METHOD FOR PRODUCING MIXED CRYSTAL OF DISODIUM 5'−GUANYLATE AND DISODIUM 5'−INOSINATE

Title:

METHOD FOR PRODUCING MIXED CRYSTAL OF DISODIUM 5'−GUANYLATE AND DISODIUM 5'−INOSINATE

Document Type and Number:

WIPO Patent Application WO/2003/011886

Kind Code:

A1

Abstract:

A method for producing a mixed crystal of disodium 5'−guanylate and disodium 5'−inosinate (I&plus G mixed crystal), which comprises adding an aqueous mixed solution of disodium 5'−guanylate and disodium 5'−inosinate and a hydrophilic organic solvent simultaneously to a crystallization vessel while maintaining the proportion of the hydrophilic organic solvent in the liquid phase in the crystallization vessel at a level of 30 to 70 vol %, to thereby precipitate an I&plus G mixed crystal&semi and the method for producing an I&plus G mixed crystal, which further comprises adding a 5'−IMP2Na crystal and&sol or an I&plus G mixed crystal as a seed crystal. The method allows the suppression of the by−production of the amorphous solid of 5'−GMP2Na affecting adversely the separation of the crystal, which results in the production with high productivity of the mixed crystal with almost no amorphous solid which exhibits good separation.

Inventors:

KANEKO TOYOKAZU (JP)
YONOU YASUO (JP)
HIRANO NAOTO (JP)
ABE SHIGEMITSU (JP)
TOUMORI KUNIHIKO (JP)

Application Number:

PCT/JP2002/007345

Publication Date:

February 13, 2003

Filing Date:

July 19, 2002

Export Citation:

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Assignee:

AJINOMOTO KK (JP)
KANEKO TOYOKAZU (JP)
YONOU YASUO (JP)
HIRANO NAOTO (JP)
ABE SHIGEMITSU (JP)
TOUMORI KUNIHIKO (JP)

International Classes:

A23L27/10; C07H1/00; C07H19/20; (IPC1-7): C07H19/20

Foreign References:

JPS4012914B1	1965-06-23
JPS4716783B1	1972-05-17
JPS50160295A	1975-12-25
JPH03223299A	1991-10-02
JPS4615668B1

Other References: