Title:
METHOD FOR PRODUCING PLANT BENZYLISOQUINOLINE ALKALOID
Document Type and Number:
WIPO Patent Application WO/2012/039438
Kind Code:
A1
Abstract:
A method for synthesizing (s)-reticulin being important as a junction intermediate in biosynthetic pathway of benzylisoquinoline alkaloid by culturing the transgenic microbes expressing the enzyme necessary for the biosynthesis.
Inventors:
NAKAGAWA AKIRA (JP)
MINAMI HIROMICHI (JP)
KATAYAMA TAKANE (JP)
KUMAGAI HIDEHIKO (JP)
MINAMI HIROMICHI (JP)
KATAYAMA TAKANE (JP)
KUMAGAI HIDEHIKO (JP)
Application Number:
PCT/JP2011/071520
Publication Date:
March 29, 2012
Filing Date:
September 21, 2011
Export Citation:
Assignee:
ISHIKAWA PREFECTURAL PUBLIC UNIVERSITY CORP (JP)
NAKAGAWA AKIRA (JP)
MINAMI HIROMICHI (JP)
KATAYAMA TAKANE (JP)
KUMAGAI HIDEHIKO (JP)
NAKAGAWA AKIRA (JP)
MINAMI HIROMICHI (JP)
KATAYAMA TAKANE (JP)
KUMAGAI HIDEHIKO (JP)
International Classes:
C12P17/12; C12N1/21; C12N15/09
Domestic Patent References:
| WO2008153094A1 | 2008-12-18 | |||
| WO2006091676A2 | 2006-08-31 |
Other References:
HIROMICHI MINAMI ET AL.: "Biseibutsu ni yoru Koto Shokubutsu Alkaloid no Seisan", KAGAKU TO SEIBUTSU, vol. 47, 2009, pages 528 - 530
LOEFFLER, S. ET AL.: "The hydroxylation step in the biosynthetic pathway leading from norcoclaurine to reticuline.", PHYTOCHEMISTRY, vol. 29, 1990, pages 3499 - 3503, XP026615890, DOI: doi:10.1016/0031-9422(90)85264-G
FACCHINI, P.J. ET AL.: "Differential and tissue- specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy.", J BIOL CHEM., vol. 269, 1994, pages 26684 - 26690
LUTKE-EVERSLOH, T. ET AL.: "L-tyrosine production by deregulated strains of Escherichia coli.", APPL MICROBIOL BIOTECHNOL., vol. 75, 2007, pages 103 - 110, XP019513622, DOI: doi:10.1007/s00253-006-0792-9
KEGG PATHWAY, TYROSINE METABOLISM-ESCHERICHIA COLI K-12 MG1655
LOEFFLER, S. ET AL.: "The hydroxylation step in the biosynthetic pathway leading from norcoclaurine to reticuline.", PHYTOCHEMISTRY, vol. 29, 1990, pages 3499 - 3503, XP026615890, DOI: doi:10.1016/0031-9422(90)85264-G
FACCHINI, P.J. ET AL.: "Differential and tissue- specific expression of a gene family for tyrosine/dopa decarboxylase in opium poppy.", J BIOL CHEM., vol. 269, 1994, pages 26684 - 26690
LUTKE-EVERSLOH, T. ET AL.: "L-tyrosine production by deregulated strains of Escherichia coli.", APPL MICROBIOL BIOTECHNOL., vol. 75, 2007, pages 103 - 110, XP019513622, DOI: doi:10.1007/s00253-006-0792-9
KEGG PATHWAY, TYROSINE METABOLISM-ESCHERICHIA COLI K-12 MG1655
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (JP)
Mitsuo Tanaka (JP)
Mitsuo Tanaka (JP)
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