Title:
METHOD OF PRODUCING OPTICALLY ACTIVE N-(HALOPROPYL)AMINO ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2009/016879
Kind Code:
A1
Abstract:
It is intended to provide a process for producing an optically active N-(halopropyl)amino
acid derivative. This method comprises: the step wherein an optically active
alanine ester represented by the formula (I) or its salt (hereinafter sometimes
referred to simply as “alanine ester”) is reacted with a halogenated
propane represented by the formula (II) to give a compound represented by the
formula (III):and the step wherein a protective group is introduced into the
nitrogen atom in the compound represented by the formula (III) as described above
to thereby give an optically active N-(halopropyl)amino acid derivative represented
by the formula (IV). It is intended to provide a method of effectively producing
an optically active N-(halopropyl)amino acid derivative.
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Inventors:
MATSUMOTO JUN (JP)
INOUE TORU (JP)
INOUE TORU (JP)
Application Number:
PCT/JP2008/059603
Publication Date:
February 05, 2009
Filing Date:
May 19, 2008
Export Citation:
Assignee:
NAGASE & CO LTD (JP)
MATSUMOTO JUN (JP)
INOUE TORU (JP)
MATSUMOTO JUN (JP)
INOUE TORU (JP)
International Classes:
C07C231/02; C07C227/14; C07C227/30; C07C229/12; C07C233/83; C07C269/04; C07C271/22; C07B53/00
Foreign References:
| JP2005082572A | 2005-03-31 | |||
| JP2005082572A | 2005-03-31 |
Other References:
JOURNAL OF ORGANIC CHEMISTRY, vol. 55, no. 10, 1990, pages 3068 - 3074, XP008130514
JOURNAL OF ORGANIC CHEMISTRY, vol. 51, no. 20, 1986, pages 3882 - 3890, XP008130498
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 1, no. 9, 1991, pages 441 - 444, XP026679526
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 125, no. 43, 2003, pages 13012 - 13013, XP008130469
T. KAWABATA ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 125, 2003, pages 13012 - 13013
O. V. BYKHOVSKAYA ET AL., RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION, vol. 54, November 2005 (2005-11-01), pages 2642 - 2647
See also references of EP 2192110A4
JOURNAL OF ORGANIC CHEMISTRY, vol. 51, no. 20, 1986, pages 3882 - 3890, XP008130498
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 1, no. 9, 1991, pages 441 - 444, XP026679526
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 125, no. 43, 2003, pages 13012 - 13013, XP008130469
T. KAWABATA ET AL., JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 125, 2003, pages 13012 - 13013
O. V. BYKHOVSKAYA ET AL., RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION, vol. 54, November 2005 (2005-11-01), pages 2642 - 2647
See also references of EP 2192110A4
Attorney, Agent or Firm:
NANJO, Hiromichi (Okina Bldg.2-9, Nishitenma 3-chome,Kita-ku, Osaka-sh, Osaka 47, JP)
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