Title:
A METHOD FOR PRODUCING MODIFIED RESVERATROL
Document Type and Number:
WIPO Patent Application WO/2015/028324
Kind Code:
A3
Abstract:
Methods for producing glycosylated and methylated resveratrol in a genetically engineered cell, by bioconversion,and in vitro are disclosed herein.
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Inventors:
BAERENDS RICHARD JAN STEVEN (CH)
SIMON ERNESTO (DK)
MEYER JEAN PHILIPPE (CH)
VAZQUEZ CARLOS CASADO (CH)
SIMON ERNESTO (DK)
MEYER JEAN PHILIPPE (CH)
VAZQUEZ CARLOS CASADO (CH)
Application Number:
PCT/EP2014/067520
Publication Date:
April 23, 2015
Filing Date:
August 15, 2014
Export Citation:
Assignee:
EVOLVA SA (CH)
International Classes:
C12N9/10; C12N1/18; C12P7/22; C12P7/62
Domestic Patent References:
| WO2007034190A2 | 2007-03-29 |
Foreign References:
| EP1510586A1 | 2005-03-02 |
Other References:
SHIN-ICHI OZAKI ET AL: "Regioselective glucosidation of-resveratrol inexpressing glucosyltransferase from Phytolacca americana", BIOTECHNOLOGY LETTERS, SPRINGER NETHERLANDS, DORDRECHT, vol. 34, no. 3, 3 November 2011 (2011-11-03), pages 475 - 481, XP035011935, ISSN: 1573-6776, DOI: 10.1007/S10529-011-0784-4
HANSEN E H ET AL: "Substrate specificities of family 1 UGTs gained by domain swapping", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 70, no. 4, 1 March 2009 (2009-03-01), pages 473 - 482, XP026029323, ISSN: 0031-9422, [retrieved on 20090302], DOI: 10.1016/J.PHYTOCHEM.2009.01.013
WANG ET AL: "Structure, mechanism and engineering of plant natural product glycosyltransferases", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 583, no. 20, 20 October 2009 (2009-10-20), pages 3303 - 3309, XP026693927, ISSN: 0014-5793, [retrieved on 20090929], DOI: 10.1016/J.FEBSLET.2009.09.042
MORA-PALE MAURICIO ET AL: "Metabolic engineering and in vitro biosynthesis of phytochemicals and non-natural analogues", PLANT SCIENCE, vol. 210, 17 May 2013 (2013-05-17), pages 10 - 24, XP028675614, ISSN: 0168-9452, DOI: 10.1016/J.PLANTSCI.2013.05.005
YOHEI KATSUYAMA ET AL: "Precursor-directed biosynthesis of stilbene methyl ethers in Escherichia coli", BIOTECHNOLOGY JOURNAL, vol. 2, no. 10, 1 October 2007 (2007-10-01), pages 1286 - 1293, XP055169806, ISSN: 1860-6768, DOI: 10.1002/biot.200700098
HORINOUCHI ET AL: "Combinatorial biosynthesis of plant medicinal polyketides by microorganisms", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 13, no. 2, 1 April 2009 (2009-04-01), pages 197 - 204, XP026087409, ISSN: 1367-5931, [retrieved on 20090304], DOI: 10.1016/J.CBPA.2009.02.004
L. SCHMIDLIN ET AL: "A Stress-Inducible Resveratrol O-Methyltransferase Involved in the Biosynthesis of Pterostilbene in Grapevine", PLANT PHYSIOLOGY, vol. 148, no. 3, 1 November 2008 (2008-11-01), pages 1630 - 1639, XP055169897, ISSN: 0032-0889, DOI: 10.1104/pp.108.126003
TRANTAS E ET AL: "Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces cerevisiae", METABOLIC ENGINEERING, ACADEMIC PRESS, US, vol. 11, no. 6, 1 November 2009 (2009-11-01), pages 355 - 366, XP026736584, ISSN: 1096-7176, [retrieved on 20090722], DOI: 10.1016/J.YMBEN.2009.07.004
See also references of EP 3039132A2
HANSEN E H ET AL: "Substrate specificities of family 1 UGTs gained by domain swapping", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 70, no. 4, 1 March 2009 (2009-03-01), pages 473 - 482, XP026029323, ISSN: 0031-9422, [retrieved on 20090302], DOI: 10.1016/J.PHYTOCHEM.2009.01.013
WANG ET AL: "Structure, mechanism and engineering of plant natural product glycosyltransferases", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 583, no. 20, 20 October 2009 (2009-10-20), pages 3303 - 3309, XP026693927, ISSN: 0014-5793, [retrieved on 20090929], DOI: 10.1016/J.FEBSLET.2009.09.042
MORA-PALE MAURICIO ET AL: "Metabolic engineering and in vitro biosynthesis of phytochemicals and non-natural analogues", PLANT SCIENCE, vol. 210, 17 May 2013 (2013-05-17), pages 10 - 24, XP028675614, ISSN: 0168-9452, DOI: 10.1016/J.PLANTSCI.2013.05.005
YOHEI KATSUYAMA ET AL: "Precursor-directed biosynthesis of stilbene methyl ethers in Escherichia coli", BIOTECHNOLOGY JOURNAL, vol. 2, no. 10, 1 October 2007 (2007-10-01), pages 1286 - 1293, XP055169806, ISSN: 1860-6768, DOI: 10.1002/biot.200700098
HORINOUCHI ET AL: "Combinatorial biosynthesis of plant medicinal polyketides by microorganisms", CURRENT OPINION IN CHEMICAL BIOLOGY, CURRENT BIOLOGY LTD, LONDON, GB, vol. 13, no. 2, 1 April 2009 (2009-04-01), pages 197 - 204, XP026087409, ISSN: 1367-5931, [retrieved on 20090304], DOI: 10.1016/J.CBPA.2009.02.004
L. SCHMIDLIN ET AL: "A Stress-Inducible Resveratrol O-Methyltransferase Involved in the Biosynthesis of Pterostilbene in Grapevine", PLANT PHYSIOLOGY, vol. 148, no. 3, 1 November 2008 (2008-11-01), pages 1630 - 1639, XP055169897, ISSN: 0032-0889, DOI: 10.1104/pp.108.126003
TRANTAS E ET AL: "Metabolic engineering of the complete pathway leading to heterologous biosynthesis of various flavonoids and stilbenoids in Saccharomyces cerevisiae", METABOLIC ENGINEERING, ACADEMIC PRESS, US, vol. 11, no. 6, 1 November 2009 (2009-11-01), pages 355 - 366, XP026736584, ISSN: 1096-7176, [retrieved on 20090722], DOI: 10.1016/J.YMBEN.2009.07.004
See also references of EP 3039132A2
Attorney, Agent or Firm:
SMAGGASGALE, Gillian, Helen (London WC2B 5SQ, GB)
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