Title:
METHOD FOR PRODUCING METABOLITES BY MICROBIAL WAY
Document Type and Number:
WIPO Patent Application WO2004046366
Kind Code:
A3
Abstract:
The invention relates to a method for producing metabolites by microbial way. The inventive method makes it possible to specifically influence an ATP synthesis, thereby controlling the synthesis of metabolites. Said invention also relates to a ctaF gene which codes a cytochrome AA3 oxydase born by Corinebacterium glutamicum. The ctaF gene codes a protein having a function of fourth sub-unit of cytochrome AA3 oxydase.
Inventors:
NIEBISCH AXEL (DE)
BOTT MICHAEL (DE)
BOTT MICHAEL (DE)
Application Number:
PCT/DE2003/003826
Publication Date:
August 19, 2004
Filing Date:
November 19, 2003
Export Citation:
Assignee:
FORSCHUNGSZENTRUM JUELICH GMBH (DE)
NIEBISCH AXEL (DE)
BOTT MICHAEL (DE)
NIEBISCH AXEL (DE)
BOTT MICHAEL (DE)
International Classes:
C12N1/21; C12N9/02; C12P1/04; C12P13/04; (IPC1-7): C12N9/02; C12N1/21; C12N15/53; C12P7/02; C12P7/40; C12P13/04; C12P17/12; C12P17/16; C12P17/18; C12P19/30; C12P19/38; C12Q1/26
Domestic Patent References:
| WO2002022799A2 | 2002-03-21 |
Foreign References:
| EP1170376A1 | 2002-01-09 | |||
| EP1038969A2 | 2000-09-27 | |||
| EP1195433A2 | 2002-04-10 | |||
| EP1108790A2 | 2001-06-20 |
Other References:
NIEBISCH AXEL ET AL: "Purification of a cytochrome bc-aa3 supercomplex with quinol oxidase activity from Corynebacterium glutamicum. Identification of a fourth subunity of cytochrome aa3 oxidase and mutational analysis of diheme cytochrome c1.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 7 FEB 2003, vol. 278, no. 6, 7 February 2003 (2003-02-07), pages 4339 - 4346, XP002283681, ISSN: 0021-9258
WITT H ET AL: "Isolation, analysis, and deletion of the gene coding for subunit IV of cytochrome c oxidase in Paracoccus denitrificans.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 28 FEB 1997, vol. 272, no. 9, 28 February 1997 (1997-02-28), pages 5514 - 5517, XP002284314, ISSN: 0021-9258
SARASTE M ET AL: "THE BACILLUS-SUBTILIS CYTOCHROME-C OXIDASE VARIATIONS ON A CONSERVED PROTEIN THEME", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 195, no. 2, 1991, pages 517 - 526, XP008031335, ISSN: 0014-2956
WITT H ET AL: "Isolation, analysis, and deletion of the gene coding for subunit IV of cytochrome c oxidase in Paracoccus denitrificans.", THE JOURNAL OF BIOLOGICAL CHEMISTRY. 28 FEB 1997, vol. 272, no. 9, 28 February 1997 (1997-02-28), pages 5514 - 5517, XP002284314, ISSN: 0021-9258
SARASTE M ET AL: "THE BACILLUS-SUBTILIS CYTOCHROME-C OXIDASE VARIATIONS ON A CONSERVED PROTEIN THEME", EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 195, no. 2, 1991, pages 517 - 526, XP008031335, ISSN: 0014-2956
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