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Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2011/004778
Kind Code:
A1
Abstract:
Disclosed is a method for producing a compound represented by formula (3) or a salt thereof, comprising a step of reacting an optical isomer mixture of a compound represented by formula (1) with optically active mandelic acid in a solvent, thereby depositing a salt of an optically active compound with optically active mandelic acid represented by formula (2), a step of obtaining the deposited salt, and a step of treating the obtained salt with an acid or a base. According to the production method, a compound useful as a synthetic intermediate for a pharmaceutical preparation can be produced. In formulae, R represents an alkyl group having 1 to 4 carbon atoms or a benzyl group, and * represents a chiral center.

Inventors:
MATSUI, Kozo (1-10-11, Seiwadai Kita-ku, Kobe-sh, Hyogo 21, 〒6511121, JP)
松井浩三 (〒21 兵庫県神戸市北区星和台1-10-11 Hyogo, 〒6511121, JP)
Application Number:
JP2010/061358
Publication Date:
January 13, 2011
Filing Date:
June 28, 2010
Export Citation:
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Assignee:
SUMITOMO CHEMICAL COMPANY, LIMITED (27-1, Shinkawa 2-chome Chuo-k, Tokyo 60, 〒1048260, JP)
住友化学株式会社 (〒60 東京都中央区新川二丁目27番1号 Tokyo, 〒1048260, JP)
MATSUI, Kozo (1-10-11, Seiwadai Kita-ku, Kobe-sh, Hyogo 21, 〒6511121, JP)
International Classes:
C07D211/56; C07B57/00
Domestic Patent References:
WO2008028654A1
WO2009001730A1
WO2007063903A1
WO2008114819A1
Other References:
BREUER M ET AL.: 'Industrielle Verfahren zur Herstellung von optisch aktiven Zwischenprodukten' ANGEWANDTE CHEMIE vol. 116, 2004, pages 806 - 843
Attorney, Agent or Firm:
NAKAYAMA, Tohru et al. (Limited 5-33, Kitahama 4-chome, Chuo-ku, Osaka-sh, Osaka 50, 〒5418550, JP)
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