Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE SUCCINIMIDE DERIVATIVE AND INTERMEDIATE THEREOF
Document Type and Number:
WIPO Patent Application WO/2010/090031
Kind Code:
A1
Abstract:
Disclosed is a method for producing an optically active succinimide derivative which is a key intermediate of (3R)-2'-(4-bromo-2-fluorobenzyl)spiro[pyrrolidine-3,4'(1'H)-pyrrolo[1,2-a]pyrazine]-1',2,3',5(2'H)-tetraone. The method for producing an optically active succinimide derivative comprises the following reaction steps.
Inventors:
KASAI MASAJI (JP)
KITA SHINJI (JP)
OGAWA TADASHI (JP)
TOKAI HIDEAKI (JP)
KITA SHINJI (JP)
OGAWA TADASHI (JP)
TOKAI HIDEAKI (JP)
Application Number:
PCT/JP2010/000695
Publication Date:
August 12, 2010
Filing Date:
February 05, 2010
Export Citation:
Assignee:
DAINIPPON SUMITOMO PHARMA CO (JP)
KYOWA HAKKO BIO CO LTD (JP)
KASAI MASAJI (JP)
KITA SHINJI (JP)
OGAWA TADASHI (JP)
TOKAI HIDEAKI (JP)
KYOWA HAKKO BIO CO LTD (JP)
KASAI MASAJI (JP)
KITA SHINJI (JP)
OGAWA TADASHI (JP)
TOKAI HIDEAKI (JP)
International Classes:
C12P17/10; C07C227/16; C07C229/24; C07C231/02; C07C237/04; C07C269/06; C07C271/22; C12P7/62
Domestic Patent References:
| WO2008035735A1 | 2008-03-27 | |||
| WO2008035735A1 | 2008-03-27 |
Foreign References:
| JPH06192222A | 1994-07-12 | |||
| JPH10245369A | 1998-09-14 | |||
| JPH05186472A | 1993-07-27 | |||
| JPH06192222A | 1994-07-12 |
Other References:
NAKAYAMA Y. ET AL.: "New serine protease inhibitors with leukotriene B4 (LTB4) receptor binding affinity", BIOORG. MED. CHEM., vol. 5, no. 5, May 1997 (1997-05-01), pages 971 - 985, XP001181712
CONDE SANTIAGO ET AL.: "Regioselective Lipase-Catalysed Amidation of N-Blocked L- and D-Aspartic Acid Diesters", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2002, no. 5, 12 February 2002 (2002-02-12), pages 922 - 929
TETRAHEDRON LETTERS, vol. 39, no. 31, 1998, pages 5571 - 5574
TETRAHEDRON LETT., vol. 41, no. 26, 2000
JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, 1998, pages 4118 - 4129
T.W GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
CONDE SANTIAGO ET AL.: "Regioselective Lipase-Catalysed Amidation of N-Blocked L- and D-Aspartic Acid Diesters", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2002, no. 5, 12 February 2002 (2002-02-12), pages 922 - 929
TETRAHEDRON LETTERS, vol. 39, no. 31, 1998, pages 5571 - 5574
TETRAHEDRON LETT., vol. 41, no. 26, 2000
JOURNAL OF MEDICINAL CHEMISTRY, vol. 41, 1998, pages 4118 - 4129
T.W GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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