Title:
METHOD FOR PRODUCING OLIGONUCLEOTIDE
Document Type and Number:
WIPO Patent Application WO/2017/086397
Kind Code:
A1
Abstract:
Provided is a novel method for producing an oligonucleotide using a nucleoside or oligonucleotide that is easy to isolate and has high storage stability. A method for producing an oligonucleotide including a step for carrying out H-phosphonation of the 5'-hydroxy group or 3'-hydroxy group of a nucleoside or oligonucleotide that has a pseudo-solid-phase protecting group at at least one location selected from the group consisting of the 2' position, the 3' position, the 5' position, and nucleobase moieties, and that has a hydroxy group at the 5' position or the 3' position.
Inventors:
SUGAWARA YUDAI (JP)
Application Number:
PCT/JP2016/084150
Publication Date:
May 26, 2017
Filing Date:
November 17, 2016
Export Citation:
Assignee:
NISSAN CHEMICAL IND LTD (JP)
International Classes:
C07H21/04; C07H19/10; C07H19/20
Domestic Patent References:
WO2014077292A1 | 2014-05-22 | |||
WO2012157723A1 | 2012-11-22 | |||
WO2013122236A1 | 2013-08-22 | |||
WO2005028494A1 | 2005-03-31 |
Foreign References:
JPS60174797A | 1985-09-09 | |||
JP2010275254A | 2010-12-09 |
Other References:
BAKER, B. R. ET AL.: "Irreversible enzyme inhibitors. 195. Inhibitors of thymidine kinase from Walker 256 carcinoma derived from thymidine 5'-acetate", JOURNAL OF MEDICINAL CHEMISTRY, vol. 15, no. 9, 1972, pages 940 - 944, XP002025085, ISSN: 0022-2623
GOPALAKRISHNAN, B. ET AL.: "A Virtual Screening Approach for Thymidine Monophosphate Kinase Inhibitors as Antitubercular Agents Based on Docking and Pharmacophore Models", JOURNAL OF CHEMICAL INFORMATION AND MODELING, vol. 45, no. 4, 2005, pages 1101 - 1108, XP002443827, ISSN: 1549-9596
See also references of EP 3378869A4
GOPALAKRISHNAN, B. ET AL.: "A Virtual Screening Approach for Thymidine Monophosphate Kinase Inhibitors as Antitubercular Agents Based on Docking and Pharmacophore Models", JOURNAL OF CHEMICAL INFORMATION AND MODELING, vol. 45, no. 4, 2005, pages 1101 - 1108, XP002443827, ISSN: 1549-9596
See also references of EP 3378869A4
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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