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Title:
METHOD FOR PRODUCING N-(3,5-DICHLOROPYRID-4-YL)-N-METHYL-3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXYBENZAMIDE
Document Type and Number:
WIPO Patent Application WO/2018/003867
Kind Code:
A1
Abstract:
The present invention provides a method for producing a compound represented by formula (I), which comprises a step for obtaining a compound represented by formula (I) by reacting a compound represented by formula (II) and an alkali metal salt represented by formula (III) with each other. (In the formulae, X represents a halogen atom or a C1-4 alkyl carbonyloxy group; and M represents an alkali metal ion.)

Inventors:
TAKADA YASUNORI (JP)
AMANO SATOSHI (JP)
ATARASHI KENJI (JP)
YASUKOCHI TAKASHI (JP)
SONOBE ATSUSHI (JP)
Application Number:
PCT/JP2017/023772
Publication Date:
January 04, 2018
Filing Date:
June 28, 2017
Export Citation:
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Assignee:
HISAMITSU PHARMACEUTICAL CO (JP)
International Classes:
C07D213/75; A61K31/44; A61P11/00; A61P11/02; A61P17/00; A61P27/02; A61P29/00; A61P37/02; A61P37/08
Domestic Patent References:
WO2016063906A12016-04-28
Foreign References:
JP2006519818A2006-08-31
CN103497150A2014-01-08
Other References:
XIANG, Z-J. ET AL.: "Synthesis and polymorphic study of roflumilast N-oxide", JOURNAL OF CHINA PHARMACEUTICAL UNIVERSITY, vol. 43, no. 6, 2012, pages 492 - 496
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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