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Title:
METHOD FOR PRODUCING NOBILETIN-CONTAINING SOLID DISPERSION
Document Type and Number:
WIPO Patent Application WO/2018/025871
Kind Code:
A1
Abstract:
Provided are: a nobiletin composition having excellent solubility in water; and a method for producing the nobiletin composition in a simple manner. A method for producing a nobiletin-containing solid dispersion, comprising the steps of: mixing nobiletin or a nobiletin-containing substance with a water-soluble hesperidin derivative and then melting the resultant mixture by heating; and cooling the molten product thus melted to solidify the molten product. A nobiletin-containing composition produced by the method.

Inventors:
IWASHITA, Masazumi (2606 Akabane, Ichikai-machi, Haga-gu, Tochigi 97, 〒3213497, JP)
UMEHARA, Masahiro (1-3Bunka 2-chome, Sumida-k, Tokyo 01, 〒1318501, JP)
ONISHI, Shintaro (2606 Akabane, Ichikai-machi, Haga-gu, Tochigi 97, 〒3213497, JP)
YAMAMOTO, Masaki (2606 Akabane, Ichikai-machi, Haga-gu, Tochigi 97, 〒3213497, JP)
YAMAGAMI, Keisuke (20 Higashi-fukashiba, Kamisu-sh, Ibaraki 03, 〒3140103, JP)
ISHIGAMI, Takaaki (20 Higashi-fukashiba, Kamisu-sh, Ibaraki 03, 〒3140103, JP)
Application Number:
JP2017/027923
Publication Date:
February 08, 2018
Filing Date:
August 01, 2017
Export Citation:
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Assignee:
KAO CORPORATION (14-10, Nihonbashi Kayabacho 1-chome Chuo-k, Tokyo 10, 〒1038210, JP)
International Classes:
A61K31/352; A23L33/10; A61K47/22; A61P3/00; A61P25/00; A61P25/28; A61P43/00
Domestic Patent References:
2016-03-03
Foreign References:
JP2014125461A2014-07-07
Other References:
ONOUE, S ET AL.: "Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability", J PHARM SCI., vol. 100, no. 9, 2011, pages 3793 - 3801, XP055462040
ONOUE S ET AL.: "Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects", EUR J PHARM SCI., vol. 49, no. 4, 2013, pages 453 - 460, XP028676551
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (Sawanotsuru Ningyocho Bldg, 1-3-8 Nihonbashi Ningyocho, Chuo-k, Tokyo 13, 〒1030013, JP)
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