Title:
METHOD FOR PRODUCING P1,P4-DI(URIDINE 5'-)TETRAPHOSPHATE
Document Type and Number:
WIPO Patent Application WO/2014/103704
Kind Code:
A1
Abstract:
A method for producing P1,P4-di(uridine 5'-)tetraphosphate (UP4U) is developed, which does not require the use of free UTP and does not undergo the decrease in synthesis efficiency.
A method for producing UP4U, characterized by reacting a phosphoric-acid-activating compound represented by formula [II] or [III] with a phosphoric acid compound selected from the group consisting of UMP, UDP, UTP and pyrophosphoric acid or a salt thereof (excluding free UTP) in water or a hydrophilic organic solvent in the presence of a metal ion selected from the group consisting of an iron (II) ion, an iron (III) ion, a trivalent aluminum ion, a trivalent lanthanum ion and a trivalent cerium ion.
(Each of R1, X and n in formula [II] and X in formula [III] is as defined in claim 1.)
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Inventors:
YAMADA KOHEI (JP)
Application Number:
PCT/JP2013/083100
Publication Date:
July 03, 2014
Filing Date:
December 10, 2013
Export Citation:
Assignee:
YAMASA CORP (JP)
International Classes:
C07H19/10; A61K31/7072; A61K31/7105; A61P11/00; A61P11/10; C07B61/00
Domestic Patent References:
| WO2008012949A1 | 2008-01-31 | |||
| WO2008012949A1 | 2008-01-31 | |||
| WO2008024169A1 | 2008-02-28 |
Other References:
SHIMAZU, MASAMITSU ET AL.: "Facile synthesis of nucleotides containing polyphosphates by manganese(II) and cadmium(II) ion-catalyzed pyrophosphate bond formation in aqueous solution", TETRAHEDRON LETTERS, vol. 31, no. 2, 1990, pages 235 - 238, XP002636622
HUANG, KAISHENG ET AL.: "Engineering Human Fhit, a Diadenosine Triphosphate Hydrolase, into an Efficient Dinucleoside Polyphosphate Synthase", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 31, 2004, pages 9548 - 9549, XP055261676
BIOORG. & MEDICINAL CHEMISTRY LETTERS, vol. 11, 2001, pages 157 - 160
ORG. BIOMOL. CHEM., vol. 2011, no. 9, 2011, pages 730 - 738
NUCLEIC ACIDS RESEARCH, vol. 4, 1977, pages 2843
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 126, 2004, pages 9548
See also references of EP 2940030A4
HUANG, KAISHENG ET AL.: "Engineering Human Fhit, a Diadenosine Triphosphate Hydrolase, into an Efficient Dinucleoside Polyphosphate Synthase", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, no. 31, 2004, pages 9548 - 9549, XP055261676
BIOORG. & MEDICINAL CHEMISTRY LETTERS, vol. 11, 2001, pages 157 - 160
ORG. BIOMOL. CHEM., vol. 2011, no. 9, 2011, pages 730 - 738
NUCLEIC ACIDS RESEARCH, vol. 4, 1977, pages 2843
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 126, 2004, pages 9548
See also references of EP 2940030A4
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
Patent business corporation Alga patent firm (JP)
Patent business corporation Alga patent firm (JP)
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