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Title:
METHOD FOR PRODUCING NERVE CELLS FROM HUMAN NEURAL STEM CELLS BY DIFFERENTIATION INDUCTION TREATMENT, REAGENT FOR INDUCING DIFFERENTIATION OF NERVE CELLS, AND NERVE CELL DIFFERENTIATION INDUCTION KIT
Document Type and Number:
WIPO Patent Application WO/2019/009205
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a method for promoting the neural differentiation of neural stem cells. A method for producing nerve cells from human neural stem cells by a differentiation induction treatment, the method including a step of carrying out a differentiation induction treatment of human neural stem cells using a FAD-containing culture medium for nerve cell differentiation induction use.

Inventors:
HIRANO KAZUMI (JP)
NAMIHIRA MASAKAZU (JP)
Application Number:
PCT/JP2018/024843
Publication Date:
January 10, 2019
Filing Date:
June 29, 2018
Export Citation:
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Assignee:
AIST (JP)
International Classes:
C12N5/0793; C12M3/00; C12N5/0797; C12N5/10
Other References:
HIRANO K. ET AL.: "LSD1 Mediates Neuronal Differentiation of Human Fetal Neural Stem Cells by Controlling the Expression of a Novel Target Gene", HEYL, STEM CELLS, vol. 34, no. 7, July 2016 (2016-07-01), pages 1872 - 1882, XP055677486
ZIBETTI C. ET AL.: "Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system", J. NEUROSCI., vol. 30, no. 7, 17 February 2010 (2010-02-17), pages 2521 - 2532, XP055677487
OST A. ET AL.: "Epigenetic modulation of metabolic decisions", CURR. OPIN. CELL BIOL., vol. 33, April 2015 (2015-04-01), pages 88 - 94, XP055677498
SUN G. ET AL.: "Histone demethylase LSD1 regulates neural stem cell proliferation", MOL. CELL . BIOL., vol. 30, no. 8, April 2010 (2010-04-01), pages 1997 - 2005, XP055326195, DOI: 10.1128/MCB.01116-09
HIRANO K. ET AL.: "FAD influx enhances neuronal differentiation of human neural stem cells by facilitating nuclear localization of LSD1", FEBS OPEN BIO, vol. 7, no. 12, 17 October 2017 (2017-10-17), pages 1932 - 1942, XP055677505
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