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Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE DIAMINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2010/104106
Kind Code:
A1
Abstract:
Disclosed is a method for industrially producing compound (1) and compound (4) to provide an important intermediate for producing an FXa inhibitor. Specifically disclosed is a production method characterized by comprising: a first step of adding a quaternary ammonium salt and a metal azide salt to water to give an aqueous solution of an azide reagent complex comprising the quaternary ammonium salt- the metal azide salt, and then dehydrating said aqueous solution using an aromatic hydrocarbon-based solvent to thereby give a liquid mixture of the azide reagent complex comprising the quaternary ammonium salt-the metal azide salt with the aromatic hydrocarbon-based solvent having a moisture content less than or equal to 0.2%; and a second step of adding compound (2) (wherein L represents a leaving group) to the liquid mixture prepared in the aforesaid first step.

Inventors:
KAWANAMI, Koutarou (())
Application Number:
JP2010/053976
Publication Date:
September 16, 2010
Filing Date:
March 10, 2010
Export Citation:
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Assignee:
DAIICHI SANKYO COMPANY,LIMITED (3-5-1, Nihonbashi HonchoChuo-k, Tokyo 26, 〒1038426, JP)
第一三共株式会社 (〒26 東京都中央区日本橋本町三丁目5番1号 Tokyo, 〒1038426, JP)
International Classes:
C07C269/06; C07C269/08; C07C271/24; C07D513/04; C07B53/00; C07B55/00; C07B61/00
Domestic Patent References:
WO2007032498A12007-03-22
WO2007032498A12007-03-22
WO2004058715A12004-07-15
WO2003016302A12003-02-27
WO2003000680A12003-01-03
Foreign References:
JPH04227629A1992-08-17
JP2000344735A2000-12-12
JPH11180899A1999-07-06
Other References:
See also references of EP 2407450A4
Attorney, Agent or Firm:
ISHIBASHI Koki et al. (LIMITED 1-16-13,Kitakasai, Edogawa-k, Tokyo 81, 〒1340081, JP)
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