Title:
METHOD FOR PRODUCING N4-BENZOYLCYTIDINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2005/021571
Kind Code:
A1
Abstract:
Disclosed is a method for producing a compound represented by the general formula (5) below wherein a compound represented by the general formula (1) below or a salt thereof is reacted with a dimethoxytrityl halide for isolating a compound represented by the general formula (3) below, and then the isolated compound represented by the general formula (3) below is reacted with a benzoic anhydride or a benzoic acid halide in an organic solvent.
Inventors:
UMETANI HIDEKI (JP)
TSUCHIYA KATSUTOSHI (JP)
TAKAHASHI KIYOSHI (JP)
TSUCHIYA KATSUTOSHI (JP)
TAKAHASHI KIYOSHI (JP)
Application Number:
PCT/JP2004/012161
Publication Date:
March 10, 2005
Filing Date:
August 25, 2004
Export Citation:
Assignee:
MITSUI CHEMICALS INC (JP)
UMETANI HIDEKI (JP)
TSUCHIYA KATSUTOSHI (JP)
TAKAHASHI KIYOSHI (JP)
UMETANI HIDEKI (JP)
TSUCHIYA KATSUTOSHI (JP)
TAKAHASHI KIYOSHI (JP)
International Classes:
C07H19/073; (IPC1-7): C07H19/073
Foreign References:
| JPH01308294A | 1989-12-12 | |||
| JP2000510446A | 2000-08-15 | |||
| JP2000264897A | 2000-09-26 |
Other References:
MARASCO C.J. ET AL.: "A convenient method for the direct incorporation of 5-fluoro-2'-deoxycytidine into oligodeoxynucleotides", J. ORG. CHEM., vol. 57, 1992, pages 6363 - 6365, XP002983307
GAFFNEY G.S. ET AL.: "Trensient protection: efficient one-flask syntheses of protected deoxynucleosides", J. AM. CHEM. SOC., vol. 104, 1982, pages 1316 - 1319, XP002136167
SEELA F.ET AL.: "Phosphoramidites and oligonucleotides contaning 7-deazapurines and pyrimidines carrying aminopropargyl side chains", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 20, 2001, pages 1421 - 1424, XP002983308
GAFFNEY G.S. ET AL.: "Trensient protection: efficient one-flask syntheses of protected deoxynucleosides", J. AM. CHEM. SOC., vol. 104, 1982, pages 1316 - 1319, XP002136167
SEELA F.ET AL.: "Phosphoramidites and oligonucleotides contaning 7-deazapurines and pyrimidines carrying aminopropargyl side chains", NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS, vol. 20, 2001, pages 1421 - 1424, XP002983308
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