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Patent Searching and Data


Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/154738
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel method for producing an optically active amine compound that is useful as an intermediate for a medicine, an agrochemical, an electronic material and the like. A method for producing an optically active amine compound without requiring a step of introducing a protecting group for an amino group or a deprotection step, said method using an enamine compound represented by formula (4) which is substituted by a C1-C3 perfluoroalkyl group such as a trifluoromethyl group as a starting raw material, and comprising reacting the enamine compound with a hydrogen gas in an alcohol solvent in the presence of an optically active ruthenium complex catalyst.

Inventors:
KONDO Shoichi (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
KURIHARA Kazunori (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
NISHIMURA Takuya (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
YAMAMOTO Akio (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
UNI Miyuki (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
TAKAHASHI Keiji (Ltd. Chemical Research Laboratories 10-1, Tsuboi-Nishi 2-chome, Funabashi-sh, Chiba 07, 〒2748507, JP)
Application Number:
JP2017/008333
Publication Date:
September 14, 2017
Filing Date:
March 02, 2017
Export Citation:
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Assignee:
NISSAN CHEMICAL INDUSTRIES, LTD. (7-1 Kanda-Nishiki-cho 3-chome, Chiyoda-ku Tokyo, 54, 〒1010054, JP)
International Classes:
C07C227/32; C07C229/20; B01J31/24; C07B53/00; C07B61/00
Foreign References:
JP2004075684A2004-03-11
JP2012162484A2012-08-30
Other References:
YASUHIRO ISHIDA ET AL.: "A practical method to access enantiopure beta-perfluoroalkyl-beta-amino acids: diastereoselective reduction of cyclic enamino-esters", TETRAHEDRON LETTERS, vol. 50, no. 17, 2009, pages 1889 - 1892, XP025972732
WENBIAO CEN ET AL.: "A convenient synthesis of perfluoroalkylated enamines and vinyl phosphonates", JOURNAL OF FLUORINE CHEMISTRY, vol. 73, no. 2, 1995, pages 161 - 164, XP004020532
FLORENT HUGUENOT ET AL.: "Convenient Asymmetric Synthesis of beta-Trifluoromethyl-beta-amino Acid, beta- Amino Ketones, and γ-Amino Alcohols via Reformatsky and Mannich-Type Reactions from 2- Trifluoromethyl-1,3-oxazolidines", JOURNAL OF ORGANIC CHEMISTRY, vol. 71, no. 5, 2006, pages 2159 - 2162
Attorney, Agent or Firm:
SENMYO Kenji et al. (4th Floor, SIA Kanda Square 17, Kanda-konyacho, Chiyoda-k, Tokyo 35, 〒1010035, JP)
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