Title:
METHOD FOR PRODUCING NONHUMAN ANIMAL
Document Type and Number:
WIPO Patent Application WO/2019/151331
Kind Code:
A1
Abstract:
The present invention pertains to a method for producing a nonhuman animal that lacks a target cell due to target cell death caused by administrating a stimulant to a nonhuman animal in which a cell death-inducing molecule that induces cell death in the presence of the stimulant is expressed in the target cell. The nonhuman animal includes (i) a recombinase Cre gene incorporated in only one of a pair of homologous chromosomes such that the expression thereof is controlled by the promoter of a first gene that is expressed in the target cell, and (ii) a gene encoding two loxP sequences and the cell death-inducing molecule incorporated in only one of a pair of homologous chromosomes such that, only in the presence of recombinase Cre, the cell death-inducing molecule is expressed under the control of the promoter of a second gene that is expressed in the target cell.
Inventors:
SAWA SHINICHIRO (JP)
Application Number:
PCT/JP2019/003185
Publication Date:
August 08, 2019
Filing Date:
January 30, 2019
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A01K67/027; C12N15/09
Domestic Patent References:
| WO2018003450A1 | 2018-01-04 | |||
| WO2018003451A1 | 2018-01-04 | |||
| WO2018003452A1 | 2018-01-04 |
Other References:
SAWA, SHINICHIRO: "Generation of RORgt+ Innate lymphpid cell deficient mouse", RESEARCH PERFORMANCE REPORT ON GRANTS-IN-AID FOR SCIENTIFIC RESEARCH, 2 September 2016 (2016-09-02), XP055628458, Retrieved from the Internet [retrieved on 20190412]
RAHIM, MIR MUNIR A. ET AL.: "The mouse NKR-PlB:Clr-b recognition system is a negative regulator of innate immune responses", BLOOD, vol. 125, no. 14, 2015, pages 2217 - 2227, XP055628461
MAGRI, GIULIANA ET AL.: "Copycat innate lymphoid cells dampen gut inflammation", CELL RESEARCH, vol. 25, no. 9, 2015, pages 991 - 992, XP055628463
SEYDEL, F. ET AL.: "GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic(NOD) mouse myeloid cells", JOURNAL OF AUTOIMMUNITY, vol. 31, 2008, pages 377 - 384, XP025693670
RAHIM, MIR MUNIR A. ET AL.: "The mouse NKR-PlB:Clr-b recognition system is a negative regulator of innate immune responses", BLOOD, vol. 125, no. 14, 2015, pages 2217 - 2227, XP055628461
MAGRI, GIULIANA ET AL.: "Copycat innate lymphoid cells dampen gut inflammation", CELL RESEARCH, vol. 25, no. 9, 2015, pages 991 - 992, XP055628463
SEYDEL, F. ET AL.: "GM-CSF induces STAT5 binding at epigenetic regulatory sites within the Csf2 promoter of non-obese diabetic(NOD) mouse myeloid cells", JOURNAL OF AUTOIMMUNITY, vol. 31, 2008, pages 377 - 384, XP025693670
Attorney, Agent or Firm:
NISHIZAWA Kazuyoshi et al. (JP)
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