Title:
METHOD FOR PRODUCING PHENOXYETHANOL DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2017/159669
Kind Code:
A1
Abstract:
Provided is a method for producing a phenoxyethanol derivative. This method for producing a compound represented by formula (II) is characterized in that a compound represented by formula (I) (in the formula, R1 is a substituted or unsubstituted alkyl) is reduced in the presence of lithium borohydride.
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Inventors:
TOYAMA TAKAYUKI (JP)
MIYAKE NAOKI (JP)
MIYAKE NAOKI (JP)
Application Number:
PCT/JP2017/010159
Publication Date:
September 21, 2017
Filing Date:
March 14, 2017
Export Citation:
Assignee:
SHIONOGI & CO (JP)
International Classes:
C07C41/26; A61K31/085; A61P43/00; C07C43/23
Domestic Patent References:
| WO2012089606A1 | 2012-07-05 | |||
| WO2012089607A1 | 2012-07-05 | |||
| WO2016043189A1 | 2016-03-24 | |||
| WO2016110805A1 | 2016-07-14 | |||
| WO2008099059A1 | 2008-08-21 | |||
| WO2011089385A1 | 2011-07-28 | |||
| WO2014060640A1 | 2014-04-24 | |||
| WO2014060639A1 | 2014-04-24 |
Foreign References:
| JPH08511793A | 1996-12-10 | |||
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| JP2010518150A | 2010-05-27 | |||
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Other References:
BONACCINI, C. ET AL.: "Synthesis, Biological Evaluation and Docking Studies of Casuarine Analogues: Effects of Structural Modifications at Ring B on Inhibitory Activity Towards Glucoamylase", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2010, no. 29, 2010, pages 5574 - 5585, XP055601639, ISSN: 1434-193X, DOI: 10.1002/ejoc.201000632
MAYER,S.C. ET AL.: "Discovery of Begacestat, a Nothch-1-Sparing y -Secretase Inhibitor for the Treatment of Alzheimer' s Disease", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 23, 2008, pages 7348 - 7351, XP002587471, DOI: doi:10.1021/JM801252W
DREW, M. G.B . ET AL.: "Synthesis of disaccarides countaining a-linked GlcNAc or beta -linked ManNAc units", TETRAHEDRON, vol. 57, no. 37, 2001, pages 7919 - 7937, XP004304435
GIANNIS, A. ET AL.: "LiBH4 (NaBH4) /Me3SiCl, an Unusually Strong and Versatile Reducing Agent", ANGEWANDTE CHEMIE INTERNATIONAL EDITION IN ENGLISH, vol. 28, no. 2, 1989, pages 218 - 220, XP002787884
See also references of EP 3415491A4
MAYER,S.C. ET AL.: "Discovery of Begacestat, a Nothch-1-Sparing y -Secretase Inhibitor for the Treatment of Alzheimer' s Disease", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 23, 2008, pages 7348 - 7351, XP002587471, DOI: doi:10.1021/JM801252W
DREW, M. G.B . ET AL.: "Synthesis of disaccarides countaining a-linked GlcNAc or beta -linked ManNAc units", TETRAHEDRON, vol. 57, no. 37, 2001, pages 7919 - 7937, XP004304435
GIANNIS, A. ET AL.: "LiBH4 (NaBH4) /Me3SiCl, an Unusually Strong and Versatile Reducing Agent", ANGEWANDTE CHEMIE INTERNATIONAL EDITION IN ENGLISH, vol. 28, no. 2, 1989, pages 218 - 220, XP002787884
See also references of EP 3415491A4
Attorney, Agent or Firm:
YAMAUCHI, Hideaki et al. (JP)
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