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Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE VALERIC ACID DERIVATIVES USING OPTICAL RESOLUTION BY ENZYME
Document Type and Number:
WIPO Patent Application WO/2017/155025
Kind Code:
A1
Abstract:
Provided is a method for producing compound (1) or (6) by optical resolution using a specific hydrolase. (In the formula, R represents a protecting group of a carboxy group, R1 and R2 each independently represent a hydrogen atom or a protecting group of an amino group.)

Inventors:
UEDA, Tsuyoshi (LIMITED 3-5-1,Nihonbashi Honcho,Chuo-k, Tokyo 26, 〒1038426, JP)
Application Number:
JP2017/009447
Publication Date:
September 14, 2017
Filing Date:
March 09, 2017
Export Citation:
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Assignee:
DAIICHI SANKYO COMPANY,LIMITED (3-5-1, Nihonbashi HonchoChuo-k, Tokyo 26, 〒1038426, JP)
International Classes:
C12P41/00; C07D233/64; C12P17/10; C07B57/00; C07B61/00
Domestic Patent References:
WO2011115064A12011-09-22
WO2012063252A22012-05-18
Foreign References:
JP2009520492A2009-05-28
JP2007512016A2007-05-17
JP2006510364A2006-03-30
JP2006075032A2006-03-23
JP2007117034A2007-05-17
JP2007516971A2007-06-28
Other References:
B UTCHER, K. J. ET AL.: "Convergent asymmetric synthesis of two complex TRPV1 antagonists", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 15, 2011, pages 1192 - 1200, XP055422008
YATAGAI, M. ET AL.: "Synthesis of optically active a-methyl amino acids using biotransformation as a key step", ACS SYMPOSIUM SERIES, vol. 1009, 2009, pages 394 - 406, XP055422012
Attorney, Agent or Firm:
ISHIBASHI, Koki et al. (LIMITED 1-2-58, Hiromach, Shinagawa-ku Tokyo 05, 〒1400005, JP)
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