Title:
METHOD FOR PRODUCING N-SUBSTITUTED AMINO ACID RESIDUE-CONTAINING CYCLIC PEPTIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2024/080333
Kind Code:
A1
Abstract:
The present inventors found that a target cyclic peptide compound can be efficiently produced while preventing epimerization and reducing multimer formation, by linking the N-terminal amino acid residue with the C-terminal amino acid residue of a peptide compound, in which at least one of the N-terminal and C-terminal amino acid residues is a cyclic amino acid residue, in a solvent containing one or more selected from the group consisting of acetonitrile, dimethyl carbonate, 2-MeTHF and anisole.
Inventors:
HOSHINO YUKI (JP)
SERIZAWA HIROKI (JP)
NOGI KEISUKE (JP)
MATSUDA MASAAKI (JP)
TAMURA MIHO (JP)
SERIZAWA HIROKI (JP)
NOGI KEISUKE (JP)
MATSUDA MASAAKI (JP)
TAMURA MIHO (JP)
Application Number:
PCT/JP2023/037071
Publication Date:
April 18, 2024
Filing Date:
October 12, 2023
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07K7/64; C07K1/02
Domestic Patent References:
| WO2022138598A1 | 2022-06-30 | |||
| WO2022138891A1 | 2022-06-30 | |||
| WO2021090855A1 | 2021-05-14 | |||
| WO2021090856A1 | 2021-05-14 | |||
| WO2018225851A1 | 2018-12-13 |
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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