Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE 1-BROMO-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL] ETHANE
Document Type and Number:
WIPO Patent Application WO/2012/011516
Kind Code:
A1
Abstract:
Disclosed is a method that is for producing 1-bromo-1-[3,5-bis(trifluoromethyl)phenyl] ethane having high optical purity, and that is a method containing a step for brominating optically active 1-[3,5-bis(trifluoromethyl)phenyl] ethanol using, as a brominating agent, either a) the combination of a phosphorus halide and hydrogen bromide, b) the combination of 1,2-dibromo-1,1,2,2-tetrachloroethane and the organophosphorus compound represented by general formula I, which is P(R1)(R2)(R3) (in the formula: R1, R2 and R3 each independently indicate a C6-10 aryl group, a C6-10 aryloxy group, a C1-10 alkyl group, a C1-10 alkoxyl group, a C3-6 cycloalkyl group, or a C3-6 cycloalkoxyl group), or c) the combination of N-bromosuccinimide and a dialkyl sulphide.
Inventors:
KUSAKABE TAICHI (JP)
MATSUDA KENNOSUKE (JP)
YAMAZAKI KOICHI (JP)
OHGIYA TADAAKI (JP)
SHIBUYA KIMIYUKI (JP)
MATSUDA KENNOSUKE (JP)
YAMAZAKI KOICHI (JP)
OHGIYA TADAAKI (JP)
SHIBUYA KIMIYUKI (JP)
Application Number:
PCT/JP2011/066512
Publication Date:
January 26, 2012
Filing Date:
July 21, 2011
Export Citation:
Assignee:
KOWA CO (JP)
KUSAKABE TAICHI (JP)
MATSUDA KENNOSUKE (JP)
YAMAZAKI KOICHI (JP)
OHGIYA TADAAKI (JP)
SHIBUYA KIMIYUKI (JP)
KUSAKABE TAICHI (JP)
MATSUDA KENNOSUKE (JP)
YAMAZAKI KOICHI (JP)
OHGIYA TADAAKI (JP)
SHIBUYA KIMIYUKI (JP)
International Classes:
C07C17/16; C07C22/08; C07B53/00
Domestic Patent References:
WO2009062371A1 | 2009-05-22 | |||
WO2008129951A1 | 2008-10-30 | |||
WO2007044829A2 | 2007-04-19 |
Foreign References:
JP2010077116A | 2010-04-08 | |||
JP3938651B2 | 2007-06-27 |
Other References:
J. AM. CHEM. SOC., vol. 125, 2003, pages 2129 - 2135
J. ORG. CHEM., vol. 71, 2006, pages 7378 - 7390
TETRAHEDRON LETT., vol. 48, 2007, pages 8001 - 8004
J. ORG. CHEM., vol. 26, 1961, pages 3645 - 3649
INDIAN J. CHEM., SEC B, vol. 44B, 2005, pages 557 - 562
SYNTHESIS COMMUN., 1983, pages 139 - 141
TETRAHEDRON LETT., vol. 42, 1972, pages 4339 - 4342
"Guide Book of Japanese Pharmacopoeia", 1996, HIROKAWA PUBLISHING CO.
See also references of EP 2597079A4
J. ORG. CHEM., vol. 71, 2006, pages 7378 - 7390
TETRAHEDRON LETT., vol. 48, 2007, pages 8001 - 8004
J. ORG. CHEM., vol. 26, 1961, pages 3645 - 3649
INDIAN J. CHEM., SEC B, vol. 44B, 2005, pages 557 - 562
SYNTHESIS COMMUN., 1983, pages 139 - 141
TETRAHEDRON LETT., vol. 42, 1972, pages 4339 - 4342
"Guide Book of Japanese Pharmacopoeia", 1996, HIROKAWA PUBLISHING CO.
See also references of EP 2597079A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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Claims:
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