a Oa 69a) 1a 26a24a6a 104a 21aOa 69a) 1a 26a24a6a 104a 21a 20.512829a) l3a J20a 69ata 70a J26a 24a 36aJ94a 21a"97a20.512829a) l3a J20a 69ata 70a J26a 24a 36aJ94a 21a"97a 20.51282 ! 86al79a 1108a ! 76a 12oal1a ! 26a ! 24a 194a ! 104a 121a 197a 20.58608|79al108al76a 12oa ! 1a 170a ! 26a 124a 136a|94a |104a j21a 20.5860879a08a20a 69a 1a26a) 24a36a 94a'104a ! 21a97a'20.5860879a08a20a 69a 1a26a) 24a36a 94a'104a ! 21a97a' 20.58608186al79a 11082120a 69al7Cal26al24a ! 36al94a 1104a {21a 20.58608186ai13a 176a 12oa 169a ! 70a ! 26a 124a ! 36a ! 94a ! 104a ! 21a 20.65934i79ail08a20a 69a1a 70a 26a 24a 36a) l04a 21a97a20.65934i79ail08a20a 69a1a 70a 26a 24a 36a) l04a 21a97a 20.65934 79a) 20a ! 69a ! la) 70a 26a24a 36a 94a 104a) 21a 97a20.65934 79a) 20a ! 69a ! la) 70a 26a24a 36a 94a 104a) 21a 97a 20,6593479ah08a76a 20a ! 69a1a26a24a 36a 94a ! l04a) 21a 20.7326) 86aj79a 13a 108a ! 20a69a 1a 26a 24a 36a04a21a 20.732686a79a h08a ! 20a la7Qa 26a24a 36a 104a 21a 97a"'20.732686a79a h08a ! 20a la7Qa 26a24a 36a 104a 21a 97a"' 20.7326 86a79a) 76a 20a 69a 1a 26a 24a J36a104a 21a 97a 21 a 97a21 a 97a 20.732679a13a') 08a20a 69ajla 70a26aJ24a36a ! l04a21a 20.9523886a79a 108ai20a ! 69a ! la ! 26a24a) 36a'104a 21a 97a 21.0256486ajl3a 108a ! 120a J20aj69a 26a 24a 36a 94a 104a 21a 21.025686ai79a"108a20a 69a26a 24a36a 94a 104a 21a 97a 21.0989i86a|20a 169a ! 1a 170a 126a 124a 136z 194al104a |21a ! 97a 1 21.24542 86a 108a76a J20a 69a) 26a 24a 36a) 94a104a 21a) 97a 21.2454286a79a 108af76a 20a 69a 1a J26a 24a 36a 94a 21a 21.3186886at79a13a) 76a"'20a ! la26a) 24a 36aJ94a 104a 21a21.3186886at79a13a) 76a"'20a ! la26a) 24a 36aJ94a 104a 21a 21.3186886a79a (l3a 108a20a1a 26a 24a 36a 94a 104a 21a 21. 3919486a79a 76a 20a ! ta 70a 26a 24a 36a 94a 104a ! 21a 21.465213a108a20a ! 69a 70a 26a 24a 36a 94a 104s 21a 97a 21.465286a ! 79a 13a 76a 20a) 69a26a24a 36a 94a 104a 21a 21.5384686 l08a20a 69a ! 70aJ26a 24a 36a 94a 104a 21a 97a 21.6117286a79a 13a 108a20a26a 24a 36a 94a 104a 21a 97a 21.6117286a79a 76a 20a 69a 1a 26a 24a 36a 94a 21a 97a 21.6117286a79a 13a 20a 69a1a 70a 26a 24a ! 36a104a21a21.6117286a79a 13a 20a 69a1a 70a 26a 24a ! 36a104a21a 21.61172 ! 86a79a 13a 108a20a70a26a24a 36a 94a 104a 21a 21. 68498 ! 86a13a 20a 1a70a 26a 24a 36a 94a 104a 21a 97a 21.6849886a13a 108a20a 69a 70a 26a 24a 36a 94a 104a 21a 21. 6849879a13a 20a 69a 1a 70a 26a 24a J36a104a 21a 97a 21.7582486a79a 76a 20a 1a 26a 24a 36a 94ajl04a 21a 97a 21.75824 86a 13a 76a 20a 69a 1a 26a 24a 36a 94a 104a 21a 21.7582486a13a 20a 69a 70a 26a 24a 36a 94a 104a 21a 97a 21.7582486a79a 13a 108a20a 69a 26a 24a 36a 94a 104a 21a 21.831579a13a 108a20a 69a1a 26a 24a 36a 104a 21a 97a 21. 9047686a 13a 108a20a 69a 1a26a 24a36a 94a104a21a